巻号一覧
16 巻, 6 号
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臨床研究
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西平 浩一, 中畑 龍俊, 赤羽 太郎1975 年 16 巻 6 号 p. 581-588
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありThe in vitro colony formation by marrow from 16 children with normal bone marrow and 27 children with acute leukemia (16 cases at onset or relapse, and 11 cases during complete remossion) has been studied. The number of colonies per 2×105 cells in normal bone marrow ranged between 126 to 504, and the average count was 259 colonies. This was a higher number of colonies than that in adult bone marrow. After 7 days of culture, colonies were macroscopically recognized as white spots. The ratio between compact colonies to loose colonies was approximately 2:1, when classified using an inverted microscope.
In 12 cases which had counts in excess of 95% of blasts at onset or relapse of acute leukemia, there was a decrease in colony formation. One case of ALL showed an almost normal colony forming capacity. All of the 4 cases with 30 to 60% of blasts developed colonies, but the number of colonies was less than that of normal bone marrow. Colony forming capacity in 11 cases with remission was similar to normal bone marrow. We consider that in some cases of acute leukemia at onset or relapse there may be blasts that can differentiate and maturate.抄録全体を表示PDF形式でダウンロード (945K) -
—Daunomycin, Cytosine arabinoside, Vincristine及び副腎皮質ホルモンの四者併用療法について—山口 博志, 岡部 信和, 井上 晃, 市丸 道人1975 年 16 巻 6 号 p. 589-598
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありTo improve the remission rate of acute non-lymphatic leukemia, newer combinations of anti-leukemic agents were developed based on leukemic cell kinetics and pharmacological mechanisms. The combined treatment with Daunorubicin, Cytosine Arabinoside, Vincristine and Prednisolone; (DCVP) and initial treatment with Cytosine Arabinoside, and Vincristine followed by Daunorubicin and Prednisolone (New DCVP) were studied and compared with the standard DCMP program. Fifty-three cases of adult non-lymphatic leukemia were randomly divided into 3 groups, and were treated with DCMP, DCVP and New DCVP, resulting in complete remission rates of 42.9% (12/28), 90.0% (9/10) and 80.8% (12/15) respectively. Time required to obtain complete remission was 48 days with DCMP, 53 days with DCVP and 41 days with New DCVP; most patients did not require more than 2 courses of treatment. The DCVP and New DCVP groups had one death each versus 24 deaths in the DCMP group. The duration of remission and survival time of those which obtained remission were respectively 12 weeks and 15 months with DCMP, over 14 weeks and over 12 months with DCVP, and over 26 weeks and over 13 months with New DCVP. All 3 treatment programs caused serious bone marrow suppression; New DCVP produced the least suppression. Prominent side effects were impaired liver function with DCMP, and peripheral neuropathy with both DCVP and New DCVP. When considered with leukemic cell kinetics and pharmacological mechanisms of anti-leukemic agents, the above results indicate that New DCVP is the more rational and effective of the treatment programs studied.抄録全体を表示PDF形式でダウンロード (801K) -
松田 重三1975 年 16 巻 6 号 p. 599-613
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありNitroblue tetrazolium dye reduction test (NBT test) is used as one of the neutrophil function tests, especially for measurement of the ingestion and bactericidal potent of neutrophils.
Since the first report of Baehner & Nathan, this test has been employed for screening of chronic granulomatous diseases of infancy. But later, Park insisted that NBT test could be used for the differential diagnosis of non-bacterial infection from bacterial.
Thereafter this method was modified and simplified, but still remained some thechnical problems, which included the complexity of the test procedure and its inherent errors. In this paper Park's method was developed, using microcapillary tube to dissolve some of these problems.
Furthermore, it was confirmed that this test was valuable for differentiation of the bacterial and non-bacterial infections and for check of abnormalities of plasma factors, especially of complement-properdin systems.抄録全体を表示PDF形式でダウンロード (984K) -
船迫 真人, 山路 功, 中山 伊智郎, 津田 患昭, 花野 靖久, 上江洲 朝洋, 泉 良治, 谷本 幸三, 奥 浩子, 太田 喜一郎1975 年 16 巻 6 号 p. 614-619
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありHyperfunction of the reticuloendothelial system (R. E. S.), lipid imbalance, autoimmune factor and others have been reported to cause hemolysis in chronic liver disorders.
According to the present results, the cause of hemolysis in the chronic liver disorders was partly due to the production of Malonyl-di-aldehyde (M. D. A.) and the lability of hexose monophosphate shunt (H. M. S.) in the erythrocyte membrane in addition to the above-mentioned mechanisms.
Our data revealed no relationship of hemolysis and plasma factors, such as serum cholesterol, albumin and γ-globulin.
