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Volume 62, Issue 1
Displaying 1-15 of 15 articles from this issue
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[in Japanese]2002 Volume 62 Issue 1 Pages 1
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
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[in Japanese]2002 Volume 62 Issue 1 Pages 2-6
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
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[in Japanese]2002 Volume 62 Issue 1 Pages 7-10
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
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[in Japanese]2002 Volume 62 Issue 1 Pages 11-13
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
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[in Japanese]2002 Volume 62 Issue 1 Pages 14-15
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
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[in Japanese]2002 Volume 62 Issue 1 Pages 16-19
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
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[in Japanese]2002 Volume 62 Issue 1 Pages 20-23
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
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Daisuke TANIOKA, Kiyoshi MATSUMOTO, Jun GOTO, Hiromitsu EZURE2002 Volume 62 Issue 1 Pages 24-27
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThis article reports, for the first time, the nerve fiber composition of the human lemniscus medialis. This nerve fiber bundle is a part of the pathways of the posterior funiculus-medial lemniscus system to convey deep sensations; vibratory or discriminative touch sensation. There have been no data so far regarding nerve fibers due to the limitation in preparing sections. We adopted a new method for secondary fixation and for embedding to evaluate the size differences of nerve fibers in the human lemniscus medialis in which there are at least two kinds of nerve fibers, thick and thin fibers. However, the connections and functions of the nerve fibers have not been known up to now.View full abstractDownload PDF (2373K) -
Kenya TADOKORO, Toshiaki KUNIMURA, Yuusuke ISHIKAWA, Toshio MOROHOSHI, ...2002 Volume 62 Issue 1 Pages 28-35
Published: February 28, 2002
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSOne feature of Intraductal Papillary-Mucinous Tumors (IPMT) is the production of a large amount of mucin. The hyperplasia-adenoma-carcinoma sequence is suggested as the carcinogenic mechanism. In this study, we classified 28 IPMT cases into four groups and examined the proliferative potential, the mucin producing potential, and molecular biological characteristics. In addition, we examined the immunohistochemical characteristics of mucin. It was shown that the malignant potential rose in proportion to indices for the prolif erative potential, Mitotic Index, PCNA, and Ki-67-LI (Labeling Index) . We examined the mucin producing potential of IPMT, which shows multiple graded malignancy. Groups I and II, which showed a lower grade of malignancy, produced large amounts of mucin mainly consisting of neutral glicoprotein, the proliferative potential rose, while the producing potential cell. As the proliferative potential became higher the tumor acquired the potential for producing large amounts of mucin again, and the main constituent of mucin changed to acid mucopolysaccharides. In groups III and IV, MUC-l positive cells appeared. We thought the tumor cells acquired an invasive potential, and the malignant grade rose at this phase.View full abstractDownload PDF (5127K) -
Takahiro ENDO, Akiko SASAKI, Hiroyuki JIMBO, Yukio IKEDA, Kiyoshi MATU ...2002 Volume 62 Issue 1 Pages 36-42
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt is considered that necrosis and degeneration of neurons resulting from traumatic brain injury induces secondary swelling of astrocytes, endothelial cell injury and brain edema from destruction of the BBB (blood brain barrier) . The process of inducing brain edema might be related to not only regressive changes of cells but also accelerated reparation of cells and tissues. To clarify the reparation mechanism of cells and tissues in the central nervous system after brain injury, we studied the expression of the ERM ( Ezurin /Radixin /Moesin ) family proteins which is one of the factors of signal transduction on the brain cold injury model. We used 21 rat cold injury models (control : 3, sham operation 3, Day 1: 3, Day 4 : 3, Day 7 : 3, Day 10 : 3, Day 14 : 3), and each specimen was examined immunohistochemically using anti-ERM antibodies. To identify the cell, double staining was performed using GFAP and NF (neurof filament) . Ezurin was expressed in the peripheral areas of the injured brain and hippocampus from day 4. Radaxin was expressed in the ipsilateral hippocampus from day 7. Moesin was expressed in the peripheral areas of the injured brain from day 4, although it was not expressed in the control specimens. In the study of double staining, the ERM ( Ezurin/Radixin/Moesin) proteins were detected in the GFAP positive cells but not in the NF positive cells. In addition, Moesin positive cells were stained with PCNA (proliferaing cell nuclear antigen) . It is suggested that the expression of ERM family proteins which lines cell attachment may play an important role in signal communication between neurons and astrocytes after brain injury.View full abstractDownload PDF (3542K) -
