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Volume 73, Issue 2
Displaying 1-11 of 11 articles from this issue
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I. Studies of Early Androgenized Male RatTaketoshi Saka, Yoshiaki Kumamoto1982 Volume 73 Issue 2 Pages 121-133
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSIt was well known that testosterone propionate-treated neonatal female rats showed persistent oesterous condition after their puberty, due to the masculinization of the sexual center and the loss of the regularity. However, few examination have been done on the male rats treated in the same way.
In our experiment, the male rats were injected subcutaneouslyy with 0.5mg testosterone propionate once at 2 days of age and 1mg for 3 days. We examined its effect on the sexual center according to the finding of the germinal epithelium and the change of the accessory sexual organ weight.
In normal male rats the secretion of gonadotropin has been reported to start with pubescent growth of the sexual center. It takes 40 days to nearly complete the growth of the accessory sexual organ and the spermatogenesis.
Nevertheless, in the group androgen-treated immediately after birth, the remarkable delay of the pubescent growth was recognized in both accessory sexual organ and the spermatogenesis at 40 days of age. But at 60 days the pubescent delay of the accessory sexual organ growth overtook the normal maturation level and the spermatogenesis almost came to maturity.
From these findings, we assumed that the administration of testosterone propionate in high doses in the critical period of the sexual center differentiation in the hypothalamus induced some suppressive changes in the sexual center and a delay of pubescent growth occurred. But the suppressive change of the sexual center overtook the normal growth about 40 days later than the time the normal puberty started.
From these results, we may conclude that the administration of androgen in high doses to neonatal male rats causes “Experimental Retarded Puberty”.View full abstractDownload PDF (7938K) -
II. Studies of Early Androgenized Male RatTaketoshi Saka, Yoshiaki Kumamoto1982 Volume 73 Issue 2 Pages 134-142
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSImmediately after birth, the sexual behavioral center was still undifferentiated, and had a possibility of differentiation into the behavioral pattern of either sex. The determination of the sexual behavior was dependent upon the sexual hormone enviroment in the blood during the critical period.
In the previous report, we discussed the growth delay of the testicle and accessory sexual organs in male rats, due to the suppression of gonadotropin secretion in the hypothalamus, after the treatment of testosterone propionate in high doses in the critical period.
The present study was undertaken to see if the early androgenization acted to the sexual behavior in the rats after their maturity under the same condition of the previous report: we observed the male sexual behavior (Exp. A1, A2) and female sexual behavior (Exp. B2) after we removed the testicle from the rat and administered estradiol benzoate and progesterone. Then, we examined the effect of the early androgenization on the sexual behavioral center, with the respect to the ratio of both male and female sexual behaviors. In spite of the normal endocrine enviroment, the suppression of the male sexual behavior was recognized in the group of early androgenized male rats after their maturity. On the contrary, the feminine sexual behavior was recognized frequently.
From these results, we assumed that the treatment in high doses of testosterone propionate in the critical period affected strongly not only the gonadotropin secretion center but the sexual center directly, finally it made the masculinization of the sexual center imperfect.View full abstractDownload PDF (1143K) -
(3) Basic Studies of Transplantable Human Prostatic Carcinoma in Nude Mice and Susceptibility Testing of Several Platinum CompoundsMasao Akimoto, Narumi Tsuboi, Naoki Kawamura, Hitoshi Nakajima, Yasuo ...1982 Volume 73 Issue 2 Pages 143-154
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSBasic studies and susceptibility testing of platina compounds was performed on a strain of human prostate cancer implanted into a nude mouse (Pro-1). The following results were obtained:
1) Subimplantation of the strain was successful in almost 100%, almost all are viable and no change was seen in the state of proliferation.
2) No hormone receptor of this strain was present, its susceptibility to estrogen is low and it was considered to have little hormone dependence.
3) The platina compound was directly administered into the abdominal cavities. There was no difference of susceptibility of platina compounds on the tumor proliferation curve noted between day 1 or next day after implantation, day 5 and day 9 on one hand and day 8, day 12 and day 16 in which new blood vessels developed on the other hand.
