Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
Volume 70, Issue 5
Displaying 1-7 of 7 articles from this issue
Final Lecture
Original
  • —Measurements Using CT Images—
    Yayoi ABE, Toshiaki HASUMI, Yoshiaki HOSAKA
    2010 Volume 70 Issue 5 Pages 391-398
    Published: October 28, 2010
    Released on J-STAGE: May 27, 2011
    JOURNAL FREE ACCESS
    Enophthalmos is a common result of orbital fractures and zygomatic fractures. Reconstruction of the orbita is very important, because enophthalmos leads to not only functional but also cosmetic problems. We have experienced cases in which the eyeball became recessed following an operation or trauma. Even when we performed an overcorrective reconstruction surgical procedure, several patients showed tardive enophthalmos. The purpose of this study was to investigate the changes in eyeball position after operation or trauma. We measured the degree of eyeball displacement in 16 patients by using computed tomographic data collected immediately after operation and at one year. In 12 patients, enophthalmos was progressed, and the average change was 1.38mm. We propose that the progression of enophthalmos was primarily caused by atrophy and cicatrisation of the soft tissue of the orbita. This change in the soft tissue is the result of traumatic hemorrhage, edema and the operative procedure. These findings suggest that we should perform an even more overcorrective reconstruction surgical procedure than in the past.
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  • Hirotsugu ARIIZUMI, Eisuke SHIOZAWA, Mayumi HOMMA, Toshiko YAMOCHI-ONI ...
    2010 Volume 70 Issue 5 Pages 399-411
    Published: October 28, 2010
    Released on J-STAGE: May 27, 2011
    JOURNAL FREE ACCESS
    We retrospectively studied the clinicopathological factors of patients with T- and NK-cell neoplasms (T/NK-N) based on the 4th edition of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues in Showa University Hospital. This study included 107 patients with T/NK-N, including 25 (23.4%) with peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS); 19 (17.8%) with adult T-cell leukemia/lymphoma (ATLL); 17 (15.9%) with extranodal NK/T cell lymphoma, nasal type (ENKTL); 10 (9.3%) with angioimmunoblastic T-cell lymphoma (AITL); 9 (8.4%) with primary cutaneous CD30 positive T-cell lymphoproliferative disorders (C-CD30 + LPD); 8 (7.5%) with T lymphoblastic leukemia/lymphoma (T-ALL/LBL); 8 (7.5%) with mycosis fungoides (MF); 4 (3.7%) with anaplastic large cell lymphoma, ALK negative (ALCL, ALK-); and 7 with others. Among all analyzable patients, the 5-year overall survival (OS) rate was 41% and the median duration of OS was 34.8 months. Patients with C-CD30 + LPD had significantly longer survival rates than those with ATLL and AITL. Patients with a level of serum-soluble interleukin-2 receptor (sIL-2R) 1300 U/mL at diagnosis had significantly lower survival rates (P = 0.02). With the exception of ATLL patients, high sIL-2R level at diagnosis was significantly associated with reduced survival (P = 0.02). sIL-2R levels at diagnosis were lower in patients with ENKTL, C-CD30 + LPD, ALCL, ALK-, MF, and T-ALL/LBL than in those with other subtypes. At diagnosis, serum iron levels below the normal range (male, 50 μg/dL; female, 35 μg/dL) and total iron-binding capacity < 250 μg/dL were significantly associated with reduced survival (P = 0.02). Our study suggests that high sIL-2R levels and iron restriction at diagnosis are poor prognostic factors. To date, there have been no reports on the correlation of iron restriction and T/NK-N. In order to establish a prognostic model including parameters of iron metabolism, a greater number of patients should be evaluated in larger clinical trials.
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  • —with Reference to Pulmonary Isolation Procedure with Catheter Ablation—
    Genyo OGAWA, Shin INOUE, Taka-aki MATSUYAMA, Mutsuki MAKINO, Hidekazu ...
