Numerical aberration of chromosome 17 of 14 cases of colorectal carcinoma with multiple primary cancer (: multiple cancer) was compaired with that of 35 cases of colorectal carcinoma without any other cancer (: single cancer). Fluorescence
in situ hybridization with p17H8 was performed on touch smear from fresh materials. The proportion of aneusomy 17 (NCAI: numerical chromosome aberration index) in multiple cancers was significantly higher than that of single cancers (37.7±10.5% VS 46.1±8.0%;
p<0.01). Although NCAI of single cancers conformed to cancer progression (26.1±4.7% in Dukes A, 33.1±7.1% in Dukes B, 39.9±6.9% in Dukes C, and 45.7±12.0% in Dukes D), that of multiple cancers was high in all stages (44.7±7.3%, 44.4±6.8%, 50.4±11.2%, and 49.6±5.6%, respectively). Furthermore, the multiple numerical aberration of chromosome 17 in multiple cancers was more often than that of single cancers (64.3% VS 22.9%;
p<0.01).
View full abstract