All issues
Volume 86, Issue 12
Displaying 1-22 of 22 articles from this issue
- |<
- <
- 1
- >
- >|
-
Takeo ASADA, Yoshiyasu SAKO, Yutaka FUKUSHIMA, Toru KITA, Takeo MIYAKE1989 Volume 86 Issue 12 Pages 2705-2712
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe studied the effect of press stimulation applied to the back skin on gastric emptying and serum gastrin response to solid food in healthy subjects. Although gastric emptying and serum gastrin response were significantly suppressed by press stimulation of T6-9 dermatomes corresponding to the spinal levels which sympathetic outflow to the stomach arise, they were not affected by press stimulation of T10-L1 dermatomes. Plasma levels of ACTH, epinephrine and norepinephrine, which usually increase by stresses acting on the brain, did not change by press stimulation of T6-10 dermatomes. These results suggest that press stimulation applied to the back skin of T6-9 dermatomes suppress gastric emptying and gastrin response to solid food mainly through the spinal cord.View full abstractDownload PDF (3452K) -
Satoru IWANE1989 Volume 86 Issue 12 Pages 2713-2720
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe effect of dietary fiber on colonic carcinogenesis was studied endoscopically in rats administered 1, 2-dimethylhydrazine. Colonic tumors appeared about six weeks later in ras fed 15% cellulose diet or 40% wheat bran diet than in those fed basal diet. Furthermore, the incidence of colonic tumor was significantly lower from 23th week to 26th week in the cellulose diet group(p<0.01)and at 26th week in the wheat ban diet group(p<0.05)than in the basal diet group. Although, the incidence of colonic tumor and the mean number of the tumors per rat at sacrifice (30th week) were not significant different between these two high-fiber diet groups and the basal diet group. These two diets significantly increased feces 3 to 4 times in weight and 5 times in volume than basal diet.
However, 15% pectin diet could neither inhibit colonic carcinogenesis and nor increase the fecal weight. These results suggested that cellulose and some dietary fibers of wheat bran were effective to retard colonic carcinogenesis, and that the increased fecal weight and volume by fibers may be involved in the inhibitory effect.View full abstractDownload PDF (1461K) -
Hiroaki ISHIMARU, Takahide MATSUDA, Toshio HARA1989 Volume 86 Issue 12 Pages 2721-2727
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIL2R+ Leu11+ cells (A) and HLADR+ Leu11+ cells (B) of peripheral blood in patients with various liver diseases and ASCs were measured using double colour immunofluorescence assay of MoAb with FACS flowcytometry.
1) The mean % of IL2R+ Leu11+ cells which was 0.5±0.2 in healthy controls, decreased significantly in HCC in comparison with CALD, ASC and healthy controls, and in ASC rather than in healthy controls. They (A) were less than 0.1% in eight of thirteen cases with HCC, in one of twenty cases with CALD and of eleven ASCs, respectively.
2) In the mean % of HLADR+ Leu11+ cells which was 2.9±1.8 in healthy controls there was not a significant difference among HCC, CALD, ASC, AH and healthy controls. They (B) were less than 0.1% only in one case with HCC.
3) The value of fluorescence intensity of IL2R on IL2R+ Leu11+ cells reduced in B-CALD, ASC, AH and HCC, and one of HLADR on HLADR+ Leu11+ cells increased in CALD.
These results suggested that the decrease of IL2R+ Leu11+ cells was due to the existence of HCC.View full abstractDownload PDF (782K) -
Masato ABEI, Naomi TANAKA, Toshiaki OSUGA, Shoji HARADA1989 Volume 86 Issue 12 Pages 2728-2734
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe products of three human glutathione S-tansferase (GST) loci (GST1, GST2 and GST3) were purified and their immunochemical properties as well as immunohistological localization in liver were studied. Three group of isozymes were different in molecular weight, substrate specificities and antigenicity. Two homodimers (type 1 and type 2) of GST1 which shows genetic polymorphism, were similar in immunochemical properties other than isoelectric point. Inactivity of GST1 0 was due to impaired protein synthesis. Immunohistologically, GST1 isozyme was homogeneously stained in cytoplasm of hepatocytes throught the lobule of liver showing GST1 1, GST1 2 and GST1 2-1 phenotypes. On the other hand, GST2 isozyme was stained in the cytoplasm as well as the nucleus of hepatocytes throughout the hepatic lobule in all cases. GST3 isozyme was strongly stained in biliary epithelium. These results indicae that the human liver GSTs are composed of three immunochemically distinct isozymes, which exhibit significant difference in inter-individual, specific cellular and organellar distibution.View full abstractDownload PDF (1587K) -
Susumu TAKANO, Masao OMATA, Masao OHTO, Yoichi SATOMURA1989 Volume 86 Issue 12 Pages 2735-2741
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSTwo thousand five hundred ninety-six consecutive patients who received blood transfusion for the first time within one week and had no liver dysfunction before transfusion had been selected from 8637 patients who received blood transfusion at the hospital between 1982 and 1987. The influence of dose, components of transfused blood and sex, age of recipients on the incidence of post-transfusion hepatitis was investigated. The rate of development of hepatitis depended on the dose of transfusion, not on sex and age of recipients. The rate of development of hepatitis raised as number of transfused blood increased without limiting point to 100%. The carier rate of healthy population of non-A, non-B hepatitis virus was estimated 1.39%. Stored blood, concentrated red blood cell and fresh blood are high risk components and fresh frozen plasma was low risk component.View full abstractDownload PDF (954K) -
Hiroto MATSUDA, Yasuo TAKEDA, Toshio UENO, Ryoyu TAKEDA1989 Volume 86 Issue 12 Pages 2742-2748
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn the present study, we have measured the serum concentration of PIIIP in patients with various liver diseases, and studied serial changes in serum PIIIP after TAE and its gel filtration pattern in 10 cases of hepatocellular carcinoma undergone TAE.
