Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Volume 77 , Issue 9
Showing 1-19 articles out of 19 articles from the selected issue
  • Hiroshi KANAZAWA
    1980 Volume 77 Issue 9 Pages 1345-1354
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The etiology of stress ulcer has been extensively discussed. However, the pathogenesis of stress ulcer was still unresolved. In the present studies, author have attempted to evaluate the roles of catecholamines and sympathetic nervous system in restraint and water immersion stress in rats.
    Method: The area of ulcer was expressed by ulcer index and catecholamine contents in the brain and adrenal gland were analysed biochemically.
    Results: Administration of epinephrine and phenylephrine as α-stimulant, showed significantly decrease on the ulcer index. Due to the treatment of surgical sympathectomy and adrenalectomy, the ulcer index was significantly increased. On the other hand, the relationship between ulcer index and brain catecholamine contents or adrenal catecholamine contents in the various time intervals revealed a reverse correlation. Due to the increment of brain catecholamine contents after dosing of MAO-I, ulcer index was decreased.
    Conclusion: From the results mentioned above, catecholamines and sympatheticadrenal axis was assumed to have an inhibitory effect on the stress ulcer formation.
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  • A Study on the Mechanism of Diarrhea due to CDCA Therapy
    Takashi NAKAMURA, Atsushi OHKUNI, Masami YAMANAKA
    1980 Volume 77 Issue 9 Pages 1355-1361
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The authors studied a mechanism of diarrhea during CDCA therapy of gallstones, using an in vitro model of golden hamster small intestine. CDCA, 1mM, inhibited glucose transport in everted hamster intestine, and also significantly decreased Na+-K+-ATPase activity of the small intestinal mucosa, although histological change was not found in the intestinal mucosa. UDCA, 1mM, on the other hand, did not cause these remarkable abnormalities.
    Considering these results, inhibition of glucose absorption in the small intestine, mediated by decrease of Na+-K+-ATPase activity, may share one of the causes of diarrhea during CDCA therapy.
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  • Yasushi TAKAGI
    1980 Volume 77 Issue 9 Pages 1362-1368
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The change of cholesterol composition of high-density lipoprotein (HDL) was examined in 36 cases of chronic liver diseases (10 of chronic hepatitis, 18 of liver cirrhosis, and 8 of h epatoma) .
    Their HDL-cholesterol levels were significantly reduced (p<0.01), often to very low levels in liver cirrhosis and hepatoma, whose mean levels were 36.5, 35.1 mg/dl, respectively. Moreover, their cholesterol ester and esterified ratio in HDL were useful to evaluate their stage, or severity of their damage.
    The percentage of abnormal values in chronic liver diseases was 57% of HDL-cholesterol and 76% of cholesterol esterified ratio in HDL, which were as high as ICG retention ratio (88%), or lecithin cholesterol acyltransferase (86%).
    From these data, I conclude that the cholesterol, cholesterol ester and esterified ratio in HDL can be considered as a good parameter of functional liver mass.
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  • Masaji NAMBU, Toshihiko NAMIHISA, Yuji YAMASHIRO, Hirobumi OHAMA, Mino ...
    1980 Volume 77 Issue 9 Pages 1369-1377
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    We observed the disappearance of bile acids in serum following an oral administration of 300mg ursodeoxycholic acid (UDCA) in 7 patients with constitutional hyperbilirubinemias, in one patient with constitutional. ICG excretory defect and in 5 healthy subjects. Serum bile acids were determined using gas liquid chromatography.
    A secondary rise of UDCA during plasma disappearance was revealed in patients with Dubin-Johnson syndrome and in a patient with unconjugated hyperbilirubinemia associated with delayed plasma BSP clearance. In 4 patients with Rotor's syndrome the plasma disappearance of UDCA was divided into two types, two patients showed parabolic disappearance curve and other patients showed almost normal disappearance curve. In a patient with constitutional ICG excretory defect the disappearance of UDCA was delayed since the maximal level at 60 minutes after an administration.
