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Volume 53 (1993)
- Issue 6 Pages 529-
- Issue 5 Pages 423-
- Issue 4 Pages 343-
- Issue 3 Pages 235-
- Issue 2 Pages 123-
- Issue 1 Pages 1-
Volume 53, Issue 3
Displaying 1-16 of 16 articles from this issue
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Koihci KADOMATSU, Masaya ANZAI1993 Volume 53 Issue 3 Pages 235-246
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDuring the 12 years from January, 1980 to May, 1992, 445 cases of single cleft palate visited our hospital to undergo initial surgery and speech therapy. Of these cases, 242 aged 4 and above, on whom comparatively correct evaluation of speech disorder was possible, were selected as subjects for this study. At a statistical processing, SAS was used, and an assessment was made regarding the influences exerted onset of speech disorder by Hayashi's quantified classification II with x2-test and speech disorder as external criteria. Factors related to the onset of speech disorder were sex, cleft type, number of weeks after birth, birth weight, abnormal pregnancy history, abnormal pregnancy course, age at surgery, surgical manipulation, movement of soft palate, age at initial examination of speech and mental development. The factors that clearly exerted powerful influence on the onset of speech disorder were age at surgery, age at initial examination of speech, surgical manipulation, cleft type aid age. From the results of this research, for which consideration was given to the mutual influence of all known factors contributing to the onset of postoperative speech disorder it is clear that it is very risky to evaluate speech by only one factor. The evaluation of speech must take the influences of many items into consideration. The onset of speech disorder can be estimated from these results, to some extent, and the results are usable for informed consent of parents of cleft palate patients.View full abstractDownload PDF (1459K) -
—RELATIONSHIP TO TISSUE EXPRESSION AND DNA PLOIDY PATTERN—Yoshinori MOGI, Masatoshi KAWAMURA, Kazunari ARAI, Kunihiko FUKUCHI, Y ...1993 Volume 53 Issue 3 Pages 247-253
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSBlood c-erbB-2 concentration was measured by a newly developed chemiluminescent immunoassay, in 56 patients suffering from gastric cancer. Relations between blood c-erbB-2 concentration and the expression of c-erbB-2 protein in carcinoma tissue, the DNA ploidy pattern was examined. Blood c-erbB-2 concentration was higher in the more advanced stage, and no significant difference in blood c-erbB-2 concentration was detected between differentiated and undifferentiated types of gastric carcinoma. Positive expression of c-erbB-2 protein in carcinoma tissue was detected in 8/22 (36.4%) of the cases, and blood c-erbB-2 concentration in positive cases was significantly higher than that in negatively expressed cases. This finding indicates that blood c-erbB-2 concentration can be a marker for suspecting the expression of c-erbB-2 in carcinoma tissue. Blood c-erbB-2 concentration in DNA diploidy cases was higher than that in DNA aneuploidy cases. From these findings, blood c-erbB-2 concentration can be a sensitive indicator for guessing the stage and/or the prognosis of gastric carcinoma.View full abstractDownload PDF (2141K) -
Etsuko MARUOKA, Toshio MOROHOSHI, Mikio KANDA1993 Volume 53 Issue 3 Pages 254-263
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSExpensive alcohol intake is injurious to many internal organs. Swelling of the salivary glands in chronic alcohol abuse is an interesting finding. Especially the parotid gland swelling is worthy of mention. The pathology and the pathogenesis of the swelling of salivary glands in chronic alcohol abuse were investigated in the present study. W e microscopically examined the submandibular glands, livers and pancreata of 45 autopsy cases of alcohol abuse who had consumed 540ml of Japanese sake per day for more than 10 years, and compared these with 25 age and sex matched autopsy cases of non-alcoholic patients. The weight and volume of the submandibular glands including the parotid glands were significantly increased in the cases of alcoholic abuse. Microscopically, ductitis or periductitis caused by protein plugs or calcareous deposition ; atrophy and loss of aciner cells ; and compensatory fibrosis and fatty infiltration of intra and inter-lobular spaces were charactaristically noted. Ultimately, the increase of fibrous and fatty tissues plus the atrophy and loss of parenchymal cells of the submandibular glands were the main causes of swelling of the submandibular glands. Interlobular fibrosis of the submandibular glands caused by ductitis or periductitis was predominantly, and mild fine fibrosis, so called primary fibrosis, was also found around periaciner cells. These findings were similar to those of chronic alcoholic pancreatitis. In the present study, although alcoholic injury of the liver and pancreas were markedly developed, there was no direct evidence relating that damage the changes of the submandibular glands.View full abstractDownload PDF (6670K) -
Masahito TAIRA, Tetsuo OOGA1993 Volume 53 Issue 3 Pages 264-272
Published: June 28, 1993
