Studies were made on canine kidneys in which hyperparathyroidism was induced experimentally by means of administration of parathyroid extract. The histologic and histochemical findings were as follows:
1. In contrary with results in other reports, the histologic and histochemical changes were observed chiefly in the proximal convoluted tubules.
2. PAS-positive material in cytoplasm of the tubular epithelium and tubular lumen was also noted especially in the proximal convoluted tubules. This has been interpreted as increased deploy-merized mucopolysaccharide. This material seems to have an affinity to calcium, thus causing calcification to occur.
3. Several enzymatic activities, such as those of acid phosphatase, alkaline phosphatase, succinic dehydrogenase, lactic dehydrogenase and aminopeptidase were observed histochemically, and they were found to be decreased in the epithelium of proximal convoluted tubules.
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