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Volume 60 (2000)
- Issue 6 Pages 657-
- Issue 5 Pages 553-
- Issue 4 Pages 423-
- Issue 3 Pages 309-
- Issue 2 Pages 147-
- Issue 1 Pages 1-
Volume 60, Issue 6
Displaying 1-17 of 17 articles from this issue
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Takumi ABE, Kiyoshi MATSUMOTO, Dieter K. LUEDECKE2000 Volume 60 Issue 6 Pages 657-663
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTransnasal surgery has been performed in only a small number of cases of childhood craniopharyngiomas, and its efficacy is still a matter of debate. We analyzed the results of primary transnasal surgery in 9 children (4 boys and 5 girls) with infradiaphragmatic craniopharyngiomas under 15 years of age at surgery (7.7-14.9 yr) and who were treated between 1985 and 1996, when more refined surgical and diagnostic techniques were available. The transnasal approach was chosen because of sellar enlargement and the presence of an infradiaphragmatic tumor. The duration of the clinical follow-up period was at least 1 year. Five children required drilling of incompletely pneumatized sphenoid sinuses to reach the sella, but in no cases were the anatomic differences related to patient age or size thought to be a limiting factor in the transnasal procedure. The normal pituitary gland was incised to expose a dorsally located tumor in each of seven children (77.8%) . This surgical procedure has never provoked any major functional damage to the anterior pituitary gland. Complete tumor resection was achieved in three children and subtotal removal in six. Persistent diabetes insipidus occurred after total tumor resection in one child. Gamma knife was performed in one patient with tumor regrowth. Based on the present findings, transnasal surgery seemes to be indicated for most of inf radiaphragmatic craniopharyngiomas in children. The concept of subtotal tumor removal with preservation of pituitary function, avoiding damage to hypothalamic structures and excessive cerebrospinal fluid leakage, seems to be justified in children.View full abstractDownload PDF (2145K) -
Masahiko YAMAGUCHI, Yasuo YOSHIZAWA, Kaoru KUMADA, Yutaka SANADA, Hiro ...2000 Volume 60 Issue 6 Pages 664-669
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSObject: The significance of splenectomy was investigated in seven cases of splenectomy for splenomegaly due to lymphoid malignancy. Cases included one NK/T cell lymphoma, one hairy cell leukemia (HCL), two Hodgkin's diseases, and three non-Hodgkin lymphomas (NHL) . The NK/T cell lymphoma case died one month after splenectomy. The HCL case and one case of Hodgkin's disease localized in the spleen survived without chemotherapy for two and ten years after splenectomy, respectively. Another Hodgkin's disease case and one NHL patient died because of disease recurrence nine and eighteen postoperative months, respectively. Two other NHL cases survived with chemotherapy for ten and twenty-three postoperative months, respectively. Splenectomy not only improved bulk symptoms or cytopenias for splenomegaly, but it also cured HCL and lymphoid malignancy localized in the spleen. However, splenectomy could lead to operative death in severe cases. Therefore, it is concluded that splenectomy should be done in cases of splenomegaly due to lymphoid malignancy with information about histological diagnosis and future prognosis.View full abstractDownload PDF (689K) -
Kenji KATO, Takashi HATTORI, Yasuhiro FUNATSU, Yutaka ENDO, Naoyuki UR ...2000 Volume 60 Issue 6 Pages 670-676
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSUsing immunohistochemical staining, we have examined the expression of Matrix Metalloproteinase-9 (MMP-9), Sialyl LewisA (Sialyl Lea), and Laminin in 49 colorectal cancers and analyzed the correlation of clinicopathological factors and liver metastasis. The positive rate of MMP-9 was significantly high (77%) in cases with liver metastasis (p=0.025) . Sialyl Lea staining was 96% (47/49) positive in 49 cases. Stromal staining was 54% in cases of liver metastasis. Statistical analysis showed that the presence of a stromal staining pattern correlated with the development of venous invasion (p=0.017) . It was difficult to evaluate the liver metastasis and venous invasion by means of only Sialyl Lea staining because of the abundance of the quasipositive rate. Laminin was positive only in 15% of cases with liver metastasis. In this study, the presence of MMP-9 in cancerous tissues might be a good marker of liver metastasis..View full abstractDownload PDF (2674K) -
Sota Takasaki2000 Volume 60 Issue 6 Pages 677-686
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe antitumor effect of human interferon (INF-β) and mouse interferon on the growth of human melanoma cells (SK-14) transplanted in nude mice was examined. The cell growth in nude mice was supressed by a daily administration of IFN-β, depending on the dosage and administration route. The most marked effect was obtained by intra-tumoral injection of INF-β, and intra peritonial injection of IFN-β was unsuccessful. A lesser therapeuetic effect was achieved by intratumoral injection of mouse interferon, whitch led us to speculate that the antitumor effect of IFN-β might be explained by its anticellar activity rather than its immunomodulating effect. Pharmacokinetic studies of INF-β in nude mice indicated that a relatively high interferon titer in the tumor mass and lymph node was detected for a long time after intratumoral injection. On the other hand, the plasma, lung and liver levels of interferon were almost undetectable. Inhibition of nodal metastasis was also suggested. Clinical observations of fourteen cases of cutaneous and mucosal primary melanoma of the head and neck encountered during the past twenty years were reviewed.Two patients who underwent radical excision of a wide area survived for over 10 years. However, the specific anatomical structure of the head and neck make such treatment difficult. Three patients who underwent palliative reducing operations with chemotherapy, radiotherapy and immunotherapy died within three years. Seven cases were treated with interferon. In these cases, a complete response was observed in five cases treated with intrtumoral injection of interferon, and a partial response was observed in one patient who underwent intraarterial administration of interferon. The role of interferon in the treatment of melanoma in the head and neck are worthy of special mention.View full abstractDownload PDF (5779K) -