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSThe occurrence of troublesome behavior involves various psychological and physiological factors, and often makes therapy and countermeasures difficult. Recently, some devices in dementia disease have been reported that permit multi-faceted and more objective information to be obtained. However, there is no report on the prognostic estimation of troublesome behavior. Troublesome behavior in the present investigation considers the amount of burden on the helper and the main reason for hospitalization. These include such things as interruptions of the sleep of others (family or other patients) and wandering. To estimate whether relief might be obtained during hospitalization, a review has been made of the important items of GBS scale. For the survey, a review was made of 47 cases who interrupted the sleep of others, and 42 cases of wandering among 75 cases that excluded 16 “dropouts” within 120 days after hospitalization. The survey was made in the therapeutic ward for senile dementia in a hospital in Hitachi city. Using a statistical analysis system (SAS), with the chisquare test and a multi-variable analytical quantifying theory class-2, factors determining the relief of troublesome behavior were reviewed. In both the interruption of the sleep of others and wandering, location orientation-problems or the GBS scale indicated the greatest contribution. It was clearly found that the patients with location orientation-problems were puzzled even in the patient's own ward or home. The second degree of contribution included different factors that affected relief with respect to interruption of the sleep of others and wandering. The former basically involves mental functions, and the much milder symptoms present a higher probability for relief. Prognosis of the latter involves motor-functions in addition to the mental functions. The lower involvement of motor-function allowed better relief of wandering. During hospitalization, application of the GBS scale suggested the possibility for estimation of prognosis for the troublesome behavior. Thus, evaluation of location might orientation be very important in relation to mental functions.View full abstractDownload PDF (1046K) -
Hiroko YOSHIDA, Shoichi YOSHIDA, Tsuyoki KADOFUKU, Tsuneo SATO1993 Volume 53 Issue 3 Pages 273-280
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSChanges of serum proteins in rats with streptozotocin (STZ) -induced diabetes were analyzed by two-dimensional electrophoresis in non-denaturing conditions ; marked decreases or increases of several specific proteins were detected. W e report here, characterizations of four of those proteins (P1to P4), that changed especially after STZ administration. P1, with pI 4.4, decreased, and P2-P4, with pI 4.7, 4.2 and 4.7, respectively, increased. All were glycoproteins. Both P2and P3were determined by sequential analysis of peptide fragments digested wii: h lysylendopeptidase to be T-kininogen. No sequences coinciding with P1or P4were found in the Protein Database. P4was believed to be an α2HS-glycoprotein from its two-dimensional electrophoretic position, but had no properties known to human α2HS-glycoprotein. Purified P1and rat serum showed a single precipitin line in the α1-region in immunoelectrophoresis. This suggests that purified P1is immunochemically homogeneous, and the only protein that reacts with anti-P1in rat serum is P1. Anti-P1formed a precipitin line against mouse serum and partially fused with rat P1, but did not react with human, dog, cattle or horse sera. Serum P1concentration in control rats was about 6 mg/ml, and decreased below 50 % within 3 weeks after STZ administration. The P1concentration recovered when blood glucose was controlled at its normal level with insulin, 3 weeks after STZ administration, and decreased again to original level when rats were again maintained without treatment. The changed P2-P4also recovered when blood glucose was controlled at its normal level, suggesting close relation with diabetes, or at least with blood glucose level, after STZ administration.View full abstractDownload PDF (5491K) -
—IMMUNOHISTOLOGICAL STUDY USING ANTI-SERA FOR PCNA—Hiroaki KIKUCHI, Toshio MOROHOSHI, Tosiaki KUNIMURA, Mikio KANDA, Osam ...1993 Volume 53 Issue 3 Pages 281-289
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe biological malignant potentiality of 23 cases of mucinous carcinoma of the breast was studied. Each case was examined histopathologically and immunohistochemically using anti-PCNA antibody staining by the SAB method. Histologically, mucinous carcinoma was classified into 2 types, a pure type and a mixed type. 6 cases were classified as pure type, and 17 cases as mixed type characterized by mucinous and common components. Both types were sub-classified into 2 types: epithelial type and mucoid type. The labelling index of PCNA (PI) was higher in the mixed type than in the pure type, and in the epithelial type, PI was higher than in the mucoid type. Furthermore, PI of the non-mucinous part was about 2 times as high in the mixed type with scirrhous or solid tubular components as in the mucinous part. In conclusion, PI seems to be an important factor in deciding the prognosis of mucinous carcinoma, in addition to histology, infiltration and cellularity.View full abstractDownload PDF (7209K) -
Akihiko KITAMI, Takashi SUZUKI, Gouichi HORI1993 Volume 53 Issue 3 Pages 290-294
