All issues
Successor
Predecessor
Volume 75, Issue 5
Displaying 1-15 of 15 articles from this issue
- |<
- <
- 1
- >
- >|
-
II. Results of a Long-term Follow-up and Technical ProblemsHiromi Kumon, Yasutomo Nasu, Yosuke Matsumura, Hiroyuki Ohmori1984 Volume 75 Issue 5 Pages 731-738
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSWe studied prognostic significance of ABH isoantigens in 22 patients who was initially with grade 1, stage O-A transitional cell carcinoma of the bladder. The presence or absence of the antigens in these carcinomas was previously reported. In a follow-up study, of 9 cases devoided of the antigens, 4 progressed to fatal conditions, one to grade 3 lesion, 3 showed one or more local recurrences and one no recurrence. On the other hand, of 13 cases with the antigens, 7 showed no tumor recurrence for at least 5 years and 6 showed recurrence which were confined only to the submucosal layer. These results indicate that the analysis of isoantigens is most valuable for predicting malignant potential of transitional cell carcinoma. Concerning how to detect the antigens, we compared the commonly used specific red-cell adherence test with immunofluorescence, immunoperoxidase and scanning immunoelectron microscopy. The immnuoperoxidase method was found to be far superior to others in several points including sensitivity and reproducibility.View full abstractDownload PDF (5884K) -
III. Detection by PAP Method and A Classification of Staining PatternYasutomo Nasu, Hiromi Kumon, Yosuke Matsumura, Hiroyuki Ohmori1984 Volume 75 Issue 5 Pages 739-743
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSWe employed the peroxidase-antiperoxidase method (PAP) to detect the Blood Group Antigens (BGA) in bladder tumors. PAP was found to be satisfactory in the staining specificity, sensitivity and reproducivility. H-antigen could also be detected successfully. Staining patterns of BGA by PAP were examined in 58 cases of bladder tumors with various histological grade and classified into four types;
Type I: Stained homogeneously and as intensely as normal urothelium.
Type II: Stained homogeneously but less intensely than normal urothelium.
Type III: Stained non-homogeneously with scattered negative areas.
Type IV: Stained negatively with no positive areas.View full abstractDownload PDF (2480K) -
Shoichiro Nakamura, Yumiko Shirane, Koji Hiraishi, Kazuo Kurokawa1984 Volume 75 Issue 5 Pages 744-750
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSγ-Carboxyglutamic acid (Gla) has been found in calcium-containing urinary stones.
We have measured Gla in 24-hour urine collections from 41 male and 30 female Ca stone formers as well as 24 male and 11 female normal subjects.
In the normal males, we found a significantly increased excretion of Gla per day, amounting 48.6±8.8μmol compared to 36.6±6.4 in normal females (p<0.01).
The mean value of Gla was 38.3±7.8μmol/day in male Ca stone formers which was significantly lower than that in the normal males (p<0.01).
Urinary Gla concentration was 20.8±8.7μmol/l in female Ca stone formers which was significantly lower than 28.6±8.9μmol/l in normal females.
In male Ca stone formers, significant correlations at p<0.01 were found between the values of 24-hour urinary Gla and uric acid, urinary Gla and Ca concentrations and urinary Gla and uric acid concentrations.
In female Ca stone formers, significant correlations were observed between the values of 24-hour urinary Gla and oxalic acid or uric acid (p<0.05), and urinary Gla and Ca or uric acid concentrations (p<0.01).