    There was no similar disappearance of other bile acids after an administration of UDCA in these disorders. There was no correlation between fasting serum bile acids concentrations and patterns of the UDCA plasma disappearance.
    We have reported a new bile acid, 3β, 7β-dihydroxy-5β-cholan-24-oic acid (3, 7β-cholanoic acid), and this bile acid in serum was determined before and after an administration of UDCA. The fasting level of this bile acid showed 0.08+0.07 (mean+SD) μg/ml in 5 healthy subjects. In patients with constitutional hyperbilirubinemias serum concentrations of this bile acid distributed in normal range. And in a patient with constitutional ICG excretory defect the highest level, 0.24μg/ml, was found. There was no definite change of serum 3β, 7β-cholanoic acid concentrations following an oral administration of UDCA.
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  • Part 1. Serodiagnosis of Sporadic Acute Viral Hepatitis Type A
    Kenjiro KAWAHARA
    1980 Volume 77 Issue 9 Pages 1378-1389
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Antibody to hepatitis A virus (anti-HAV) was analysed on paired sera from 122 cases with sporadic acute viral hepatitis by competitive binding radioimmunoassay procedure (using HAVAB-Kit). The increase of anti-HAV titer in paired sera of patients with hepatitis type A was most obvious when the initial sera were taken within 1 week after the onset. Whereas in cases with hepatitis type A whose initial sera were obtained in 3 weeks or more after the onset, it was difficult to confirm the diagnosis by simple determination of anti-HAV in paired sera. However, the presence of anti-HAV activity of IgMclass was detected in initial sera of cases with hepatitis type A. And in such cases the anti-HAV titer of convalescent sera were higher at least to some extent than that of initial sera in each dilution of 1:1, 1:100 and 1:200. Whereas no increase of anti-HAV titer could be found in any dilution in paired sera of cases with non A, non B hepatitis.
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  • Akiyuki OHKUBO, Yasuhiko IWASAKI, Hiroshi SATOH, Kinori KOSAKA, Takeo ...
    1980 Volume 77 Issue 9 Pages 1390-1396
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Factors which affect the results of modulation of host immune response in the treatment of chronic active hepatitis were studied. The efficacy of the treatment was evaluated by means of liver function tests such as serum albumin, SGOT, ICG retension rate, TTT, and serum r-globulin levels. Clinical improvement after treatment with steroid, or steroid and azathioprine, was found in 21 cases (the steroid effective group) out of 34 cases, but not in 13 cases (the steroid ineffective group). Between the effective group and the ineffective group, none of the followings was different: distribution in ages, sex ratio, severity in histological findings in liver tissues obtained by needle biopsy, serum r-globulin levels, and prevalence of HBs antigen in serum. Complications such as steroid diabetes were occurred with similar frequency in both groups. However, HLA-Bw54 were found in 8 out of 19 cases in the effective group in contrast to 1 out of 13 cases in the ineffective group. The frequency of Bw54 was statistically different between the two groups. Levamisole was used in the treatment of 12 cases containing 3 cases of the steroid effective group and 4 cases of the steroid ineffective group. Clinical improvement after treatment with levamisole was found in 3 out of 4 cases of the steroid ineffective group, but not in any of 3 cases of the steroid effective group. It was suggested that no less than two kinds of immunological deterioration might be involved in the development of chronic active hepatitis, and that the clarification of the immunological deterioration was important for control of inflammation of chronic active hepatitis with modulation of host immune response.
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  • Makoto YOSHIBA, Takemasa SANJO, Noboru INOUE, Tadahiro SAKAI, Yoshihir ...
    1980 Volume 77 Issue 9 Pages 1397-1402
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Seven patients with fulminant hepatic failure were treated by 4.8 liters of plasma exchange using our newly developed device with a plasma separater composed of celluloseacetate hollow fiber. Three out of 7 patients survived, and definite prolongation of survival time was observed in dead cases. However, dead cases failed to recover from coma, and 3 patients fell into ultimate brain death.
