Das Problem Wahn spielt heute noch in den psychiatrischen Forschungsgebieten eine große Rolle. Nach der Beschreibung einer Krankengeschichte wurden die Nosologie und die Aufteilung der paranoischen Symptome sorgfältig berichtet und man betonte, daß sick zwischen der paranoiden Schizophrenie, Paraphrenie sowie der Paranoia emn wesentlicher Wirkungsunterschied des Energiepotentials bei den Betreffenden findet. Jedoch sind die Untersuchung des Wahns und ihre Interpretation nicht nur den Gegenstand der Psychiatrie im engeren Sinne, weil die Wahnerscheinung auch in den sozio-kulturellen Sphäre, die man z.B. in der Katastrophenzeit während des Kriegs und in der Panik erleben kann, auftauchen sollte. In übrigens wurde das klinische Kriterium des Wahns sorgfältig geschrieben. Weildiese Begriffsbestimmung aber zu viel gebraucht worden ist, mußten wir hier das moderne Konzept K. Conrads vorstellen. Bei ihm liegt das Wesen der Wahnkranken darin, daß die“Kopernikanische Wende ”gar nicht vollziehen kann. (Autoreferat)

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Male rabbits receiving single intravenous doses of leucine exhibit increase in the amounts of factors VII and IX and in prothrombin activity among the various coagulation factors in the circulating blood. The effects are due to mobilization, by the amino acid, of these factors which have already been formed. The results of the study herein described also seem to suggest that prothrombin is not merely a circulating precursor of thrombin but acts as an accelerator of thromboplastin formation.

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Thirty juvenile dogs were used for experimental study. Abdominal cavity pressure was experimentally increased with the criterion of peripheral venous pressure. To study the influence of increase in abdominal pressure on respiratory and circulatory disturbances, analysis of aspired gas and blood gas, determinations of the values of lactic acid and pyruvic acid in the peripheral blood and calculation of excess lactate were carried out.
The following results were obtained.
1. When abdominal pressure was increased by 3 times as much as initial value (low pressure group), the metabolic conditions tended to be improved with the lapse of time. On the other hand, when abdominal pressure was increased 5-6 times as much as initial value ( high pressure group), the metabolic conditions were aggravated into irreversible conditions with the lapse of time.
2. Fluctuations in metabolic conditions induced by increasing abdominal pressure were principally characterized with metabolic acidosis due to an increase in lactic acid. In the low pressure group respiration was compensated by hyperventilation and metabolic acidosis occurred slightly, and the same phenomenon was shown during first 60 minutes in the high pressure group.
3. After 90 minutes, the high pressure group showed hyperventilation replaced by hypoventilation with elevation of PaCO₂, which indicated the disappearance of compensatory function for respiration and transition of metabolic acidosis to respiratory metabolic acidosis combined with respiratory acidosis.
4. Immediately after an increase of high abdominal compression, a remarkable increase in lactic acid and excess lactate was observed. The finding might be considered the appearance of tissue hypoxia and acceleration of anaerobic metabolism.
5. It was considered that some correlation existed among pH, lactic acid and excess lactate, and also between PaO₂ and excess lactate.
The experiment showed that an appropriate operation method for the infantile hernia should be selected according to the degree of abdominal cavity pressure with a criterion of the peripheral venous pressure. It is considered more important, to grasp the changes of metabolic conditions by determining the values of lactic acid and excess lactate, together with the analysis of pH value of blood and the analysis of blood gas through out the post operative course.