    2010 Volume 70 Issue 5 Pages 412-417
    Published: October 28, 2010
    Released on J-STAGE: May 27, 2011
    JOURNAL FREE ACCESS
    To eliminate abnormal electrical activity in the posterior wall of the left atrium, extensive pulmonary vein isolation is performed to treat symptomatic, drug-refractory atrial fibrillation. In addition to clinical visual information, detailed anatomical knowledge of the left atrium is necessary to create an effective ablation line. We studied the dimensions and histological properties of the anatomical obstacles surrounding the pulmonary vein in human heart autopsy specimens. Specimens were obtained from 23 individuals (median age: 63 years); none showed a clinical history of tachyarrhythmia or major cardiac abnormalities. Distances between the following structures were measured: right superior pulmonary vein – fossa ovalis, right inferior pulmonary vein – fossa ovalis, fossa ovalis – mitral annulus, left superior pulmonary vein – left atrial appendage, left atrial appendage – mitral annulus, left inferior pulmonary vein – mitral annulus, and left superior pulmonary vein – left inferior pulmonary vein. Among the obstacles of the left atrium, the narrowest isthmus encircling the pulmonary vein was the ridge between the left superior pulmonary vein and left atrial appendage with a median width of 8.4 mm, minimum and maximum values varied as much as four fold. No correlation between the heart weight and distances between obstacles was found. A detailed understanding of the precise anatomy of the left atrium and its individual diversity seems helpful for the determination of the ablation line.
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Case Reports
  • Tetsuhiro GOTO, Tohru OHNAKA, YOSITAKE Osamu, Kentaro NAKAO
    2010 Volume 70 Issue 5 Pages 418-423
    Published: October 28, 2010
    Released on J-STAGE: May 27, 2011
    JOURNAL FREE ACCESS
    An 86-year-old woman visited our hospital with the chief complaint of vomiting. Upper gastrointestinal endoscopic examination showed the giant ulcer confinement tumor-type lesion in the greater curvature of the lower body and fornix in the stomach, and showed a he low elevated flat-type lesion in the lesser curvature of the middle body in the stomach. Histological examination by endoscopy revealed poorly-differentiated adenocarcinoma from the lesion of the lesser curvature of the middle body in the stomach. Samples from the greater curvature of the lower body and fornix in the stomach were assessed to be necrotic tissue. Endoscopic examination and pathological examination indicated multiple advanced gastric cancer and early gastric cancer. The patient underwent a total gastrectomy. The resected tumors were assessed to be type 0-I + IIc in the lesser curvature of the middle body and type 2 in the greater curvature of the lower body and fornix. Histological results indicated signet-ring cell carcinoma of type 0-IIa + IIc and malignant lymphoma of type 2. Although malignant lymphoma could not have been diagnosed before the operation, we encountered a very rare case of the coexistence of early adenocarcinoma and malignant lymphoma in the stomach.
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  • Toshie MATSUMIYA, Mitsumasa YODA, Gen ONO, Nobuyuki KAWATE, Masasumi M ...
    2010 Volume 70 Issue 5 Pages 424-429
    Published: October 28, 2010
    Released on J-STAGE: May 27, 2011
    JOURNAL FREE ACCESS
    Dermatomyositis (DM) is a rare inflammatory myopathy with characteristic skin manifestations and an increased incidence of internal malignancies. Some cases with DM are complicated with dysphagia leading to death caused by aspiration pneumonia. Primary fallopian tube carcinoma (FTC) is the least common site of origin for a malignant neoplasm of the female genital tract. Also, there are few reports describing cases of rehabilitation of DM with FTC. This report describes the first documented case of DM and concurrent FTC. Case: A 62-year-old woman presented with DM complicated with dysphagia; she was subsequently found to have FTC. During her rehabilitation for dysphagia and functional strength improvements, underlying FTC was a disturbing factor. Conclusion: The appopriate approach toward dysphagia as well as functional improvement, should be performed for patients of DM, particularly in the cases associated with malignancy.
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  • Eisuke SHIOZAWA, Toshiko YAMOCHI-ONIZUKA, Yusuke SARUTA, Yoshihiro UME ...
    2010 Volume 70 Issue 5 Pages 430-436
    Published: October 28, 2010
    Released on J-STAGE: May 27, 2011
    JOURNAL FREE ACCESS
    We report a 62-year-old man who was a human T-lymphotropic virus type 1 (HTLV-1) carrier with strongyloidiasis. He was born in Okinawa, Japan, an area endemic for both Strongyloides stercoralis and HTLV-1. On admission he presented with nausea and abdominal bloating and then he developed severe respiratory distress with septic shock. S.stercoralis rhabditiform larvae were found by sputum microscopy and then he was diagnosed as a disseminated strongyloidiasis with severe pulmonary strongyloidiasis. HTLV-1 carriers are at increased risk of developing severe strongyloidiasis.
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