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Volume 50 (1990)
- Issue 6 Pages 585-
- Issue 5 Pages 463-
- Issue 4 Pages 361-
- Issue 3 Pages 219-
- Issue 2 Pages 115-
- Issue 1 Pages 3-
Volume 50, Issue 2
Displaying 1-13 of 13 articles from this issue
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Mayumi TSUCHIYA, Chifuyu TAKESHIGE1990 Volume 50 Issue 2 Pages 115-122
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAnalgesia caused by low frequency stimulation of the acupuncture point (AA), and of the non-acupuncture point after lesioning the analgesia inhibitory system (NAA), was abolished by hypophysectomy. The relation of the pituitary gland to production of AA and NAA was investigated with regard to the neuronal mechanism previously observed in the arcuate nucleus. We showed, at that time, that the final sector of the path from the acupuncture point to the pituitary gland is in the medial part of the hypothalamic arcuate nudes (M-HARN), AA is produced by activation of the descending pain inhibitory system (DPIS), and the initial sector of the DPIS is in the posterior part of the hypothalamic arcuate nucleus (P-HARN) . Pain threshold was measured by rat tail flick latency (TFL) . Drugs were applied through fine cannulae inserted into the brain. β-Endorphin, ACTH or dopamine microinjected into the P-HARN produced analgesia dose, dependently. Analgesia of β-endorphin disappeared, and analgesia of ACTH and dopamine were unchanged after denervation of the M-HARN. Lesioning the anterior part of the hypothalamic arcuate nucleus (A-HARN) abolished NAA and analgesia produced by stimulation of the anterior hypothalamus (NAA-AH), which was previously thought to be the final sector of the NAA pathway to the pituitary gland was abolished by lesion of the A-HARN, and potential was evoked in the A-HARN by stimulation of the non-acupuncture point and of the NAA-AH. Thus the A-HARN was more rostrally located than the NAA-AH in the NAA afferent pathway. Analgesia of ACTH microinjected into the P-HARN was abolished, while that of dopamine or β-endorphin was not changed after denervation of the A-HARN. Lesion of the median eminence (ME) abolished AA, but stimulation of ME did not produce analgesia. Potential was evoked in the ME by stimulation of the acupuncture point (tibial muscle) . From these results it was concluded that there is dopaminergic transmission between the M-HARN and P-HARN in AA, and between the A-HARN and P-HARN in NAA, and this transmission might be present only in the presence of presynaptic action of βendorphin or ACTH released from the pituitary gland.View full abstractDownload PDF (827K) -
Miki KUSHIMA1990 Volume 50 Issue 2 Pages 123-129
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTo improve the accuracy of gynecological cytodiagnosis, we studied 214 cases, in the Showa University Hospital, that had epithelial abnormalities in uterine cervical and vaginal cytology. There was discrepancy between cytological classification and histological diagnosis in 80 cases (37.4 %) .
In cytologic examination, so-called class III cases were suspected dysplasia. Upon reassessing cytologic and histologic slides, 8 cytologic class III cases were found to be mild dysplasia that had been improperly diagnosed histologically because of inaccurate observation of histological specimens, and 34 cytologic class III cases had histological evidence of squamous cell carcinoma including 16 with carcinoma in situ.
The reasons for the discrepancy between cytology and histology were :
