Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
Volume 43, Issue 1
Displaying 1-13 of 13 articles from this issue
  • Masakazu SUZUKI, Seiji TAKITA
    1983 Volume 43 Issue 1 Pages 1-13
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Copper and zinc metabolism of healthy children and in various types of diseased children, especially acute febrile mucocutaneous lymphnode syndrome (MCLS), was investigated. During acute stage of MCLS serum copper, concentration increased, while serum zinc concentration decreased, and normalized gradually during convalescent stage. It seems that this hypercupremia and hypozincemia during acute stage of MCLS are not due to the effect of environmental factors. The cases of abnormal course of MCLS, associated with coronary aneurysm, recrudescence and thrombocytopenia, showed higher concentration of serum copper and lower concentration of serum zinc than ordinary cases of MCLS. So it seems to be necessary to examine serum copper and zine concentration continuously as the indicator of heart involvement. During acute stage of bacterial infection, serum copper concentration increased, but purulent meningitis showed only mild increase in serum copper concentration. In general, viral infection did not show remarkable change in serum copper level, except in infectious mononucleosis, measles and exanthema subitum, which showed high concentration of serum copper during eruption stage. Serum copper concentration were also high in leukemia and malignant abdominal tumor, but brain tumor was within normal range of serum copper concentration. On the other hand, serum zinc level showed a slightly high level in acute upper respiratory infection, acute pneumonia and so on, but nephrotic syndrome showed a remarkably low concentration of serum zinc.
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  • Hiroko KUMURA, Katumi ASANUMA
    1983 Volume 43 Issue 1 Pages 15-23
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    The authors have carried out various experiments, aiming at causing pancreatic disorders, and in one experiment scorpion venom, which is known as the cause of hyperamylasemia, was used as a test material. Histopathological examination of the salivary glands in over-secreting condition, especially the submaxillary and parotid glands was performed together with a comparative study of pancreatic changes, which will be herein reported. The overall findings were swelling of the parotid gland in the early stage of the treatment, swelling and atrophic tendency in the middle stage, and swelling and degeneration in the late stage of treatment regardless of the manner in which the venom is administered; and atrophy was observed in the submaxillary gland throughout from the early stage to the advanced stage. In other words, the swelling of the acinar cells and atrophy caused by scorpion venom, a hypersialosis stimulant, are manifestations of hyperfunction (after recovery of the cells in the long period of treatment) and fatigue of the cells in the tissue, respectively. The difference between the parotid and submaxillary glands is considered to depend on the function of each organ. Comparative studies of lesions between the pancreas and the salivary gland disclosed degenerative change with major involvement of hydropic edema, caused by the fatigue of the cells due to hypersialosis in the former, and the major change in the latter is caused by the cellular fatigue due to hyperfunction with slight degenerative change of the cells, or focal and localized change, if present, that is, the so-called cell-impaired change is very slight. The difference between them seems to be attributable to the different effect of the venom on each organ, as well as to the difference in histological structure of the acinous gland, though both acinous gland have the same structure.
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  • Akira YASUI, Yoshiaki NISHIDA, Miki SHIBUSAWA, Jun-ichi ISHII, Sohei F ...
    1983 Volume 43 Issue 1 Pages 25-30
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Murakami and Suzuki defined linear ulcer as that which stretches perpendicularly to the direction of the lesser curvature, of which is its axis and with a length over 3.0 cm. But with time, many ideas concerning its definition and concept have evolved. Moreover, studies from different angles have been conducted and various opinions have come to be given about its pathogenesis and origin. We limited this survey to cases of linear ulcer resected surgically. Among them, the fact that the linear ulcer scar rate which was only 3% has risen to 28% after 20 years is a great change. There are no conflicting views on the shortening of the linear ulcer, but it is rare that one encounters a clinically typical case these days. No changes are seen in the length of the linear ulcer itself, but it is notable that the region of the lesion seen from the pylorus ring has become 1.8 cm on the average higher that those of the past. This indicates that the degree of the shortening of the lesser curvature is lessening. Other changes can be seen in age classification such as the 40 age group showing highest incidence in the past, but the same seen in the 40 to 60 age group these days. Linear ulcer was not detected in males and females 20 years of age and in females over 70 years of age during this study. Moreover, it was described that the early gastric cancer with linear ulcer scar.