    Serial determination of prothrombin time, various plasma proteins, blood total bile acids and various amino acids revealed that although prolongation of prothrombin time and deficiency of the plasma protein was corrected largely, elevated blood level of aromatic amino acids was not reduced.
    These results suggest that although our plasma exchange therapy effectively assist part of liver function by giving large amount of plasma components, it only limitedly substitutes detoxicating capacity of the liver.
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  • I. An Invitation on the Motor Dysfunction of the Biliary System
    Masayoshi URAOKA
    1980 Volume 77 Issue 9 Pages 1403-1412
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Cholescintigraphy was performed on 53 subjects with motor dysfunction of the biliary system, and on 10 subjects with normal control, using 99mTc-Pyridoxylidene isoleucine. Analytical studies were also done on the exercise of the gallbladder and on the bile flow in both the gallbladder and the end of the choledochus. The results were as follows.
    1) Patterns of uptake of bile by the gallbladder were classified into 5 types, and the contraction patterns of the gallbladder were classified into 3 types.
    2) There was a positive correlation between the uptake rate of bile by the gallbladder and the contraction rate of the gallbladder in the normal group, but there was little correlation in the group with motor dysfunction of the biliary system.
    3) There was a positive correlation between the tonus of the gallbladder and the sphincter of Oddi in the normal group, which was also recognized in the most of dysfunctioned group.
    4) It was indicated that contraction of the gallbladder follows the passage of bile through the end of the choledochus after Caerulein administration.
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  • I. Effect of VIP on Normal Pancreas
    Kazutomo INOUE, Tamotsu KAWANO, Koichi SHIMA, Teruji KIM, Takashi SUZU ...
    1980 Volume 77 Issue 9 Pages 1413-1423
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Two methods were used for measurement of the normal pancreatic tissue blood flow in dogs: a hydrogen gas clearance method and a thermoelectric method.
    The basal blood flow in both the right and the left lobes of the pancreas could be measured simultaneously by the hydrogen gas clearance method, and no significant difference was found between the basal blood flow of the right and the left lobe.
    After we examined the reproducibility and reliability of the thermoelectric method, changes in the pancreatic tissue blood flow in response to VIP were measured continuously by this method. Prompt and significant increases were induced by both synthetic chicken and porcine VIP and no significant difference was observed between the effect of synthetic chicken and porcine VIP in this biological action. However, synthetic chicken VIP was weaker than synthetic porcine VIP in lowering systemic arterial pressure.
    Synthetic chicken VIP stimulated increases in exocrine pancreatic and biliary secretions and in portal insulin and glucose levels. The present study suggests that the stimulatory effects of VIP on endocrine and exocrine functions of the pancreas are closely related to the increased pancreatic blood flow elicited by VIP.
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  • Shinichiro FUJII, Tatsuji HOMMA, Atsuo NAGATA, Hisao OGUCHI, Kimie HAT ...
    1980 Volume 77 Issue 9 Pages 1424-1433
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    Four cases of macroamylasemia were reported and the components bound to amylase were studied. The macroamylase in 3 of 4 cases were electrophoretically in β-globulinn region and their amylase activity was blocked by anti-IgA antibody, which suggested that macroamylase in these 3 cases war IgA-binding type. The molecular size of these macroamylase was between 7S and 19S which was dissociated to normal size after they were chromatographed by low pH at 3.4. In the remaining one case, the serum amylase was 7S macroamylase and the electrophoretic mobility was in γ-globulin region. The treatment by low pH at 3.4 failed to develope normal amylase in molecular size in this case. These characters of this peculiar macroamylase resembled to those of glycogen-binding amylase. However, neuraminidase treatment of this macroamylase did not show almost any change in electophoretic mobility in contrast to glycogen-binding amylase. Furthermore, no adsorption of amylase in this case was observed in Con-A chromatography which retained considerable amounts of glycogen-binding amylase. Immunoelectrophoretic studies revealed that the components bound to amylase in this case were albumin and α--lipoprotein. The proportion of macroamylase to normal amylase in these four cases have varied considerably during follow-up period. The etiology of this fluctuation remains to be elucidated in future studies.
