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Volume 84, Issue 10
Displaying 1-19 of 19 articles from this issue
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Fumiaki KOIZUMI, Takeshi KAWAMURA, Akira ISHIMORI, Mamoru NAKAMURA, Hi ...1987 Volume 84 Issue 10 Pages 2303-2306
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn the present study, pancreatic polypeptide (PP) levels both in basal state and after stimulation by meal were determined in 16 controls, 28 patients with gastric ulcer and 21 patients with duodenal ulcer and their correlation with gastric emptying was examined. In patients with gastric and duodenal ulcers, basal levels as well as stimulated of plasma PP during 95min of observation period were higher than those in controls except for the values at 5min. As no correlation was seen between integrated PP response to the meal and T1/2 for gastric emptying in any of three groups, it was indicated that gastric emptying has only a minor role in postprandial PP response.View full abstractDownload PDF (516K) -
Shinichi OTA, Akira TERANO, Junji SHIGA, Hideyuki HIRAISHI, Tadahito S ...1987 Volume 84 Issue 10 Pages 2307-2313
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe protective effect of prostaglandin (PG) to gastric mucosa has been called"cytoprotection". Recently, however it has been reported that 16, 16-dimethyl PGE2 (dmPGE2) prevented deep necrosis of gastric mucosa induced by absolute ethanol (ET) but did not protect surface epithelium. The purpose of present study was to aseess the protective effect of dmPGE2 and 17s, 20-dimethyl-6-oxo PGE1 methyl ester (PGE1d) against ET or HCl induced damage to gastric mucosa histologically and ultrastructurally. Fasted rats received saline, dmPGE2, or PGE1d orally. 30min later saline, ET, or 0.6N HCl were administered orally. 30min later rats were killed and stomachs were studied macroscopically, histologically, and scanning electron microscopically. DmPGE2 and PGE1d prevented deep hemorrhagic necrosis of gastric mucosa dose-dependently. While 100μg/kg of dmPGE2 and PGE1d almost completely prevented deep mucosal lesions against ET or HCl, disruption of surface epithelium was not significantly protected by either dmPGE2 or PGE1d. These data suggest that prevention of deep hemorrhagic necrosis against necrotizing agents might be essential protective effect of PGs.View full abstractDownload PDF (2983K) -
Hideo IKEDA1987 Volume 84 Issue 10 Pages 2314-2322
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSSerum secretory IgA and dimeric IgA were studied in 35 cases with inflammatory bowel disease.
Serum IgA level was higher in Crohn's disease (294.2±81.3mg/dl, CD) than ulcerative colitis (251.4±73.1mg/dl, UC). Serum secretory IgA level was higher in active CD (30.3±9.5μg/ml) than UC(9.6±5.6μg/ml) and normal control (12.6±6.8μg/ml, NC).
Serum dimeric IgA level was increased in CD and UC compared with NC (16.4±4.1%), and the highest in active CD (37.1±4.8%) than all others.
Serum secretory IgA level was significantly correlated with srum IgA, dimeric IgA and erythrocyte sedimentation rate in CD, however, there was no significant correlation in UC.
The determination of seum secretory IgA level would be a reliable index of CD activity, but not for UC activity.
The increase of serum IgA would be due to the possible back flow of secretory IgA and dimeric IgA with increased production in Crohn's disease.View full abstractDownload PDF (937K) -
Takuji FUJISAWA, Eiichiro ONO, Akihiko KIMURA, Ken YUGE1987 Volume 84 Issue 10 Pages 2323-2330
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe investigated the endocrinological function in 12 children with inflammatory bowel disease (IBD) (8 of ulcerative colitis, 4 of Crohn's disease). These patients showed low serum levels of triiodothyronine (T3) (n=3), high serum prolactin (PRL) (n=2), and normal basal value of thyroid- stimulating hormone (TSH) and an exaggerated and prolonged TSH response in thyrotropin releasing hormone (TRH) test (n=3), delayed and prolonged luteinizing hormone (LH) response in luteinizing hormone-releasing hormone (LH-RH) test (n=2), prepubertal LH response in LH-RH test in spite of the clinical evidence of puberty (n=2), hyporesponsiveness in human chorionic gonadotropin (HCG) test (n=2). These results suggested that endocrinological changes were secondary reaction mainly due to malnutrition and/or malabsorption. In conclusion, growth failure and delayed sexual development in IBD have a malnutritional basis as main etiololgical factor. In clinical management of children with IBD, it should be critical to identify the early possible state of nutritional failure and to institute appropriate nutritional support and supplementation.View full abstractDownload PDF (987K) -
Tatsuyuki SATOH, Masahiko TAKAMASU, Kyouhei MARUYAMA, Yoshinobu FUSE, ...1987 Volume 84 Issue 10 Pages 2331-2336
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe investigated the duodenal vescular architecture and mucosal blood volume in cysteamine induced duodenal ulcer. The tissue blood volume was measured by the tissue spectrum analyzer.