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThymomas are the most common anterior mediastinal tumors. The clinical course of patients with thymomas varies widely despite their histologically benign appearance. Treatment decisions are based on local invasion. To determine the degree of malignancy among thymomas, thymomas were examined by DNA microphotometry. The DNA histograms were analysed for ploidy pattern and histogram pattern (by Asamuraet al.) . W e tried to decide adjuvant therapy from DNA histograms. Normal thymuses and two of the thymomas were DNA diploid whereas ten thymomas were aneuploid. There was no relationship between the ploidy pattern and the clinical stage of the thymomas. Normal thymuses and three of the thymomas were of Histogram pattern I, and nine thymomas were of pattern II . Histogram pattern II was seen in 50 % of the noninvasive thymomas, and in 88 % of the invasive thymomas. One case of a noninvasive thymoma recurring after surgery revealed Histogram pattern II. Histogram patterns may be useful in making decisions for adjuvant therapy.View full abstractDownload PDF (475K) -
—A HISTOPATHOLOGICAL AND BIOMETRICAL STUDY OF LIVER BIOPSY—Tomoki AIZAWA, Toshio MOROHOSHI1993 Volume 53 Issue 3 Pages 295-304
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe examined 1100 liver biopsy cases clinicopathologically and pathomorphologically to determine histological figures and pathogenesis of granulomatous lesions in hepatic tissue. The granulomatous lesions were histologically classified into 2 types, based on the presence of fatty droplets, such as lipogranuloma (LG) and non-lipogranuloma (NLG) . Each type was divided into 2 subtypes according to its elements, such as histiocytic subtype (HLG, HNLG) and epithelioid subtype (ELG, ENLG) . There were 69 cases of (6.3 %) granulomatous lesions : 51 cases of LG (36 of HLG, 15 of ELG), and 18 cases of ENLG. LG appeared frequently in alcoholic liver injury and hypernutritional fatty liver. NLG appeared frequently in PBC. LG was prominent in hepatic lobules such as pericentral vein areas, whereas ENLG was evident in portal areas. Relations between the degree of hepatocytic fatty degeneration and the cases of LG were parallel. From these findings, LG appeared to be the basis of hepatocytic fatty degeneration, and was considered to be an inflammatory reaction to ruptured fatty droplets. The ELG was larger than the HLG, and more histocytes were evident in the ELG than in the HLG. The serum transaminase level in ELG cases was higher than that in HLG cases. ELG was thus considered to react more actively than HLG. However, HNLG was thought to be the reactive change to necrotic lesions ; and ENLG was considered to be both direct reaction to necrotic lesions, and more complicated reaction, including immunoreaction.View full abstractDownload PDF (9427K) -
Satoshi SUZUKI, Kazushige ARAI, Hiroshi ARAI, Ippei KAMIJI, Makoto NAK ...1993 Volume 53 Issue 3 Pages 305-311
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe started RF Hyperthermia from April, 1985. Since it is often difficult to apply heat to a deep-seated malignant tumor in the abdominal cavity, we welcomed the development of a new device. We have conducted clinical trials of hyperthermia using the Jasmin 3.1000. This device, developed by Odam Co. of France, is a RF capacitive heating device with 3 electrodes. The frequency is 13.56MHz, and it has 3 generators each with a maximum output of 600W. We report the characteristics of this device and the results of clinical trials. Metastatic liver tumor (11 cases), hepatoma (6 cases), and abdominal tumor (5 cases) were used as the subjects in clinical trials. The responses of metastatic liver tumors were PR, 2 cases; NC, 7 cases ; and PD, 2 cases. The mean survival time was 12.2 months. In cases of hepatoma the responses were: NC, 5 cases; and PD, 1 case. Mean survival time was 17.3 months. Responses of abdominal tumors were: PR, 1 case; and NC, 4 cases. Mean survival time was 7.2 months. To the present time, no serious side effects have been found and heating has been relatively good.View full abstractDownload PDF (5787K) -
Hiroyuki JINBO, Takumi ABE, Kazuo HANAKAWA, Takeshi NISHINO, Norihiko ...1993 Volume 53 Issue 3 Pages 312-316
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe reviewed 20 cases in which 15 to 45 year-old patients were hospitalized for nontraumatic intracerebral hemorrhages (ICHs) between 1990 and 1992. In this series, the etiology of five cases from 15 to 29 year-old (mean age, 21.4 years) could not be determined. The sites of hemorrhage were : subcortical (three), the head of the caudate (one), and putamen (one) . The overall prognosis (two underwent surgery and three were treated medically) was good. In each case several explanations were possible, but in several final diagnosis they remained undetermined. These cases indicate that several points of view must be considered when determining the cause of hemorrhage.View full abstractDownload PDF (2433K) -
Toshiko ONIZUKA, Taijiro ISHIYAMA, Keiichiro KAWAKAMI, Hideyuki UENO, ...1993 Volume 53 Issue 3 Pages 317-321