By compensation of erythrocyte enzymodynamics of H. M. S., erythrocyte resistance in vitro increased and no relationship between M. D. A., G-6-P. D. and catalase was noted in the chronic liver disorders.抄録全体を表示PDF形式でダウンロード (337K)
症例
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佐藤 幹二, 今井 康雄, 高安 宗顕, 玉城 允之, 丹下 剛, 中沢 正樹, 戸川 敦, 今村 幸雄1975 年 16 巻 6 号 p. 620-627
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありThis is the first autopsied case in Japan of multiple myeloma, in which dimeric and tetrameric form of k type Bence Jones protein was demonstrated in the serum and in the urine.
A 57 year-old man was admitted to Hunabashi Saisei-kai Hospital in Oct. 1970 with chief complaints of general malaise, massive proteinuria and anemia. The diagnosis of multiple myeloma with dimeric and tetrameric form of Bence Jones proteinaemia and proteinuria was made on hematological and immunochemical examinations. Prednisolone was quite effective and the patient was discharged in Feb. 1971. One and a half years later, intractable pains insiduously developed in the chest and back and he was readmitted in Oct. 1972. Pneumonia, chronic bronchitis and refractory anemia developed and chacexia gradually progressed. He was not responsive to prednisolone and died in Nov. 1973. Throughout the clinical course the renal function was maintained fairly well and distict azotemia was never seen. In addition, it should be pointed out that the albuminuria in this patient was always slight, in contrast to the distinct amount of tetrameric Bence Jones proteinuria (molecular weight: ca 90,000).
On autopsy, mature and immature plasmacytic cell infiltration was found in the bone marrows, liver, spleen and perineural tissues. Hyaline thrombi were occasionally seen in the lungs, heart and pancreas. No amyloid deposit was observed. The kidney was slightly atrophic, however, no significanty pathognomonic lesion was demonstrated on histological and electronmicroscopical examination.
It was suggested, therefore, that the apparently paradoxical excretion of tetrameric Bence Jones protein in the urine was not due to abnormal glomerular filtration in this case. The physical and immunochemical studies on this peculiar Bence Jones protein will be reported in another communication.抄録全体を表示PDF形式でダウンロード (1007K) -
小宮山 淳, 江口 光興, 赤羽 太郎, 飯沼 和枝1975 年 16 巻 6 号 p. 628-635
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありThe patient was a 2 2/12-year-old girl who was hospitalized because of fever, anemia, emaciation, and exophthalmos. On admission, myeloblasts were present as many as 11% of leukocytes in peripheral blood and 95% of nucleated cells in bone marrow. Bilateral exophthalmos became prominent and tumorous masses developed on her cranium in the final stage of illness.
The electron microscopy revealed a peculiar cytoplasmic inclusion in approximately 80% of leukemic cells. The inclusions were usually round to oval, 0.1∼1.0 μ in diameter, and bordered by a single or double membrane. The components within the limiting membrane included various substances such as ribosomes or ribosome-like particles of 150∼200 Å, filamentous material, lamellar structures, granules, and so on. Canalicular structures and endoplasmic reticulum were also observed in some of the inclusions. Intense acid phosphatase activity was demonstrated in the inclusion.
The inclusions observed here appear to differ from those described in leukemic cells. On the basis of their morphologic characteristics and strong acid phosphatase activity, it seems likely that they are autophagic vacuoles.抄録全体を表示PDF形式でダウンロード (2108K) -
桜井 徹志, 工藤 秀機, 長沢 俊郎, 依田 安弘, 川田 健一, 中島 隆, 阿部 帥, 柏木 平八郎, 野村 武夫, 山田 清美1975 年 16 巻 6 号 p. 636-643
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありCytogenetic studies were repeated throughout the acute phase of chronic myelocytic leukemia in a 59-year-old male.
A major hypodiploid cell line of chromosome constitution 45, XY, Ph1, -18 developed in association with acute transformation. When hematologic remission was achieved by the combination chemotherapy consisting of vincristine and prednisolone, the frequency of this karyotype was markedly decreased with increase of 46, XY, Ph1 cells which had characterized the chronic phase of his disease. Relapse was accompanied by increase of the hypodiploid cells, which again decreased as reinduction was accomplished by the same chemotherapy. The second relapse was characterized by the evolution of a new cell line with a further degree of aneuploidy 44, XY, Ph1, -18, -C in addition to the original hypodiploid cell line. Subsequently, resistance to vincristine developed and death ensued due to E. coli sepsis 14 months after acute transformation. A positive correlation was found between the frequency of hypodiploid cells and percentage of myeloblasts in the marrow during the entire course of the acute phase.
The clinical significance of chromosome analysis in patients during the blastic phase of chronic myelocytic leukemia was discussed.抄録全体を表示PDF形式でダウンロード (630K)
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