The fibrinolytic activity in haematuria, especially the effect of blood component on fibrinolytic activity of urine were investigated. The fibrinolytic activity in urine were determined by means of unheated and heated fibrin plates prepared by “method of Astrup and Müllertz”. The fibrinolytic activity of crude extract of urine is called as “FA in urine” and that of the extract of urine absorbed by 2M KSCN is called as “Act in urine”.
The results are summarized as follows:
1) In normal human blood both Act and FA were not determined.
2) Act in urine were not recognized in normal urine but some FA in urine were determined.
3) Urine samples were obtained from two patients with prostatic hypertrophy, two bladder tumors and one essential renal bleeding.
4) In each case, the level of the FA in urine were relatively high within normal limit.
When haematuria developed, the level of FA in urine were decreased; but as soon as urine became clear, the value of that converted to the patient own level.
5) Whereas, Act is urine were not recognized in the urine if the urine is not haematuria, but it immediately appears upon haematuria.
6) In one patient, who had bladder tumor followed by the uremia with generalized tumor metastasis, there had been no FA in urine, but some Act is urine for 7 days just before his death. These phenomena were unable to be explained with the fact of haematuria.
7) On the haematuria by ureteral catheterization, especially Act in urine elevates than the usual elevation of the values of FA in urine.
8) In the whole blood is added into the urine, the level of FA in urin decreases slightly, conversely Act in urine developes.
9) Addition of euglobulin to normal urine made a same effect with whole blood.
10) From those facts, it is thought to me that proactivator and activator in the blood would be activated and would produce active activator and active plasmin.
Therefore we must consider the influence of blood components for the estimation of the fibrinolytic activity in haematuria.
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