Cysteamine was given to Wistar rats (weighing 250g) subcutaneoulsy in a dose of 400mg/kg. The artery and vein were canulated, the blood was wash out, and then injected with Berlineblue. The duodenum and stomach were dissected out, placed in 10% fromalin and dehydrated in ethyl alcohol. After specimens were cleared by methyl salithylate, we examined vascular architecture under stereomicroscope. And then, same specimens were fixed in 10% formalin and paraffin-embedded sections were stained with H-E and nuclear fast red.
The results were as follows;
1) From the vascular architecture, cysteamine-induced duodenal ulcer usually developed on the region of the two vascular networks, one is from pyloric canal of the stomach, and another from the anal side of the duodenum.
2) Three or 6 hours after administration of cysteamine, the tissue blood volume decreased, but no vascular structural change was observed.
3) Twenty-four hours later, the tissue hemoglobin volume was increased at the ulcer margin and marginal vessels were dilatated.View full abstractDownload PDF (1822K) -
Toshifumi OHKUSA, Masahiro YAMADA, Tuyoshi TAKENAGA, Chieko KITAZUME, ...1987 Volume 84 Issue 10 Pages 2337-2346
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn the previous study, we reported induction of experimental ulcerative colitis in Syrian hamsters by administration of dextran sulfate sodium (DSS; M.W., 54000). It was demonstrated that metronidazole (MNZ), antianerobicmicrobial agent, had a protective effect in this experimental ulcerative colitis.
By oral administration of 1% and 5% DSS to Syrian hamsters in their drinking water, ulcerative lesions in the large intestines were induced in all animals. On the other hand, pretreatment with metronidazole to recipients of DSS prevented gross and microscopic colonic ulceration in 5 of 10(50%) animals receiving 1% DSS+MNZ solution, and 4 of 7 (57%) animals receiving 5% DSS+MNZ solution.
Upon the examinations of fecal microflora before and after the administration of DSS, Bacteroidaceae increased in number significantly. On the other hand, the decrease in the number of Bacteroidaceae was seen in animals receiving MNZ and DSS solution.
These results suggest that metronidazole administration reduced the concentration of Bacterioidaceae and prevented DSS-induced colitis in majority of animals.View full abstractDownload PDF (1987K) -
Its Demonstration by 99m Tc Methylene Diphosphonate Bone ScintigraphyShu-ichi SEZAI, Suguru ISHIZAWA, Katsumasa YOSHINO, Sei-ichi MATSUURA, ...1987 Volume 84 Issue 10 Pages 2347-2352
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn order to investigate the osteodystrophy in liver cirrhosis, 21 liver cirrhotic patients having no malignancy and normal renal function were examined by 99m Tc Methylene Diphosphonate (MDP) bone scintigraphy. The cirrhotic subjects consisted of 14 males and 7 females. Their age was 31-80, average 55.7 years. The causes of their cirrhotic damage were 1 primary biliary cirrhosis, 9 alcoholic, 2 HB viral and 9 cryptogenic. The contents of their illness showed 9 cases in A, 4 in B and 8 in C of Child's classification.
Abnormal hot spot(s) on bone in the cirrhotics could be observed very frequently in 99m Tc MDP bone scintigraphy (47.6%; 10/21 cases). Those spots were seen more frequently in female and advanced stage of cirrhosis. The number of spot(s) increased also in advanced liver cirrhosis. Serum Ca, P and PTH were in normal range. All of three vitamin D3 fractions decreased and especially 1, 25(OH)2D3 was depressed more in scinti-positive cases.
