This report is based on the results of radiological studies on renal hemodynamics for experimental hypertension in thirty dogs which moderate sustained hypertension was produced by unilateral stenosis of renal artery without removal of the opposite kidney.
The dogs were divided into three groups depending on the period of hypertension following construction of unilateral renal artery; the first stage, until the 10th day after constriction; the second, from 11th day to one month; and the third, from one month six-th month.
Intravenous pyelography, transfemoral retrograde aortography, renal vein catheterization, indian ink injection into the abdominal aorta, and microscopic examination of the kidney were examined.
Conclusions are as follows:
1. Intravenous pyelography showed a hyperconcentration of the contrast media on the constricted side of all dogs in hypertensive groups. The grade of hyperconcentration of the contract media was affected by the difference of urine volume which was depending upon glomerulo-tubular balance.
2. Aortograms in the first stage showed that stenotic figures were illustrated at the same area which the vessels had been constricted, and intrarenal arteries were constricted and circulations through the kidney were severely impaired.
3. Aortogram in the second stage showed that almost were normal but some of them made a poststenotic dilatation.
4. Aortgrams of the third stage showed the a marked reduction of the renal mass on the constricted side comparing with the opposite one that involved in compensative hypertrophy. Collateral circulation on the constricted side was formed in two cases.
These experimental results were applied to the diagnosis of the unilateral renal hypertension by which the disease will be diagnosed and treated more correctly.

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The respiration and glycolysis of vesicle tumors were calculated, comparing with histological findings, of 42 cases out of 68 who has visited the clinic of urology, school of medicine, Chiba Univ. from September 1961 to February 1964.
According to the classification of Dean et al. (1954), the author dicided the tumors into three types; papillom I (beningnancy), papillom II (Suspected malignancy) and carcinoma (undoubted malignancy).
The result of measurement is as follows: Warburg quotient (the ratio of aerobic glycolysis and repiration) indicated remarkable difference between papillom I and malignant tumor, while papilloma II did not necessarily reflect histological findings, showing considerable variation of values according to the portion measured.
Some tumors in papilloma II with marked intraepithelial and multiple growth revealed high anerobic glycolysis and active respiration.
Highly proliferating multiple papillomatons cancer showed also high anerobic and aerobic glycolysis.
Prolongation of measuring time brought about wider difference of Warburg quotient between benign malignant tumors.
In other words, the value indicated, in malignant tumors, less decrease in the course of time.

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(1) Both ACTH and Metopirone tests were performed on twelve patients with prostatic carcinoma before and after several kinds of endocrinologic treatments, in order to investigate the changes in pituitary-adrenal functions. Urinary 17-OHCS (Porter-Silber chromogens) was measured in succession before and after ACTH and Metropirone administrations. The treatments consisted of castration, estrogen administration and pituitary irradiation.
(2) Pre-treatment levels of urinary 17-OHCS in the patients of postatic carcinoma did not differ from those of controls of same age. And there was no abnormality in the results of ACTH and Metpirone test before any treatments.
(3) Ten to twelve days after castration, urinary 17-OHCS levels showed a slight, but insignificant elevation. The results of ACTH and Metopirone tests showed no significant difference from the pre-treatment values.
(4) Estrogen administration resulted in reduction of urinary 17-OHCS, which was restored to the pre-treatment levels as soon as estrogens were withdrawn. A marked reduction in pituitary ACTH reserve was observed during estrogen administration, while the results of ACTH tests did not show any changes. Though the changes of Metopirone tests were marked during estrogen therapy, they returned soon to the pre-treatment values with the withdrawal of estrogen, even if after administration of a longer period.
(5) After pituitary irradiation of 4, 000 to 7, 500r (surface doses) the urinary 17-OHCS levels remained within the control values. The results of ACTH and Metpirone tests showed on abnormality following irradiation of 4, 000 to 6, 000r, but a patient who had received 7, 500r irradiation showed a moderate reduction of pituitary ACTH reserve.
(6) Reduction in pituitary ACTH reserve during estrogen administration indicated the possibility that estrogen administration might suppress the pituitary function as inhibiting ACTH secretion in some degree, because the results of ACTH tests showed no changes. It is suggested that the effectiveness of estrogens on postatic carcinoma might be explained not only by antagonistic action against androgens and suppressive action of gonadotropin secretion, but also by suppression of adrenal androgen-secretion due to ACTH inhibition. Estrogen administration should be continued as long as hormone dependency of the carcinoma was maintained. It was also verified that estrogen administration did not supperess adrenal function.
(7) In cases of pituitary irradiation no replacement of corticoides was required provided that the doses remained within 6, 000r. In cases of irradiation more than 7, 500r, replacement therapy of corticosteroids should be instituted of Metopirone test, which was one of reasonable indicators of the pituitary functions, showed a reduction of pituitary ACTH reserve.

