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Volume 75, Issue 6
Displaying 1-13 of 13 articles from this issue
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Tsuguo Yagishita1984 Volume 75 Issue 6 Pages 893-902
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSIn order to study the correlation between the biochemical and histological changes in the carcinogenic process, especially in a precancerous stage, seven-week old male Donryu rats were daily given tap water containing 0.05% N-butyl-N-butanol (4) nitrosamine (BBN) ad libitum and they were killed 1, 2, 3, 4, 5, 10, 15 or 20 weeks after the start of administration to examine glycolysis and histological changes of the vesical tissue.
The results were as follows:
1) Although there was no obvious histological change at 5 weeks after BBN administration, the hyperplasia of the vesical tissue became obvious at 10 weeks and the tumorigenesis was apparent after 15 weeks in every case.
2) Glycolytic activity of the vesical tissue slices were measured by 14CO2 production from (1-14C) glucose and (6-14C) glucose.
Under aerobic conditions, both 14CO2 productions from (1-14C) glucose and (6-14C) glucose increased with the duration of BBN administration.
14CO2 ratio values decreased, indicating that the Embden-Meyerhof pathway became dominant in BBN groups. The anaerobic production of 14CO2 which was derived almost exclusively from (1-14C) glucose, increased in BBN groups with formation of tumor. These findings strongly support the contention that, in tumor cells, the hexose monophosphate pathway is operating actively even under anaerobic conditions.
3) The activities of glucose-6-phosphate dehydrogenase (G6-PDH) and 6-phosphogluconate dehydrogenase (6-PGDH), the key enzymes of the hexose monophosphate pathway, were measured in cell free extracts from the vesical tissue. The acivity of G6-PDH was twice higher than that of control as early as 3 weeks and the activity of 6-PGDH was twice higher than that of control 5 weeks after the start of administration.
This results might suggest that the G6-PDH plays an important role in the elucidation of carcinogenic process and will be a good marker for early diagnosis of a tumor.View full abstractDownload PDF (3061K) -
3. Single-Agent Therapy with FT-207 or VinblastineYoshiaki Satomi, Yutaka Senga, Momokuni Fukuda, Mitsuru Nakahashi, Hir ...1984 Volume 75 Issue 6 Pages 903-908
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe present study (the 3rd report) was undertaken to assess the efficacy of single agent chemotherapy with Ft-207 or vinblastine for advanced renal cell carcinoma.
1) Thirteen patients with renal cell carcinoma (stage IV) recieved Ft-207. One patient showed a complete response (8%); 5 patients showed no change and 7 patients had progressive disease. There were no serious side effects.
2) Vinblastine was admimistered i. v. at a dose of 0.1mg/kg-0.2mg/kg weekly to 11 patients. In no patients was the therapy enough to lead complete or partial response of metastases, despite that in some reports vinblastine was described to be effective to renal cell carcinoma.
3) It is concluded that single agent therapy with Ft-207 or vinblastine to renal cell carcinoma is not effective.View full abstractDownload PDF (1712K) -
4. InterferonYoshiaki Satomi, Yutaka Senga, Momokuni Fukuda, Tsuneo Kawai1984 Volume 75 Issue 6 Pages 909-916
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe present study (the fourth report) was undertaken to assess the efficacy of human lymphoblastoid interferon (α) (HLBI) on advanced renal cell carcinoma.
1) HLBI was administered i. m. at a dose of 6×106 units/day to 19 patients. We assessed the efficacy in the 14 patients who had received HLBI for more than 60 days. Two patients (14%) showed partial responses; 3 patients (21%) minor responses, 4 patients (29%) no change and 5 patients (36%) progressive disease. We concluded that interferon was worthy of use in the treatment of advanced renal cell carcinoma as a initial choice.
2) The evaluation of tumor response in renal cell carcinoma was performed in patients to whom HLBI were administered for more than 60 days because tumor responses were usually observed within 20 to 60 days of treatment.
3) Tumor responses were observed more frequently in patients with low grade carcinoma (4/7) than in high grade (1/7).
4) The severest side effects were general fatigue (asthenia) and anorexia, which were often the main cause of discontinuation of the drug.View full abstractDownload PDF (4750K) -
FINE NEEDLE ASPIRATION BIOPSY OF METASTATIC LESIONS AND REGIONAL LYMPH-NODES IN GENITOURINARY CANCERTomoaki Fujioka, Nobuhisa Ishii, Masaaki Shindo, Ko Majima, Hiroyuki K ...1984 Volume 75 Issue 6 Pages 917-926
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSFine needle aspiration biopsy is commonly used for renal cyst and prostatic disease.