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The author studied upon the Adenocarcinoma (Ad. Ca) and Carcinoma Solidum Simplex (Ca. SS) of the stomach in comparison of forty-three carcinomas of the cardia with fifteen usual carcinomas of the stomach which were proved intramural esophageal invasion. The purpose of the study is to grasp the histological patterns of the intramural esophageal extension of carcinoma of the stomach, the oral distance of the invasion of carcinoma, the oral resection line and the correlation between the histological view and the site of origin.
Results were as follows:
(1) The 96.2 % had a histologic diagnosis of the Ad. Ca as differentiated carcinoma and the only 3.8 % had the Ca. SS as undifferentiated carcinoma, among those tumors the center were within 3cm from the Esophago Cardiac Junction (ECJ) and also the size within 40 cm².
(2) The submucosa and the propria mucosa of the esophagus were mostly invaded by the stomach cancer. The place of origin, the types of Borrmann the histological patterns and the changes of the esophageal mucosa did not associated with the patterns of the intramural esophageal invasion of the stomach cancer.
(3) The oral distance of the esophageal invasion of the stomach cancer was very much correlated with the types of Borrmann, the histological patterns, the shape of the oral edge of carcinoma and the changes in the mucosa of esophagus, but was not correlated with the size of the tumor.
(4) The resection line of esophagus from ECJ during operation demands about 45 mm for the crcinoma of the cardiac portion and about 30 mm for the usual stomach cancer, the former satisfies 97.8 % of ow (-) and the latter 93.3 %.
(5) In case of the carcinoma (in case of the usual carcinoma, the center of which occupies under cardia), about 25 mm (20 mm) of the oral resection line of the esophagus is necessary for Borrmann 1 and 2, about 35 mm (20 mm) for Borrmann 3, and about 45 mm (30 mm) for Borrmann 4.
(6) From the view point of histological pattern, there still leave much room for consideration. Namely, the resection line is decided about 20 mm (20 mm) for Ad. Ca. Pap, about 30 mm (30 mm) for Ad. Ca. tub. SS were needed.
(7) According to the oral edge of tumor, about 25 mm (25 mm) for the type of A and N, and about 45 mm (30 mm) for the type of P and U were needed.
(8) Concerning the changes of the esophageal mucosa which covers the tumor, about 15 mm (25 mm) for the hypertrophy about 25 mm (15 mm) for the unchanged, and about 45 mm (30 mm) for the atrophy were needed.

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The investigation on correlation among blood flow, histological pattern and capillary quantity was carried out in the breast carcinoma.
The blood flow of tumor was calculated by a half time (Tl/2) examined by ¹³³Xe clearance curve and following formula.
B. F. (ml/100 g/min) =100×λ×log_e2/T1/2
The angiography was performed on the resected breast tissue. The resected breast tissue was made into slices of 2-4 mm thick after fixation and microangiography was taken.
As a results, 1) significant difference was observed in blood flow between scirrhous carcinoma and others but not observed between medullary tubular carcinoma and papillary tubular carcinoma.2) Capillary quantity was poorer in scirrhous carcinoma than in medullary tubular carcinoma as well as in papillary tubular carcinoma.
Blood flow and capillary quantity were different according to histological pattern in the breast carcinoma but seemed to be related each other.

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The thickness of the hypodermic fatty layer was measured on 74 subjects aged between 40 and 80 who have motor impediments resulting from apoplectic strokes. The measurements were taken from 36 different points of the body and the results were compared with those taken from healthy persons of a similar age, as well as patients of leprosy, lung tuberculosis and in the course of high calorie alimentation.
The thickness of the hypodermic fatty layer of the apoplectic patients was greater on the trunk and the proximal part of the extremities, and smaller on the distal parts of the extremities. And the disparity in thickness between the thicker parts and the thinner parts was larger than that of the forgoing comparable subjects. The thickness of the hypodermic fatty layer on the apoplectic patients did not vary statistically according to sex. On the other subjects, however, it was always thicker in the female.
Comparing the thickness of the hypodermic fatty layer on the ill and healthy sides of hemiplegia patients, it was slightly greater on the ill side than on the healthy in the upper extremities and the extensor part of lower extremities.

