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Volume 34, Issue 1
Displaying 1-10 of 10 articles from this issue
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Hiroshi Nawata1974 Volume 34 Issue 1 Pages 1-14
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSImmunization study in experimental Salmonellosis by a mutant of Salmonella typhimurium has been carried out. The mutant used as a live attenuated vaccine in this experiment is DMT1 derived from M (mutabile-type variant of Murase) . DMT1 forms dwarf colonies on both nutrient agar and galactose-nutrient agar. Lactose-nonfermentative and causes spontaneous agglutination. It is very sensitive to Na2SO3 and fresh human serum. Inoculation dose of 10-2 mg of DMT1 appeared to be safe for mouse in the preliminary toxicity test. Back mutation toward the wild-type could not be recognized.
However, the mutation of DMT1 to MT-like mutant, which is very similar to MT of Murase in various characteristics, occurred in some rates, and virulence of the MT-like seemed to be somewhat higher than DMT1; two out of 5 mice died by the intraperitoneal inoculation of 10-2 mg, but not by lower than 10-3 mg.
Mice were immunized with the intraperitoneal administration of live DMT1 and challenged with 10-5 mg of the wild-type. About one half of mice immunized with 10-3 mg of DMTI survived, and about one third survived in the group of mice immunized with 10-4 mg. Therefore, DMT1 is considered to have a fairly marked protective effects on the experimental Salmonellosis of mouse. A small number of mice (4 out of 86) inoculated with 10-3 mg of DMT1 died during the immunization period. The cause of death seemed to be due to the mutation of DMT1 to MT-like in vivo.View full abstractDownload PDF (1497K) -
Shigeo Yamada, Masayuki Yokota, Yuichiro Arai, Noriaki Mitsuhashi, Koz ...1974 Volume 34 Issue 1 Pages 15-24
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe effect of adrenaline derivatives, such as ethyl-adrianol, butyl-sympatol and meta-proterenol on the circulatory system were investigated, and it was found that the pressor action mechanism of ethyl-adrianol appears to stimulate the adrenals to release noradrenaline-like substances as well as promoting contractive action on peripheral blood vessels. Butyl-sympatol and meta-proterenol show a depressor action as a result of the peripheral vasodilating action caused by stimulation of adrenergic β-receptor. Ethyl-adrianol, butyl-sympatol and meta-proterenol activate cardiac performance. Particularly evident was the increase of cardiac contractile force. Ethyl-adrianol had a contractive effect on peripheral blood vessels, while butyl-sympatol and meta-proterenol had dilating effects. A contrastive effect on isolated seminal vesicles of rats was also observed with this adrenaline derivatives.
Adrenergic β-receptor stimulants are utilized bronchodilating agents. Certain isoproterenol derivatives cause adverse side effects such as substernal constriction, angina pectorislike pain and hypotensive effects. The authors have reported that adrenaline derivatives cause a dilating effect on the bronchial muscles and in order of potency, it was found that isoproterenol, meta-proterenol, adrenaline, ethyl-adrianol, noradrenaline and butyl-sympatol had this action.
The objective of the studay was to investigate the effect of adrenaline derivatives, such as ethyl-adrianol, butyl-sympatol and meta-proterenol on the circulatory system, the results of which are in compared with those of adrenaline and noradrenaline.View full abstractDownload PDF (3574K) -
Akiko Yoshida1974 Volume 34 Issue 1 Pages 25-32
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn the present experiment, rabbits were divided into four groups (i. e. group A, B, C and D) to receive saponin at four graded dosage levels, 0, 1, 4, or 8 mg per kg of body weight daily.
Each dosage group was subdivided in to acute group given the toxic substance for less than fifty days and chronic group receiving it for more than sixty days.
Then pathologic histological study on the liver was carried out.
Results
1) In rabbits in the acute groups, zonal necrosis of hepatic cells showed the highest incidence in the midlobular region, followed, in order, by the centrilobular area and the perilobular region.
