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Volume 70, Issue 5
Displaying 1-6 of 6 articles from this issue
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Tatsuo SAITOH, Naoshi NAKAMURA, Wataru TAKAHASHI, Tadao SANJO, Toshio ...1973 Volume 70 Issue 5 Pages 435-441
Published: 1973
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSMosbach and Bevans (1956) have shown that rabbits develop consistently gallstones and cholecystitis by incorporating 0.25% to 1% dihydrocholesterol in their diets. In the present study, changes of cholesterol levels in rabbit serum and liver after administration of 1% dihydrocholesterol for two weeks were observed. Histological study on gallbladder, liver, pancreas and concrements in gallbladder were also performed.
In chemical analysis, significant increase of total cholesterol in the liver was observed. Estimation of free cholesterol in the liver showed same levels as control group. So, marked increase in total cholesterol might depend upon increase of ester type of cholesterol in the liver.
On the other hand, serum cholesterol levels showed insignificant changes. When 12% olive oil was added to the regular diet, serum free cholesterol showed increase and contrary liver free cholesterol decreased markedly.
These findings revealed that olive oil administration in the diet had some influence to cholesterol metabolism in rabbits.
Histologically, desquamation of epithels in the mucous membrane and marked hypertrophy of the muscular layer of gallbladder wall were evident.
Cellular infiltration in Glisson's sheath and interlobular area of the liver was slightly observed in most cases. No pathological changes were shown in the pancreas. Concrements in the gallbladder, white, irregular, shaped and fragile, are revealed of irregular arrangement of granule aggregation microscopically. No findings are obtained in contact microradiogram and under polarized light.View full abstractDownload PDF (1907K) -
Kouzou KOBAYASHI1973 Volume 70 Issue 5 Pages 442-455
Published: 1973
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIt has been generally stated that the ulcer formation can be attributed to the circulatory disturbances of the gastric mucous membrane.
The arterio-venous anastomose (A.V.A.) is also recognized to play one of the important roles to regulate the blood flow in the gastric mucous membrane but its physiological mechanism is still unknown in detail.
In order to clarify this this problem, the injections of two kinds of pigment were performed intraarterially and intravenously respectively ("double injection method") using the rats and the distribution of the pigments at the A.V.A. were observed microscopically.
1) In the stomach of the rat the existence of A.V.A. was not at the mucous membrane layer but mainly at the submucosal layer.
2) On the other hand, in the duodenum, A.V.A. was rather recognizable at the mucous membrane layer on the top of the villi than at the submucosal layer.
3) The sizes of A.V.A. were slight by different between those of the stomach (10-13μ) and these of the duodenum (10-11μ).
4) The intravenous administration of adrenalin caused the dilatation of A.V.A., while that of histamin the constriction of it.
5) Some observations were performed concerning the relation of the A.V.A. status to the formation of ulcers in the stomach and the duodenum.View full abstractDownload PDF (2541K) -
[in Japanese]1973 Volume 70 Issue 5 Pages 456-463
Published: 1973
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (964K) -
[in Japanese]1973 Volume 70 Issue 5 Pages 464-474
Published: 1973
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (1570K) -
Masaharu TSUCHIYA, Kiyotaka KAMEGAYA, Keizo TAKAGI, Masaya ODA, Isao O ...1973 Volume 70 Issue 5 Pages 475-484
Published: 1973
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSSince the epochmaking report of the Tatarinov's in 1964, α-fetoprotein in the adults has been detected almost exclusively in cases with the hepatoma. Evidences, however, have accumulated that the metastatic carcinoma to the liver also can induce the production of α-fetoprotein in rare cases.
The present paper reports a case of gastric carcinoma, Borrmann type III, with metastasis to the liver exhibiting a remarkably high concentration of serum α-fetoprotein.
A 64-year-old Japanese female was admitted to Keio University Hospital in Octover 1971, because of tarry stool. Fluoroscopic examination and gastrocamera revealed a Borrmann type III of gastric carcinoma at the antrum, which was found histologically to be adenocarcinoma tubulare. α-fetoprotein, up to 384mg/dl in the serum at one time, was detected to decrease remarkably following the application of the carcinostatic substances. The patient went downhill course and expired in January, 1972.
The post-mortem examination revealed the carcinoma of the stomach with metastasis to the liver, pancreas, and perigastric lymph nodes. The metastatic tumor nodules in the liver measured up to 4cm in diameter.
The tissue extracts of a portion of the tumor nodule in the liver and that of the liver tissue surrounding the tumor contained α-fetoprotein, 48ng/ml and 43ng/ml each. This suggests the possibility that α-fetoprotein can be produced by the metastatic carcinoma to the liver as well non-tumorous liver tissue.
38 cases of metastatic gastric carcinoma to the liver with positive α-fetoprotein have been reported in Japan. It is, however, interesting that this case showed the very high value of serum α-fetoprotein.View full abstractDownload PDF (2155K) -
Tetsuo HAYAKAWA, Yasushi TODA, Aiji NODA, Sumio NAKAJIMA, Toshiyuki SU ...1973 Volume 70 Issue 5 Pages 485-490
Published: 1973
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSHuman pancreatic and salivary amylases were assayed by Caraway's method using Wako's soluble starch and by a chromogenic method (RBB assay) using a Remazol brilliant blue R starch (Amylose Azure). Pancreatic amylase digested Amylose Azure at a greater rate than the soluble starch and salivary amylase digested the latter at a greater rate than the former.
Detectability of abnormally high serum and urine amylases in pancreatic diseases were compared with the above two assay methods. Detectability of abnormally high serum amylase was higher by RBB assay (30%) than by Caraway's assay (23%). Detectability of abnormlly high urine amylase output detectability by RBB assay (38%) was twice as high as that by Caraway's assay (18%).
These results suggest that human pancreatic amylase can be more sensitively determined by RBB assay, hyperamylasemia and hyperamylasuria caused by pancreatic diseases could be more specifically detected than those caused by other diseases, and RBB assay could increase specificity of amylase tests in diagnosis of pancreatic diseases.View full abstractDownload PDF (725K)
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