We have performed percutaneous fine needle aspiration biopsy of superficial palpable masses, intrathoracic or intrapelvic lesion and retropertioneal lymphnodes for either diagnosis of the tumor or detection of the metastasis in 28 urogenital cancer patients. To the superficial lesions, a regular 20cc plastic syringe with a 21 G needle was directed into the mass to get inside materials. To deep lesions, a 21 or 23 G PTC needle with one handle grip was led to the target to be punctured, which was demonstrated by X-ray examinations such as chest X-ray, urography and lymphography. In 12 cases of the superficial biopsy, the cytology of aspirated specimens showed tumor cells. Two cases of malignant lymphoma were diagnosed by the aspiration biopsy of intrathoracic lesion or intrapelvic tumor. Out of 14 deep lymphnode biopsies, it was possible to perform cytological examination in 11 patients. The cytology was the same as that of the surgical specimens aspitated in 10 out of the 11 cases. Therefore, false negative was 9.1% and no false positive was experienced. The preoperative stage was not different from the postoperative stage in 64.8% of the total 14 cases and in 81.8% of the 11 aspiration cases.
In experience, fine needle percutaneous aspiration biopsy can take the replace of open surgical biopsy in cases of superficial lesions and deep large tumors. Fine needle aspiration of deep lymphnodes has satisfactory accuracy in diagnosing metastasis, and can provide a diagnosis for treatment planning procedure. But it is uncertain that aspiration biopsy has ability to supersede the staging lymphadenctomy, considering unsatisfactory material, false negative and the need of lymphography.View full abstractDownload PDF (10598K) -
Teruhiro Nakada1984 Volume 75 Issue 6 Pages 927-933
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSStroke-prone and -resistant spontaneously hypertensive rats were treated with pepstatin or clonidine from 6 weeks of age to 8 weeks of age. Fiborus protein of testes or in vivo incorpotation of 3H-lysine into the protein fractions was determined in each rat strain on the final day.
Significant differences were noted between hypertensive rats and normotensive Wistar Kyoto rats, the former rats having greater incorporation rates of 3H-lysine into non-collagenous protein in testicular or mesenteric artery than the normotensive rats. Administration of clonidine decreased the incorporation of 3H-lysine into non-collagenous protein or collagen in the testicular artery concomitantly with the reduction of blood pressure in each rat strain. Pepstatin failed to reduce the incorporation of 3H-lysine into these protein fractions in any vessels examined, and it also failed to alter the blood pressure in hypertensive rats. The amonut of collagen or elastin in testes of hypertensive rats was greater than that of normotensive rats. The data indicate that increased non-collagenous protein and collagen in testicular arteries or mesenteric arteries in SHR or SHRSP can raise the blood pressure in its early hypertensive stage. In addition, increased amount of collagen and elastin in testes of SHRSP apperars tobe derived from hypertensive lesions of testicular arteries.View full abstractDownload PDF (1997K) -
Haruo Ito, Kenji Kawamura, Zengo Kataumi, Hidenori Sumiya, Hideki Fuse ...1984 Volume 75 Issue 6 Pages 934-939
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSIn 7 vasectomized patients, reanastomosis of the duct was performed under microscopic observation. The operative technique consisted of monolayer anastomosis by using 9-0 monofilament nylon with 8-12 stitches. The age of the patients ranged form 25 to 49 years old, with a mean of 41 years old. The periods from vasectomies to the operation ranged from 4 months to 19 years, the mean being 9 years. The reason for which vasovasostomy was hoped was improvement in illness of the wife and that in economical status in 1 case each. In all of the remaining 5 cases the reason was remarriage. In all but 1 case who had undergone the operation only 1 month before, pregnancy occurred (6 out of 6 cases or 100%). We considered that monolayer suturing is not inferior to double layer suturing which is employed in many institutes now. After the operation pregnancies followed from 2 months to 1 year and 1 month, the mean being 6 months. No correlation was seen between the time form vasectomy to vasovasostomy and that from vasovasostomy to conception. The testicular biopsies performed in 2 cases whose vasectomies were done 2 and 6 years ago revealed testicular score count as low as 6.7 and 6.6, respectively.View full abstractDownload PDF (3520K) -
Hisashi Matsushima, Hideyuki Akaza, Hiroichi Kishi, Takashi Umeda, Kaz ...1984 Volume 75 Issue 6 Pages 940-944
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThere are some cases of clinically diagnosed superficial bladder cancer which are finally indicated for total cystectomy after several conservative treatments such as transurethral electroresection and transurethral electrocoagulation (fulguration). In the past 6 years we have experienced 12 cases which were first treated transurethrally and finally undèrgone total cystectomy in our department. Herin, we report the recent 2 cases of them and analyse these 12 cases retrospectively. Total cystectomy for superficial bladder cancer should be considered in the following conditions.