2) In the chronic dosage groups, on the other hand, necrosis of liver cells was noted to be most frequently centrilobular and lowest in incidence in the perilobular region as in the acute dosage group.
3) Such localized expressions of intralobular histopathologic changes as vacuolar degeneration, granular degeneration of liver cells, capillary hyperemia and dilatation, dilated bile ducts and so forth, were noted to be most frequent in the centrilobular region of the liver of animals that had received the highest doses both acute and chronic dosage groups. These microscopic findings are precursory to hepatic necrotization and, as may be pointed out from the hematological and pathomorphological standpoints, are strongly suggestive of hypoxiac nature of the toxicologic responsa.View full abstractDownload PDF (3685K) -
Hideki Kodama1974 Volume 34 Issue 1 Pages 33-48
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe 18 th day embryos, in which were administerd the solution of 1, 10, 50γ cadmium at 5 th embryo days, were killed and the studied mainly histologically on the end of tibia and kidney. Protein and glucose in allantoic fluid of these embryos were analysed quontativelly be paper-chromatograph.
The results are summarized as follows :
1) By microradiography and tetracline labelling, delay of enchondrale ossification at the end of tibia was found in direct proportion to increase dose of adminstered cadmium.
2) On histological, the extent of the cartilage zone and the density of their caltilage cells decreased in inversaly proportional to dose of cadmium and at the same time were seen the degenerative swelling of the cell and irreguality of the cell arrangment in columnar zone.
3) A few decreasing of the glycogen in the stationary cartilage zone were recognized by PAS staning in the cadmium adminsted groups.
4) A few decreasing of mucopolysaccharide in stationary and columnar cartilages were seen by Alcian blue and Toluidine blue staining.
5) It was seen on the cadmium administerd groups that the eminent vacuolar and granular degeneration of the renal tubule and falling of the epithel cells into renal tubule.
6) In the allantoic fluid, the contens of protain and glucose were ditected propotionary with dose of administerd cadmium.View full abstractDownload PDF (17557K) -
Masanori Ohashi1974 Volume 34 Issue 1 Pages 49-59
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn the present experiment, Saponin solution was administrated subcutaneously to rats twice a week in different doses of 1 mg, 4 mgs and 8 mgs per kg. Then hematological examination and histopathological investigation were made on the changes in the lungs dividing the animals into three groups according to survival period.
Hematological findings showed progressive drops in both red blood cells and hemoglo-bin, after administration of the solution, and increase in the number of reticulocytes.
Histopathologically the group given the small amount of the solution shows the changes which referred to vital reaction related to dilatation and incomplete expansion of alveoli, swelling and edema of alveolar septum, and infiltration of round cells, and the group given the large amount mainly shows the changes of disturbance of the circulation, which become more distinct in proportion to the quantity and the period of medication. Furthermore qualitative changes are manifested as swelling and degeneration of the vessels followed by fibrous hypertrophy and fibrosis around vessels. These changes are based on hypoxia by action of Saponin solution. Therefore it is considered for uniqueness of the lung structure that the changes are concentrated in alveolar septum.
It is assumed that these changes suggest a tendency to proceed toward fibroscrelosis, according to prologation of the time elapsed.View full abstractDownload PDF (3610K) -
Kimio Honda, Koichiro Oshikawa, Yoshiki Mabuchi, Teruaki Tomaru, Isao ...1974 Volume 34 Issue 1 Pages 60-65
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSPancuronium bromide is a new non-depolarizing muscle relaxant of aminosterioidal structure without hormonal activity.
The authors administered pancuronium bromide to 55 adult patients of abdominal surgery, under halothane-oxygen-nitrous oxide anesthesia.
The results were as follows ;
1) Onset of muscular relaxation was rapid. Its effect was moderate and lasted for 82 minutes in average.
