巻号一覧
12 巻 (1971)
- 6 号 p. 513-
- 5 号 p. 417-
- 4 号 p. 335-
- 3 号 p. 207-
- 2 号 p. 61-
- 1 号 p. 1-
12 巻, 5 号
選択された号の論文の9件中1～9を表示しています
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綜説
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山田 兼雄1971 年 12 巻 5 号 p. 417-428
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (955K)
臨床研究
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長谷川 弥人, 板津 安彦, 浅井 一太郎, 三輪 史朗, 天木 一太, 伊藤 宗元, 長村 重之, 高橋 隆一, 日野 志郎, 宮田 久寿 ...1971 年 12 巻 5 号 p. 429-436
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありThe effectiveness of a new antileukemic agent, 6-mercaptopurine riboside (Thioinosine) on acute myelogenous leukemia (AML) was studied.
Forty-two patients (19 males and 23 females) including 34 cases with AML were given 45 courses of Thioinosine administration in combination with glucocorticoids (GC). Fifty-five patients (27 males and 28 females) including 54 cases with AML were treated with 6-mercaptopurine (6 MP) plus GC and served as control. The average daily doses of Thioinosine and 6 MP were 300 mg (50∼400 mg) and 100 mg (30∼150 mg) respectively.
The rate of remission at the initial treatment with Thioinosine plus GC was 82.2%, whereas that with 6 MP plus GC was 62.9%. The rate of remission after second trials was 30% with Thioinosine plus GC, and 40% with 6 MP plus GC. The number of cases in theses studies, however, was too small to draw statistically significant differences between the two treatment groups (p>0.05).
In average, 42 days were required to induce initial remission with Thioinosine and 44.2 days with 6 MP.
From these data, it was suggested that the effectiveness of Thioinosine in treatment of AML was as potent as 6 MP.
One of the most frequent side effects of Thioinosine and 6 MP were liver impairment (36.5% and 22.6% respectively). The development of this side effect with Thioinosine seemed to come some what earlier thanwith 6 MP.抄録全体を表示PDF形式でダウンロード (559K) -
高久 史麿, 青木 洋祐, 中尾 喜久1971 年 12 巻 5 号 p. 437-443
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありA new method to assay the ALA synthetase activity of human bone marrow erythroid cells by measuring the incorporation of 14C-α-ketoglutarate into ALA in bone marrow cell homogenate has been developed. Preliminary experiments to find out the optimal conditions for the assay of the enzyme as well as those to confirm the reliability of the assay were performed.
The ALA-synthetase activity was almost 150 times higher in the erythroblasts than in the peripheral blood reticulocytes. In human bone marrow cells obtained from thirteen hematologically normal persons the ALA-synthetase activity ranged from 45.4 to 88.8 μμ moles α-ketoglutarate incorporated per 106 erythroblasts per hour. Mean±S.D. value was 69.5±13.6.抄録全体を表示PDF形式でダウンロード (544K) -
—悪性リンパ腫を中心に—木村 郁郎, 大熨 泰亮, 国政 郁哉, 高野 純行1971 年 12 巻 5 号 p. 444-449
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありBleomycin was administered to 14 patients with malignant lymphoma (5 cases of reticulum cell sarcoma, 6 cases of Hodgkin's disease, 1 cases of lymphosarcoma and 2 cases of histologically unclassifed type). The drug was also given to 9 patients with leukemia.
In 10 of the 12 cases of malignant lymphoma enlarged lymph nodes clearly shrank after single Bleomycin administration. And a remarkable effect appeared promptly in 5 of them. These results indicated that Bleomycin might well be used as a remission inducer. In some cases of leukemia treated with Bleomycin the leukocyte counts were decreased, but its life-prolongation effect in leukemic cases needed further observation. Attention should be paid for its side effects in lung. Combination treatment with Bleomycin and fibroblast-inhibiting agents (CPBP) was useful for remission as well as for prevention of pulmonary disturbances. The use of Bleomycin in the treatment of malignant lymphoma was expected to improve the chemotherapy result in this disease.抄録全体を表示PDF形式でダウンロード (637K)
症例
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池崎 英文, 浦川 栄, 本田 恂1971 年 12 巻 5 号 p. 450-457
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありA 56 year-old male, who had received angiography by thorotrast about 30 years ago, was admitted to our hospital because of anemia on Nov. 12, '69.
His peripheral blood pictures and sternal marrow features showed the status of the preleukemic stage such as leukemoid reaction until the manifestation of erythroleukemia on Jan. 22, '70.
The specific droplet shadows caused by the deposition of thorotrast could be observed in the x-ray film of the upper abdomen.
He was suffering from severe anemia, epistaxis, hematemesis, flux, hematuria, and infection of lung since the end of March, '70 and at last died of the severe bleeding diathesis on May. 7. '70.
The findings of autopsy were as follows:
1) Thorotrast granules or mass were observed in Glisson sheath, interstitium, and around the central venous vessles of the liver.
2) Especially, the histological findings of the spleen and the bone marrow suggested the causal relation between the atypical proliferation of erythroleukemic cells and the deposition of thorotrast.
