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Takashi NAKAMURA, Koji YAKABI
2000 Volume 97 Issue 5 Pages
551-559
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Taiichi OTANI
2000 Volume 97 Issue 5 Pages
560-567
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Teruyuki SUGIYAMA, Masaru SHIMIZU, Hiroo OHNISHI, Norihiro NOGUCHI, Ke ...
2000 Volume 97 Issue 5 Pages
568-574
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Hepatitis C virus (HCV) infection induces a variety of extrahepatic manifestations such as oral lichen planus (OLP). To clarify the role of HCV in the development of OLP, we investigated the occurrence of OLP in patients with chronic hepatitis C treated with interferon (IFN). Of 275 patients with chronic hepatitis C, 6 developed OLP during the IFN treatment. However, OLP developed in none of 230 patients with chronic hepatitis C who did not undergo the IFN therapy. The IFN treatment in chronic hepatitis C patients developed OLP significantly, as compared with the non-treated group (p<0.05). 4 of 6 patients who developed OLP during the IFN treatment had a complete response with normalization of ALT levels and undetectable HCV RNA after the treatment. There were no significant correlations between the effect of the IFN treatment and outcome of OLP. Furthermore, 3 of the 6 patients developed OLP, when serum HCV RNA became negative. These results suggest that direct viral factors may not be important in the pathogenesis of OLP in patients with chronic hepatitis C. Immunological changes caused by IFN may play a role in the development of OLP associated with HCV infection.
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Michimori KOHNO, Minoru YAMADA, Takekiyo OKUMURA, Kotaro HORI, Ushio H ...
2000 Volume 97 Issue 5 Pages
575-579
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Kazuo MARUTA, Masako NATUME, Koushirou HORI, Daisuke ISHIZUKA, Aritosh ...
2000 Volume 97 Issue 5 Pages
580-584
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Yasuyuki ENOMOTO, Mariko ITSUBO, Tomonobu KAWABE, Kazuhiko KOIKE, Hiro ...
2000 Volume 97 Issue 5 Pages
585-589
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Aki HORIMOTO, Shigeyuki TAKENAKA, Toshika MORI, Hiroshi OHATA, Takeshi ...
2000 Volume 97 Issue 5 Pages
590-594
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Satoshi YONEDA, Masahide YOSHIKAWA, Hiroo IMAZU, Hiroshi FUKUI, Yoshik ...
2000 Volume 97 Issue 5 Pages
595-599
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Takeo KANEKO, Tetsuo UENO, Yuzo MARUYAMA, Harutsugu SODEYAMA
2000 Volume 97 Issue 5 Pages
600-604
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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Hiroshi SUGIYAMA, Minoru SASAKI, Takahiko ASANO, Hidehiro KAWAI, Tomoh ...
2000 Volume 97 Issue 5 Pages
605-611
Published: May 05, 2000
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Satoshi KOBAYASHI, Masaki TERASAKI, Yasukatsu OKAMOTO, Eiji SAKAMOTO, ...
2000 Volume 97 Issue 5 Pages
612-615
Published: May 05, 2000
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Hiroshi TOKUYAMA, Yuzi NAKAYAMA, Miho TSUNO, Makoto OBAYASHI, Tomoki N ...
2000 Volume 97 Issue 5 Pages
616-618
Published: May 05, 2000
Released on J-STAGE: February 26, 2008
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