臨床血液
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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10 巻, 2 号
選択された号の論文の9件中1～9を表示しています
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第10回総会
会長講演
綜説
臨床研究
  • Consumption-Coagulopathy
    村上 元孝, 松田 保, 恩地 一彰, 梅田 俊彦, 河村 洋一, 西野 哲夫, 平沢 謙太郎, 平丸 三樹, 万見 新太郎, 加藤 正義
    1969 年 10 巻 2 号 p. 110-118
    発行日: 1969年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.10.110
    ジャーナル 認証あり
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    9 cases of consumption-coagulopathy were described.
    These included 3 cases of carcinomatosis and 2 cases of acute promyelocytic leukemia. In the remaining 4 cases, the initial courses were mycotic infection, paroxysmal nocturnal hemoglobinuria, infectious mononucleosis and liver cirrhosis, respectively.
    The clot promoting substances, which were probably active intermediate products of clotting system, were demonstrated in 3 cases. Autopsy was done in 6 cases, and disseminated intravascular thrombi were observed in only 2 cases without evidences of increased fibrinolysis. No hemostatic effect was observed with the administration of synthetic fibrinolytic inhibitors, whereas a marked inhibition in fibrinolytic activity was observed following intravenous infusion of small doses of heparin.
    From these data, it is postulated that some clinical conditions such as increased fibrinolysis and decreased platelet adhesiveness in the early stage of myocardial infarction may be accounted for by the mechanism similar to consumption-coagulopathy.
    The relationship between hypercoagulability and consumption-coagulopathy is discussed.
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症例
  • 骨髄および脾臓に特異な泡沫細胞の増殖をみた1例
    三浦 亮, 柴田 昭, 小野寺 清寿, 鈴木 厚生, 坂本 忍, 鈴木 千征
    1969 年 10 巻 2 号 p. 119-124
    発行日: 1969年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.10.119
    ジャーナル 認証あり
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    A case of 53 years old woman with foam cells in bone marrow and spleen was reported.
    She was admitted because of fever and left upper abdominal pain. Hepatosplenomegaly was prominent. Laboratory studies revealed moderate leucocytosis and thrombocytosis. Lymphocytes had large vacuoles. Alkaline phosphatase activity of granulocytes was not decreased. The value of total lipid, phospholipid and cholesterol in serum were moderately elevated. The ultrastructure of lymphocytes vacuoles suggested lipid accummulation.
    The bone marrow picture was hyperplastic and there were many foam cells which showed strong activity of acid phosphatase. There were many phagosomes in foam cells on electron microscopic observation.
    She was treated with steroid, antibiotics and busulfan. Eight months later after admission, she died of dyspnea.
    The autopsy revealed that there were many foam cells in splenic sinuses.
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第10回総会
例会
  • 第1回　血管透過性研究会抄録
    1969 年 10 巻 2 号 p. 273-301
    発行日: 1969年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.10.273
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    In this paper the method for capillary fragility by the use of Sato's petechiometer was examined. Comparative study showed that the infraclavicular area is most proper in view-points of both width and stability in value compared with available areas such as inner sides of the arm. Results would better be represented as a critical pressure: a minimum negative pressure to develop a single petechia rather than as gradings of 0 to ?? corresponding to the number of petechiae developed after a definite negative pressure. Normal critical pressure at the infraclavicular area was 82±34.8 mmHg in average of 10 normal males, and 74±25.4 mmHg in average of 10 normal females. These critical pressures were found not to be correlated with either results of tourniquet test or thrombocyte counts in both normal subjects and patients with hematologic disorders.
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