4) It was noted that repeated subimplantation did not change the susceptibility to anti-cancer drugs. We performed the susceptibility testing 1) based on the tumor proliferation curve, and 2) from the pathohistological appearance. Our conclusions are:
1) CDDP was effective in three doses, 5mg/kg, 2.5mg/kg and 1.25mg/kg.
2) 1-GHP was effective at 25mg/kg and 12.5mg/kg.
3) d-GHP was effective at 50mg/kg and 25mg/kg.
4) There was no effect seen with DBCP.
5) 1-OHP was effective only at 20mg/kg.
Regarding a safe therapeutic range, you can see that CDDP was safest and most effective, followed by d-GHP and 1-GHP. There was a close relationship noted between the pathohistological changes and the tumor proliferation curve.View full abstractDownload PDF (7023K) -
Iwao Fukui1982 Volume 73 Issue 2 Pages 155-168
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSNon-papillary carcinoma in situ and its borderline lesions of the urinary bladder were histologically defined and the clinical features of twenty five patients including 6 with carcinoma in situ, 3 with severe epithelial atypia and 16 with microinvasive cancer were presented.
The incidence of patients with these early lesions in all bladder tumor patients in this clinic was approxymately six per cent. Clinical symptoms and endoscopic findings mimicked those of acute or chronic cystitis and they were not suggestive of these early lesions. Urinary cytology showed characteristic appearance, sparse exfoliation of malignant cells, and seemed to be most useful clinical tool for the diagnosis. All 19 patients who received this examination showed positive results. In addition, urinary cytology was also useful for the assessment of response in patients who were given conservative treatments such as irradiation or intravesical chemotherapy and for the detection of subsequent recurrence or malignant progression.
For the, accurate histologic diagnosis multiple mucosal biopsies with methylene blue vital staining test was recommended. Four of 5 patients with carcinoma in situ and two of 3 with severe epithelial atypia who received conservative procedures developed microinvasive cancer within 6 to 72 months (mean: 30.5) following the diagnosis. Patients with microinvasive cancer who received surgical treatments, especially conservative methods, showed disastrous results, probably due to the high incidence of submucosal lymphatic permeation. It was, therefore, considered that microinvasive cancer should be histologically differentiated from carcinoma in situ or severe epithelial atypia and should be treated as a deeply invasive cancer, although it is classified into socalled superficial bladder cancer and shows almost similar clinical features as carcinoma in situ or severe epithelial atypia.View full abstractDownload PDF (10199K) -
Report 7. Administration of HMG and HCG for Bilateral CryptorchidismAkihiko Okuyama, Takuo Koide, Takao Sonoda, Hiroshi Ito, Toshiaki Yosh ...1982 Volume 73 Issue 2 Pages 169-176
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESS1. Human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) were administered intramuscularly with each dose of 150IU and 1, 000IU weekly for bilateral cryptorchid patients (n=16), whose testes were already surgically fixed in early childhood, from early pubertal stage (P2.3) to after puberty for the purpose of recovery of fertility. As the control, non-treated bilatelal cryptorchid cases (n=10), normal early pubertal boys (n=10) and normal adult males (n=11) were selected.
2. First LH-RH and HCG tests were performed in cases before treatment, non treated (bilateral cryptorchid) cases and normal early pubertal boys and second LH-RH and HCG tests were performed after puberty in each three groups. After the second tests, in treated and non-treated cases, examinations of sperm and testicular biopsies (Johnsen's score count was used) were performed.
3. In the first tests, serum basal levels of FSH and peak levels of LH and FSH to LH-RH were significantly higher in both treated and non-treated cases than normal early pubertal boys.
4. In the second tests, serum basal levels of LH and FSH and peak levels to LH-RH were significantly higher and serum basal levels of testosterone and response to HCG were significantly lower in non-treated cases than those of normal adult males, and serum basal levels of LH and FSH and peak levels to LH-RH were significantly higher and response to HCG were significantly lower in non-treated cases than those of treated cases.