1. The specimens were not suitable for observation (fixation and staining errors) .
2. There were few or no cells from the lesions (sampling errors) .
3. Observation of the specimens were inadequate for exact diagnosis.
The methods of sampling, fixation and staining are important factors in preparing adequate smears for cytologic diagnosis. Furthermore, careful observation of the cytologic and histologic specimens is very important.View full abstractDownload PDF (2710K) -
Masako TERASAKI1990 Volume 50 Issue 2 Pages 130-141
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTinnitus is a symptom often encountered in daily clinical practice. Objective evaluation, however, is usually difficult, and judgment of the effects of therapy varies. We had patients write a“diary of tinnitus”as a means of accurately assessing the therapeutic effects of intravenous injection of xylocaine and stimulation of the stellate ganglion. Immediate effectiveness, and the subjective improvement rating were studied. We judged the magnitude, nature and mental effects of tinnitus, and therapeutic effects from chronological changes in the magnitude of tinnitus recorded in the diary. The results of our study show that therapeutic effects on tinnitus can be predicted somewhat from the underlying disease, the pathology, the character of the patient, and the therapy. Thus, the “diary of tinnitus”is considered to be a significant method for judging the therapeutic effects of treatment.View full abstractDownload PDF (1320K) -
Masanobu WATANABE, Tohru YOSHIDA, Yoshio HIGAKI, Hideki YOSHIDA, Kazuo ...1990 Volume 50 Issue 2 Pages 142-148
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSHuman testicular steroidogenesis was studied by determining the concentration of dehydroepiandrosterone (DHA), androstenediol (AD), testosterone (T), androstenedione (Δ4A), DHA-sulfate, AD-sulfate, T-sulfate and gonadotropins in venous blood samples collected from spermatic veins during castration. Blood samples were drawn from spermatic and peripheral veins at 0, 15, 30, 60, 90 and 120 min after injection of 100μg LH-RH. The concentrations of gonadotropin and steroid were measured by radioimmunoassay. The results were as follows : 1) LH and FSH levels in spermatic venous blood were very close to those in peripheral venous blood after the LH-RH injection. 2) The concentrations of DHA, AD and T increased promptly at 5 min and was significantly greater than the 0 min level at 5-120 min after LH-RH injection. The post-injection levels of Δ4A were higher than the 0 min level, but statistically significant (p<0.05) elevation of Δ4A occurred only at 90 min after the LH-RH injection. Although there was significant correlation between T levels, DHA levels and AD levels at 30-120 min after LH-RH injection, Δ4A levels did not correlate with T, DHA or AD levels. 3) The concentrations of T-sulfate and AD-sulfate did not increase significantly but the concentrations of DHA-sulfate increased significantly at 5-90 min after LH-RH injection compared with the 0 min level. The DHA-sulfate levels correlated with the AD-sulfate levels at 5-120 min. On the basis of the results from these stimulation studies, we concluded that human testicular steroidogenesis responds to intrinstic LH induced by LH-RH injection in vivo. In this human testicular steroidogenesis, it is strongly suggested that the Δ5-pathway is preferred to the Δ4-pathway. It is suggested that the human testis secretes DHA-sulfate in vivo.View full abstractDownload PDF (778K) -
—EVALUATION OF X-RAY CT, TRANSRECTAL ULTRASONOGRAPHY AND MAGNETIC RESONANCE IMAGING ON THE BASIS OF VESICULOGRAM—Takeshi TORII, Kazuo WATANABE, Hiroyuki TAKIZAWA, Kohzo FUJI, Keiichi ...1990 Volume 50 Issue 2 Pages 149-155
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe aim of present study was evaluation of the diagnostic efficacy of vesiculo-CT (CT), transrectal ultrasonography (US) and magnetic resonance imaging (MRI) in the detection of seminal vesicle invasion of prostatic cancer. Findings in conventional vesiculography were used as a reference criterion for the tumor invasion. Studies were conducted in 29 patients with prostatic cancer diagnosed histopathologically by biopsy. Five were excluded from the analysis because of technical failure in the vesiculography. In the vesiculogram, positive images of seminal vesicle invasion by prostatic cancer were obtained in eight cases, of which seven produced positive images in CT and two in US. Two underwent MRI and produced positive images. All sixteen cases with negative vesiculographic images were also negative in CT. However, only fourteen had negative images in US. Three with negative vesiculography also presented negative images in MRI. The diagnostic ability of CT in seminal vesicle invasion by prostatic cancer was considered to be superion to that of US. MRI also seemed to be efficient, but the number of subject cases was too small to draw a definite conclusion.View full abstractDownload PDF (5677K) -
