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Volume 31, Issue 6
Displaying 1-5 of 5 articles from this issue
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Mitsugu Shiga1971 Volume 31 Issue 6 Pages 289-296
Published: June 28, 1971
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSCell cycle dependency was to be analysed more in detail especially that of G-1 phase because of the vital importance of this phase in preparing DNA precursors including TMP synthesis, metabolism around which has been suggested radio-sensitive in our laboratory. Double labelin method, H-TdR, and C-TdR was used in this experiment, which was expected the cell to mark the cycle more in detail.
As the result,
1. Irradiation did not influence the cell of S-phase in taking-up thymidine.
2. Cells in S-phase including from early S to late S were more radio-resistant than in the other phase, G-2, M. and G-1, taken together.
3. However, the cells in early S phase proved high radiosensitivity contrary to the entire S phase marked in single thymidine labeling.
These findings were worth while in giving some proof upon the assumption that the metabolism around TMP Synthesis was too much disturbed by irradiation the cell to survive.View full abstractDownload PDF (3293K) -
Shunichi Seki1971 Volume 31 Issue 6 Pages 297-303
Published: June 28, 1971
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTime relationship in combined effect of irradiation and 5-Fu (5-fluorouracil) was studied in Ehrlich ascites tumor. Solid growth pattern in size, the tumor cells taken from‘donner’mice being transplanted into subcutane of‘recipient’mice, was the criteria. Irradiation and drug were administred to the tumor bearing donner mice, in peritoneal cavity of which the tumor cells were growing, to get rid of the effect of radiation as well as of drug upon the tumor transplanted recipient host mice and to be able to decide the drug administration time at will prior to transplanation. One hour administration of drug in this experiment was performed by injection of the drug into donner's peritoneal cavity one hour prior to withdrawal of cells for transplantation.
As the results, administration of 5-FU 4 hours after irradiation was most effective for tumor cell damage.
The tumor cells 4 hours after irradiation proved the least DNA synthetic rate owing presumably to accumulation of the cells in G-1 phase, and 5-FU strongly prevented thymidine synthesis which must be taken place prior to S (or in G-1) . Radiation induced accumulation in G-1 together with drug prevention of thymidine synthesis in G-1 reduced the survival of the tumor cells beside the sole radiation damage. There was solid growth pattern suggestive of the contribution of immunity in this experiment being left to be explored.View full abstractDownload PDF (791K) -
Tsunahiro Tanaka1971 Volume 31 Issue 6 Pages 304-314
Published: June 28, 1971
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSRenal damages were examined up to 3 months following irradiation administered on one kidney with dose of 1000R or 3000R in dog.
Renogram, scintigram as well as histological findings were evuluted in this experiment. Latex particles, several micron in diametr, were injected to obliterate the renal capillaries anywhere at the narrow point in caliber. It was expected that blood supply was to decrease distal to this point and that radiation induced narrowing of capillary owing to edema or fibrosis migt be detectable.
As the results, though early renal damage was difficult to detect, scintigram provided some informations of renal disturbance as early as seveal days of irradiation.
Because of the progressive changes of intersitium and of capillary in sequential histological findings in relatively low dose level, the parenchymal damage might well be said secondary to them. Therefore, we were in opinion that the kidney was never radio-resistant organ in treatment of patient.View full abstractDownload PDF (10241K) -
Nobuhiko Tokita1971 Volume 31 Issue 6 Pages 315-324
Published: June 28, 1971
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (730K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1971 Volume 31 Issue 6 Pages 326-331
Published: June 28, 1971
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (761K)
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