Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
Volume 61, Issue 4
Displaying 1-17 of 17 articles from this issue
  • [in Japanese]
    2001 Volume 61 Issue 4 Pages 379
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    2001 Volume 61 Issue 4 Pages 380-383
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese]
    2001 Volume 61 Issue 4 Pages 384-389
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese]
    2001 Volume 61 Issue 4 Pages 390-396
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    2001 Volume 61 Issue 4 Pages 397-400
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    2001 Volume 61 Issue 4 Pages 401-404
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
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  • [in Japanese], [in Japanese], [in Japanese]
    2001 Volume 61 Issue 4 Pages 405-409
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
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  • [in Japanese]
    2001 Volume 61 Issue 4 Pages 410-418
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
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  • —An Analysis of 88 Cases of T Cell Lymphoma which were Diagnosed in this Hospital during the Past 23 Years—
    Takao SUZUKI, Koji KISHIMOTO, Genshu TATE, Toshiyuki MITSUYA
    2001 Volume 61 Issue 4 Pages 419-430
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    We employed histochemical approaches to analyze the expression of the cell surface markers (CD4, CD8 and CD56), cytotoxic molecules (Granzyme B and TIA-1), P-Glycoprotein (P-Gp), as well as Epstein-Barr virus encoded small ribonucleic acid (EBER) in T cell lymphoma cases and examined the correlation between the expression profiles of these molecules and the prognosis of T cell lymphoma. Positive cases of these markers among 88 cases of T cell lymphoma were as follows; CD4: 46/88 (52.2%), CD8: 13/88 (14.8%), CD56: 12/88 (13.6%), Granzyme B: 22/88 (25.0%), TIA-1: 25/88 (28.4%), P-Gp: 29/88 (33.9%), EBER: 26/88 (29.5%) . 12 cases of T cell lymphoma were positive for CD56 and, interestingly, all 12 cases were positive for not only Granzyme B but also TIA-1. Among the 12 cases, 11 cases were positive for EBER. 10 cases and 5 cases were positive for P-Gp and CD8, respectively. However, all 12 cases were negative for CD4. Logrank test based on the Kaplan-Meier survival curve revealed that positive cases for CD8, CD56, P-Gp and EBER showed poor prognosis compared with negative cases (p<0.05) ; furthermore, EBER positive cases showed poor prognosis compared with EBER negative cases among the CD56 negative cases. Our results suggest that an analysis of the expression profiles of CD8, CD56, P-Gp, EBER is important not only for histopathological classification of the malignant lymphoma but also for clinicopathological evaluation of T cell lymphoma.
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  • Hong FANG, Naoki NAGAI, Yoshiharu HOSHIYAMA, Takeshi KAWAGUCHI, Asahik ...
    2001 Volume 61 Issue 4 Pages 431-437
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    A survey was carried out to study allergic symptoms among 2, 135 secondary school pupils in Shanghai of China. Among them, 403 pupils were tested for the specific antibody titer of total IgE, mites. Japanese cedar trees, willow cedar trees, cypress trees amd parasites. After studying the relation between the antibody valence in blood and the symptoms, 195 pupils the largest group were found to have a positive mite antibody. Those who sneeze frequently have the highest ratio of positive mite antibody. It was found among those who sneeze frequently that 45 pupils with a positive parasite antibody also had a high possibility of positive rate. Among the subjects with positive or negative parasite antibody, those with positive mite antibody composed 91.1% of the group with a positive parasite antibody, while the negative parasite antibody group was 43.0%. On the other hand, there were only 4pupils with a positive parasite antibody who had a negative mite antibody. Among those with a positive parasite antibody, a high percentage were also carriers of a positive mite antibody In addition. Also among those with a negative parasite antibody were found to have a difference of symptoms due to the existence or non-existence of the mite antibody. With the above results, it is concluded that there is a close relation ship between symptoms of a pollen allergic person and the existence of the mite antibody. There fore, it is necessary to consider the effect of the existence of the mite antibody when studying its correlation with pollen allergies and the parasite antibody.
