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Volume 59 (1999)
- Issue 6 Pages 577-
- Issue 5 Pages 485-
- Issue 4 Pages 377-
- Issue 3 Pages 211-
- Issue 2 Pages 93-
- Issue 1 Pages 1-
Volume 59, Issue 2
Displaying 1-18 of 18 articles from this issue
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[in Japanese]1999 Volume 59 Issue 2 Pages 93-101
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 2 Pages 102-110
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 2 Pages 111-112
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 2 Pages 113-116
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese]1999 Volume 59 Issue 2 Pages 117-119
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese]1999 Volume 59 Issue 2 Pages 120-127
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 2 Pages 128-132
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
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Miki KUSHIMA1999 Volume 59 Issue 2 Pages 133-137
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn histopathologic diagnosis of the endometrium, it is very very difficult to distinguish atypical endometrial hyperplasia from well differentiated endometrioid adenocarcinoma. Some points of histopathologic diagnosis of the endometrium in HE stain and immunohistochemical staining are discussed. Marked proliferation of atypical epithelial cells, such as papillary, confluent or cribriform growth and desmoplasia of stroma are suggested presence of stromal invasion in HE stain. Immunohistochemical stain of p53, CD44 and cyclin A are negative for all reported cases of atypical hyperplasia and positive for some cases of endometrioid carcinoma, but, not all cases of endometrioid carcinoma are positive, so these immunohistochemical stains are not enough for diagnosis of endometrioid adenocarcinoma.
In conclusion, stromal invasion in the HE stain is a most important point to diagnose endometrioid adenocarcinoma.View full abstractDownload PDF (2556K) -
ASSESSMENTS OF OXIDATIVE STRESS AND EFFECTS OF N-ACETYLCYSTEINEYasuro FUJIWARA, Hiroshi NAKANO, Hideaki NAGASAKI, Naoyasu KITAMURA, H ...1999 Volume 59 Issue 2 Pages 138-144
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe investigated whether rat livers with obstructive jaundice produced with bile duct ligation (BDL) for 2 weeks are more vulnerable to stress of lipopolysaccharide (LPS) than those with sham operation ; f uthermore, we examined the effects of N-acetylcysteine (NAC) on LPS stimulation in rats with BDL. Results of serum concentration of a glutathione-S-transferase showed that LPS stimulation induces more severe hepatocellular injury in cholestatic rats more than in the sham rats. In addition, LPS stimulation aggravated mitochondrial function in the cholestatic rats than in the sham rats, as shown by the results of the mitochondrial reduced and oxidized glutathione pool and the hepatic adenosine triphosphate concentration. Intraperitoneal administration of NAC for 2 weeks improved mitochondrial function and hepatocellular injury. However, oxidative stress of polymorphonuclear leukocytes (PMNLs) infiltrating the hepatic tissue increased by NAC administration. The present results indicate that the cholestatic liver is vulnerable to the stress of LPS, NAC administration suppresses stress of LPS in the cholestatic liver, and that oxidative stress of PMNLs is not involved in mitochondrial dysfunction and hepatocellular injury in the cholestatic liver.View full abstractDownload PDF (766K) -
Yasumi KANEKO, Jun-hui DUAN, Noboru GOTO, Yasuhiro NAGAI1999 Volume 59 Issue 2 Pages 145-150
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThere are only a little morphometric data analysing the age-related changes of human nerve fibers. In the present study a new staining method that permits simultaneous observation of the axon and the surrounding myelin sheath was used to study the morphometric changes which occur in the human nerve fibers during the aging process. The following combination of equipment was employed in this study : an image-analyzing digitizer, a microscope with a drawing tube and a computer for data storage and statistical analysis. The numbers and transverse areas of axons were measured in 5 human maxillary nerves. The average number, the average area, the total area, the average perimeter and the total perimeter of axons decreased from 50 to 90 years of age ; in particular, a dramatic changes occurred from 80-90 years of age. Under microscopic observation, the maxillary nerves in a 95-year-old specimen consisted chiefly of relatively small axons (Fig. 2) compared to those of a 59-year-old specimen (Fig. 1) . A significant reverse correlation was observed between the various age groups and the five items listed above. Our results deduce that definite changes occur in the maxillary nerves with aging.View full abstractDownload PDF (1586K) -
Jun SASAKI, Masahiko YAMAGUCHI, Akihiko MATSUMIYA, Tadashi MATSUMOTO, ...1999 Volume 59 Issue 2 Pages 151-159
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSHepatic trauma classification according to the Japanese Association for the Surgery of Trauma was classified by the morphological pattern of liver injury, so that it does not always indicate the severity of liver injury. We reviewed 58 cases of hepatic trauma transferred to the Emergency Center in Showa University Fujigaoka Hospital from 1985 to 1998 to compare the hepatic trauma classification with liver function tests and to investigate the prognostic risk factors for hepatic trauma.
