The cystometric study since Dubois (1876), including fundamentals concerning the physiology of the vesical smooth muscles as well as the nervous system, has been so no ticeably achieved by Rose (1927), Simons (1935), Imaiziumi (1942) and others in finding a clue to the solution of the remaining problems of urology. However expected results to be measured have never been known through cystometry in cases of the functional diseases of the bladder, as nocturnal enuresis, to say an example. This is either because these functional diseases lie outside the range of the cystomery, or because the vesical pressure, as stated by Boag and Smith (1938), does not indicate entire functions of the bladder, but is affected by some secondary factors such as the abdominal pressure and the reflexes between various visceral organs. The author has made the first experiments to reveal the relations of the abdominal pressure to the vesical pressure to which foregoing authors have paged greatest attention.
Method of Study.
As the abdominal pressure-tube, I used Wada's method after making some modifications by replacing a special metal tube, in order to cover the hours-long experiments. For instillation, Mariotte's bottle was modified as to enable continuous instillments under the same pressure and temperature throughout the experiments. Only male rabbits weighing over two kilograms were used, and to fix them, a stand was devised for free fixation at the desired position, rendering it possible to shift the whole body of the animal up and down or only the fore part of the body up and down.
As the solution for the vesical instillment, the original prescription of Mognus was applied. Thus the vesical pressure has been drawn on kymoraphion by use of tambour.
Results.
1. The vesical pressure of the normal rabbits goes hand in hand with the abdominal pressure, the former being always influenced by the latter.
2. Stimulations of sounds, light and smoke upon the sensory organs as ears, eyes and nose respectively, cause the ascent of the vesical pressure. This is secondarily caused by the rise of the abdominal pressure.
3. The vesical pressure goes up and down as the body is raised and lowered. This is also secondary, according to the changes of the abdominal pressure by the specific gravities of the abdominal viscera and the serous fluid.
4. The hypogastric pressure is not affected by the respirating movements of the abdominal wall. Hence the vesical pressure is free from them. Both pressures go up exclusively an case of deep breadth.
5. While the vesical pressure goes up as its capacity increases, the abdominal pressure goes down.
6. At the time of the micturition reflex, the vesical pressure goes up as the animal acts in a peculiar way to the reflex, and the abdominal pressure also ascends. Under the artificiallyhalted micturition the abdominal pressure goes up more strikingly rather than the rythmic ascent of thesveical pressure. The abdominal pressure thus changes to make the micturition easier.
7. Agents are classified as follows according to their effects upon the vesical pressure as the abdominal pressure.
a. Adrenalin and atropin to lower both vesical and abdominal pressures.
b. Adrenalin (temporarily), pilocarpin, acethylcholin, pituitrin and urotropin to lower the abdominal pressure and to raise the vesical pressure.
c. Vagostimin to raise the vesical pressure alone.
d. BaCl₂ to raise the vesical pressure, accompanying the ascent of the abdominal pressure.
e. Strychinin to raise the abdominal pressure which seemingly raises the vesical pressure.
8. Summary concerning the vesical effects of various agents:
1. Abrenalin causes temporary rise, later drop of the vesical pressure, supporting Edmund and Roth and opposing the stimulation theory by Yoshida.
2. Ascent of the vesical pressure and increases of the rythmic contractions of the bladder, both caused by BaCl₂ are not so

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1) Among normal organs of the adults (88 pieces), prostate gland had decisively large amounts of acid phosphatase (5 cases, 517-3100KAU/g); other organs had remarkably small amounts of it; bladder, adrenal gland, testis, kidney, rectum, liver, lymph nodes, spleen and spermatic cord showed lower values in that order (12.8-1.7KAU/g). As to the sexual difference, in the cases of the kidney, female was lower; In adrenal glands, male was lower than that of the opposite sex.
2) Inflamed and fibromyomatic type of enlarged prostate gland and inflamed area and neoplastic parts of the bladder had lower acid phosphatase values than normal; on the contrary every metastatic focus of prostatic carcinoma in the internal organs had markedly raised acid phosphatase value in comparison with normal tissue.
3) Among normal organs of fetus (10 cases) the acid phosphatase value of prostatic tissue was not particularly higher than others; the highest was adrenal gland (11.7KAU/g); in the other organs studied, the difference between fetus and adults was small. According to fetal months and sex there were no differences in the phosphatase value of those other organs.

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1) Atonin (preparation of lateral lobes of pituitary gland) acts significantly hypertonic, particularly in the abnormal hypotonic bladders. The changes of minimum and maximum desire to void are both slight compared with that of the maximum voluntary pressure and tonus curve.
2) Hypohorin(preparation of anterior lobes of pituitary gland) and interenin (preparation of cortex of adrenal gland) act hypotonic, however the action of the latter is more evident than that of the former. Frequent injection of interenin was proved to be effective for the treatment of abnormal hypertonic bladders.
3) Thyrasin (preparation of thyroid gland) sometimes shows slight hypertonic action.
4) Amolisin (testosteron acetat) shows rather hypertonic action, particularly in the abnormal hypotonic bladders. Males somewhat more remarkably react than females.
5) Ovahormone (benzoic acid ester of estron) shows rather hypotonic action, particularly in the abnormal hypertonic bladders. Females more remarkably react than males.

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