Metacarpal bone X-p with an alumimum step wedge as a reference was analyzed by a microdensitometry (MD) method (Inoue T et al) and the pattern of osteopathy (i.e. porosis, malacia and poromalacia) was examined according to Sumi Y et al. MD method was not known yet if there was any definite correlation with bone scintigraphy and the osteopathic pattern belonged to border categories.
In conclusion, more attension on hepatic osteodystrophy will be significantly necessary due to the fact that it has been found very frequently in liver cirrhosis. 99m Tc MDP bone scintigraphy is a good means for detection of the hepatic osteodystrophy.View full abstractDownload PDF (1178K) -
Shinya NAKAJIMA, Tetuo KUROKI, Osamu KURAI, Shuhei NISHIGUCHI, Shinobu ...1987 Volume 84 Issue 10 Pages 2353-2360
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe analyzed the binding of 125I-labeled IFN to peripheral blood mononuclear cells (PBMC) before, during, and after IFN therapy in 10 patients with chronic type B hepatitis. Six of the patients were given daily injections of IFN for 4 weeks. The binding of 125I-labeled IFN to PBMC decreased to 50% during therapy, and retured to the base-line level by 2 week after the end of therapy. The other 4 patients were treated with IFN for 2 weeks, not treated for the next 2 weeks, and treated again for 2 more weeks. Binding decreased to 45% during therapy. It had retured to 92% of the base-line level 1 week after the first round of therapy and to 101% 1 week later. Binding was 85% 1 week after the second round of therapy and 92% 1 week later. Assays of serum DNA-P showed that viral replication did not increase greatly during the 2 weeks without IFN. The study of IFN receptors may help to make IFN treatment more effective.View full abstractDownload PDF (860K) -
Electron Microscopic Studies on the Disintegration of the Bile DuctsJiro TAKEZAWA, Shoji YAMADA1987 Volume 84 Issue 10 Pages 2361-2369
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSUltrastructural changes of intrahepatic bile ducts in primary biliary cirrhosis (11 cases) and chronic hepatitis (7 cases) were investigated.
Results were as follows:
1) Disruption of basement membrane and falling of epithelial cells into periductal space were revealed in a large bile duct which showed chronic non-suppurative destructive cholangitis (CNSDC) and a large bile duct without CNSDC in PBC.
2) Infiltration of lymphocytes into bile duct epithelium was more prominent in PBC than in chronic hepatitis.
3) In PBC, "dark cell"metamorphosis was often observed in the epithelial cells in contact with the lymphocytes infiltrating into bile duct epithelium.
Form these results, in PBC, disruption of basement membrane and falling of epithelial cells into periductal space may be specific changes in process of disintegration of bile ducts and sensitized T lymphocytes seem to be responsible for the bile duct damage.View full abstractDownload PDF (3409K) -
With Specical Reference to the Relationship Between Evolution of Jaundice and Diameter of the Gallbladder LumenTomoki HATORI, Koji ISHI, Kazunori AIKAWA, Yasukiyo SUMINO1987 Volume 84 Issue 10 Pages 2370-2376
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSSerial (total 242 times) ultrasonographic examinations of the gallbladder were carried out in 34 cases of acute viral hepatitis (30 cases with jaundice, and 4 cases without jaundice). In the cases with jaundice, the thickend gallbladder wall (more than 4mm) was seen in 21 cases (group A), and was not seen in 9 cases (group B). Positive correlation was recognized between the thickness of the gallbladder wall and diameter of the gallbladder lumen (DGL) in the examination on admission (r=0.540, p<0.01). Serum total bile acid levels were significantly higher (p<0.001), and serum albumin were lower (p<0.01) in group A than in group B on admission.
There seemed to be a negative correlation between the evolution of serum total bilirubin level and the change in DGL. The enlargement of DGL was delayed in patients with prolonged jaundice. These results suggest that serial ultrasonographic examinations are useful in predicting the peak of serum bilirubin levels and determining the prognosis of acute viral hepatitis.View full abstractDownload PDF (1313K) -
Especially, Relation to Aggravation of Liver FunctionKenji IKEDA, Hiromitsu KUMADA, Yasuji ARASE, Ikuo NAKAMURA, Kazuaki CH ...1987 Volume 84 Issue 10 Pages 2377-2385
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSEffects and side effects of oral antitumor agents were investigated in 86 patients with hepatocelular carcinoma treated by transcatheter arterial embolization (TAE). Almost all cases were associated with liver cirrhosis. Patients were classified into three groups as follows: 27 with tegafur 600mg/day administration after TAE (group A), 25 with UFT (compound of tegafur 400mg/day and uracil) administration after TAE (group B), and 34 without any anticancer drug after TAE (group C).
