We studied the clinical courses of 70 pregnancies in 47 women with ulcerative colitis (UC) and 18 pregnancies in 12women with Crohn's disease (CD) retrospectively. We concluded as follows. 1. Pregnancy has less influence on the course of UC. 2. The patients with UC who kept remission for more than 1 year befere conception have less risk of relapse and severity during pregnancy. 3. The patients with active UC at the time of conception tend to worsen during pregnancy. The patients whose onset of UC is during pregnancy tend to worsen. 4. UC has a littele influence on the course of pregnancy except severe active disease. 5. It is not obtained that pregnancy becomes a relapsing factor of CD. 6. CD during pregnancy has little influences on the course of pregnancy, if it is remitted. 7. Salazosulfapyridine and corticosteroids therapy has less influence on the fetus and the course of pregnancy.
AIM: Non-ulcer dyspepsia (NUD) is a common disorder in clinical field. The pathogenesis of NUD are still unclear, especially the participation of Helicobacter pylori (H. pylori) in NUD is controversy. Aim of the present study was to clarify the effect of H. pylori at view of urea breath test on liquids and solids gastric emptying in patients with NUD. SUBJECTS AND METHODS: H. pylori positive (n=24) and negative NUD subjects (n=11), and H. pylori positive non-NUD subjects (n=10) as control group were studied. Liquids and solids gastric emptying was evaluated according to the acetaminophen method and sulfamethzole modified method. δ13C-AUC was calculated as estimation of H. pylori by 13C-urea breath test. H.pylori positive NUD was classified into high δ13C-AUC group (n=11), median group (n=8) and low group (n=5). High δ13C-AUC group (n=6) and low δ13C-AUC group (n=4) group were treated by eradication therapy. In H. pylori positive NUD subjects, high and low δ13C-AUC group were estimated the changes of liquids and solids gastric emptying, symptoms before and after eradication. RESULTS: H. pylori positive NUD group has higher liquids gastric emptying that H. pylori negative NUD group (7.6±2.8 vs. 4.9±1.4, p=0.0022). No difference was observed between H. pylori positive and H. pylori negative group on solids gastric emptying. There was no significant difference in liquids gastric emptying among high-, median- and low-δ13C-AUC group of H. pylori positive NUD subjects. Solids gastric emptying was significantly delayed in high δ13C-AUC group, compared with low δ13C-AUC group (10.3±3.7 vs. 5.3±3.1, p=0.014). δ13C-AUC was not correlated to liquids gastric emptying, but to solids gastric emptying (r=−0.573. p=0.006). In Non-NUD group as control group, δ13C-AUC has not correlation to liquids and solids gastric emptying. H.pylori positive NUD has higher δ13C-AUC than Non-NUD group. Eradicated low δ13C-AUC group did not show significant changes in liquids gastric emptying, but did improvement of solids gastric emptying and symptoms scores. Eradicated low δ13C-AUC group did not show any significant changes. CONCLUSION: In non-ulcer dyspepsia patients. H. pylori does not influence liquids gastric emptying, but does solids gastric emptying according to δ13C-AUC of H. pylori, especially high δ13C-AUC patients.