3) The tissue of portal lymphnode showed the deposition of thorotrast and slight atrophy.
4) Wide-spread bleeding, sideroblastosis, and necrosis could be seen in the tissue of liver, spleen, lung, digestive tract, and kidney.
5) Fungus disease of lung and adrenocortex atrophy were proved.
It has been reported that most of the malignant tumors induced by thorotrast were epithelial tumors such as cholangioma or liver cartinoma and non-epithelial tumors induced by thorotrast were very rere in Japan.
But in Europe and America, non-epithelial tumors such as liver sarcoma, Hodgkin's sarcoma, leukemia etc. were reported to occupy about 40% of all malignant tumors induced by thorotrast.
This case report of the acute erythroleukemia induced by thorotrast is considered the first or second case in Japan.抄録全体を表示PDF形式でダウンロード (1233K) -
太田 宏, 池田 靖1971 年 12 巻 5 号 p. 458-467
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありTwo cases of IgD myeloma are reported. The first patient, 53 year-old male, was referred to Mitsubishi Nagoya Hospital because of proteinuria, and diagnosed as multiple myeloma by serum and urine analysis as well as bone marrow findings. Although he had responded partially to steroid and Melphalan therapy, he developed renal failure and died one year after the diagnosis. M-component of the patients serum was identified as IgD by immunoelectrophoresis with anti-IgD serum, and the serum level of IgD varied from 1,300 mg to 2,850 mg/dl during his course. Light chain of the M-component and Bence-Jones protein was of λ-type. The M-component had a sedimentation constant of 5.95 S and the myeloma cells were shown to produce IgD by immunofluorescence technique.
The second patient, 28 year-old male, with the complaint of chest pain was diagnosed as multiple myeloma because of multiple bone lesion with plasma cell proliferation and urinary excretion of profuse Bence-Jones protein (type κ). Increase of serum IgD level (46 mg/dl) and decrease of other classes of immunoglobulin were shown by immunoelectrophoresis and by quantitation with radial immunoffusion, whereas no apparent M-component was revealed by conventional electrophoresis on cellulose acetate membrane.
Some discussion were made on the clinical and morphological characteristics of IgD myeloma and on the importance for serum analysis with anti-IgD serum especially in cases of Bence-Jones type myeloma.抄録全体を表示PDF形式でダウンロード (1577K) -
伊藤 怜子, 新谷 和夫, 中尾 恿1971 年 12 巻 5 号 p. 468-473
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありA 31 year old man was admitted on June 23, 1970, complaining of irregular high fever with vomitting, marked headache and myalgia in paroxysms, and profound weakness. He had returned to Tokyo from Europe on May 14, 1970. On his way, he stayed for a week in some region of Africa and the above symptoms developed on 5th day after his arrival in Japan.
On admission, he was pale with slight jaundice. Liver and spleen were palpable two fingerbreadths below the costal margin. His blood examination showed marked normochromic anemia and leukopenia (WBC 2800/mm3) with increased neutrophilic series and a few atypical immature cells. The first examination of his sternal bone marrow showed a slight increase in the primitive cells of myelogenous series although the blast cells were 5.0%, in which were found some atypical cell in nature.
By these findings, he was suggested to be in the early stage of AML, such as preleukemic acute human leukemia, even though there was a lack of typical signs of AML.
Therefore he was treated with some anti-leukemic agents for only 3 days., and suddenly many Plasmodium falciparum were detected from blood smear obtained on June 26. On June 29, anti-malaria treatment was started with chloroquine diphosphate and soon after he was greatly improved. In previous bone marrow and blood smears which were re-examined after correct diagnosis had been made, only a few malaria plasmodium could be found.
Until now, no such cases of malaria which showed a leukemic blood picture have been reported in Japan. Because of the rarity of leukemoid reaction caused by falciparum malaria, this case was reported.抄録全体を表示PDF形式でダウンロード (697K) -
北中 勇, 岸田 繁, 藤永 逸, 服部 絢一1971 年 12 巻 5 号 p. 474-478
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありA 10-year-old male had had repeated episodes of gingival bleeding, epistaxis and subcutneous hemorrhages since infancy. Family history revealed that his parents were of consanguineous marriage and his mother's bleeding time was prolonged.
An 18-year-old female also had had repeated episodes of gingival bleeding and epistaxis since infancy. No hemorrhagic diathesis was found in any member of her family.
In both cases, the bleeding time was prolonged and Factor VIII activity was decreased. Platelet adhesiveness as measured by the Salzman method was decreased in case 1, and was normal in case 2. However, other blood coagulation tests such as platelet count and morphology, platelet Factor III activity, platelet aggregation, whole blood clotting time and clot retraction were within normal range in both cases. After transfusion of plasma cryoprecipitate, Facter VIII activity markedly increased above the expected value and bleeding time was not changed in case 1, whereas in case 2 Factor VIII activity only slightly increased and bleeding time was shortened.
These inconsistent data may suggest that plasma vessel factor and AHG-stimulator are different in property each other.抄録全体を表示PDF形式でダウンロード (413K)
例会
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1971 年 12 巻 5 号 p. 479-493
発行日: 1971年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (1436K)
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