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Volume 68, Issue 6
Displaying 1-7 of 7 articles from this issue
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Koichiro Shimada1977 Volume 68 Issue 6 Pages 517-536
Published: 1977
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSA slight modification of the whole blood culture method designed by Pellegrino, and Mizoguchi has been used in this study. The degree of lymphocyte transformation induced by PHA was determined by estimating 3H-thymidine uptake, and the rate of blastogenesis was expressed as stimulation index (S. I.).
The response was studied in normal individuals, and patients with urologic cancers and other diseases. Furthermore, it was investigated under certain conditions that were designed for studying the presence of humoral factors concerning the cellular immunity mechanism.
The results obtained are as follows:
1. In 60 mormal individuals ranging in age from 3 to 80, their S. I. had a tendency to decrease with of age.
2. In a group of 86 patients with urologic diseases, most of the S. I. of patients with the neoplasms revealed low values as compared with those of the non-malignant patients.
3. In a group of 29 postoperative bladder cancer patients, their S. I.'s were considerably lower in recurrent patients than in non-recurrent patients.
4. In a group composed of 13 normal individuals and 15 patients with the malignancies, addition of a pooled serum from over 130 persons with blood group AB to their rinsed blood cell specimens without serum factors resulted in a marked decrease of S. I. as compared with that of autologous serum.
5. In 14 cancer patients, whose S. I.'s were less than 60 by the whole blood culture technique, the mixtures of their rinsed blood cell specimens and each serum from 5 persons with blood group AB resulted in a considerable increase of S. I.
6. In the same matching of blood group, the addition of each serum from 13 patients with the malignancies, whose S. I.'s were less than 60, to each rinsed blood cell specimen obtained from 15 normal individuals tended to decrease their original S. I.
7. The slightly modified blood culture method was considered to be a useful and convenient procedure to study immune deficiencies.View full abstractDownload PDF (2387K) -
Yoshikazu Ito, Isao Kurosawa, Hidetoshi Yamanaka, Atsushi Koya, Kyoich ...1977 Volume 68 Issue 6 Pages 537-552
Published: 1977
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSWe tried some animal experiments in order to elucidate the mechanism of antiandrogenic action, especially antiprostatic action of chlormadinone acetate (CMA). CMA inhibited the uptake of testosterone by the prostate. CMA itself was incorporated into the prostate cell selectively and inhibited the binding of cytosol 5α-DHT-recepter (The direct action of CMA at the prostatic cell level). CMA has both the direct and indirect actions on the prostate. The indirect action was mainly due to the acceleration of testosterone metabolic enzyme system in the liver and the inhibition of testosterone biosynthesis in the testis. The prostate of intact adult rat was slightly atrophied by the treatment of a small dose of CMA. On the other hand, the involution of rat prostate was intensified by the additive effect of the indirect action to the direct action of CMA, when a greater dose of CMA was administered to intact adult rats.
The study on the changes in plasma hormone-contents and the biochemical finding of hypertrophic nodule suggested that improvement of dysuria of patients with BPH was mainly due to the direct effect of CMA.View full abstractDownload PDF (4129K) -
ROENTGENOLOGICAL AND HISTOLOGICAL INVESTIGATIONYasuhiko Onoye1977 Volume 68 Issue 6 Pages 553-568
Published: 1977
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSSoft-tissue shadow outline of the bladder can be seen in some cases of bladder outlet obstruction. An attempt has been made to determine the significance of the soft-tissue shadow by correlating cystogram with histological findings of the bladder detrusor muscle not only in experimental animals but in clinical cases.
Firstly, the soft-tissue shadow could be demonstrated in some cases of the bladder neck obstruction by means of excretory cystogram, retrograde cystourethrogram and double contrast cystogram, the last one being proved to be the best method to detect the soft-tissue shadow.
Secondly, the finding of the soft-tissue shadow appeared to betray the existence of bladder neck obstruction during the compensatory phase of the bladder detrusor muscle, while in the decompensatory phase soft-tissue shadow could not be demonstrated in any cases of bladder neck obstruction.
Thirdly, histological studies clarified that bladder wall showed a hypertrophy of the detrusor muscle and a proliferation of the stromal tissues in the positive case of soft-tissue shadow.
In conclusion, it is not so difficult to find the urinary tract obstruction in advanced cases. However, compensatory detrusor hypertrophy demonstrates soft-tissue shadow by the roentgenography, which serves to diagnose early bladder neck obstruction without any subjective complaint or objective disturbance.View full abstractDownload PDF (11722K) -
Junnosuke Fukui, Kiyoshi Kodaira, Setsuo Watanabe, Tohru Takezaki, Nob ...1977 Volume 68 Issue 6 Pages 569-589
Published: 1977
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSTwenty cases of tethered cord syndrome which we experienced are presented.
All of the cases were under 18 years of age except one who was at the age of 45 as listed in Table 1. 70% of the cases were under 15 years old. Most of the cases were children.
As shown in Table 2, many patients complained of urinary incontinence and dysuria as clinical symptoms.
All of the cases had the autonomous neurogenic bladder according to the classification of Lewis' cystometrogram. According to the classification of Sato's cystometrogram, 13 cases were hypertonic, 4 cases normotonic and 3 cases hypotonic. Many of them were unexpectedly hypertonic although they had the autonomous neurogenic bladder (Table 2).