The following results were obtained. 1) Serum concentration of PIIIP was 12.3±6.1ng/ml in normal controls and elevated significantly in liver cirrhosis, liver cirrhosis with hepatocellular carcinoma, chronic active hepatitis, and acute hepatitis. 2) There was no significant difference in the serum concentrations of PIIIP between liver cirrhosis and liver cirrhosis with hepatocellular carcinoma. The result suggested that serum PIIIP cannot be a specific marker of hepatocellular carcinoma. However, the serum PIIIP concentration was decreased 2 or 4 weeks after TAE in effective cases, whereas increased in ineffective cases. Thus, the measurement of serial change in the serum PIIIP after TAE was considered to be useful for evaluating the effectiveness of TAE. 3) In analysing the elution patterns of serum PIIIP by gel chromatography, the peak of 125I-PIIIP antigen decreased 4 weeks after TAE in effective cases, whereas, no change was observed in the elution profile by gel chromatography 4 weeks after TAE in ineffective cases.
These results seem to be caused by necrosis of hepatocellular carcinoma by TAE, and suggest the possibility that PIIIP is produced in hepatocellular carcinoma tissue.View full abstractDownload PDF (864K) -
Tohru KIMURA, Fuminori MORIYASU, Toshihiko KAWASAKI, Shigeki ONO, Yuki ...1989 Volume 86 Issue 12 Pages 2749-2756
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSTo evaluate the relationship between esophageal varices and the azygos vein-which is generally considered to drain the major part of the esophageal variceal blood-we examined 36 patients with portal hypertension using percutaneous transhepatic cine-portography. The patients were classified into three groups (azygos, cervical and combined) according to the amount of blood to be considered drained by the azygos vein. Eighteen patients (50%) fell into the azygos type group, five (14%) into the cervical, and 13 (36%) into the combined. Highly developed esophageal varices were recognized endoscopically in all patients in the combined and cervical type groups while some of the patients in the azygos type group had less well developed varices. In the azygos type group, there was a tendency for the varices to be increasingly severe the higher the part of the azygos vein they drained into. Because it helps us to fully comprehend the significance of the azygos venous blood flow and the occasionally uncertain effect of endoscopic injection sclerotherapy for esophageal varices, it is important to evaluate the drainage route of esophageal varices in vivo and in detail. Percutaneous transhepatic cine-portography is the useful method for this purpose as it enables us to visualize even the most minute blood stream.View full abstractDownload PDF (1917K) -
Naoko IKEOKA, Takeyuki MONNA, Susumu SHIOMI, Tetsuo KUROKI, Kenzo KOBA ...1989 Volume 86 Issue 12 Pages 2757-2764
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSPortal circulation in patients with liver diseases was evaluated by 99mTc-pertechnetate per-rectal portal scintigraphy, and we retrospective examined the relationship between the extent of abnormality in the portal circulation and the development of esophageal varices.
The per-rectal portal shunt index (PRPSI) was calculated for 13 healthy subjects and 79 patients with chronic hepatitis and 214 with cirrhosis of the liver. In the healthy subjects, the mean PRPSI was 4.8%. In the patients with hepatitis, the mean PRPSI was 8.4%, and in the patients with cirrhosis, it was 48.5%.
The PRPSI was significantly higher in the cirrhotic patients with esophageal varices than in the without, and also in the cirrhotic patients with encephalopathy than in those without.
The cumulative incidence of esophageal varices in the 3 years of the study in patients whose PRPSI was 20% or over was significantly higher than that in patients whose PRPSI was under 20%.
