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Volume 59 (1999)
- Issue 6 Pages 577-
- Issue 5 Pages 485-
- Issue 4 Pages 377-
- Issue 3 Pages 211-
- Issue 2 Pages 93-
- Issue 1 Pages 1-
Volume 59, Issue 6
Displaying 1-18 of 18 articles from this issue
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[in Japanese]1999 Volume 59 Issue 6 Pages 577
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese]1999 Volume 59 Issue 6 Pages 578-585
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 6 Pages 586-591
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese]1999 Volume 59 Issue 6 Pages 592-598
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese], [in Japanese], [in Japanese]1999 Volume 59 Issue 6 Pages 599-605
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 6 Pages 606-610
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 59 Issue 6 Pages 611-617
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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—In Case of Subjects Without Respiratory Disease—Tadashi MIZOROGI, Masahiro YOSHIIKE1999 Volume 59 Issue 6 Pages 618-628
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThis paper discusses the influence of the degree of activity on ventilatory function. The subjects were 163 people from 65 to 99 years of age (mean 77.7±8.2yrs) with no respiratory disease. The degree of activity was designated in accordance with The Judgement Standard of ADL Dependency (the Ministry of Health and Welfare), and was divided into 6 levels : N (normal), J1 (goes out by bus or train), J2 (goes out in the neighborhood), A1 (needs help for outdoor activities), A2 (needs help for indoor activities), B (spends a long time in bed) . %VC, FEV1.0%, PEFR, V25/Ht, MEP, MIP, chest girth, ROM of thoracic spine were measured. ADL and the time frame of daily life was also analyzed for 85 of the subjects. %VC, PEFR, MEP, MIP, chest girth and ROM of spine significantly decreased with a lowering of activity level. Chest girth significantly decreased in J1, and %VC also decreased in J2. The rate of restrictive ventilatory disorder (%VC<80%) increased according to the activity level : 0 % in N and J1, 42% in J2, 61% in A1, and over 90% in A2 and B. Because of the characteristics of the subjects, it was thought that these changes were due to the disuse syndrome. There was no significant change in FEV1.0% and V25/Ht with the change of the degree of activity. Moreover, no certain tendency was found in obstructive ventilatory change. Factors which contributed a great deal to an increase of %VC were the degree of activity, lower chest girth, MIP, the duration of hobby or housekeeping and the duration of upright position. Conversely, factors which contributed less to the amount of %VC were age, FEV1.0%, MEP and time of getting up or going to bed. These factors mean that restrictive changes of the ventilatory system occur at a very early stage of activity decline despite independent ADL or absence of respiratory disorder. Physical therapy and activation of daily life are needed.View full abstractDownload PDF (1071K) -
Yukako YAMAZAKI, Keiko IMAI, Keinosuke NARA, Shinichi IWAI, Susumu TOK ...1999 Volume 59 Issue 6 Pages 629-634
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSCefditoren pivoxil, a cephem antibiotic, has been widely accepted clinically. In this study, drug distribution to the brain was evaluated using the microdialysis method and the effect of cefditoren on brain tissue was investigated. The implanted microdialysis probes in the rat striatum and the jugular vein were perfused with Ringer's solution. A dialysate was collected every 20 min after administration of cef ditoren (10, 30, 100mg/kg i.p.) or of loxacin (New quinolon antibiotics, 30mg/ kg i.p.) . Cef ditoren and of loxacin concentrations in the dialysates were determined by the HPLC/ECD system. Cefditoren (10, 30mg/kg) levels promptly increased in both the brain and blood, reached maximum concentrations at 60 and 40 min, respectively and then decreased gradually until 5hr after administration. In the cef ditoren 100 mg/kg treated group, the blood concentration increased promptly and drastically even though the cef ditoren level in the brain increased slightly. Similar changes were observed in the of loxiacin treated group. In conclusion, the effect of cefditoren on the brain tissue is marginal since the extraceller concentration is quite low in an ordinary dose determined by the microdialysis technique.View full abstractDownload PDF (1780K) -
—Re-Examination of Malignant Histiocytosis—Toshiyuki MITSUYA, Koji KISHIMOTO, Takao SUZUKI, Genshu TATE1999 Volume 59 Issue 6 Pages 635-645
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA malignant histiocytosis (MH) had been considered a main entity of the hemophagocytic syndrome (HPS), but as a result of advances in immunological and molecular biological diagnostic technology in the 1990s, many of the cases diagnosed as MH have been re-categorized as non-Hodgkin's lymphoma.In 1984, we reported 8 cases which had been clinically diagnosed as so-called malignant reticulosis and subsequently diagnosed as MH based on the findings of postmortem examination. When we re-evaluated these 8 cases by various approaches which included immunohistochemical examinations against B, T / NK, histiocytic markers, cytotoxic molecules and oncogene products as well as in situ hybridization (ISH) to detect EB virus encoded small RNAs ( EBER), it turned out that half of them were finally diagnosed as B-cell lymphoma and half as T-cell lymphoma ; in addition, two cases of T cell lymphoma were cytotoxic lymphoma.
It was reported that the extra-nodular NK/T cell lympoma was the major causes of LAHS, however, this study of 8 cases showed that lymphoma cells in all cases were negative for CD56, one of the NK cell marker. Analysis of the EBV infection by ISH indicated that the EBER-1 was detected only one case among 4 T cell-LAHS cases.View full abstractDownload PDF (7675K) -
[in Japanese]1999 Volume 59 Issue 6 Pages 647-653
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 6 Pages 653-655
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 6 Pages 655-660
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese]1999 Volume 59 Issue 6 Pages 660-664
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese]1999 Volume 59 Issue 6 Pages 664-667
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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1999 Volume 59 Issue 6 Pages 667-671
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1999 Volume 59 Issue 6 Pages 673-677
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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[in Japanese], [in Japanese]1999 Volume 59 Issue 6 Pages 678-684
Published: December 28, 1999
Released on J-STAGE: September 09, 2010
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