Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
Search
Advanced search
OR
Browse
Search
Volume 72, Issue 1
Displaying 1-20 of 20 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Feature Articles: The Functions of Showa University Hospital as a Medical Center in the Disaster Area
Special Lecture
Educational Lecture
Graphic
Original
  • EFFECT OF DOPAMINE RECEPTOR ANTAGONIST ON CONSTIPATION IN THE RAT MODEL OF PARKINSON'S DISEASE
    Yu SAITO, Masataka SUNAGAWA, Hiroaki IWANAMI, Norihiro GOMI, Takeshi K ...
    2012 Volume 72 Issue 1 Pages 100-107
    Published: February 28, 2012
    Released on J-STAGE: December 14, 2012
    DOIhttps://doi.org/10.14930/jsma.72.100
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Parkinson's disease, PD, a progressive neurodegenerative disorder characterized by extrapyramidal symptoms, is often associated with non-motor symptoms. Though constipation appears most frequently among these symptoms, the mechanism of constipation in PD has not been clarified and an appropriate treatment method has not been established. Intestinal motility is regulated by extrinsic autonomic nerves, the enteric nervous system (ENS) and the interstitial cells of Cajal. Of these forms of regulation, we have been focusing attention on the dopaminergic nervous system in ENS to investigate its involvement in constipation of PD model rats. It is known that dopamine has an inhibitory effect on intestinal movement through dopamine receptor D2, D2R. We have already reported that the colon of PD model rats has an enhanced sensitivity to dopamine, and this can be due to an increase in D2R. In this study, we have investigated the sensitivity of the small intestine to dopamine, and examined the effectiveness of domperidone, a D2R antagonist, against constipation in PD model rats. We administered apomorphine, a dopamine receptor agonist, and recorded contraction movement of the isolated small intestine in Krebs solution; the motility of the intestinal tract of the PD model rats was significantly suppressed for a period longer than that of the control rats. Next, when domperidone was administered to the PD model rats, the decline in the food transportation speed in the small intestine was improved, and fecal weight was significantly increased. These results suggested that the small intestinal tract of the PD rat became more sensitive to dopamine similar to the colon, which indicated the influence on the movement of the intestinal tract, and that the D2R antagonist was effective for constipation in PD.
    View full abstract
    Download PDF (627K)
  • IMMUNOHISTOCHEMICAL ANALYSIS OF THE CELL CYCLE-ASSOCIATED PROTEINS IN DIFFUSE LARGE B-CELL LYMPHOMA
    Yoshihiro UMEMURA, Mayumi HOMMA, Eisuke SHIOZAWA, Toshiko YAMOCHI-ONIZ ...
    2012 Volume 72 Issue 1 Pages 108-117
    Published: February 28, 2012
    Released on J-STAGE: December 14, 2012
    DOIhttps://doi.org/10.14930/jsma.72.108
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Diffuse large B-cell lymphoma (DLBCL) is one of the most common lymphoid neoplasms, characterized by heterogeneity in the clinical, immunophenotypic, and genetic features. The proliferation and progression of neoplastic cells are known to be closely related to abnormalities in various positive and negative cell-cycle regulators. Skp2 positively regulates the G1-S transition by promoting degradation of the cyclin-dependent kinase inhibitor p27. Skp2 is frequently overexpressed in a variety of cancer cells and has been implicated in oncogenesis. In this study, we performed immunohistochemical analysis of the cell cycle-associated proteins, Skp2, p27, and Ki-67, in 33 patients with diffuse large B-cell lymphoma (DLBCL), and evaluated the correlation between the clinicopathological characteristics and the expression levels of these proteins. In 33 patients, Skp2 expression was correlated with Ki-67. The patients also were classified into two groups according to the so-called “Hans classifier”: Germinal centre B-cell like (GCB) type and non-GCB type. Skp2 expression correlated with Ki-67 in the non-GCB type, but not in the GCB type. There was no significant correlation between Skp2 and p27, or p27 and Ki-67. It was suggested that Skp2 is a valuable marker for predicting proliferation of neoplastic cells in DLBCL.