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  • Itaru KATO
    1983 Volume 43 Issue 1 Pages 31-41
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    The cross-sectional area and thickness of the subcutaneous fatty layer of the upper abdominal plane were measured on the CT photographs of 77 persons (48 males, 29 females) . The upper abdominal plane was divided into cranial and caudal sections, and six measuring (A-F) points were made according to Erdheim's lattice line. The data were examined and compared with those of the other methods. The following results were obtained: 1) The percentage of subcutaneous fatty layer to the total cross-sectional area was 7.1 % in males and 10.2 % in females in the cranial section, and 11.1 % in males and 15.4 % in females in the caudal section. This percentage increased with age and was the highest in subjects in their fifties. 2) The thickness of the subcutaneous fatty layer was greater in the order of F-point (posterior median line), A-point (anterior median line) and B-point (mamillar line) in males, and A-point, F-point, and B-point in females in the cranial section, and, also, A-point, D-point (lumbar line) and E-point (gluteal line) in both sexes in the caudal section. 3) The thickness of subcutaneous fatty layer increased with the age at all points and was the greatest in subjects in their forties or fifties. This tendency was remarkable in twenty-and thirty-ycar-old males in the F- and A-points and in A-point in females in their twenties in the cranial section. In the caudal section, the thickness in A-point increased remarkably during the twenties and thirties in males and during the twenties in females. 4) Comparing data thus obtained with those of the other methods, the thickness of subcutaneous fatty layer in the present study corresponded to one half of value of the skin fold method, and was quite close to the direct method value in all points except A- and F-points, which were greater in this study than in others.
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  • Ryosaku ITO
    1983 Volume 43 Issue 1 Pages 43-54
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    In order to elucidate the functional characteristics of the spinohumeral muscles which consist of the serratus anterior, trapezius, rhomboideus major and minor and levator scapulae muscles, the following procedures were followed: muscle layer width was measured, the number of muscle fibers were determined and their size and weights were measured and compared with monkey muscles. The muscles examined were obtained from the right sides of 10 persons (five males and five females) . The sumples were injected and fixed with 10% formalin solution, and embedded in celloidin, sectioned into 20μ slices and stained with H. E. dye. The following results were obtained: 1) Muscle weight was the greatest in trapezius and the secondmost in serratus anterior, and were generally greater in males than in females. The width of muscle layers in the cranial portion of serratus anterior, intermediate portion of trapezius and cranial portion of rhomboideus major were greater than in the other muscle portions. 2) The number of muscle fibers per square mm. was largest in serratus anterior, the next in rhomboideus major and levator scapulae, and the smallest in the intermediate portion of the trapezius. They were generally larger in females than in males. 3) The mean size of muscle fibers was the greatest in the intermediate portion of the trapezius, the next in rhomboideus minor and levator scapulae, and the smallest in rhomboideus major and serratus anterior. The mean size of muscle fibers of serratus anterior and trapezius was greater in males than in females. 4) Compared with the crab-eating monkey, the muscle fiber organization in serratus anterior and rhomboideus were remarkably developed in the caudal portion of each muscle in monkey, but the development of these muscles in man was the same throughout all parts of the muscles. The developments in the intermediate portion of trapezius were excellent in man but poor in monkey.