2) Blood pressure and heart rate showed no remarkable changes.
3) None of serious side-effect was observed except hiccup occurred in 3 cases during upper digestive tract operation.
4) Residual curarisation was reversed easily and completely by neostigmine.View full abstractDownload PDF (3589K) -
Kohei Kurosawa, Isao Sato, Yasuhiko Onuma, Hidenosuke Araki1974 Volume 34 Issue 1 Pages 66-70
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSStatistical examination of 223 cases of breech presentation and 4, 148 cases of head presentation revealed that was very important to prevent premature delivery in cases of breech presentation. It also was revealed that great care should be taken in prognosis of fetus development when a primipara was supposed to have a giant fetus.View full abstractDownload PDF (527K) -
Kiyoji Kanai, Yoichi Katayama, Hsu Jui-Kuang, Masayoshi Asahi1974 Volume 34 Issue 1 Pages 71-76
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSNeuro-otological findings were attained on a patient in whom surgery and cerebral angiograms revealed the presence of hematoma in the internal capsule of the left tenporal capsule of the left tenporal lobe and basal ganglion following an attack of cerebral apoplexy. His hearing ability and vestibular functions were followed.
Hearing acuity—within physiological senile changes
The recuit phenomenon—negative
Bekesy's audiometry-Jergers classification type I
Binaural differentiation test—marked fall, which was consistent with the paralyzed side.
The OKP test—poor on the right side, which was consistent with the paralyzed side.
The right directional preponderance was shown in positional and positioning nystagmus.
The caloric test—no difference between the right and left sides.
A damage to the high level auditory center in the area of from the left medial geniculate body to the hearing cortex was surmised from the hearing test, and a damage to the left center of the occulomotory system from the vestibular test.
Based on the cerebroangiogram and surgical findings, a diagnosis of a hematoma of the size of ultra-chicken egg in the area from the basal ganglion to the left internal capsule due to the external type of hypertensive cerebral hemorrhage was made.
When the two results were compared, there was a marked difference of binaural differentiation test and OKP test between the right and left sides, and it was surmised that this difference was implicative of deviation of the hemorrhagic focus to one side.
In other words, it could be surmised that because the hematoma of the size of ultrachicken egg located in the external part of the left internal capsule was close to the epithalamus and lateral geniculate body, which consititute part of the occulomotor system, respectively, and also to the medial geniculate body of the auditory system, said parts were damaged compression with the hematoma.
It was thus demonstrated that the hearing tests and vestibular tests are contributory to diagnosing the state of the nerve center.View full abstractDownload PDF (3673K) -
Yozo Mikami, Keizo Sakamoto, Kenichi Shimura, Yoshikatsu Kuroki1974 Volume 34 Issue 1 Pages 77-81
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA case of deltoid muscle contructure by which adduction imposibility is recoverd after removal of fibrous scar in muscle is reported and studied documentary.
Etiologycaly this contructure is consider to be followed many repeated intramuscural injections for asthma bronchiale, but can not be ascribed to disposition of patient.View full abstractDownload PDF (4974K) -
-ON THE AUROTHERAPY-Yoshiaki Mori, Muneaki Taki, Yozo Mikami, Michinori Hirata, Akira Hira ...1974 Volume 34 Issue 1 Pages 82-86
Published: February 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe aurotherapy was performed on 78 patients with rheumatoid arthritis. The dose and Au concentration in serum were discussed in the effective and the ineffective cases respectively.
Though cases observed were not many enough, the total dose in the effective cases was 600 mg and Au concentration in serum was 200 γ/dl and the effect appeared 8-20 weeks after administration. Side Effects appeared independently of the dose and the duration, even under the condition of Au concentration in serum under 100 γ/dl. In spite of an adequate dose, duration and concentration, there were 7 cases with no effect. One was in Stage 1 and the others in Stage 4. Six of seven cases were operated.View full abstractDownload PDF (426K)
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