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1) Purpose of investigation
It is well-known that impotence is frequently seen in male diabetics. However, only a few reports, for example by Rubin and Babbott, and Schoffling, have concerned with its frequency and the literature on its etiology reveals considerable disagreement. Miller and Mason, Horstmann Bergqvist and Schoffling considered endocrinologic factors to be of importance, while other investigators regarded them as a symptom of diabetic meuropathy. The purpose of this investigation is to study on the frequency and eteology of impotence in male diabetics and its treatment.
2) Methods of investigation
a) Postal inquies were made in 34 male diabetics and 260 male nondiabetic physicians belonging to the association of medical doctors of the prefecture and their sexual function was compared.
b) Mainly endocrinologic and neurologic investigations were carried out in 29 cases of male diabetics ranging from 45 to 79 years of age who were treated at the Department of Urology. Kumamoto University Hospital. The results were compared between the patients with and those without impotence.
3) Results
a) Impotence was found in 8 out of 34 diabetics (26.7%), while it was in 18 out of 260 nondiabetic physicians (6.9%). The onset of impotence was about 10 years earlier in diabetics than in non-diabetic physicians.
b) In general, diabetics with impotence were more aged and have suffered from a longer course of diabetes than those uncomplicated by impotence.
c) The main cause of impotence in diabetes was an inability to erect. In most cases sexual desire lasted for some time while erection was not possible.
d) Patients with impotence generally showed impaired glucose tolerance, while fasting blood glucose levels were not always high.
e) There was no significant difference in 17-KS levels between diabetics and non-diabetics, and between diabetics with impotence and those without impotence. Fraction IV and V showed a tendency to decrease in diabetics with impotence.
f) Histologic examination of the testicle in diabetics revealed hypospermatogenesis and thickning of the basal membrane of tubuli seminiferi, irrespective of the complication of impotence.
g) The association of diabetic neuropathies was seen in 16 out of 17 diabetics with impotence (94.4%), and in 1 out of 7 diabetics without impotence (14.3%). Micturitional difficulties were seen in 7 out of 22 diabetics with impotence (31.8%), but not in the case without impotence.
h) All of 21 diabetics with impotence showed abnormal cystometrogams, for example increased capacity and pressure (type I) in 6 cases (28.6%), lightly hypotonic type (type II) in 9 (42.9%), typical hypotonic type (type III) in 2 (9.5%), and hypertonic type (type IV) in 4 (19.0%). One diabetic without impotence out of (14.3%) showed type VI cystometrogram.
i) Erection was restored in 6 of 12 treated cases. Those with type IV cytstometrograms responded best to treatment. The therapeutic effectiveness appeared in accordance with the changes in the cystometrogram. The most effective agent was vitamin B₁ preparation in high dosage, erection being restored in 5 out of 7 cases who had received this treatment. It may be stated that the shorter the duration of inability to erect, the more favorable is the response to treatment. The effectiveness was not influenced by the duration of diabetes.
4) Comment
It is concluded, based on the above-stated results, that the main cause of impotence in male diabetics is one of the diabetic neuropathies resulted from the disturbance of autonomic and somatic nerves responsible for a reflex are between the center of erection and the penis. The endocrinologic disturbances due to abnormal metabolism may be a secondary factor.

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Cancer in the genitourinary tract is the increasing problem. The lymphatic system, which plays an important role in metastasis is still obscure and vast field is left for investigation.
This paper presents animal and clinical study of the lymphatic flow, utilizing radioactive colloidal gold ¹⁹⁸Au.
(1) Animal study; after subcutaneous injection of ¹⁹⁸Au on the dorsal part of dog's foot, uptake of radioactivity of various organs was investigated by scientillation counter, rate meter, well counter etc.
Thoracic duct canulation was performed and the uptake correlation between thoracic duct lymph and peripheral lymph node was investigated, using accelerationg and delaying factors as well as obsering the effect of anethesia and death.
(2) Clinical study; 104 cases (normal 85/abnormal 19) were investigated for femo-inguinal and iliacal nodes uptake after injection of ¹⁹⁸Au to dorsal part of feet.
a) 6 hours after injection, all of them (104/104) had some uptake, proved by scintillation counter.
b) 1 hour after injection, only 2 out of 57 without accelerating factors, 19 out 19 with them in normal legs, compared to 0 out of 4 without them, 3 uou of 3 with them in edema legs had uptake
3) Urological study (comparison of lymphangiography and 198An lymphscanning) 38 urological and gynecological patients were investigated.
Abnormal scintiscanning found in 2/3 in kidney and adrenal tumor, 1/1 in giant tumor in the pelvis, 4/4 in penis and genital tumor, 1/7 in bladder tumor and 1/13 in uterus carcinoma.
Though my study is still limited, I feel that ¹⁹⁸Au is useful for investigation of lymphatic flow and its clinical urological study can be applied to broad field.

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We were investigated clinical and experimental use of t-AMCHA which was synthesized as a new more potent inhibitor of fibrinolysis than EACA.
1. On the treatment for the diseases caused fibrinolysis or with fibrinolysis, t-AMCHA was effective, as if to be observed on the so-called idiopathic renal bleeding.
2. On a prophylactic for the side effect of the injection of streptomycin to a fifth cerebral nerve and a favorable turn of the irritation symptome of the urinary bladder by pouring into the urinary bladder on the cystitis, t-AMCHA had more week effect than EACA and mixed-AMCHA.
3. The inhibitory effect of t-AMCHA to fibrinolysis of urine (human and rabbit) was more potent than EACA.
4. The inhibitory effect of t-AMCHA to fibrinolysis of trypsin was also more potent than EACA.
5. On the inhibitory effect of capillary osmotic substances, the different substances had most potent inhibitory effect severally, namely, t-AMCHA had that to leucotaxin-like substance, mixed-AMCHA had to bradykinin (Sandoz), and EACA had that to serotonin.
But this studies would more to be investigated.

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