As basic study of the gastric suction biopsy, the artificial changes of the gastric mucosa of dogs were examined, and as clinical study, the findings of gastrocamera and gastric suction biopsy were compared. The examination of gastritis distribution in the stomach by the suction biopsy was also performed.
1) Improved biopsy instruments of Henning and Tohoku University types were used.
2) Gastric suction biopsies of dogs were performed at 80, 100 and 150 mmHg. The biopsy specimens obtained at 100 mmHg contained all layers of the mucosa including muscularis mucosae. When it was compared with the surgical specimen, no appreciable change was found except the fragment obtained by the suction biopsy tended to be slightly thin.
3) It was confirmed macroscopically and histologically that the mucosa lesion produced by the biopsy in the experiment nearly healed in 7 to 10 days.
In clinical cases, almost complete healing by the 10th day after the suction biopsy was observed by gastrocamera.
4) Occult blood in stool became negative in 4 days. There was no complication due to the biopsy which required any treatment.
5) As clinical study, the combined examination of the gastrocamera and gastric suction biopsy under fluoroscopy was done in 566 patients with complaints of gastro intestinal troubles.
A total of 1352 biopsies were taken from the cardia, body and pylorus of the stomach with 1 to 7 specimens from each portion.
6) In the findings of gastrocamera, atrophic gastritis was classified into I-IV and + M (superficial atrophic gastritis). The pathological finding of biopsies was classified into acute gastritis and chronic gastritis.
7) In the correlation between the findings of gastrocamera and biopsies in the body of the stomach, the findings of gastrocamera as normal or superficial gastritis did not always agree in those of the biopsies. However, findings in atrophic gastritis, especially atrophic gastritis + M agreed well in those of the biopsies.
8) In the pyloric portion of the stomach, the findings of gastrocamera in normal mucosa or superficial gastritis did not agree so well as in the body of the stomach, but the findings in atrophic gastritis did show good gareement.
Metaplasic change of the mucosa was found frequently in the biopsy in proportion as gastritis became worse.
9) Generally the findings of gastrocamera taken at the optical distance showed good agreement in those of the biopsies.
10) The findings by gastrocamera which had been bases for the diagnosis were analysed to correlate to the findings of the biopsy.
In the cases of atrophic gastritis diagnosed as severe gastritis by gastrocamera, deformation of epithelial cells and pit, and intestinal metaplasia were frequently observed in the biopsies.
11) In the findings of biopsies from each portion of the stomach, the biopsies from the upper portion and lower portion of the body revealed similar appearance in atrophic changes in most of cases.
12) In comparison with the biopsies from the pyloric antrum and canal, similar findings were found in the great majority of cases.
13) In comparison among the biopsies from the cardia, and the upper and lower portions of the body, the similar findings of atrophic changes were found in about half of the cases.
14) In comparison with the biopsies from the body and pylorus, the similar findings were found in the great majority of cases.
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