Tumor necrosis rates at the time of 3 months and 6 months after TAE were better in groups A and B than that in group C. One-year survival rates after TAE were slightly better in groups A and B, but no significant difference was shown among 3 groups when statistical correction was made by stratification of tumor staging.
Appearance rates of ascites and/or encephalopathy within 6 months were significantly higher in groups A and B than in group C (33.3%, 30.4%, 5.9%, respectively, p<0.05). Various liver function tests were more aggravated in group A and B in the clinical course. Long term use of anticancer drugs may worsen liver reserves, and they should be cautiously administered for hepatocellular carcinoma associated with liver cirrhosis.View full abstractDownload PDF (1099K) -
Yasuhiro TAKEMORI, Norio SAWABU, Yoshitake SATOMURA, Hideki OHTA, Hiro ...1987 Volume 84 Issue 10 Pages 2386-2392
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn order to evaluate the usefulness of CA-125 in patients with digestive diseases, serum levels of the antigen were determined in 455 patients with various malignancies and 303 patients with benign diseases.
Elevated srum CA-125 levels (_??_35U/ml) were observed in 66% of pancreatic cancers, 51% of hepatocellular cancers and 47% of biliary tract cancers in order of frequency. Among the pancreatic cancers studied, CA-125 were positive in 7 of the 14 CA 19-9 negative patients (<37U/ml), 24 of the 37 DU-PAN-2 negative patients (<400U/ml) and 13 of the 28 CEA negative patients (<2.5ng/ml). Almost all of the positive cases among the stomach and colon cancers were founded in more than stage IV or inoperable patients. Especially in patients with peritoneal metastasis, the incidence of CA-125 was significantly higher than those of the other markers. It is suggested that CA-125 elevation reflects the peritoneal metastasis. On the other hand, the false-positive rate was low in benign disease. However, high levels of CA-125 were observed in almost all cases of decompensated liver cirrhosis, fulminant hepatitis and severe acute pancreatitis with ascites. Changes of the antigen correlated with progression or regression of ascites.
The assay of serum CA-125 is considered to be useful not only in diagnosis of patients with digestive cancers, espcially pancreatobiliary cancer but also in evaluation of ascites formation or peritoneal involvement.View full abstractDownload PDF (904K) -
Hiroaki TANAKA, Mitsuo IIDA, Norio KOHROGI, Osamu TSURUTA, Masatoshi F ...1987 Volume 84 Issue 10 Pages 2393-2398
Published: 1987
Released on J-STAGE: December 26, 2007
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Ichiro UYAMA, Shuhei IIDA, Atsushi SEKI, Nobuyuki TOSHIMA, Yoshitugu T ...1987 Volume 84 Issue 10 Pages 2399-2402
Published: 1987
Released on J-STAGE: December 26, 2007
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Ryo MYOEN, Kenji AKIYAMA, Masahiro OGASAWARA, Kazutoshi HORITA, Takaak ...1987 Volume 84 Issue 10 Pages 2403-2408
Published: 1987
Released on J-STAGE: December 26, 2007
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Susumu SHIOMI, Shigeyoshi HARIHARA, Akishige OBATA, Tokan SHIN, Koshun ...1987 Volume 84 Issue 10 Pages 2409-2412
Published: 1987
Released on J-STAGE: December 26, 2007
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A CASE REPORTKunio KASUGAI, Tomihiro HAYAKAWA, Makoto MIYAJI, Kenji KATAGIRI, Makot ...1987 Volume 84 Issue 10 Pages 2413-2417
Published: 1987
Released on J-STAGE: December 26, 2007
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Takeshi AZUMA, [in Japanese], [in Japanese], [in Japanese]1987 Volume 84 Issue 10 Pages 2418
Published: 1987
Released on J-STAGE: December 26, 2007
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Hidenori KANAZAWA, [in Japanese], [in Japanese], [in Japanese], [in Ja ...1987 Volume 84 Issue 10 Pages 2419
Published: 1987
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (234K)
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