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESS77-year-old female was diagnosed as having IgA-λ type multiple myeloma from 1988. She was admitted to our hospital in February 1992 because of anemia, increased monoclonal IgA and pleuropericardial effusion. Numerous atypical plasma cells were seen in the effusion. Systematic chemotherapy was carried out, but was not effective. She died in April 1992. At autopsy, atypical plasma cells were found invading the pleura, pericardium and paragastal lymph node. It was a rare case of multiple myeloma associated with pleuropericardial effusion.View full abstractDownload PDF (3765K) -
Masami ISHIKAWA, Masahiro NAKADA, Yuu WATARAI, Takao OKAMATSU1993 Volume 53 Issue 3 Pages 322-325
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThis report describes a neonate with sirenomelia, the mermaid syndrome. Vaginal delivery of a live 1, 817 g infant with excellent Apgar scores was performed at 38w. Anomalies noted were : fused lower extremities, sacral and pelvic bony anomalies, imperforate anus, esophageal atresia with tracheo-esophageal fistula, bilateral renal agenesis, and genital abnormalities. Laparotomy, gastrostomy and colostomy were performed, but the infant died of renal failure and cardiac failure after 8 days. The syndrome of caudal regression is thought to be the result of caudal injuries that are incompatible with life. However, two survival cases of sirenomelia have been reported. We should think that the outcome depends on the severity of the associated visceral anomalies, and not solely on the presence of sirenomelia itself.View full abstractDownload PDF (2027K) -
Yuzo MOURI, Masao KOBORI, Makoto HASHIMOTO, Chisato SHIMADA, Akiyoshi ...1993 Volume 53 Issue 3 Pages 326-329
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA case of severe hypoxemia during anesthesia of subarachnoid hemorrhage is reported. The patient was a 22-year-old female, who was scheduled for an emergency operation. Severe hypoxemia due to pulmonary edema developed during the induction of anesthesia. Although she received various treatments for hypoxemia, her condition did not improve. The operation was discontinued and she was placed in ICU. Chest X-ray showed a typical pattern of snowstorm-like shadowing. We ventilated her with PEEP, and adminis-tered manitol, sodium pentobarbital and steroid. Following this therapy, her respiratory and circulatory condition improved remarkably after one day. The operation was completed one week later, and her postoperative course was uneventful. Neurogenic pulmonary edema was considered to be the most probable course of her acute respiratory failure. It is associated with a massive sympathetic response, and usually develops after subarachnoid hemorrhage, head trauma, etc. In this case, the respiratory dysfunction was considered to be a result of the stimulus of the induction of anesthesia.View full abstractDownload PDF (4891K) -
Yoshihiro FUKOUE, Masahiko MURAKAMI, Yoshinori SHIMIZU, Kentaro NAKAO, ...1993 Volume 53 Issue 3 Pages 330-333
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA 66-year-old male was brought to our emergency clinic for treatment of injuries resulting from a traffic accident. Abdominal injuries were thoroughly examined by ultrasonic diagnostic methods. Results indicated a mass in his right kidney, and he was admitted to our hospital for more comprehensive examination. The mass was diagnosed as kidney cancer. Endoscopy of the upper alimentary canal for preoperative systemic exploration disclosed Yamada type III polyps, about 5 mm across, at the greater curvature of the antrum and the lesser curvature of the inferior body ; and a 32×7 mm Yamada type IV polyp, red and lobulated, at the lesser curvature of the inferior body. Hot biopsy and polypectomy were then performed. Histpathologically, the Yamada type III polyps were hyperplastic and the Yamada type IV polyp had hyperplastic change with moderately differentiated adenocarcinoma at the top. This suggested a hyperplastic polyp developing into cancer. We present this case as a relative rarity, a hyperplastic polyp developing into cancer and renal cancer.View full abstractDownload PDF (3113K) -
Masahiko MURAKAMI, Yoshinori SHIMIZU, Yoshihiro FUKOUE, Ugen LEE, Masa ...1993 Volume 53 Issue 3 Pages 334-336
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe encountered a case of acute gastric mucosal lesion that developed after upper gastrointestinal endoscopy. The patient was a 37-year-old male. Four days after undergoing endoscopy of the upper gastrointestine at a medical checkup clinic, he was seized with abrupt, severe pain in the upper abdomen, and came to this hospital for further examination. Endoscopy was again performed. This time, shallow, shiny ulcerations of the hemorrhagic and multiple types were detected around the antrum. Fasting, replenishers, and antiulcer drug therapy led to nearly complete recovery (except for a slight scar) after one week later. In recent years, this type of ulceration has tended to increase due to the popular practice of upper gastrointestinal endoscopy. At present, H. P. infections are thought to be the major causative factor in the pathogenesis of these ulcers. This demands that scrupulous care be taken in washing and disinfecting the endoscope.View full abstractDownload PDF (2015K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1993 Volume 53 Issue 3 Pages 337-341
Published: June 28, 1993
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (534K)
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