Keizo SUGISAKI, Sanju IWAMOTO, Makoto ISHIDA, Satoshi TAMAOKI, Kentaro ...2002 Volume 62 Issue 1 Pages 43-49
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe observed the effects of interferon (IFN) -γ and interleukin (IL) -4, a cytokine of Thl and Th2, on an antigen presenting cell using a human dendritic cell-like cell line, ELD-1, which we had established previously. The ELD-1 cell, in a mixed culture with a T cell, induces the production of IFN-γ by allo reaction. The activity was dependent on ICAM-1, IL-12 and the HLA-DR antigen, and it was inhibited by pre-treatment with IL-4 and aggravated by pre-treatment with IFN-γ. The change of IL-12 expression of the ELD-1 cell was determined by FAGS analysis which revealed that IL-12 increased each time after IL-4, IFN-γ and T cell treatments, respectively; however, when IFN-γpre-treated ELD-1 cells and T cells were mixed, a synergistic aggravation effect was observed, which became inhibitory after IL-4 treatment. Both ICAM-1 and HLA-DR were strengthened by IFN-γtreatment, and HLA-DR was also augmented further by the T cell addition. In contrast ICAM-1 inhibition and inhibition of the reaction by addition of the T cell were observed for IL-4. These data suggested that ELD-1 cells increased an ability to activate Thl cells during cross-talks with T cells in an IFN-γ dependent manner, and that IL-4 interfered with the cross-talks.View full abstractDownload PDF (838K) -
Mingchuan ZHAO, Yukio IKEDA, Hiroyuki JIMBO, Ataru FUKUDA, Koichi SUGI ...2002 Volume 62 Issue 1 Pages 50-56
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSOxidative stress may contribute to many pathophysiologic changes that occur after subarachnoid hemorrhage. 8-hydroxy-2'-deoxyguanosine (8-OHdG), proposed to be a biomarker for DNA damage by oxidative stress, and 8-iso-prostaglandinF2α (8-iPGF2α) are prostaglandin isomers that are formed nonenzymatically by free radical-induced oxidation of arachidonic acid. 8-iPGF2αis also proposed to be an oxidative stress marker of cell membrane damage. Measurement of 8-OHdG and 8-iPGF2αmay offer a sensitive, specific, and noninvasive method for measuring oxidant stress in clinical practice. In this study, simultaneous measurements of both stress markers in subarachnoid hemorrhages were carried out. Urine was collected every day over two weeks from 7 patients with subarachnoid hemorrhage and analyzed with an ELISA Kit. There was a significant correlation between the two markers in both the rate of production (p<0.001, r=0.487) and urinary concentration (p<0.001, r=0.564) . We also observed the time course of the two markers. The levels of 8-OHdG and 8-iPGF2αshowed a similar tendency: a marked elevation in the 2nd or the 3rd, 6 days relative to the other days. These data suggest that oxygen radicals produced by subarachnoid hemorrhage would cause similar damage to DNA and the cell membrane, The sequential change of 8-iPGF2αindicates the occurrence of cerebral ischemia due to vasospasm following subarachnoid hemorrhage.View full abstractDownload PDF (2527K) -
Kazumi TAGUCHI, Satoshi KIMURA2002 Volume 62 Issue 1 Pages 57-62
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSOvomucoid is a heat resistant protein found in egg white with a molecular weight of 28000. Although ovomucoid-specific IgE titration has of late been regarded useful in determining consumption of heated hen's eggs, specific statistical data on its sensitivity are few. We undertook a study on its sensitivity and correlation with related antigens using specimens referred to our laboratory. The study population consisted of 1778 cases referred to our laboratory from January to October 2001 from other departments for allergen tests for food allergy. 724 cases (40.7%) tested positive for ovomucoid-specific IgE antibodies. With regard to age variation, peak sensitivity was at age 2 with 46.0%, and decreased with increasing age. In addition, in 50 normal subjects, there was only one case of Class 1 antibody titer, and 0% in Class 2 or higher. Regarding relations with other food allergens, there was a high correlation with allergens with respect to antigenicity, with egg white showing the highest correlation (r=0.869), followed by egg yolk (r=0.861), and milk (r=0.574) . Moreover, when egg white and ovomucoid were measured simultaneously, egg white tested positive and ovomucoid, negative in 236 out of 899 cases (26.8%) . In contrast, only 24 out of 687 specimens (3.5%) were ovomucoid positive and egg white negative. From these results, it is estimated that approximately one-fourth of patients with an egg white allergy can consume heated hen's eggs.