The results suggested that this non-invasive method shuld be useful for predictions of the formation of esophageal varices.View full abstractDownload PDF (3509K) -
Akihiko FURUSAWA, Masashi UNOURA, Kazuo NOTSUMATA, Takeshi MORIOKA, Ko ...1989 Volume 86 Issue 12 Pages 2765-2772
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSClinicopathological analyses were performed on 11 cases of juvenile (less than 40 years) hepatocellular carcinomas (HCC) and compared with those of 187 cases of nonjuvenile HCCs. 91% of juvenile HCC cases were positive for HBsAg in their sera and it was much higher than that of nonjuvenile group (p<0.05). Familial clustering of HBV carriers or advanced liver diseases was found in 50%. 73% of juvenile HCC cases had cirrhosis. Abdominal pain was found most frequently as initial symptom. All except one case, who had surgical resection of the tumor, were rapidly fatal. Interestingly the association of paraneoplastic syndrome (PNS) was more frequently seen in juvenile HCC cases (36.3%) than in nonjuvenile HCC ones (5.9%, p<0.05). In juvenile HCC cases with PNS, LC was less associated, serum alphafetoprotein tested higher and prognosis was worse than those without PNS. Therefore, these results imply that HBV plays an important role for the development of juvenile HCC and juvenile HCC patients with PNS show characteristic features in HCC patients in Japan.View full abstractDownload PDF (1147K) -
Isolation on 210 kDa microtubule associated protein from rabbit liverMasafumi KOMATSU, Akio YAMAMOTO, Mitsuo GOTO, Fumio TOBORI, Hitoshi YA ...1989 Volume 86 Issue 12 Pages 2773-2778
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe biochemical characteristics and cellular localization of microtubule associated proteins (MAPs) were studied using rabbit liver. The MAPs fraction, isolated from rabbit liver crude extract by a modification of Vallee's method, consisted of several proteins, as identified by SDS-polyacrylamide gel electrophoresis. The most prominent of these was a 210 kDa protein (rabbit 210 kDa MAP). The molecular weight of rabbit 210 kDa MAP was distinct from that of the major brain MAPs, MAP1, MAP2 and Tau, isolated from rabbit brain crude extract by same method.
Monoclonal antibodies (mAb) to this rabbit 210 kDa MAP were raised. Using immunoblotting method, we confirmed that anti-rabbit 210 kDa MAP mAb reacted to 210 kDa protein from rabbit liver excrude, while this mAb also reacted to 210 kDa protein from rabbit brain excrude.
Immunofluorescent staining using fixed rabbit liver was carried out using these mAb. In frozen sections of the rabbit liver, the antigen related to mAb 7B10 was localised in the hepatic cells and epithelial cells of the bile duct but not in the smooth muscle cells and endothelial cells.View full abstractDownload PDF (2290K) -
Satoshi KONDO, Yuji NIMURA, Naokazu HAYAKAWA, Junichi KAMIYA, Katsushi ...1989 Volume 86 Issue 12 Pages 2779-2786
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSCholangiographic investigations in 16 patients with primary intrahepatic cholesterol stones leaded some characteristic findings as follows. 1. Several numbers of stones were filled within locally dilated portion of the subsegmental or more peripheral intrahepatic bile duct branches, with no or minimal dilatation of the more peripheral portion and no stenosis-like lesions of the more hilar portion. 2. The lesion was single or multiple scattered in the liver and intrahepatic cholangiogram excluding involved segments was almost normal. 3. Although extrahepatic bile duct and/or gallbladder stones were often associated, the normal gallbladder, cystic duct and papillary portion and slightly dilated common bile duct were demonstrated. These cholangiographic findings were compatible with the endoscopic findings that inflammatory changes of the bile duct were rarely observed.