These results suggest that urinary Gla excretion has an inhibitory activity in Ca stone formation.View full abstractDownload PDF (732K) -
Isamu Motoi1984 Volume 75 Issue 5 Pages 751-765
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe pharmacokinetics of gentamicin sulfate (GM) have been investigated in rabbits with unilateral or bilateral hydronephrosis. An experimental model of hydronephrosis was produced by an incomplete ligation of the ureter at a lower portion, and 5mg/kg of GM was intravenously injected 7 days after ligation. GM concentrations in serum, urine and renal tissue were measured by substrate-labeled fluorescent immunoassay. The pharmacokinetic parameters of GM were obtained by analyzing the serum levels of GM on the basis of a two-compartment open model. In rabbits with bilateral hydronephrosis, the elimination rate constant, β-phase rate constant and total body clearance decreased, serum half-life (β) was prolonged, and the area under the curve of serum concentration increased as compared to normal control rabbits. The elimination rate constant, β-phase rate constant and total body clearance were all correlated with the creatinine clearance (p<0.01). The split renal clearance and urinary recovery of GM decreased in the hydronephrotic kidneys, and increased in the intact kidneys of rabbits with unilateral hydronephrosis. The split renal clearance and urinary recovery were correlated with the creatinine clearance of the individual kidney (p<0.01), respectively. The urinary concentration of GM in the hydronephrotic kidneys decreased with the lowering of urinary concentrating ability. Renal cortical and medullary concentrations of GM decreased in the hydronephrotic kidneys, and the renal cortical concentrations were correlated with the creatinine clearance and cortical blood flow of the individual kidney (p<0.01), respectively.
These experimental results suggest that proper doses and administration intervals for GM should be adopted on the basis of the creatinine clearance in individual cases with hydronephrosis in order to maintain therapeutic and nontoxic serum levels of GM. Since GM levels in the tissue of the hydronephrotic kidneys were lower than those of the contralateral intact kidneys, GM administration taking into account split renal function should be utilized in cases with hydronephrosis.View full abstractDownload PDF (1875K) -
Yasuo Hashinaka, Shiro Takahara, Yoshinari Kato, Takashi Oda, Shunsuke ...1984 Volume 75 Issue 5 Pages 766-771
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSOne hundred and six kidney transplants were perfomed at our clinic from February 1973 until December 1982. They consisted of 99 living related transplants and 7 cadaveric transplants. The total survival rate was 95% at 1 year and 89% at 5 year.
The graft survival rate in the living related transplant was 85% at 1 year and 73% at 5 year. On the other hand, the number of cadaveric transplant was only 7 and the graft survival rate was 51% at 6 month. The decrease of posttransplant serious complications resulted in good patient survival and graft survival in the living related transplant. No case with urological complications was led to graft loss or patient death.
Two factors, histocompatibility and pretransplant blood transfusion which would have an influence upon graft survival, were analysed. 5 year graft survival of no mismatch in HLA AB was 100%, which was significantly higher than that of 1 or 2 mismatch (p<0.01). The correlation between pretransplant transfusion and graft survival of the living related transplantation was present at 1 year and 2 year graft survival, but was not at 5 year.View full abstractDownload PDF (789K) -
IMMUNOHISTOCHEMICAL LOCALIZATION OF THE BACTERIAL ANTIGEN IN THE MALACOPLAKIA OF THE URINARY BLADDERTakashi Deguchi, Ikuo Shinoda, Satoshi Ishihara, Toshimi Takeuchi, Shi ...1984 Volume 75 Issue 5 Pages 772-777
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSAn immunohistochemical study was done in the bladder tissue of a patient with bladder malakoplakia. The etiology of the malakoplakia remains still unknown, but several etiologic factors were suggested. In most cases reported, Escherichia coli was cultured from the urine and affected tissues. Electron microscipic observation revealed that the bacteria remained in the cytoplasmic vacuoles of monocytes and were digested in the phagolysosome, and that Michaelis-Gutmann bodies developed by the deposition of crystallin on the degraded structures of the bacteria in the phagolysosome. We produced antisera against E. coli that was isolated from the urine of the patient wtih malakoplakia of the urinary bladder. With this antibody, immunohistochemical localization of the bacterial antigen was observed in biopsy specimen. It was shown that bacterial antigen was localized in the submucosal tissues widely, especially in histiocytes as cytoplasmic granules of varying sizes. Therefore, immunohistochemically, bacterial infection was revealed to play an important role in the formation of the histopathological features characteristic of the malakoplakia.View full abstractDownload PDF (3655K) -
Yasunori Nishio, Keiichi Matsumoto, Mikinobu Ohtani, Tadao Kakizoe1984 Volume 75 Issue 5 Pages 778-786
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSSixty-one cases of pure seminoma of the testis were treated at the Department of Urology, National Cancer Center Hospital, Tokyo, from 1962 to June, 1983.