5. Score counts in treated cases were significantly higher than those of non-treated cases and eleven cases (69%) of treated cases showed counts from 8.0 to 9.5, meanwhile five cases (50%) of treated cases showed counts below 6.0.
6. For the density of sperm, nine (56%) of treated cases showed oligozoospermia (2-24×106/ml) and the rest of the cases azoospermia, meanwhile two (20%) of non-treated cases showed oligozoospermia (1-5×106/ml) and the rest of the cases azoospermia.View full abstractDownload PDF (942K) -
CLINICAL REPORT AND ANALYSIS ON DIAGNOSIS AND TREATMENTHideo Hidai, Yuzo Kinoshita, Tetsuo Murayama, Keikoku Miyai, Junichi K ...1982 Volume 73 Issue 2 Pages 177-188
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSHerein are reported on 12 cases of renal artery aneurysm experienced at the Yokohama City University Hospital together with clinical analysis on 153 cases of renal artery aneurysm compiled from Japanese medical literatures.
Surgical methods we have employed were nephrectomy in 3 cases, ex vivo aneurysmectomy and autotransplantation in 3 cases and in situ aneurysmectomy in 1 case.
Three cases of ruptured aneurysm and 1 case of impending rupture were salvaged.
Surgery on renal artery aneurysm is indicated when the aneurysm is more than 10mm in diameter and is not calcified or incompletely calcified and when hypertension, functional disturbance or pain is attributable to that lesion.
Aneurysmectomy in ex vivo setting is recommended as the method of choice if in situ surgery can not warrant success because of technical problem and/or ischemic damage.View full abstractDownload PDF (8403K) -
Teruaki Akaeda1982 Volume 73 Issue 2 Pages 189-205
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSPsychiatric, neurological, and endocrinological studies on impotence in 61 patients who had been treated by chronic dialysis were carried out, and Testosterone (T) substitution therapy was performed, obtaining the following results concerning hormonal movement and therapeutic efficacy.
1) According to the questionnaires on the effects of chronic dialysis on impotence, sexual desire, erection, and ejaculation were all reduced as compared to normal in many patients after the institution of dialysis, suggesting a close relationship between chronic dialysis and impotence.
2) In MAS, the patients showed an anxiety tendency which, however, was not ralated to impotence. In Y-G tests, the majority or 81% of the patients were classified into A, B and D types (extroversive and positive).
3) Bulbocavernosus reflex disappeared in 4 patients and anal reflex in 7, but there was no relationship between these findings and impotence.
4) Plasma LH, FSH, PRL, T, DHEA and DHEA-S were measured as endocrine function test, showing a rise in LH and PRL and a fall in T. In luteinizing hormone releasing hormone tolerance tests, both LH and FSH showed various degrees of response from none to excessive response with delayed fall.
5) PRL showed high values in the group of reduced sexual potency. T showed lowered basic values and reduction in response in HCG tolerance tests in the group of reduced sexual desire.
6) T substitution therapy with testosterone cypionate was carried out to study its effects on hormonal values and impotence. LH and FSH were controlled well from the early stage of treatment, suggesting the participation of negative feedback. Impotence was improved in 13 of 14 patients (93%), suggesting that low T values played an important role in the onset of impotence in the patients treated by chronic dialysis.View full abstractDownload PDF (2155K) -
Haruo Ito, Hideo Minagawa, Hideki Fuse, Kenji Kawamura, Hitoshi Naito, ...1982 Volume 73 Issue 2 Pages 206-210
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSA case of immotile-cilia syndrome was presented. Thirty-one-year-old man with the chief complaint of infertility had suffered from respiratory tract infection since early childhood.
A review of the family tree reveals no chronic respiratory tract infection or infertility. Physical examination was negative except for dextrocardia. Gonadotropins and androgen were within normal range.
Semen analysis was as follows; volume 3.6ml, count 92×106/ml, motility 0%, live spermatozoa 70%, abnormal spermatozoa 8%.