    View full abstract
    Download PDF (582K)
Case Report
  • A CASE OF OROPHARYNGEAL CANCER (T4aN3M0) WITH MARKED IMPROVEMENT BY CONCURRENT CHEMORADIOTHERAPY
    Yojiro KAWAMURA, Toshikazu SHIMANE, Kenichiro KAWAGUCHI, Takatoshi TOK ...
    2012 Volume 72 Issue 1 Pages 118-123
    Published: February 28, 2012
    Released on J-STAGE: December 14, 2012
    DOIhttps://doi.org/10.14930/jsma.72.118
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Various therapies such as radiation therapy, intra-arterial chemotherapy, concurrent chemoradiotherapy, and surgery have been used to treat oropharyngeal cancers. Here, we report the good outcome achieved using S-1 and nedaplatin with concurrent radiotherapy (SN therapy) to treat a patient with oropharyngeal cancer (T4aN3M0).
    A 67-year-old man was referred to our hospital for evaluation because of discomfort in the pharyngeal region and a cervical mass. Clinical and cytologic examinations revealed a large squamous cell carcinoma in the left peritonsillar area, which was occupying the oropharyngeal lumen. Computed tomography revealed oropharyngeal cancer (T4aN3M0), and the patient was treated with SN therapy.
    Although the primary tumor had disappeared on contrast-enhanced computed tomography after the first-line treatment, left cervical lymphadenopathy remained and was classified as level V by ultrasound-guided fine-needle aspiration cytology. However, no viable cancer cells were observed in the lymph nodes excised during left neck dissection, indicating that a complete response had been achieved with the first-line treatment.
    No recurrence or metastasis has been observed at follow-up, although this is a relatively short follow-up period of only 8 months to date. This case suggests that SN therapy can be effective for the treatment of advanced oropharyngeal cancer from the viewpoints of radical treatment and preservation of organ function.
    View full abstract
    Download PDF (472K)
  • FISTULA FORMATION FOLLOWING RESOLUTION OF AN INFRAPATELLAR GANGLION: A CASE REPORT
    Yasutaka KAJI, Yasushi YOSHIKAWA, Ryo YAMAMURA, Hiroki NISHIKAWA, Hiro ...
    2012 Volume 72 Issue 1 Pages 124-127
    Published: February 28, 2012
    Released on J-STAGE: December 14, 2012
    DOIhttps://doi.org/10.14930/jsma.72.124
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We report the case of a 61-year-old female. A tumor was observed in her right knee following an injury sustained by a fall one year earlier, and she underwent a puncture at a clinic after being diagnosed with ganglion. The subject was referred to us when a fistula discharging jelly-like liquid subsequently formed at the puncture site. There was no redness, swelling, or limited range of motion in her right knee upon examination, and the McMurray test was negative. On observation, the fistula exuded a jelly-like liquid. The infrapatellaris exhibited a low signal on T1-weighted imaging, and a high signal multilocular tumor shadow was observed on fat-suppressed T2-weighted imaging. An infrapatellar ganglion in the right knee was diagnosed based on magnetic resonance imaging (MRI) findings and it was subsequently excised surgically. A definitive diagnosis of infrapatellar ganglion was made on the basis of the results of histopathological examination. The patient's symptoms disappeared after resection and no recurrence was observed on MRI.