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  • Naoaki HITAKA
    1980 Volume 77 Issue 9 Pages 1434-1443
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The pancreatic duct of normal dogs is lined by columnar to cuboidal epithelial cells, covered with a thin mucus of two layers. The superficial layer is stained well with periodic acid Schiff and poorly with Scott's alcian blue, whereas the deep layer stained well with Scott's alcian blue and poorly with periodic acid Schiff. A network of the elastic fibers is observed around the wall of the pancreatic duct.
    The present study was to evaluate a significance of the mucous barrier on the ductal epithelium, elastic fibers around the duct and the surface of the acinar cells on acute pancreatitis, developed by Pfeffer's method using a closed duodenal loop in dogs. It revealed that the destruction of the mucous barrier and elastic fibers light-microscopically and the disappearance of microvilli on the surface of the acinar cells electron-microscopically were observed in the initial state, and then the ductal epithelium was disrupted, followed by flowing the pancreatic juice into the pancreas parenchyma.
    Infected bile was the most potent factor on the pathogenesis. Following these initial changes of the duct and acinar cells, pancreatitis developed and progressed from edematous to hemorrhgic and necrotic changes.
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  • Toshio FUJIKI
    1980 Volume 77 Issue 9 Pages 1444-1453
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
    The diagnosis of pancreatic disease can be and often is most difficult, especially by means of amylase determination in serum and urine alone, so that it is necessary to add several related parameters to it.
    Diagnostic value and clinical significance on parameters obtained by two-hour's clearance methods were investigated in 50 normal subjects and 206 patients with pancreatic and various disorders.
    Serum amylase, Cam, Cam/Ccr, the urinary amylase excretion per hour (u-amylase output) and the ratio of urinary amylase to creatinine concentration (u-am/cr) were effective to the diagnosis of acute pancreatitis and the observation of its clinical course, and especially u-am/cr was most sensitive indicator for acute pancreatitis.
    Increased Cam and Cam/Ccr were not specific for acute pancreatitis, on the contrary, decreased Cam and Cam/Ccr had a diagnostic value for macroamylasemia with normal renal function.
    Isoenzyme assay of amylase may be helpful for definitive diagnosis of acute pancreatitis and macroamylasemia, and further more in advanced stage of chroinc pancreatitis. Clinical significance of amylase isoenzyme clearance, which increased frequently in various disorders, is not clear.
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  • Akio INADA, Susurnu KOZAKA, Masahiro YAMASHITA, Tatsu YAMAMOTO, Iwao H ...
    1980 Volume 77 Issue 9 Pages 1454-1459
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Ryoichi KATO, Akio TAKEI, Toshio NISHIOKA, Tadashi SUGIYAMA, Takashi A ...
    1980 Volume 77 Issue 9 Pages 1460-1463
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasuhiko KUBO, Hideo IKEDA, Ryukichi KUMASHIRO, Kenji HIRAI, Masahide ...
    1980 Volume 77 Issue 9 Pages 1464-1468
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Koichi Suda, [in Japanese], [in Japanese]
    1980 Volume 77 Issue 9 Pages 1469
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Atsuyuki Kamibeppu, [in Japanese], [in Japanese], [in Japanese], [in J ...
    1980 Volume 77 Issue 9 Pages 1470
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Yasuyo HIJIKATA, [in Japanese], [in Japanese], [in Japanese], [in Japa ...
    1980 Volume 77 Issue 9 Pages 1471
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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  • Takashi Matsushiro, [in Japanese], [in Japanese], [in Japanese], [in J ...
    1980 Volume 77 Issue 9 Pages 1472
    Published: September 05, 1980
    Released: December 26, 2007
    JOURNALS FREE ACCESS
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