Absent or lowered function of nasal cilia was demonstrated by charcoal powder method.
By electron microscopic observation microtubules and spoke of sperm flagella were normal. However, outer dynein arms were not found and inner dynein arms were partially missing. In the ciliary structure of nasal epithelium of the patient, outer dynein arms were almost normal, but inner dynein arms were partially lacking.View full abstractDownload PDF (3771K) -
Nobutaka Ohta, Masahiro Hata, Kazuo Suzuki, Atsushi Tajima, Yoshio Aso1982 Volume 73 Issue 2 Pages 211-215
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe estimation of various urinary excretes has been reported valuable in the diagnosis of acute rejection of renal transplantation. They include protein, Na/K ratio, the WBC count, γ-GTP, LAP, and β2-microglobulin. This paper reports the significance of urinary ionized calcium as the diagnostic tool of acute rejection among various urinary parameters in a 19 year-old female undergoing renal transplantation. In this case, the change of urinary protein, β2-microglobulin and LAP appeared later than clinical diagnosis of acute rejection. On the other hand, urinary ionized calcium was changed simultaneously with urinary Na/K ratio and γ-GTP at the onset of acute rejection. The decrease of urinary ionized calcium was more prominent than that of urinary Na/K ratio.
The estimation of urinary ionized calcium can be easily performed at the bedside by the Orion calcium analyser. It was valuable in the early diagnosis of acute rejection in our case.
Decreased urinary ionized calcium is assumed to reflect lowered RBF, GFR and tubular function of grafted kidney suffering acute rejection.View full abstractDownload PDF (464K) -
Tetsuo Yamada, Hirokazu Taguchi, Kazumasa Usuda1982 Volume 73 Issue 2 Pages 216-220
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSA 58-year-old male was admitted with chief complain of pain on erection and curvature of penis. He had noticed the sign about 3 years ago and been treated for about a year conservatively. But the thickness gradually increased and he was unable to have sexual intercourse. Physical examination showed also thickening of the bilateral forearm. The induration of the penis which occupied almost all the dorsal area measured about 7cm×3cm. Except the glans penis and corpus cavernosum urethrae, thick corpora cavernosum and tunica albuginea were excised. The pathological change of blood vessels in the penis and skin were similar to that in collagen disease. Therefore, the etiology of our case was suggested to be a collagen disease.View full abstractDownload PDF (3867K) -
REPORT OF A CASEYutaka Uchijima, Yasuhiko Nakame, Seigo Hiraga, Koichi Okada, Motoharu ...1982 Volume 73 Issue 2 Pages 221-230
Published: 1982
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSExtraosseous osteogenic sarcomas in the kidney are extremely rare. Haining and Poole (1936) reported a case of osteogenic sarcoma of the left kidney. Subsequently there have been only 8 cases of primary osteogenic sarcoma of the kidney reported. One case which represented the 10th. is reported.
(Case) A 56-year-old woman was admitted to our urological clinic on September 16, 1976. The patient had a 2-month history of a left flank pain. Physical examination revealed a large mass in the left upper quadrant. This mass did not seem to be attached to the posterior wall of the abdomen. KUB revealed a localized parenchymal calcification in the left kidney. IVP revealed a defect of the calyceal system in the upper pole and some distortion of the calyceal system in the lower pole of the left kidney. Selective left renal arteriogram revealed a highly calcificated upper pole mass which was avascular. The patient was operated on October 21, 1976. The tumor was not attached to the spine or retroperitoneal muscles. The specimen was a very large, hard mass of tissue which measured 16 by 8 by 7cm. Histological evalution revealed spindle shaped cells which showed extreme variation in nuclear size and shape with osteoid formation consistent with osteogenic sarcoma. No abnormality in bone survey was found. The patient, however died in acute heart failure on 36 days after the operation.
In this report primary sarcoma and primary osteogenic sarcoma of the kidney was reviewed briefly.View full abstractDownload PDF (11207K)
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