Five year survival rates are 100% for Stage I and IIa (42 cases), 40% for Stage IIb (5 cases) and 32% for Stage III (14 cases).
Two of the 5 cases in Stage IIb were free of the disease after radiotherapy, but other three died of the disease.
Six of the 14 cases in Stage III had solitary metastatic lesions and the other 8 had multiple metastatic lesions. Five of the 6 cases with solitary lesions became free of disease by radiotherapy or radiotherapy and chemotherapy, but 1 case developed multiple metastases and died. Five of the 8 cases with multiple metastatic lesions were treated with radiotherapy and combination of different kinds of anti-tumor agents except Cis-DDP, but all died of the disease. The remaining 3 of the 8 cases with multiple metastatic lesions were treated with radiotherapy, combination of Cis-DDP and Ifosfamide, or CDDP, BLM and VBL, and reduction surgery. All of the three achieved complete remission and are alive.
For successful treatment of advanced seminoma cases like Stage III, meticulous combination of chemotherapy including CDDP and cytoreductive surgery appears essential.View full abstractDownload PDF (1210K) -
Fujio Masuda, Yuichiro Akasaka, Gyojiro Nakada, Tetsuro Ohnishi1984 Volume 75 Issue 5 Pages 787-794
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSDuring the 4 year period from October 1979 to September 1983, thoracoabdominal radical nephrectomy was performed in 22 cases of renal cell carcinoma. With patients in semi-recumbent position of 30 degree angle an incision was made at the level of the 8th or 9th rib to the midline just above the umbilicus.
The 8th or 9th rib was resected, and the rib bed was incised to enter the thoracic cavity. Then the diaphragm was opened to enter the peritoneal cavity to perform radical nephrectomy. In all cases lymphadenctomy was performed. The mean operating time for the whole 22 cases was 285 minutes with a mean blood loss of 983ml. However, the mean operating time for 16 cases without additional surgical procedure and intraoperative complication was 254 minutes with a mean blood loss of 742ml. No postoperative death occurred. The only intraoperative complication was vascular injury which was observed in 2 cases (or 9.1%). The incidence of postoperative complication was also as low as 2 cases (or 9.1%).
In one case exacerbation of preexisting renal failure was seen, while in the other case strong pain of the operative wound was noted. In both cases alleviation was obtained by conservative therapy. In none of the cases pulmonary complication was observed. This approach is the best operative method for renal cell carcinoma, especially in cases of large and upper pole tumor advancing to the subdiaphragm.View full abstractDownload PDF (1229K) -
1-(2) The Etiological Consideration of 4 Cases of Interstitial Cystitis with Advanced Contracted BladderTetsuo Yamada, Hirokazu Taguchi1984 Volume 75 Issue 5 Pages 795-801
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSFour cases diagnosed as interstitial cystitis in the paper titled “The clinical study of interstitial cystitis 1-(1)” were discussed about their etiology, considering from the clinical findings such as clinical history and laboratory data and pathological findings. Discussing the etiology, various opinions were reviewed. Allergy of tuberculosis, collagen disease, tonsillar focal infection and immediate type of allergy were concluded to be the etiology in each case.View full abstractDownload PDF (1051K) -
A NORMAL VALUE OF SERUM PROSTATE ANTIGEN IN JAPANESE MALES AND ITS COMPARISON WITH THAT OF AMERICANSManabu Kuriyama, Toshimi Takeuchi, Manabu Okano, Takashi Deguchi, Yosh ...1984 Volume 75 Issue 5 Pages 802-806
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSSerum prostate antigen (PA) levels in 158 apparently healthy Japanese were detected with an enzyme immunoassay and these values were compared with those of Americans (n=68). Of 26 sera from females, 2 cases have serum PA of 0.12 and 0.13ng/ml, respectively. However, in others (92%) serum PA was undetectable (<0.10ng/ml). A total of 132 sera from males (age; 17-57 y. o., average; 30.7) were evaluated for serum PA values. Of these, in 42 sera (32%), PA could not be detected. Regrading these sera having 0.10ng/ml of PA, the mean±SD was 0.33±0.28ng/ml. One point two ng/ml, mean+3S. D., was calculated as an upper cut-off value in normal Japanese males. In prostate cancer patients with pretreatment (n=45), 28 cases (62%) were shifted to positive from 23 patients (51%) whose serum PA levels were greater than an upper cut-off value in Americans, which is 2.5ng/ml.View full abstractDownload PDF (542K) -
Contributing to the Failure and Result of the Second OperationsDaiji Ishii, Shigeo Sakashita, Toshiaki Gotoh, Katsuya Nonomura, Akio ...1984 Volume 75 Issue 5 Pages 807-814
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSEighty-nine previously unoperated patients underwent anti-refux ureteroneocystostomies for 136 ureters since April 1977 to July 1983. Of them 65 patients were with VURs, 15 with non refluxing megaureters, 5 with ureteroceles and 4 with ectopic ureters. Excellent results were obtained after the operations in 93.8% of patients with VURs, 93.3% with megaureters and 77.7% with ureteroceles and ectopic ureters.