    View full abstract
    Download PDF (380K)
  • A CASE OF PSEUDOANEURYSM OF THE SUPERIOR GLUTEAL ARTERY SECONDARY TO UNSTABLE PELVIC RING FRACTURE
    Keisuke HIRATSUKA, Keiji TANAKA, Yasufumi MIYAKE, Tohru ARUGA
    2012 Volume 72 Issue 1 Pages 128-132
    Published: February 28, 2012
    Released on J-STAGE: December 14, 2012
    DOIhttps://doi.org/10.14930/jsma.72.128
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Aneurysms of the superior gluteal artery following blunt trauma are relatively rare. A 38-year-old man was injured in a traffic accident. On day 8 of hospitalization, invasive open reduction and internal fixation was performed for an unstable pelvic ring fracture. Postoperative wound infection occurred, and wound cleaning was performed on a daily basis. On day 41 of hospitalization, he began experiencing sudden buttock pain, and image diagnosis revealed a superior gluteal artery pseudoaneurysm. On day 44, transcatheter arterial embolization was performed, his symptoms were resolved, and no obstruction was observed. Distinguishing traumatic and infectious aneurysms is extremely difficult. Embolotherapy for pseudoaneurysms is an effective treatment procedure.
    View full abstract
    Download PDF (483K)
  • A CASE OF ALCAPTONURIA DIAGNOSED AFTERTOTAL HIP ARTHROPLASTY SURGERY
    Akihiro MATSUNAGA, Yoichi TOYOSHIMA, Yasushi YOSHIKAWA, Takashi SHIBUK ...
    2012 Volume 72 Issue 1 Pages 133-137
    Published: February 28, 2012
    Released on J-STAGE: December 14, 2012
    DOIhttps://doi.org/10.14930/jsma.72.133
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We encountered a case of degenerative osteoarthritis due to alcaptonuria, an inherited disorder of tyrosine metabolism. A 58-year-old woman was admitted to our hospital due to hip pain. A hip simple X-ray picture revealed terminal stage of degenerative hip osteoarthritis. A simple lumbar X-ray showed calcification of multiple lumbar discs, which was suggestive of alcaptonuria. During total hip osteoarthroplasty surgery, we noted black coloration (ochronosis) of the femoral neck, a characteristic sign of alcaptonuria. Alcaptonuria was eventually diagnosed by black coloration of the urine and detection of homogentisate in the urine using gas chromatography-mass spectrometry method. Although gait disturbance and hip pain disappeared after total hip arthroplasty surgery, careful follow-up is necessary for early detection of various complications of alkaptonuria in other organs.
    View full abstract
    Download PDF (406K)
  • A CASE OF GUYON'S CANAL SYNDROME CAUSED BY A HEMATOMA ON THE ULNAR NERVE
    —A case report—
    Kenji OHARA, Daisuke MAKIUCHI, Kenichi MIHARA, Kazuhide SUZUKI, Naoya ...
    2012 Volume 72 Issue 1 Pages 138-143
    Published: February 28, 2012
    Released on J-STAGE: December 14, 2012
    DOIhttps://doi.org/10.14930/jsma.72.138
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    This is a case report of 71-year-old female who complained about a gradually progressive symptom of her right hand. She had a claw hand deformity, numbness of the ring and the little finger, and precision grip disability. She had no episode of trauma. At first, she had visited another clinic, and had been treated with medication. Three weeks after onset, she visited our outpatient clinic in our hospital. Her physical examination findings were as follows: atrophy of the adducter pollicis brevis muscle and the abducter muscle of the little finger. Tinel's sign was positive on the proximal end of the Guyon's canal. Froment's sign was positive. Hand X-ray showed no abnormal findings. Wrist MRI showed a swollen ulnar nerve at the proximal end of the pisiform bone, but there was no space occupying lesion near the ulnar nerve. EMG tests for the ulnar nerve were immeasurable. Laboratory data did not show any abnormal values. We diagnosed this patient as Guyon's canal syndrome, Although the cause was unclear. We performed surgical treatment of Guyon canal release. We identified a mass between the bifurcated site of the ulnar nerve. We removed the mass, released the dorsal carpal ligament, and checked for other occupying lesions. Six months later, her chief complaints were resolved. From the pathological findings, the removed mass was a hematoma. In this case, we were not able to determine the etiology of this mass.
    View full abstract
    Download PDF (693K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top