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Volume 64, Issue 7
Displaying 1-5 of 5 articles from this issue
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Ken-ichi Kano, Shotaro Sato1973 Volume 64 Issue 7 Pages 529-538
Published: July 20, 1973
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe fine structure of adrenal adenomata taken from seven patients with Cushing's syndrome was investigated by electron microscope, chiefly as to cellular organelles, nuclei and cell surface. The observational results are as follows:
1) The most prominent features were an increase of the mitochondria in number and a marked development of the agranular endoplasmic reticulum. The mitochondria of the adenomatous cells showed a wide variety of morphology in size, shape or arrangement of cristae and each case presented a characteristic figure. In some cases the morphology of mitochondria was peculiar or bizarre. Nevertheless, in every adenoma there found much or less such mitochondria that were reminiscent of those of the normal zona fasciculata. This observation suggested that these adenomata might be derived from the zona fasciculata. Electron-dense droplets were frequently contained in the matrix of the mitochondria.
2) The agranular endoplasmic reticulum developed well in all cases. Electron-dense cores or fine dotty granules in the agranular endoplasmic reticulum were observed in four cases where the reticulum was found to be tubular.
3) Degree of development of the Golgi complex and the granular endoplasmic reticulum was not uniform.
4) It was interesting to indicate that GERL of Novikoff and the fibrous structure in the cytoplasm were also observed each in a case. The latter was running parallel to or rarely, at right angles with the cell surface.
It seems that each of these findings might be indicative of a morphological expression of increased secretory activities.View full abstractDownload PDF (13373K) -
III. Prostatic Contraction and Fluid Excretion in Dog After Section or Stimulation of Various Nerves Innervating the ProstateMasayoshi Shima1973 Volume 64 Issue 7 Pages 539-554
Published: July 20, 1973
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSProstatic contraction and fluid excretion in the dog were recorded electrically after section or stimulation of various nerves innervating the prostate, using a newly developed apparatus. The results obtained were as follows:
1) The prostatic contraction could be classified into H-type and P-type from the pattern of contracting wave. The former was observed typically after the hypogastric nerve stimulation and followed by the prostatic fluid excretion, while the latter occurred typically after the pelvic nerve stimulation and resulted in no excretion.
2) The periodical contraction of both two types was noticed even in resting condition. The Htype contraction was associated with the fluid excretion with a mean rate of 0.3ml/hour.
3) The innervation showed no direct influence on the contraction and secretion in resting condition.
4) The H-type contraction was a severe tonic contraction towards one direction for the purpose of the fluid excretion. A close relationship was observed between the degree of the contraction and the fluid excretion rate. The pathway of nerves controlling this type of contraction was as follows: II-IV lumbar spinal cord→connected lumbar nerves→connected ganglions of sympathetic trunk→II-IV inferior splanchnic nerves→inferior measenteric plexus→hypogastric nerve.
5) The P-type contraction was a weak clonic contraction. Its effect should be something other than the fluid excretion. The pathway of nerves controlling this type of contraction was as follows: II-III sacral spinal cord→connected sacral nerves→pelvic nerve. On the other hand, it was assumed that lower lumbar spinal cord receives centripetal stimuli from the ventral rami of lower lumbar nerves and mediates it to the above mentioned pathway originated in sacral spinal cord.
6) It was supposed that pudendal nerve has no influence on the prostatic contraction and excretion.View full abstractDownload PDF (1968K) -
Experimental and Clinical ResultsGeorge Kallistratos, Yoshimasa Hayase1973 Volume 64 Issue 7 Pages 555-576
Published: July 20, 1973
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSLitholytic agents developed recently are able to dissolve a number of kidney stones. Two methods are developed for this purpose:
a) The retrograde irrigation of the kidney cavities with chelate solutions containing ethylenediamine-tetra-acetic acid (EDTA) which can be tolerated by the mucous membrane of the urinary tract, and b) The oral or intravenous administration of suitable drugs which inhibit the formation of a solid/liquid phase (crystallisation) or which are able to react with renal stones and form water soluble compounds.
Uric acid, l-cystine and also phosphate stones, can be dissolved by means of an oral treatment. The problem of the oral treatment of oxalate stones still remains undissolved. However, the “anti-salting out” principle is applied in order to reduce the frequency of recurrent calcium oxalate stone formation. In the present paper we are reporting some experimental investigations which have been undertaken in the department of Urology of the MINERVA Research Society, and in the Research Institute for Experimental Biology and Medicine, in order to develop a conservative treatment of urolithiasis. Some clinical results are also reported as well as X-ray illustrations of successfully treated cases.View full abstractDownload PDF (18588K) -
I. Clinical Observation and Treatment of Acute Uric Acid NephropathyIichiro Kondo, Hiroshi Shiozaki, Yoshiro Shioda1973 Volume 64 Issue 7 Pages 577-588
Published: July 20, 1973
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSRenal failure due to hyperuricemia has been known to develop not only as a result of gout but also during the course of therapy of leukemia and malignant lymphoma.
We have recently experienced the ocurrence of acute renal failure in our urological cases postoperatively and/or during radiation-therapy, the causes of which could be attributed to hyperuricemia.
Here we presented eight cases of “acute uric acid nephropathy” (4 cases of prostatic cancer, 3 cases of bladder cancer, and 1 case of ureteral stone).
Our observation and analysis of these cases yielded the following findings. (1) Increase of both serum and urinary uric acid was noted postoperatively and after initiation of radiation-therapy, along with progression of renal failure as represented by azotemia. (2) Administration of “allopurinol” (xanthine oxidase inhibitor) relieved the abnormal uric acid metabolism as well as renal failure. (3) Development of acute uric acid nephropathy in these cases is considered to be a result of accumulation of numerous predisposing factors to increase uric acid production, such as surgical intervention, irradiation, use of inosine, and presence of malignant tumors, under the circumstance enough to disturb uric acid excretion such as impaired renal function.
We thus emphasize the necessity of recognizing development of “acute uric acid nephropathy” whenever production of uric acid prevails under impaired renal function, and also clinical significance of the use of “allopurinol” for relief of this nephropathy.View full abstractDownload PDF (1170K) -
Mitsuo Ohkawa, Yoshinori Yamakawa, Kazuhiro Shirai, Kyoichi Kuroda1973 Volume 64 Issue 7 Pages 589-599
Published: July 20, 1973
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe megaureter-megacystis syndrome was first described by Williams in 1954 in relation to infants who had very large bladders and grossly dilated ureters with free reflux.
We have encountered 2 cases that fit the description of the megaureter-megacystis syndrome. Case 1 was a 6-year-old boy and case 2 was a 7-year-old boy. They visited our clinic with the same chief complaint of high fever. The urinary examinations revealed pyuria in both cases especially manifest in the second case, and they were admitted for treatments and further examinations.
In each case IVP and DIP findings showed dilated calyces, pelves and ureters, and cystogram demonstrated a large bladder, grossly bilateral dilated ureters with free vesicoureteral refluxes. Voiding cystourethrograms showed normal urethras and complete emptying of the bladders in two cases. By cysstoscopy it was found that the trigone was wide and trabeculation was not present in each case. Cystometric examinations found no definite abnormalities except the large capacities in both cases. (about 900ml in case 1, (450ml in case 2.) Their total renal functions were greatly decreased similarly in two cases.
We performed preliminary nephrostomies in both cases and then the antireflux operation using the Paquin procedure in case 1. We would treat radically after the improvement of the renal function in case 2.
Some discussions were made on the clinical entities of the megaureter-megacystis syndrome, the megacystis syndrome and primary reflux.View full abstractDownload PDF (6353K)
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