For the diagnosis and prognosis of this syndrome, simultaneous measurements of the vesical pressure, urethral pressure, intra-abdominal pressure, E. M. G. of anal sphincter, tone of anal sphincter and urinary flow rate were performed in the course of micturition with the 6 channel polygraph, which we had reported, as well as the neurological test by E. M. G.
These tests were best at present to follow up the prognosis of this syndrome.
Clinical symptoms of this syndrome were mainly due to an incomplete contraction of the detrusor, incomplete dilatation of bladder neck during the micturition and detrusor-external urethral sphincter dyssynergia. The last disorder was proved by the urodynamic examination and lateral voiding cystourethrography with the continuous 70mm spot-graphy.
Many of the improved cases after the operation show an increased contraction of the detrusor, a decrease of loss of energy at the bladder neck and an improvement of detrusor-external urethral sphincter dyssynergia.
The result of our operations of this syndrome shows improvement up to 50% including 2 cases of complete recovery (25%) from the urological point of view.
It is essential to make the diagnosis of this syndrome before urological palliative operation, such as urinary diversion, to be done.View full abstractDownload PDF (11946K) -
WITH SPECIAL REFERENCE TO THE AGGREGATING EFFECT OF SERUM α1 GLOBULIN ON CaCO3 SUSPENSIONNoboru Kisaki1977 Volume 68 Issue 6 Pages 590-598
Published: 1977
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSIt is well known that not only patients with renal disease but healthy individuals also excrete proteins in the urine. However, the role played by urinary protein in the formation of stones is not as yet clearly understood. The present study was undertaken to determine if urinary protein has an action to form a stone and if so what types of protein possess such an action.
Materials and Methods: Normal human serum was separated into fractions by the use of ammonium sulfate and further refractionated with DEAE cellulose. Each of the fractions thus obtained was tested for its stone-forming action by measuring the increase in the sedimentation rate of a suspension of CaCO3 fine particle and the change in ζ-potential of this suspension that occurred on addition of these fractions. Also, proteins separated by electrophoresis through a cellulose acetate film were identified.
Results: Proteins of γ- and β-globulin fractions were found to exert little aggregating action on CaCO3 suspension. Most marked aggregation and precipitation of the colloidal substance were observed with proteins of α1-globulin fraction or with a mixture of α1-globulin and albumin.
From these findings it was considered that proteins of α1-globulin fraction or a mixture of proteins of α1-globulin and albumin in urine are the most likely predominant factor in the formation of stones in urine.View full abstractDownload PDF (2529K) -
Takahiro Akiyama, Sigeo Kaneko, Masanori Iguchi, Kouji Minami, Teruo K ...1977 Volume 68 Issue 6 Pages 599-608
Published: 1977
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe urinary and serum fibrin/fibrinogen degradation products (FDP) of 27 human renal allotransplanted patients has been measured using the techniques of TRCHII.
Urinary FDP were detected in all cases in the immediate postoperative period, but if the transplant had good function urinary FDP fell to undetectable levels in 3-10 days (mean 7.2 days). Urinary FDP were detected during rejection episodes in 26 of 31 occasions, especially in all of 20 early rejection episodes which occurred within 2 months after transplantation. In 10 of 14 cases appearances of urinary FDP preceded the clinical diagnosis of rejection episodes by periods of 1 to 5 days, and in 19 of 22 cases (86.4%) measurements were of value in early detection or prediction of rejection episodes. Disappearances of urinary FDP also tended to precede the recovery from rejection crisis. In early rejection the levels of urinary FDP has been correlated with severity of rejection and irreversibly rejected allografts excreted high levels of FDP for long periods; the measurements may be of prognostic value for the ultimate outcome. In late rejection, however, urinary FDP was not always positive even if rejection was severe and irreversible.
In one case of acute tubular necrosis positive urinary FDP continued for 12 days of the following diuretic phase. Other complications such as perirenal lymphocele, urinary tract infection and renal vein thrombosis did not cause positive urinary FDP in our study.
Serum FDP also has been measured in this series, but it may be of few values in diagnosis of rejection. Other hematologic examinations in several patients suggested that systemic changes of coagulation fibrinolysis system during rejection episodes were not significant.View full abstractDownload PDF (1223K) -
Hideari Ihara, Hiroaki Itatani, Shutaro Mizutani, Minato Takaha, Shunz ...1977 Volume 68 Issue 6 Pages 609-620
Published: 1977
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSA case of renal adenocarcinoma in the ossifying kidney is presented. The patient was a 22-year-old woman, who had been diagnosed as having renal teratoma in her right renal tumor with calcification on the basis of the urological examinations including retroperitoneal pneumography and abdominal aortography one and a half years prior to the time when she was incidentally found to have osteolytic lesion in the left clavicle on chest plain film. Further roentgenographic examinations revealed multiple osteolytic lesions of the bones, a right kidney tumor with multilocular cyst-like calcified shadow and neovaacularity.
Right nephrectomy was performed under the preoperative diagnosis of right renal malignancy with multiple bone metastases.
Grossly, multicystic lesion with irregular surface and stony hard consistence was found not inside but beside the tumor.
Microscopically, bone formation was found within the wall of the calcified cysts without tumor cells, but with tumor invasion. Sections of the tumor showed both adenomatous adenocarcinoma and dark cell type of adenocarcinoma.
Five cases of ossifying renal adenocarcinoma have been reported in Japan, but this is probably the first case of adenocarcinoma in the ossifying kidney.View full abstractDownload PDF (6842K)
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