Keiichi OHTA, Yoshinori KANNO, Yoshio HIGAKI, Kazuo IMAMURA1990 Volume 50 Issue 2 Pages 156-162
Published: April 28, 1990
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSQuantitative evaluation of the primary prostate cancer lesion and distant metastatic lesions is difficult and, as of now, there are no generally established criteria to evaluate therapy effectiveness for this disease. In our department we established criteria for the evaluation of therapeutic effectiveness, based in part on the General Rules for Clinical and Pathological Studies on Prostate Cancer, and analyzed the value of the criteria in relation to the clinical stages of the cases treated in our department. According to the stage classification criteria in the General Rules, in stages A and B, improvement was recognized in 6 cases, no change in 10 and progress of the disease was recognized in 2. In stage C there were 3 cases of improvement, 10 of no change and 1 of progress of the disease. In stage D, all cases were unchanged. However, according to our criteria for evaluating therapy effectiveness, in stages A and B there was improvement in 9 cases, 5 with no change and 4 showed progress of the disease. In stage C there were 4 cases each of improvement and no change, and 6 cases showing progress of the disease, whereas in stage D there were 9 cases of improvement, 2 of no change and 1 of progression of the disease. When evaluated according to the above-mentioned General Rules, many cases were placed in the unchanged category. The reason for this is that the clinical criteria for evaluation by the General Rules are not sensitive enough to reflect changes in the primary tumor, and we considered that our Therapy Evaluation Criteria (TEC) compensated for this. It is therefore felt that our TEC system is clinically useful.View full abstractDownload PDF (739K) -
—COMPARATIVE ANALYSIS OF TRANSRECTAL ULTRASONOTOMOGRAPHY AND MRI—Tohru YOSHIDA, Hiroyuki TAKIZAWA, Kazuo WATANABE, Kozo FUJI, Toshiichi ...1990 Volume 50 Issue 2 Pages 163-170
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe analyzed ultrasonic images and MRI, and compared their significance in differential diagnosis of stages B and C in eighteen cases of prostatic cancer. The following conclusions were reached :
1) In nine patients with untreated prostatic cancer, both ultrasound and MRI clearly showed the presence of primary focus and its development. Ultrasound provided more superior information than MRI about capsule invasion, but MRI supplied better data on relations between the prostate gland and surrounding organs, and between adipose tissues.
2) In nine cases of previously treated prostatic cancer, ultrasonic images generated considerably superior tomographic pictures of both primary foci and capsules.View full abstractDownload PDF (5556K) -
Takashi IIZUKA, Yasuhide MORIWAKI, Toshihiko UEDA, Ryohei KOIDE, Makot ...1990 Volume 50 Issue 2 Pages 171-175
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe used pharmacological experiments for medical students to study and understand the pharmacology of the autonomic nervous system. The drugs used were eye drops, and internal medicine. Intra-ocular pressure (TOP), accommodation etc. were measured. Eye drops were used in one eye, and the contralateral eye was left untreated. The TOP decreased in both eyes when epinephrine, dipivalyl epinephrine and timolol were used on one eye. We assumed that these drugs effected not only the eye treated topically, but also the autonomic nervous system. Accommodation was measured using an accommodo-poli-recorder and accommodometer AA2000. Mydriactic eye was measured using the pin-hole method. Accommodation using pilocarpine was almost unchanged. The difference in accommodation using tropicamide was 3 diopters (D) between accommodo-poli-recorder and accommodometer AA2000 measurements. We considered that this 3D difference was caused by the difference between subjective and objective refraction. Results of measurements using the pin-hole method increased 1D comparison over the method without using the pin-hole.View full abstractDownload PDF (475K) -
Shunsuke NATSUKAWA, Akira SHIOKAWA, Koji TASHIRO1990 Volume 50 Issue 2 Pages 176-186
