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Volume 72 (2012)
- Issue 6 Pages 615-
- Issue 5 Pages 531-
- Issue 4 Pages 393-
- Issue 3 Pages 291-
- Issue 2 Pages 145-
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Volume 72, Issue 5
Displaying 1-6 of 6 articles from this issue
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Invited Review
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[in Japanese]2012 Volume 72 Issue 5 Pages 531-538
Published: 2012
Released on J-STAGE: June 07, 2013
JOURNAL FREE ACCESSDownload PDF (892K)
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Toshitaka OKABE, Myong Hwa YAMAMOTO, Kennosuke YAMASHITA, Seitaro EBAR ...2012 Volume 72 Issue 5 Pages 539-546
Published: 2012
Released on J-STAGE: June 07, 2013
JOURNAL FREE ACCESSBackground: A low blood ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA ratio) is a known risk factor for ischemic heart disease, however, little is known aboutthe short-term variation of the EPA/AA ratio. Objective: To investigate possible short-term variation of the EPA/AA ratio in patients with stable angina. Methods: The subjects were 38 patients who had stable angina and at least one lesion with 75% stenosis that required revascularization based on coronary angiography findings. The EPA/AA ratio was determined at 3 time points: 1) on admission to hospital for the first percutaneous coronary intervention (PCI)(on admission EPA/AA ratio), 2) during fasting before breakfast on the day of PCI (day of PCI EPA/AA ratio), and 3) during fasting on the day after PCI (day after PCI EPA/AA ratio). Results: The mean age of the subjects was 68.7 ± 9.7 years, 73.7% were men, 73.7% had hypertension, 71.1% had dyslipidemia, and 31.6% had diabetes mellitus. On admission the EPA/AA ratio, ratio on the day of PCI, and fasting ratio on the day after PCI were 0.47 ± 0.34, 0.46 ± 0.34, and 0.44 ± 0.34, respectively. The differences between these three values were significant (P < 0.01). Conclusion: The EPA/AA ratio may show short-term variation. Therefore, to obtain accurate evaluation of this ratio as a risk factor for ischemic heart disease, it may be important to standardize the timing of blood collection.View full abstractDownload PDF (504K) -
Tomoaki MORI, Hidenori KANAI, Masako TERASAKI, Tetsuya MONDEN, Toshika ...2012 Volume 72 Issue 5 Pages 547-552
Published: 2012
Released on J-STAGE: June 07, 2013
JOURNAL FREE ACCESSBackground: Recently, attention has been drawn to tonsillectomy and steroid pulse therapy in IgA nephropathy patients. IgA nephropathy and tonsil appear to be related in some way. Further, there are some reports that the tonsils of IgA nephropathy patients show characteristics similar to chronic tonsillitis. Methods: Here, 49 patients diagnosed with IgA nephropathy by renal biopsy underwent tonsillectomy in Fujigaoka Hospital from 2007 to 2008. We analyzed the pathological findings of the tonsils with IgA nephropathy. Results: In our study, characteristic findings of tonsils with IgA nephropathy were found in over half of the cases based on all five factors. However, the relationship between these features of tonsils and the cause of IgA nephropathy could not be clarified. Therefore, further study on tonsils of IgA nephropathy patients is necessary.View full abstractDownload PDF (733K) -
Hirofumi IIZUKA2012 Volume 72 Issue 5 Pages 553-559
Published: 2012
Released on J-STAGE: June 07, 2013