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  • Mitsuko ICHIKAWA
    2001 Volume 61 Issue 4 Pages 438-447
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    One hundred and fifty-three patients with digestive cancer were analyzed to clarify the present conditions and problems of notification of cancer. On patients' admission, a hearing of their wills was employed such as how they thought of their diagnosis of the disease, or whether they wanted to be informed' of the disease. 35% of the patients suspected that they had cancer. 70% of the patients desired to be notified of their diseases. 140 of 153 patients were notified of cancer following the hearing. A questionnaire form was sent to 114 patients who had been monitoved for more than three months after operation. The filled forms were recovered from 80 patients (75%) . 84% of responders answered that it was best to be told the truth. 63% repliedthey were shocked to hear the truth, but 80% of these had been recovered withim three days after notification. Nevertheless, psychiatric supportive care is necessary after notification. In this sense, not only the physician in charge, but a nursing staff should be aware of the patients psychiatric conditions for proper care.
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  • Yoshiko KATANO, Keizo SATO
    2001 Volume 61 Issue 4 Pages 448-457
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    We studied how pregnant women and their husbands feel toward their pregnancies and unborn children. This research aims to contribute to the basic research of not only mental health during pregnancy but also the baby's future care, security, and possible abandonment and abuse. The methodology used was surveys conducted through questionnaires filled in by those surveyed. The survey was performed for 429 pregnant women and 230 husbands. The questionnaire asked: (1) Age, primigravide or multigravida, weeks into pregnancy, (2) Degree of joy and feelings of the pregnancy, (3) Whether the woman feels that the father of the baby is pleased with her pregnancy or not; and whether the father feels that the woman is pleased with her pregnancy or not, (4) The parents' thoughts towards the pregnancy, the baby and child care after delivery. We found differences in the degree of joy and feelings towards the pregnancy between the pregnant women and their husbands. When the pregnant women genuinely wanted to have the baby and felt that her husband was delighted with her pregnancy, she had a great feeling of joy, happiness and anticipation towards the unborn child. On the contrary, our study found that the father's feelings towards the baby were unaffected by the degree of happiness the pregnant woman felt. The father's feelings of his wife's pregnancy greatly influenced whether the woman could happily accept and love her baby. From this study we propose three psychological high risk factors during pregnancy: (1) for some reason, the pregnancy is not welcomed, (2) neither the pregnant woman nor her husband is pleased with the pregnancy, (3) the pregnant mother feels no joy while carrying the baby nor does she look forward to child care after delivery.
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  • Yoshiyuki KADOKURA
    2001 Volume 61 Issue 4 Pages 458-467
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
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    In the field of head and neck surgery, the cervical trachea should be excised, for example, in some cases of advanced thyroid cancer with tracheal invasion and some cases of tracheal stenosis after prolonged endotracheal intubation. After extended excision of the cervical trachea, the airway is usually reconstructed by end to end anastomosis of the trachea or transplantation of the skin and other autologous grafts. However, these surgical methods do not always produce successful results because of surgical invasion, complications and postoperative QOL. Although reconstruction of the trachea using an artificial trachea is considered to be simple and easy, there has been no suitable material for this purpose. We conducted the following animal experiments to develop collagen products for artificial trachea suitable for clinical use. 1. Eight collagen products for artificial trachea were made under different conditions. 2. Each product was transplanted into muscles of a rabbit to examine tissue affinity and absorbability of the graft. 3. Based on the results of Experiment 2, two collagen products for the artificial trachea were used for airway reconstruction of the rabbit. Postoperative changes in the reconstructed airway were histologically studied. As a result, the collagen graft for the artificial trachea was absorbed approximately 12 weeks after implantation and replaced by connective tissue with suitable rigidity. The inner wall of the reconstructed airway was lined with a ciliated columnar epithelium. We conclude that collagen products after cross-linkage with a suitable compound can be used for tracheal reconstruction.
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  • Takashi NAKAKUMA, Teruyasu UMEZAWA, SHI-YU GUO, Naoko HISAMITSU, Tokuk ...