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  • Jiro NISHIMURA
    1983 Volume 43 Issue 1 Pages 55-63
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    The myofibrous organization of the biceps femoris muscle, which plays the greatest role in the driving force behind monkey quadripedalism, was examined and compared with other muscles of the same subjects. Muscle samples were obtained from 10 adult crab-eating monkeys (4 males and 6 females) and were sectioned and stained with Sudan Black B. The following results were obtained: 1) The muscle weights were greater in M. biceps femoris that in spinohumeral muscles, M. deltoideus and M. tibialis anterior, and were greater in males than females. 2) The number of muscle fibers per sq. mm, was the smallest in the muscles compared, and were smaller in males that in females. 3) The ratio of 3 types of muscle fibers was the highest in white fibers (48.1 %), the secondmost in intermediate fibers and the smallest in red fibers. 4) As to the size of muscle fibers, white were the greatest, intermediate fiber secondmost and red were the smallest, in addition, they were greater in size in males than in females. Compared to other muscles, M. biceps femoris had the largest diameter of muscle fiber among the muscles. 5) The muscle fiber density was 72.5 % on the average and was larger in males than females. They were equivalent to those of the M. rectus abdominis of sportsmen who were studied by INOKUCHI, et al.
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  • Nobukazu DOKOH
    1983 Volume 43 Issue 1 Pages 65-73
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    In addition to congenital control, growth disorders of the facial bone have been attributed to other factors such as surgical invasion of the maxilla. For more than thirty years, animal experiments have been conducted in attempts to ascertain the extent of facial bone disorders induced by surgical procedures. The major congenital disorders of our patients have been cleft lip and palate, and most of the contemplated surgery has been for treatment of these disorders. Clinically, we suspected that partial exposure of the vomer bone, which often occurs when the cleft palate is closed, affects facial bone growth postoperatively. We investigated this possibility by resection of the partial mucous-periosteum compound tissue on the vomers of 220 rats. We divided 220 infant Wistar rats (100 g) into two equal groups, A and B. The vomer bone in group A was partially exposed by resecting the right vomerin mucous-periosteum compound tissue (6 mm×3 mm wide) under a flap made on the center of the palate. The flap was then returned to cover the palate bone and restore it to its preoperative condition. In group B, a flap was made the same as that in group A. This flap was then restored as in group A to complete the sham operation. This group was used as control. The skulls of the rats of both groups were removed and dried three months after the operations, and the length and symmetry of the maxilla was measured to determine any abnormality introduced as a result of surgery. Statistically, the maxilla of the rats in group A were significantly inclined in the direction of the side upon which we had operated, while the maxilla of the rats in group B were symmetrical. Forward growth of the maxilla of group A rats was significantly less than that of group B.
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  • Kaneshige SATOH
    1983 Volume 43 Issue 1 Pages 75-89
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    In order to detect growth impairment induced after cleft palate surgery, the author conducted a study using 190 infant male rats (100g) . The right halves of all rats' palates were operated upon ; in Group A 30, the lateral half of the mucoperiosteum on right half of the palate ; in B 30, the medial half ; and, in C 30, anteriorly from the 1st mole, was stripped off to expose the bone. In D 30, the mucoperiosteum was lifted up and half of it was laterally exised and, anteriorly, from the 1st mole, excised. In E 30, the mucoperiosteum was lifted up and then replaced. And F 40 was the control. The author examined the dry bones according to the deviation of the mid-palatal suture, calculating the ratio of the area and mole to suture distance between operated rats' and non-operated rats' sides and the reduction rates with the passage of time. The results on these calculations were defined as the influence degree of the experiments. The results on Groups A, B and D were extreme, especially on Group B ; effects on Group E were slight and Groups C and F were somewhat as mucoperiosteal exposure influenced. Therefore, the author suspected that clinical exposure of the palatal bone, as well to be undermining influences on mid-palatal suture. This is especially true in the case of palatal bone exposure, suggesting that this bone exposure, at least around the mid-palatal suture, should be avoided.