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Experiment were carried out bared on the consideration that ceruloplasmin was closely connected with synthesis of hemoglobin and deposit iron was mobilized by presence of ceruloplasmin.
Fe⁵⁹ incorporation into peripheral erythrocytes was investigated in the hungry rats injected with ceruloplasmin, folic acid and coenzym form of folic acid which was active type in the living body.
The results obtained were as follows.
1) The ceruloplasmin did not induce acceleration of Fe⁵⁹ incorporation rate into peripheral erythrocytes.
But the combined use of ceruloplasmin and tetrahydro folic acid or N⁵-methyl THFA induced acceleration of its rate.
2) Ceruloplasmin was decomposed with 1 % trypsin into several polypeptide which had one hundred thousands, fifty thousands and less than ten thousands molecular weight respectively.
The polypeptide of fifty thousands molecular weight induced promotion of rate of Fe⁵⁹ uptake.
3) The human rerum resulted in appearance of accelerating substance of Fe⁵⁹ incorporation into erythrocytes when incubated with light mitochondria isolated from kidney extracts of rats under exposition to hypoxic condition.
The ceruloplasmin solution treated with the light mitochondria also induced acceleration of Fe⁵⁹incorporation into erythrocytes.
4) The erythrocuprein did not induce promotion of Fe⁵⁹ uptake.

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A rapid spectrophotometric determination of methemoglobin was made using the blood saturated with carbon monoxide. The concentration of blood methemoglobin was caluculated from a ratio between the density of carboxyhemoglobin at maximum absorption and that of carboxyhemoglobin and acid methemoglobin at isobestic point. This method was compared with the other two methods, i.e. Zijlstra and Muller's (Z-M) and Hasegawa's method, in which methemoglobin was determined in two components system involved oxyhemoglobin and methemoglobin. Constants of calibration at 0 % and 100 % of methemoglobin were 1.77±0.03 and 0.46±0.02 in this method, whereas, constants of 1.22±0.03 and 0.59±0.04, 4.68±0.40 and 1.15±0.03 were obtained at 0 % and 100 % point by Z-M and Hasegawa's, method respectively. The mean concentration of methemoglobin determined in the identical blood specimens by this method, Z-M and Hasegawa's method were 0.28±0.43 %, 0.38±0.98 % and 0.97±0.85 % respectively. Coefficient of variation caluculated from constants of calibration or contents of methemoglobin, which were determined by this method, was smaller than those of other two methods and this method was proved to have high accuracy. Using this method the blood methemoglobin concentration of 124 specimens from the inhabitants of Hinohara village, Nishitamagun, Tokyo metropolitan area was measured and mean value of 0.4±0.6 % was obtained. This mean value was lower than that of 3.0±3.2 % obtained fromi the patients in the Hospital of Showa University.

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In der Nervenklinik Showa konnten wir einigen seltenen Nervenleiden im engeren Sinne in der letzten Jahren beobachten, die man dann als die Okulomotoriusparese in Folge des Aneurysmas, die multiple Ausfäle kaudaler Hirnnerven (das Garcin-Syndrom), den Zoster ophthalmicus, die traumatische einseitige Hypoglossuslähmung mit der Akzessoriusparese, die Myasthenia gravis pseudoparalytica sowie das jaw-winking phenomenon (das Marcus Gunnsche Symptom) diagnostizieren kann. Und war der Fall von oben gewähnter Hypoglossusparese auch auf die traumatische Radialislähmung links zusammentreffen.
Nach der genauen Beschreibung des Zustandsbildes und der Therapie haben wir betont die Füle der Fortbildung der Kenntnisseh Nervenleidens behauptet. (Autoreferat)

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A case of large bone cyst of scapula neck and fumerus head with pathological fracture in 34 yaers old man were reported, who were treated with bone cement (Simplex), and had satisfactory result.

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A 22-year-old woman was admitted on August 19, 1971, with a history of paresthesia in the legs and disturbance of gait. During the admittion, neurological examinations showed paraparesis, hyperreflexia with positive Babinski sign. There was sensory disturbance below the level of L₃. A lumbar puncture revealed normal dynamics, a total protein of 60 mg/dl, , and no cells. Myelography and selective angiography of the spinal arteries revealed very typical picture of the “worm-like” mass of vessels at the 10 th to 12 th dorsal level, which was confirmed by surgical observation. The abnormal vessels were removed by microsurgery. After the operation, there was improvement in the gait and urinary incontinence.

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