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Volume 24, Issue 4
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Masakazu Kawasumi1964 Volume 24 Issue 4 Pages 161-184
Published: July 28, 1964
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (15474K) -
Roport 4: Pharmacological Action of p-Methylphenyl Hydrazine, which is a Monoamine Oxidase InhibitorTatsuo Fujimaki1964 Volume 24 Issue 4 Pages 185-191
Published: July 28, 1964
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe relationship tetween pharmacological effects and inhibition on monoamine oxidase (MAO) by p-methylphenyl hydrazine (MPH) have been studied and following results were obtained:
1) When 10-20 mg/kg of MPH were administered for a long period of time, the development of guinea pigs were depressed and it caused damage in liver and kidney.
2) A administration of MPH caused acceleration on respiration and depression on heart movement, while no effect on blood pressure in dog.
3) By the administration of a large dose of MPH, the spontaneous movements of intestine and uterus were depressed, while by a small dose of it, the movement of uterus was accelerated.
4) MAO activities in liver and brain were inhibited remarkably by the administration of MPH in vivo and in vitro.View full abstractDownload PDF (4991K)
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