In urological fields, it can be recognized that the studies on the male sexual organs and their accessory glands have not been so well done as those on the urinary organs, and it is no exaggeration to say that there are almost no fruitful studies on the intermediary metabolism.
In this treatise, therefore the author wants to make clear the relation of sex hormone with TCA cycle metabolism by an experimental and clinical study on the intermediary metabolism esp, TCA cycle, of the male reproductive organs and their accessory glands.
As for materials, prostates, prostatic secretion and testis from dogs and rabbits, seminal vesicles from rabbits, ademonatous and cancerous prostate, semen and testis from men, are exployed.
The results obtained are summarized as follows;
1) In all of the materials investigated, TCA cycle is considered to be operative.
2) In prostatic tissue, TCA cycle metabolism (respiration) is generally lower than glycolysis, and citric acid level is higher in rabbit and human prostate adenoma than in dog's prostate, and the accumulation of lactic acid and citric acid is evident in prostate adenoma. ATP is necessary for the dissimilation of the accumulated citric acid.
3) Citric acid level is lower in cancerous prostate than in prostate adenoma.
4) On the whole, prostatic secretion proves lower respiration than glycolysis. Dog's prostatic fluid contains very low level of citric acid, as compaired with that of rabbit. That may suggest that the citric acid in the prostatic secretion originates from the seminal vesicle.
5) Human semen is rich in citric acid, but the level of citric acid is low in the semen of oligospermia or azospermia.
6) In testis, the oxidative phase of carbohydrate metabolism is impaired, and the tendency of lactic acid accumulation is observed.
7) Androgen decreases the anaerobic phase of carbolhydrate metabolism of the dog's prostate and increases the oxidative phase of that metabolism.
8) Lactic acid metabolism is disturbed, and TCA cycle metabolism is decreased and also ATP system is impaired after castration or after injection of stilbesterol. But estrogen, when injected into castrated dog, activated the enzymes belonging to the TCA cycle. Lactic acid accumulation takes place when estrogen is injected into the castrated dog, and ATP is necessary to dissimilate the lactate.
9) Androgen also decreses the glycolysis of dog's testis and promotes the transformation of pyruvic acid into TCA cycle.
10) In dog's testis, when injected estrogen, the anaerobic glycolysis is decresed and the metabolism of α-Ketoglutaric acid is impaired, and ATP is required for the dissimilation of accumulated α-ketoglutaric acid.
11) Fumaric acid tends to accumulate in dog as well as human testis.

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Durch die histologischen Untersuchungen von 10 Fällen der renalen Hämaturie, deren Ursache mit Methoden moderner Nierendiagnostik nicht eindeutig zu klären war, bin ich zu den folgenden Schlüssen gekommen.
1) Der histologische Nierenbefund von 10 Fällen sind verschieden, aber dabei spielt die Entzündungsveränderung die Hauptrolle.
2) Es gibt immer die Entzündungsvorgänge in ihrem Nierenbeckenkelchsystem.
3) Diese 10 Fälle verteilen sich auf 2 erythrozytäre Katarrhe, 2 follikuläre Pyelitis, 1 einfache Pyelitis, 3 allergie-ähnliche Veränderungen im Beckenkelchsystem und 2 Entzündungsveränderungen des Nierenparenchyms, die gleichfalls die Pyelitis haben.
4) Es soll gar nicht bezweifelt werden, dass in einem grossen Teil aller Fälle von essentieller Hämaturie die Blutung aus dem Nierenbeckenkelchsystem kommt und auf einer Entzündung des Nierenbeckens beruht.
5) Ich fand die Entzündungsveränderung des Beckenkelchsystems in manchen Fällen von den renalen Hämaturien, die als “essentielle Nierenblutung” bezeichnet werden, da sie keine Pyurie, keinen Fieber, den geringen Druckschmerz der Nierengegend, und nur die reine Hämaturie haben.
6) So möchte ich betonen, dass man bei der Diagnostik von der unklaren Nierenblutung sorgfältig sein und sie mit konservativen Methoden zum rückfallfreien Stillstand kräftig und behaarlich behandeln muss.
7) Die Ursache der unklaren Nierenblutung muss man in einzelnen untersuchen, und nicht alle, früher als “essentielle” bezeichneten Nierenblutungen lassen sich zwanglos mit dem Monismus erklären.
8) Der Ausdruck “essentielle Nierenblutung” ist emn klinischer und kein pathologisch-anatomischer Begriff, so bin ich der Meinung, dass es Fälle von Nierenblutung gibt, die klinisch keine sichere Klärung finden.

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The authors of the present report have recently diagnosed two interesting cases of seminal vesicle cyst. In each case, the existence of the cyst was ascertained by the use of seminal vesiculography, and later, was confirmed by surgical operation.
The case (1) was a male, aged 38 and having one child. He came in with the complaint in dysuria. His vesiculogram revealed the finding of the left seminal vesicle cyst. The lesion was cured by suprapubic seminal vesiculectomy.
The case (2) was a male, aged 20 and unmarried. He visited us with the complaint in hemospermia. His vesiculogram revealed the finding of the bilateral seminal vesicle cysts, and moreover, his pyelogram revealed that he was of polycystic kidney. By suprapubic removal of the worst affected ampulla on the left side, his hemospermia was remarkably improved.
Such a case of the bilateral seminal vesicle cysts accompaning polycystic kidney is quite a rare one, the like of which has never been reported in past literature.

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