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  • THE INTERACTION OF CHLORPROMAZINE AND LEVOMEPROMAZINE IN SCHIZOPHRENIC PATIENTS
    Tadataka UENO
    1983 Volume 43 Issue 1 Pages 91-98
    Published: February 28, 1983
    Released on J-STAGE: November 19, 2010
    JOURNAL FREE ACCESS
    Plasma levels of chlorpromazine (CPZ) and levomepromazine (LPZ) were measured in schizophrenic inpatients during concomitant administration at the same dosage level for each drug. A determination was simultaneously carried out using high-performance liquid chromatography, as reported in a previous paper. CPZ and LPZ levels in plasma showed the highest values at 10: 00 a. m. or 2: 00 p. m. ; the latter was always higher than the former. In patients receiving a daily dose of 200 mg of each drug, the CPZ and LPZ levels were also higher than those in patients receiving both drugs daily at a dose of 100 mg each. The correlation between plasma levels and the dosages of CPZ and LPZ has been studied in three patients receiving the drugs. The results revealed a decrease in CPZ level and an increase in LPZ level dring concurrent administration. On the other hand, CPZ tended to be excreted in urine more than did LPZ ; in addition, there seem to be pharmacokinetic interactions (inhibition of LPZ metabolism and activation of CPZ metabolism) between the two drugs, although various factors have considerable influence on clinical pharmacokinetics.
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  • [in Japanese]
    1983 Volume 43 Issue 1 Pages 99-101
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
  • Makoto ARAI, Yoshiyuki HATANO, Kenji SAIKI, Kenichiro HINO, Hitoshi FU ...
    1983 Volume 43 Issue 1 Pages 103-106
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    Here are reported three cases of pancreatitis with eosinophilia. To date, there have been only a few papers concerning pancreatitis accompanied by eosinophilia, and a reasonable explanation for its existence has not yet been established. Among the cases in this study, some gastrointestinal distress, especially diarrhea, was noted. It seemed that eosinophilic gastroenteritis might have some relation to pancreatitis accompanied by eosinophilia. Although, the detailed mechanism is still unknown, some possible causalities are discussed.
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  • Hiroshi OGASAWARA, Seiichiro TAKAHASHI, Kunihiko OKUMURA, Sinichiro YO ...
    1983 Volume 43 Issue 1 Pages 107-112
    Published: February 28, 1983
    Released on J-STAGE: November 19, 2010
    JOURNAL FREE ACCESS
    A 40-year-old woman was admitted to our hospital with the chief complaint of right hypochondralgia. Biochemically, there were no abnormal findings, but D. I. C, CT scan, and abdominal echography showed a tumor of the gallbladder and dilatation of the common bile duct. Then, E. R. C. P. was performed and the diagnosis was confirmed as a tumor of the gallbladder and cystic dilatation of the common bile duct with an abnormality in the union between the choledochus and the main pancreatic duct. (The main pancreatic duct 15 joined with the common bile duct just below the site of cystic dilatation and both the ducts form a long common terminal duct entered at the major papilla of Vater) . Cholecystectomy and choledochotomy were performed. Microscopically, the tumor of the gallbladder was an inflammatory polyp without evidence of malignancy, and choledochus showed no abnormal findings. The patient recovered completely after the operation. Finally, abdominal echography was assumed to be valuable in the differential diagnosis of gallbladder tumors and stones.
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  • Teruaki TOMARU, Shohei TAKEDA, Toyoaki KAGAWA, Kumiko NAKAI, Tohichi D ...
    1983 Volume 43 Issue 1 Pages 113-116
    Published: February 28, 1983
    Released on J-STAGE: September 09, 2010
    JOURNAL FREE ACCESS
    A 43-year-old, healthy woman underwent an hysterectomy for myoma of the uterus under spinal anesthesia. Spinal anesthesia was performed at the L2-3 interspace, with 2.5 ml of 0.3 % hyperbaric dibucaine and 0.5 mg of morphine was additionally injected. The operation was uneventful. About 7 hours after the injection, the patient was found to be comatose, apneic and cyanosed. Immediately, artificial ventilation was performed by the oral method and with the of an AMBU bag resuscitator. Doxapram was administered by, drip infusion, but severe respiratory depression continued for about 6 hours. This respiratory depression was considered due to the intrathecal morphine administration. When intrathecal morphine (even a minimal dose) is applied as a postoperative pain reliever, extreme care must be paid to the occurrence of postoperative respiratory depression.
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