The difference between egg white and ovomucoid sensitivity suggests that measurement of the specific IgE antibody may be an effective parameter in food consumption guidance for allergy patients.View full abstractDownload PDF (588K) -
Koushirou IMAI, Kazunari TOMITA, Mituhiko TAKEI, Hideyo MIYAOKA2002 Volume 62 Issue 1 Pages 63-65
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA 33-year-old woman complained of arthralgia and swelling in the left knee without any provoking cause. After being treated with a single intra-articular injection of sodium hyaluronate in our outpatient clinic, the symptoms improved, but she later returned because the knee pain had recurred and was more intense. Marked swelling and patellar ballottement were observed, but the knee did not feel hot and there was no flare. Hematological data revealed a leukocyte count of 2970/μL, C-reactive protein 2+, erythrocyte sedimentation rate of 25 mm/h, negative rheumatoid factor (RF), and uric acid value of 3.3mg/dL. The synovial fluid was yellow and slightly cloudy, and examination for crystals revealed calcium pyrophosphate. Standard bacterial cultures and a tubercle bacillus culture were negative. An X-ray examination disclosed no abnormal findings, such as calcification. Since pseudogout was suspected, arthrocentesis, irrigation, and intra-articular injection of a steroid drug were preformed several times. However, the patient experienced recurrent bouts of hydrarthrosis and pain, and arthroscopy was performed. Histopathological examination of a biopsy specimen led to a diagnosis of tuberculous gonitis.View full abstractDownload PDF (2219K) -
Masayoshi FUKUUCHI, Toshiro NAKANISHI, Takashi SHIRATO, Kazuaki SASAKI ...2002 Volume 62 Issue 1 Pages 66-71
Published: February 28, 2002
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSSpinal epidural hematoma has been a relatively rare condition. We recently encountered two cases of acute spinal epidural hematoma which developed during anticoagulant therapy. Case 1 was a 67-year-old woman who had been on oral aspirin and ticlopidine hydrochloride therapy for treatment of cerebral infarction. The woman developed pain in the lower back after rising one day. Paralysis of both extremities then developed and advanced rapidly. On first examination, complete paralysis of both extremities below the L2 level was noted, and MRI revealed spinal epidural hematoma at the Thll through L2 levels. Fresh platelet preparation was administered to improve the clotting system, and hematoma was evacuated surgically with a laminectomy. Her paralysis, however, remained unchanged after surgery. Case 2 was a 68-year-old woman who had been on oral warf arin therapy to treat atrialf ibrillation. She developed back pain suddenly, followed by paralysis of the left upper and lower extremities. The first examination noted complete paralysis below the C5 level on the left side (a sign of Brown-Sequard syndrome) . MRI disclosed epidural hematoma from the C2 through the Th2 levels. After treatment with vitamin K (a warf arin antagonist) to improve the clotting system, the patient underwent laminoplasty and evacuation of hematoma. As a result, muscle strength in the left upper and lower extremities improved to MMT 2, and she regained the ability to walk. It seems likely that idiopathic spinal epidural hematoma, caused by minute injury, was complicated by coagulation abnormalities, leading to intensification of the hematoma. Acute spinal epidural hematoma which has developed during anticoagurant therapy is unlikely to heal spontaneously. Early surgical treatment, combined with measures to improve the clotting function, seem effective.View full abstractDownload PDF (6043K)
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