Five groups of weanling male rats were each fed palm oil, palm olein, their randomly interesterified oils, and soybean oil, as control, for 28 d. Comparative studies were made on cholesterol and its metabolites in several tissues and feces from these rats and on chemical and physical properties between the palm and interesterified oils.
1) By interesterification of the palm oil, palmitic and oleic acids, rich in oil, became essentially uniformly distributed at each position of triglyceride, causing an increase in saturated triglycerides of high melting point, and improved plasticity.
2) The serum cholesterol concentrations of the interesterified palm oil and palm olein groups did not differ significantly from those of the soybean oil group, and did not change with interesterification of palm oil. The same was noted for the serum triglyceride and bile acid concentrations. As also palm oil, palmitic acid was present as a minor constituent in the serum and liver lipids of rats fed interesterified palm oil, and preferentially excreted in the feces, despite modifying the triglyceride structures.
3) Cholesterol content in both liver and adipose tissue was essentially the same in all the five groups, and cholesterol and its metabolites in feces from the interesterified palm oil and palm olein groups were present in amounts almost equal to those of the original oil groups, but significantly lower than those of the soybean oil group. However, the ratio of metabolites to cholesterol in the feces was basically the same in all groups.
Thus, the effect of interesterified palm oil on cholesterol metabolism may be equivalent to that of either its original oil or soybean oil.
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