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTo probe the characteristics of cancer in the countryside, a clinical, pathological and epidemiological study was performed on cases pathologically diagnosed at a hospital in a typical rural district and another hospital, similar in size, in a major city. Overall, no significant difference was observed, presumably because there has been progress in the dissipation of regional differences in the living environment and pattern. Characteristically, the average age of clinical cases at the rural hospital was slightly higher, probably reflecting the fact that the average age in the rural population is strikingly higher. When compared by organ, there tended to be more cases with gastric and prostatic cancers in the rural hospital and more cases with lung cancer, leukemia and uterine cancer in the urban hospital. There were virtually no differences in the numbers of cases with colon cancer, breast cancer, ovarian cancer and malignant lymphoma. The number of cases with gastric cancer was greater in the rural hospital, primarily because of institutional differences, rather than epidemiological diffecences. In regard to lung cancer, for which the influence of environmental factors is probable, smoking, air pollution and other epidemiological differences were noted. There was virtually no difference between the two areas in the numbers of cases with colon cancer, presumably because of decreasing differences in the dietary patterns and growing Westernization.View full abstractDownload PDF (1222K) -
—RELATIONS BETWEEN CLINICAL PICTURES AND SOCIAL ADAPTABILITY—Satoru INOUE, Shoji SAKURAGI, Takashi IGUCHI, Itsuo TADAMA, Yasuyuki A ...1990 Volume 50 Issue 2 Pages 187-196
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAmong outpatients with schizophrenia who received medical treatment for over five years, 183 cases from the Karasuyama Mental Hospital, which is affilated with Showa University, were analyzed. Based on the clinical pictures, the patients were divided into two types : symptom-relieved (124 cases), and symptom-revealed (59 cases) . Socio-biological and pathological surveys were made on the progress of social adaptability and correlativity between social adaptability and positive/negative symptoms. There was strong correlation between social adaptability and mental symptoms in all clinical pictures. In symptom-relieved types, there was strong correlation between social adaptability and negative symptoms, whereas for symptom-revealed types correlation of the same degree between social adaptability and positive/ negative symptoms was weak. For the symptom-revealed types, the long-term turning point (result) was found to be closely related equally with both positive and negative symptoms. There were many cases of improvement in social adaptability. The symptom-revealed types improved in the superior type of negative symptoms. This picture was demonstraded to have an affinity with the“second flexible”Zweiter Knick (Mayer-Gross) -like phenomenon.View full abstractDownload PDF (1272K) -
Yuji KATAYAMA1990 Volume 50 Issue 2 Pages 197-204
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe sound pressure in the external ear canal and the external cavity were measured in 60 normal adult ears. The sound pressure levels measured in the 60 real external ears were about equal to that in the Ear Simulator. The average volume of the external cavities of 60 ears was 1.34m1. The sound pressure level was higher in smaller external ear cavities and lower in larger cavities than in the Ear Simulator at 250 Hz, 500 Hz, 750 Hz, 1 KHz, 1.5 KHz, 2 KHz.
Open ear gain and insertion gain were measured in 23 ears wearing canal hearing aids : 10 normal ears, 7 ear drum perforation ears, 6 open mastoid cavity ears after operation by CCI-10 probe microphone system. With open ear gain of normal ears, the frequency response had a peak at 2828 Hz which gave an amplification of 16.9±3.7 dB. In a pathological ear with an open mastoid cavity after operation, insertion gain response had a deep dip at between 1.5 KHz and 2 KHz. This fact suggests that more amplification at the middle frequency range is needed for pathological ears, such as those with open mastoid cavity after operation, in fitting canal hearing aids.View full abstractDownload PDF (2060K) -
Masao NEGISHI, Kazuo KOBAYASHI, Hirotsugu IDE, Terumi TAKAHASHI, Takat ...1990 Volume 50 Issue 2 Pages 205-209
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA fortyseven-year-old female with classical RA was treated with 300mg/day D-penicillamine, therafter her serum IgA gradually decreased. After 2 years treatment, she was often infected with bronchitis. Her serum IgA was 0.5 mg/dl measured by laser nephelometer. Other immunoglebulins were not decreased. Delayed skin reactions were positive and PHA-P and ConA lymphocyte transformation tests revealed normal stimulation indices. E rosette was 66%. Surface IgA bearing cell was 4%. Secretory IgA in saliva was negative. Anti-IgA antibody and anti-milk antibody were negative. Her serum IgA is gradually being elevated after discontinuation of the D-penicillamine. Studies of cytoplasmic immunoglobulin positive cells by a T-B cell co-culture system suggest that the D-penicillamine induced selective IgA deficiency was due to T cell dysfunction.View full abstractDownload PDF (3194K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1990 Volume 50 Issue 2 Pages 210-217
Published: April 28, 1990
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (980K)
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