The authors have carried out various experiments, aiming at causing pancreatic disorders, and in one experiment scorpion venom, which is known as the cause of hyperamylasemia, was used as a test material. Histopathological examination of the salivary glands in over-secreting condition, especially the submaxillary and parotid glands was performed together with a comparative study of pancreatic changes, which will be herein reported. The overall findings were swelling of the parotid gland in the early stage of the treatment, swelling and atrophic tendency in the middle stage, and swelling and degeneration in the late stage of treatment regardless of the manner in which the venom is administered; and atrophy was observed in the submaxillary gland throughout from the early stage to the advanced stage. In other words, the swelling of the acinar cells and atrophy caused by scorpion venom, a hypersialosis stimulant, are manifestations of hyperfunction (after recovery of the cells in the long period of treatment) and fatigue of the cells in the tissue, respectively. The difference between the parotid and submaxillary glands is considered to depend on the function of each organ. Comparative studies of lesions between the pancreas and the salivary gland disclosed degenerative change with major involvement of hydropic edema, caused by the fatigue of the cells due to hypersialosis in the former, and the major change in the latter is caused by the cellular fatigue due to hyperfunction with slight degenerative change of the cells, or focal and localized change, if present, that is, the so-called cell-impaired change is very slight. The difference between them seems to be attributable to the different effect of the venom on each organ, as well as to the difference in histological structure of the acinous gland, though both acinous gland have the same structure.
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