Data of the liver function tests including AST, ALT, prothrombin time, hepaplastin test, and CT volumetry for liver injury did not increase parallel to the grade increase in hepatic trauma classification. Significant risk factors for prognosis in hepatic trauma were age, systolic blood pressure, injury severity score, hospital stay periods, prothrombin time, hepaplastin test, and bleeding volume on laparotomy whereas significant risk factors in hepatic trauma of IIIb were only prothrombin time, hepaplastin test, and bleeding volume on laparotomy.Analysis of dead cases indicated that bleeding was the major cause of death in most cases.
Results suggest that Japanese hepatic trauma classification does not always indicate the severity of liver injury, that prothrombin time and hepaplastin test on arrival may be significant prognostic risk factors for liver injury, and that control of bleding is the most inported treatment for hepatic trauma.View full abstractDownload PDF (905K) -
Yachio FUJITA, Yoshiharu HOSHIYAMA, Chitose TANAKA, Kazumi NAKAYAMA, T ...1999 Volume 59 Issue 2 Pages 160-171
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAn epidemiological study of maternal anxiety was conducted with the attendants of a class of expectant mothers held by the staff of Showa Medical School using the STAI Questionnaire and the Locus of Control which was revised by Mizukuchi and adopted for this study. The follow-up study was implemented in three periods of pre and post natal stages : 19 to 25 weeks pregnant (Prenatal 1), 30 to 36 weeks (Prenatal 2), and the postnatal period (Postnatal 3) within 4 days after delivery. The anxiety levels by the STAI improved according to the period of pregnancy although 51.8% of the attendants had deep anxiety during their first pregnancy and delivery. The anxiety level by the STAI was higher in the extrovert type groups than in the introvert type of the Locus of Control. The Prenatal 1 and Prenatal 2 groups were diagnosed by a medical doctor as having symptoms of foot swelling, preposition of placenta, urinary sugar and hypertension; other subjective symptoms were lumbalgia, weariness, upset of stomach, stiffness of hands, and a feeling of stomach heaviness which showed significantly higher anxiety levels by STAI in the Extrovert than in the Introvert type of Locus of Control. The Postnatal 3 group showed subjective symptoms. Symptoms such as dizziness and foot fatigue showed the same tendency as the above mentioned.View full abstractDownload PDF (1315K) -
Shinichiro NISHII, Hitome KOBAYASHI, Yasuya NOMURA1999 Volume 59 Issue 2 Pages 172-179
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn this study, we investigated the localization of the semicircular canals in the human temporal bone. We used films of CT target imaging of 2.0mm thick slice of the temporal bone in order to obtain anatomic measurements of the semicircular canals of sixty ears.
In addition, macroscopic measurements of the semicircular canals in twenty ears obtained from autopsies were applied.
Results obtained in this study were as follows:
1) Distance from the short process of the incus to the dome of the lateral semicircular canal using CT was 1.2mm.
2) Distance from the short process of the incus to the lateral semicircular duct using CT was 2.3mm.
3) Distance from the short process of the incus to the posterior semicircular duct using CT was 9.5mm.
4) Distance from the blue line of the lateral semicircular canal to the short process of the incus was 2.7mm.
5) Distance from the short process of the incus to the blue line of the posterior semicircular canal was 8.5mm.
6) Distance from the short process of the incus to the anterior semicircular duct was 6.5mm.
7) Distance from the head of the stapes to the anterior semicircular duct was 6.0mm.
These results suggest that CT target imaging of the inner ear is useful technique for localization of the semicircular canals.View full abstractDownload PDF (4577K) -
Masahiko OHKUBO, Hideaki NAGASAKI, Hiroshi NAKANO, Sei TAKEUCHI, Mitsu ...1999 Volume 59 Issue 2 Pages 180-187
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDetermination of the response to anticancer chemotherapy against esophageal cancer is performed using the images of X-ray and/or endoscopy, but it is not very objective. Therefore, we determined the response to preoperative anticancer chemotherapy against esophageal cancer in 18 cases using endoscopic ultrasonography (EUS) which can demonstrate intra- and extra-mural tumor expansion.
Determination of the response using EUS was performed in 12 cases by the reduction rate of the maximum area of the tumor, and in 6 cases by the reduction rate of tumor volume which is defined by accumulating the tumor areas detected at intervals of 1 cm from the anal end to the oral end of the tumor.