Makoto NONAKA, Mitsutaka KADOKURA, Daisuke KATAOKA, Shigeru YAMAMOTO, ...2000 Volume 60 Issue 6 Pages 687-691
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThoracic sympathectomy has proved successful in the treatment of palmar hyperhidrosis. To study the quality of life (QOL) after endoscopic thoracic sympathectomy (ETS) for primary palmar hyperhidrosis, patients who received bilateral ETS in Showa University Hospital were sent a questionnaire regarding long-term outcome, satisfaction, late complications, and side effects of treatment. Results were obtained from 15 patients. Symptomatic improvement was found in 93%. Compensatory hyperhidrosis was found in 93%. Improvement of the QOL was obtained in 80% of the patients. This therapeutic procedure is minimally invasive and very effective. Though there was a high incidence of compensatory hyperhidrosis, ETS improved both the symptoms and QOL in patients with primary palmar hyperhidrosis.View full abstractDownload PDF (581K) -
Masahiko YAMAGUCHI, Yasuo YOSHIZAWA, Gaku KIGAWA, Hiroshi MACHIDA, Hir ...2000 Volume 60 Issue 6 Pages 692-698
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSPerforation of the large bowel, rather than the upper gastrointestinal tract, is more likely to develop critical complications because of the delay of diagnosis and treatment. We studied 8 cases of non-traumatic large bowel perforation with leukopenia (<4000/μl) in comparison with 7 cases without leukopenia (>4000/μl) . Perforation was caused commonly by cancerous and idiopathic causes in cases with leucopenia, and by diverticulitis in cases without leukopenia. Cases with leukopenia showed significantly low levels of blood pressure and white blood cell counts before and after operation. They were likely to develop DIC after operation and treated with significantly intensive care. Mean age of subjects was 70 years old. Four cases developed septic shock and two cases, DIC preoperatively. Colostomy was made in most cases, except for one iatrogenic case which was treated by primary closure. Postoperatively, two cases recovered from septic shock but four cases experienced newly developed DIC. All cases were treated in intensive care units and hospitalized for a long period. Most cases recovered and were discharged, but one 79-year-old female case of idiopathic perforation with liver cirrhosis died 2 days after operation. In conclusion, large bowel perforation can easily develop into serious conditions because of the delay of diagnosis and treatment. It is important to perform early diagnosis and quick surgery to regain respiration and circulation stability with the treatment of sepsis and DIC.View full abstractDownload PDF (2449K) -
Hiroshi DOI, Munetaka HYAYSHI, Jiro KUWASAWA, Hiroaki MATSUMOTO, Kiyos ...2000 Volume 60 Issue 6 Pages 699-703
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTuberculous meningitis is rarely followed by the development of syringomyelia even after apparently successful chemotherapy. In the present paper, we report two cases with tuberculous meningitis who developed syringomyelia of a late onset. The two patients developed syringomyelia between 22 years and 23 years after the onset of tuberculous meningitis, respectively. One patient with syringobulbia who suffered long time without diagnosis of syringomyelia died three years after diagnosis from aspiration pneumonia. MRI of the patient showed the syrinx at the C1-2 and brainstem and the severe atrophy of the spinal cord below C3. MRI of the other patient demonstrated a large intramedullary cavity extending from T2 to L1. Syringoperitoneal shunt was performed. The operation was successful by neuroradiological criteria. Clinically the spastic gait and the sensory disturbance were improved and there was no recurrence one year after operation. Neuroradiological findings and etiology of the syrinx are discussed, and a causal relationship to tuberculous meningitis is proposed.View full abstractDownload PDF (3603K) -
2000 Volume 60 Issue 6 Pages 704
Published: 2000
Released on J-STAGE: September 09, 2010
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[in Japanese]2000 Volume 60 Issue 6 Pages 705-711
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
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[in Japanese]2000 Volume 60 Issue 6 Pages 711-719
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
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[in Japanese]2000 Volume 60 Issue 6 Pages 719-723
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
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[in Japanese]2000 Volume 60 Issue 6 Pages 723-728
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
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2000 Volume 60 Issue 6 Pages 728-734
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
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[in Japanese]2000 Volume 60 Issue 6 Pages 735-736
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
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[in Japanese]2000 Volume 60 Issue 6 Pages 737-738
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
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[in Japanese]2000 Volume 60 Issue 6 Pages 739-740
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
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2000 Volume 60 Issue 6 Pages 741-747
Published: December 28, 2000
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (908K)
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