JOURNAL FREE ACCESSVisco-elasticity is a rheological parameter which describes blood flow properties of the vasculature. Visco-elasticity of small caliber prosthesis is considered to be an important factor for long-term patency. However, the relationship between visco-elasticity and prosthesis caliber has not been clarified. In our study, the cross-section area and internal pressure of expanded polytetrafluoroethylene (ePTFE) grafts were measured by laser sensor and pressure catheter. Distensibility was calculated from the cross-section area and internal pressure. Viscocity was calculated from the hysteresis loop (cross-section area and pressure relationship) and internal pressure. Both data were measured at orifice and transmission distance at 10cm, 20cm and 30cm. Two types (5mm and 10mm caliber) of ePTFE grafts were examined. Measurements were performed under mean internal pressure hold at 100mmHg. Distensibility of 10mm ePTFE graft at orifice and transmission distance of 10mm, 20mm, 30mm were 9.1 × 10-5mmHg-1, 5.6 × 10-5mmHg-1, 4.0 × 10-5mmHg-1 and 3.5 × 10-5mmHg-1. Distensibility of 5mm ePTFE graft were 2.8 × 10-5mmHg-1, 2.6 × 10-5mmHg-1, 1.9 × 10-5mmHg-1 and 1.1 × 10-5mmHg-1, respectively. Viscosity of 10mm ePTFE graft at orifice and transmission distance of 30mm were 2.6mmHg and 0.81mmHg and those of 5mm ePTFE graft were 0.49mmHg and 0.26mmHg, respectively. Pulse wave velocity of both ePTFE grafts was measured from 20 to 40 m/s using a laser sensor. Improvement of the visco-elasticity should be considered for the long-term patency of small caliber prostheses.View full abstractDownload PDF (1284K) -
Kenji HARADA, Koji SAITO, Kodai HIRABAYASHI, Yuto MURAKAMI, Keita YAMA ...2012 Volume 72 Issue 5 Pages 560-566
Published: 2012
Released on J-STAGE: June 07, 2013
JOURNAL FREE ACCESSAseptic necrosis of the femoral head is caused by a circulatory disorder in the feeding artery. This report investigates the morphological abnormality in the vessel that causes the disorder. We studied 28 hip joints of 21 males and 7 females (avg. age 47 years; range 27 to 66) that had been resected during total hip arthroplasty. Of the 28, 6 hips were Stage 3A, 16 Stage 3B, and 6 Stage 4. We investigated four areas: the band lesion, the distal-lateral part close to the band lesion, the proximal-lateral part close to the band lesion, and the normal part of each femoral head. The vessel number was greater in the band lesion and the distal-lateral part than in the normal part and the proximal-lateral part. This fact confirms that the ingression of reparative vessels occurs at the lateral part in the head following osteonecrosis. The diameter of the vessels in the band lesion and in the distal-lateral part was significantly less in Stage 4 than in Stage 3. This result indicates that the load stress delays the reparative vessel ingression compared to the interstitial fibrosis during the delay.View full abstractDownload PDF (645K) -
Satomi ISHIHARA, Mayumi HOMMA, Yosuke SASAKI, Eisuke SHIOZAWA, Tomoko ...2012 Volume 72 Issue 5 Pages 567-573
Published: 2012
Released on J-STAGE: June 07, 2013
JOURNAL FREE ACCESSFollicular lymphoma (FL) is a neoplasm composed of follicle center B-cells, which generally has at least a partial follicular pattern. FL is classified into grades 1, 2 and 3 based on the number of centroblasts in neoplastic follicles. The proliferation and progression of neoplastic cells are known to be closely related to abnormalities in various positive and negative cell-cycle regulators. Skp2 positively regulates the G1-S transition by promoting degradation of the cyclin-dependent kinase inhibitor p27. Recent evidence has indicated an oncogenic role of Skp2 in not only carcinogenesis but also lymphomagenesis. In this study, we performed immunohistochemical analysis of the cell cycle-associated proteins, Skp2, p27, and Ki-67, in 70 patients with FL, to evaluate the correlation between FL grade and the expression levels of these proteins. In all 70 patients, Skp2 expression was inversely correlated with p27 and positively correlated with Ki-67 expression. P27 expression was inversely correlated with Ki-67 expression. Higher grade FL was associated with a higher expression of Skp2 and Ki-67, while p27 was significantly more prevalent in lower grade FL. It was suggested that Skp2 is a valuable marker to predict proliferation of the neoplastic cells in FL. Analysis of Skp2 levels may also be a useful and objective approach for grading FL.View full abstractDownload PDF (632K)
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