    2001 Volume 61 Issue 4 Pages 468-476
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    The two novel endogenous peptides, endomorphin-1 and -2 were found by Zadina et al in 1997. Both of these endomorphins are selective mu opioid receptor agonists. In the present study the effect of endomorphins on the motility of the large intestine in rats was examined. In chloralose anesthetized male Wistar rats (280-380g), spontaneous motility of the large intestine was monitored by recording the pressure of a balloon inserted 5 cm into the large intestine from the anus. Both endomorphins administered intravenously inhibited the motility of the large intestine dose dependently (10 nmol/kg-100 nmol/kg) . Inhibition of the motility lasted for 2 to 6 minutes at a dose of 10 nmol/kg. These inhibitory effects were completely antagonised by pre-administration of Naloxone (2 mg/kg) . However, the site of inhibitory action of the endomorphins has not been clarified. The effects of endomorphins and morphine on the motility of the resected large intestine were examined in rats. The spontaneous motility of the large intestine, which was resected at a level of 5 cm rostal from the anus in Krebs solution, was monitored. Motility of the resected large intestine was not inhibited by administration of endomorphins and morphine in Krebs solution. The results suggest that endomorphins inhibit motility of the large intestine through inhibition of neural activities.
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  • Norihiko KUNII, Hiroshi MORIWAKI, Izumi TOYODA, Katsuhiko SUGIMOTO, To ...
    2001 Volume 61 Issue 4 Pages 477-482
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Traumatic subarachnoid hemorrhage is rarely associated directly with the cause of death; death usually occurs as the result of complicated brain injury. However, in rare cases, traumatic subarachnoid hemorrhaging alone may be lethal; this is isolated traumatic subarachnoid hemorrhage (ITSAH) . ITSAH is detected in nearly ref erect to as all autopsies, and is rarely experienced clinically. The present authors encountered a case which developed mild trauma and was regarded as ITSAH. The patient was a 22-year-old man, who after drinkingal cohol, was severely beaten on the face several times. He fell into cardiopulmonary arrest (CPA) and was transported to the Lifesaving Emergency Center of our institution. After cardiopulmonary resuscitation the patient's cardiac beat resumed. The results of head CT revealed a diffuse thick SAH on the basilar cistern. Because of signs of acute hydrocephalus, ventricular drainage was performed. After the cerebrospinal fluid was discharged, ICP decreased although still at a relatively high level. The patient was then detachment in a state of cerebral death and died on Day 5. An autopsy showed extensive diffuse subarachnoid hemorrhaging in the skull but there was no sign of complicated cerebral injury such as brain contusion, brainstem injury, etc. In addition there was no sign of cerebral aneurysm. There was no other sigh such as injury of other organs which may have resulted in death. Traumatic subarachnoid hemorrhage was determined as the cause of death. ITSAH often develops as a result of a relatively mild injury, and rotational external force suddenly applied on the head such as beating. May often lead to the development of subarachnoid hemorrhage. Special care must be taken because from CT finding ISAH is often erroneously diagnosed as endogenous SAH caused by rupture of cerebral aneurysm.
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  • Akio MACHIDA, Seishiro MUKAI, Tomomi YAMAZAKI, Hidetoshi MAKITA, Masah ...
    2001 Volume 61 Issue 4 Pages 483-487
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    A 79-year-old woman was seen at the hospital because of abdominal pain and vomiting. Her medical history indicated that she had undergone a laparotomy for gallstones and aneurysm of the jejunal artery. When she was first seen, she was in a state of shock. Physically, there was muscle guarding the entire abdomen.
    An emergency abdominal CT scan showed ileus and hepatic portal venous gas (HPVG), and an emergency operation was performed 6 hours after admission. Upon laparotomy, necrosis from the center of the transverse colon to the descending colon and impairment of circulation involving most of the small intestine and a section from the sigmoid colon to the rectum Rs were observed.
    Extended resection of the small and large intestines with gastrostomy was carried out. During the operation, blood pressure dropped to less than 50 mmHg and the patient died 3 hours after the operation. The life of this patient could have been saved by surgery in an early phase; however, the life of this patient could not be saved because of her poor general condition. This case is presented here together with some bibliographical comments.
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  • [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    2001 Volume 61 Issue 4 Pages 488-490
    Published: August 28, 2001
    Released on J-STAGE: September 09, 2010
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