According to above mentioned findings, it is suggested that the etiology of this disease differs fom intrahepatic stones of calcium bilirubinate and dissolution therapy with bile acid may be available.View full abstractDownload PDF (3577K) -
Kenji SAKAKIBARA, Hideyuki KANOU, Tetsuo KATO, Hideki HIRAMATSU, Masat ...1989 Volume 86 Issue 12 Pages 2787-2793
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSExtracorporeal shock-wave lithotripsy (ESWL) was first applied for calculi of the bile duct system in 1985. Recent improvement of the cruhsing apparatus has enabled us to crush the biliary calculus more accurately than before, and moreover, to conduct the procedure without anesthesia, and to treat easily. We performed ESWL in 30 cases of calculus in the cholecyst using MPL-9000 (Dornier Co., Ltd.) which is said to be a crushing device of a new generation. Here, the study is presented. The results of crushing effect demonstate the efficacy in 26 of 30 cases (87%), and disappearance rate in 18 cases (60%) at present after an average follow-up period of 4.4 months. The disappearance case were mainly those with a single calculus (75% disappearance rate) or pure cholesterol calculus (100%). Concerning the complications, right upper abdominal pain which was expected to accompany excretion of the cruched fragments wasd recognized in 10 cases (33%), it was not seen in cases in which laparotomy or endoscopic papillotomy was peroformed.View full abstractDownload PDF (1142K) -
Eii KARASAWA, Hiromitsu SAISHO1989 Volume 86 Issue 12 Pages 2794-2803
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSEarly diagnosis by detecting small tumors is essential for improving therapeutic effects on carcinoma of the pancreas. Recently, diagnostic modalities of the carcinoma have greatly advanced, but the clinical usefulness of them has not been elucidated clearly in the early diagnosis. So, we assessed the diagnostic capability of such modalities as ultrasonography (US), endoscopic retrograde cholangio-pancreatography (ERCP), X-ray computed tomography (XCT) and angiography in 59 patients with carcinoma of the pancreas surgically resected. Gross- and micro-pathological findigns of the resected tumors were studied in all the patients. The tumors were divided into two groups according to the size; the one consisted of 19 tumors sized 2cm or less and the other did of 40 tumors larger than 2cm. All the tumors in the small size group were located in the pancreatic head.
The detection rate of abnormality about the carcinoma in these modalities was so various in the small size group, while it was almost similar each other in the large size group. Above all, US exhibited the highest capability in detecting small tumors of the pancreas and making the early diagnosis. In conclusion, it may be said that the use of US in combination with laboratory tests of pancreatic enzymes, followed by ERCP when necessary, is the most effective for early diagnosis of pancreatic carcinoma.View full abstractDownload PDF (1250K) -
Hiroshi YASUDA, Tetsuya MINE, Akiko IDEHARA, Eiichi SATO, Junko FUJISA ...1989 Volume 86 Issue 12 Pages 2804-2807
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (1416K) -
Yasuaki SHIRAYAMA, Tetsuhiko NAKAMURA, Kiyotaka OKUNO, Ichizou NAKAJIM ...1989 Volume 86 Issue 12 Pages 2808-2811
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (2242K) -
Yoshiharu OKIMOTO, Takuya FUJIHARA, Masanao TSUDA, Michio KINOSHITA, M ...1989 Volume 86 Issue 12 Pages 2812-2815
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (2490K) -
Yasuhiko MAKINO, Takatsune NAKAYAMA, Yoshiaki HIYAMA, Souichiro TSUKAM ...1989 Volume 86 Issue 12 Pages 2816-2821
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (1897K) -
Joji KITAYAMA, Kosuke HARA, Jiro TOMIYAMA, Noritosi ICHIKAWA, Yoshihik ...1989 Volume 86 Issue 12 Pages 2822-2827
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (2868K) -
Takaharu MASUNAGA, Makoto OOISHI, Naonori MIMOU, Kunio ODA, Toshio UEN ...1989 Volume 86 Issue 12 Pages 2828-2832
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (1568K) -
Yasutoshi MUTO, Hisataka MORIWAKI, Makoto SHIMAZAKI, Yasushi FUKUTOMI, ...1989 Volume 86 Issue 12 Pages 2833-2838
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSA high risk group of hepatocellular carcinoma (HCC) was statistically established using multiple regression analysis of 331 cases with liver cirrhosis (LC), in which 78 cases later developed HCC. Highly contributing factors to hepatocarcinogenesis were found to be positive HBsAg, age, drinking history, sex (male), history of blood transfusion, history of acute hepatitis (or jaundice) and elevated plasma lavels of alpha-fetoprotein. A prospective study was initiated in April, 1985 employing another 122 LC patients to clinically evaluate the significance of the high risk group of HCC. 28 cases with small HCC (<3cm in diameter) were newly found: 4 with chronic hepatitis and 24 with LC, among whom 22 developed from the high risk group (sensitivity 92%, specificity 44%). Three year survival rate of 28 cases thus found was 56%, and causes of death of 9 fatal patients were 4 cancer death, 4 hepatic failure and 1 gastrointestinal bleeding. In conclusion, the high risk group is valuable for the screening of early liver cancers, and treatments of hepatic failure as well as of HCC itself are important to improve the prognosis of HCC patients thus diagnosed.View full abstractDownload PDF (848K) -
Masahiro YAMADA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...1989 Volume 86 Issue 12 Pages 2839
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (136K) -
Takashi KENMOCHI, [in Japanese], [in Japanese], [in Japanese], [in Jap ...1989 Volume 86 Issue 12 Pages 2840
Published: 1989
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (179K)
- |<
- <
- 1
- >
- >|