The second anti-reflux ureteroneocystostomies were performed on 11 patients with complications, of whom 6 underwent the previous operation in our hospital after April 1977, 3 were operated before March 1977 and 2 patients were operated previously elsewhere. Postoperative complications consisted of VUR in 10 patients and obstructive ureterovesical junction in one case. Untreated bladder hyperreflexia seemed to be a contributing factor for the appearance of postoperative VUR in children. Excellent results were attained in all these patients by the second operation, primarily with the technique of transverse reimplantation (Cohen 1975 and/or Ahmed 1978).View full abstractDownload PDF (4948K) -
(II) An Evaluation of DNA Content in Follow-up of Patients with Bladder CarcinomaShigeru Fujihiro1984 Volume 75 Issue 5 Pages 815-825
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSUsing urinary exfoliated cells or tumor cells, nuclear DNA content, which is considered to show a malignant potential of tumor cells, was measured patients with bladder carcinoma. The results were compared with clinical courses of the patients who were received conservative operation such as TUR, segmental resection or local chemotherapy, i. e. intracavital instillation (Ic I) of chemotherapeutic agents with or without hyperthermia.
In 10 patients who received conservative operation, abnormal findings of DNA content returned to normal pattern after operation except in one case. This case was revealed to have another tumor by random biopsy. Therefore, the detection of DNA content seems to be a tool useful for judgement of curative operation.
A total of 32 patients with bladder carcinoma were studied to compare the prognosis with the DNA content. In a group of high grade and low stage or high grade and high stage, if patients had DNA histogram with hyperploid cells, they were eventually found to have tumor recurrence and rapid progression at a high frequency.
A group treated with Ic I (n=8) was devided into the following 3 groups based upon DNA histogram pattern. The first group who had a stemline in 2C to 4C and narrowly distributed showed good clinical effect. The second groups whose histogram was a few stemlines was observed to show various clinical responses case by case. However, the third group who had unclear stemline and widely distributed was with poor clinical response.
In summary, the detection of DNA content might be of great use in follow-up and choice of treatment method in patients with bladder carcinoma.View full abstractDownload PDF (1444K) -
Masanobu Miyata, Shigemi Mori, Kazuhide Kuroda1984 Volume 75 Issue 5 Pages 826-835
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe functional roles played by the sacral cord and rostral pons in micturition were studied in the decerebrate reflex standing cats.
1. In the intact cat, horseradish peroxidase (HRP) was injected into the ipsilateral pelvic vesical branches. Most neurons labeled retrogradely were found in the lateral part of the intermediate gray throughout ipsilateral S2 and S3, except for the caudalmost part of S3.
2. In the decerebrate cat with a closed urethra, microstimulation (0.2ms, 50Hz) delivered to the lateral part of the intermediate gray of S2 resulted in an increase of intravesical pressure and of the discharge of external urethral sphincter. Increasing the stimulus intensity resulted in an augmentation of both effects.