Determination using either X-ray or endoscopy could not be done in cases with sever stenosis in the tumor. However, determination using EUS could be done in all 18 cases.
Results suggest that EUS can detemine not only the intra and extra mural tumor expansion but also anal and oral expansion of the tumor, and that EUS can objectively determine the response to anticancer chemotherapy against esophageal cancer.View full abstractDownload PDF (3708K) -
Atsushi OZAWA, Koichi INOUE, Makoto YAMADA, Toshihiro TAKABA1999 Volume 59 Issue 2 Pages 188-194
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThis study examined whether calcium administration before ischemia as preconditioning reduced ischemic reperfusion injury.‹Methods›Isolated rat hearts were perf used for 1 minute with five kinds of Krebs-Henseleit bicarbonate buffer each with a different Ca concentration Experimental group : Groupl (control), Groups 2, 3, 4, 5 : Ca = 2.5, 3.0, 3.5, 4.0, 5.0mM/L respectively f 30 minutes before global ischemia at the normothermia (37.5°C) .
Cardiac function (Heart rate : HR, left ventricular developed pressure : LVDP, Left ventricular pressure dp / dt : LV dp / dt, coronary flow: CF) were measured during 30 minutes after reperfusion and compared with baseline. The calcium ion concentration was measured in group 3.‹Results›Groups 2, 3, 4, 5 showed a better recovery than the control group in LVDP, LVdp/ dt and CF after reperfusion. In addition, the cytosolic calcium concentration did not increase during ischemia/reperfusion compared with the control group.‹Conclusions›These results suggest that preconditioning with calcium produces tolerance to the subsequent ischemia/reperfusion and reduces reperfusion injury.View full abstractDownload PDF (780K) -
Kei TATENO, Tamio HAGIWARA, Takayoshi TANAKA, Katsutoshi MOTOHASHI, Fu ...1999 Volume 59 Issue 2 Pages 195-201
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTo isolate proteins / genes which might be involved in the development of the central nervous system, we analyzed proteins expressed transiently in the fetal rat brain, we previously reported that several proteins including putative“human-leukocyte associated ( HLA) ”Class II associated proteins (PHAP I and PHAP II ) which have been purified from the cytosolic fraction of the human lymphoblastoid B-cell line H2LCL and bind to the intracellular domain of the HLA class II were expressed predominantly in the fetal rat brain and decreased in the adult rat. In this study we attempted to identify target proteins in the fetal rat brain cytosolic fraction which might interact with PHAP I and PHAP II to understand the physiological roles of PHAP I and PHAP II . We detected several PHAP I and PHAP II binding proteins from the cytosolic fraction of the fetal rat brain with an affinity gel using recombinant PHAP I and PHAP II as a ligand. We also found protein serine kinase activity in these binding proteins which phosphorylates PHAP I protein. Recently, it has been reported that PHAP I and PHAP II have multiple functions in cells such as human pp 32, APRIL (acidic protein rich in leucines), bovined I1PP2A, rat LANP (leucine-rich acidic nuclear protein), and SET, I2PP2A, template activating factor I (TAF-1) . In this study, we suggest that PHAP I serine kinase regulates PHAP I activity.View full abstractDownload PDF (4876K) -
Takayoshi TANAKA, Tamio HAGIWARA, Kei TATENO, Katsutoshi MOTOHASHI, Fu ...1999 Volume 59 Issue 2 Pages 202-207
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe studied the proteins expressed specifically in the fetal rat brain to clarify the changing mechanism of the central nervous system from birth to death. Regarding the process for investigation of putative“human-leukocyte associated (HLA) ”Class II associated proteins (PHAP and II) which were speculated as components of the signal pathway, we reported the detection of PHAP I protein kinase activities in the PHAP II binding protein fraction of fetal rat brain cytosol and that PHAP I protein was phosphorylated mainly on the Serine residue. In this stady, we examined PHAP I kinase using mutants of PHAP I which were deleted amino acids and the procedure for detection of protein kinase activities toward protein substrates included in gels. In the phosphorylated site of PHAP I was 204 of serine residue in the highly acidic C-terminal region of the PHAP I amino acid sequence. The molecular mass of PHAP I kinase were 37kDa and 39kDa, and gel filtration chromatography suggested that PHAP I kinase was larger in vivo. PHAP I kinase has not been identified yet, however, we speculate that PHAP I kinase is one of the components of the signal pathway because the phosphorylation site is in the neighborhood of the sequence requirement for synthetic peptide-mediated translocation to the nucleus.View full abstractDownload PDF (3058K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 59 Issue 2 Pages 208-210
Published: April 28, 1999
Released on J-STAGE: September 09, 2010
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