3. In the decerebrate cat with an open urethra, microstimulation delivered to the same intermediate area did not elicit micturition.
4. In the intact cat, HRP was injected into the half side of sacral cord throughout S2 and S3. Most neurons labeled retrogradely were found in the locus coeruleus alpha and in the locus subcoeruleus ipsilaterally.
5. In the decerebrate cat with a closed urethra, microstimulation delivered to the above stated area resulted in an increase of intravesical pressure and in a decrease of sphincter discharge. Increasing the stimulus intensity resulted in a marked augmentation of the intravesical pressure with complete suppression of the sphincter discharge.
6. In the decerebrate cat with an open urethra, microstimulation delivered to the same area elicited actual micturition accompanied by postural changes which helped micturition. The elicited micturition and postural changes resembled those in natural micturition observed in the intact cat.View full abstractDownload PDF (4358K) -
Katsuo Iwata1984 Volume 75 Issue 5 Pages 836-846
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSUsing SDS-polyacrylamide gel electrophoresis, the contractile proteins of the upper urinary tract were estimated. Myosin, α-actinin and actin were identified in any region of the upper urinary tract including the upper renal pelvis, lower renal pelvis and ureter. The upper portion of the pelivis had significantly lower amounts mysion than the lower portion. The lower portion of the pelvis had lower amounts of myosin than the ureter. The ureter had the highest amount of myosin among the regions studied. The actin content of the upper pelvis was higher than that of the lower pelvis. The ureter had approximately the same amount of actin as the upper pelvis. These results suggest that each region of the upper urinary tract has the characteristic amounts of the contractile proteins.
The amounts of the contractile proteins in the dilated upper urinary tract were estimated, using experimentally induced hydroureteronephrosis of the rabbit. There was no significant difference between the contractile protein contents of the dilated pelvis and the normal pelvis. However, the amounts of the contractile proteins in the dilated ureters showed remarkable variations. A significant correlation was demonstrated between the degree of the ureteral dilatation (inner diameter) and the contractile protein contents (actin, myosin). In the moderately dilated ureters the contents of actin and myosin were higher than those of the normal control ureters. In the widely dilated ureters the myosin content decreased below the control value, whereas the actin content was approximately the same as the normal value.View full abstractDownload PDF (6401K) -
Tsunetada Yazaki, Shori Kanoh, Kenkichi Koiso, Tomokazu Umeyama, Shoji ...1984 Volume 75 Issue 5 Pages 847-852
Published: May 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESS233 urinary tract stones analyzed at the Tsukuba University Hospital during the past 77 months were investigated for the correlation of the weight with the composition and clinical aspects.
Weight of 210 stones, comprising 90.1% of all stones analyzed, was recorded at the time of infrared spectrometry. The average weight of 210 stones was 1905.9mg with the weight range from 1 to 51490mg. Most stones fell in the weight range from 10mg to 4999mg. However, some stones weighed more than 10000mg (5.6%).
Study of stone weight correlated with stone composition was as follows. Calcium oxalate stone was the lightest, with the average weight of 744mg. Calcium oxalate and calcium phosphate mixed stone was the second lightest (average weight 1043mg), magnesium ammonium phosphate stone the third (1208mg), calcium phosphate stone the fourth (2987mg) and uric acid stone the fifth (3649mg). The heaviest stone in this series was cystine stone (25149mg).
Calcium containing urinary stones fell in every weight range from 1mg to more than 10000mg. The pattern of weight distribution of uric acid stones was also similar to that of calcium containing urinary stone.
Of 53 stones passed spontaneously, 46 (86.8%) were recorded in weight range from 1mg to 1027mg. The average weight of these stones according to their component was analyzed. The lightest stone was a calcium oxalate stone (62.7mg). The second lightest stone was a uric acid (112.8mg), the third a calcium phosphate (114.5mg), the fourth a calcium oxalate and calcium phosphate mixed stone (161.1mg). The heaviest was a cystine stone (444mg). The average weights of these naturally passed stones were apparently lighter than the respective average weights of all stones of the same component.View full abstractDownload PDF (687K)
- |<
- <
- 1
- >
- >|