1) Recurrent high grade 3grade 3) cancer
2) Progress in grade
3) Progress in stage
4) Strongly suggested CIS (carcinoma in sity)
5) Recurrent bladder cancer around ureteral orifices complicated with vesicoureteral reflux
6) Ectopic and multicentric recurrences uncontrollable transurethrallyView full abstractDownload PDF (722K) -
II. Application of Flow Cytometry to Mixed Lymphocyte Culture ReactionHidenori Kanda, Seiji Kunikata, Takeshi Matsuura, Masanori Iguchi, Tak ...1984 Volume 75 Issue 6 Pages 945-950
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe DNA synthesis in mixed lymphocyte culture reaction was measured by flow cytometry. The rate of lymphocyte blastogenesis was calculated from the DNA histogram as percent dividing compartment as follows.
The cells in the S+G2+M phases of the cell cycle were regarded as belonging to the dividing compartment. Percent dividing compartment was calculated by dividing the number of cells present outside the G0/G1 phase (S+G2+M) by the half number of cells (responder cells) in the histogram.
We compared percent dividing compartment with usual stimulation index and they showed good correlation (r=0.9493, p<0.01, n=12).
Therefore, this method seems to be a useful histocompatibility test without using radioisotopes instead of ordinary MLR.View full abstractDownload PDF (614K) -
Mitsuo Ohkawa, Akira Okasho, Toshiyasu Amano, Katsuro Takemae, Matsuo ...1984 Volume 75 Issue 6 Pages 951-958
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSThe serum levels of sialic acid were measured with a specific enzymatic assay kit in 30 normal subjects, 34 patients with acute cystitis, and 14 patients with acute pyelonephritis. The values of serum sialic acid were related to those of erythrocyte sedimentation rate, total serum protein and its fractions, C reactive protein, and white blood cell count. Blood samples were obtained immediately before treatment in all subjects, and 3, 5, 7, 14, and 28 days after the beginning of antimicrobial chemotherapy in the pyelonephritis patients. The pre-treatment value of serum sialic acid in the pyelonephritis patients was significantly greater than that in the cystitis patients (p<0.001), and the value in the cytitis patients was greater than that in the control subjects (p<0.001). There was a significant correlation between the daily change of the serum sialic acid level and that of α1-globulin, α2-globulin, and the erythrocyte sedimentation rate in the pyelonephritis patients. Sialic acid proved to be a useful biochemical marker in acute urinary ract infections, especially in pyelonephritis.View full abstractDownload PDF (1087K) -
Takuji Fujinaga, Shinji Kitamura, Masanori Yoshida1984 Volume 75 Issue 6 Pages 959-966
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSTissue polypeptide antigen (TPA) is a tumor-associated antigen which is bound to the cell membrane and the endoplasmic reticulum in the cancer cell.
In the present study, urinary TPA (U-TPA) levels were measured in 167 healthy controls, 51 patients with bladder cancer, 20 with other urological cancer (except urothelial cancer), 20 with urological benign disease, 13 with non-urological cancer and 66 chemical workers exposed to bladder carcinogens. Serum TPA (S-TPA) levels were also investigated in 35 patients with bladder cancer.
The results were as follows:
1) Diurnal variation in U-TPA was demonstated.
2) The positive rates of U-TPA in each group were 5.4% in control, 92.2% in bladder cancer, 40.0% in other urological cancer, 20.0% in urological benign disease, 23.1% in non-urological cancer and 18.2% in chemical worker.
3) The positive rate and the mean value of U-TPA in the bladder cancer group were significantly higher than those of all other groups.
4) In 35 patients with bladder cancer simultaneously measured S-TPA and U-TPA, U-TPA levels showed a higher proportion of the positive rate than S-TPA levels.
5) In the bladder cancer group, there was no significant difference in U-TPA level among the histological grades, but there was a significant difference between the high stage and low stage groups.
6) All of 16 patients who were clinically free of bladder cancer after treatment had a lower U-TPA level than the pre-treatment level.
7) Simultaneous urinary cytology was positive in 27/51 (52.9%) which was less marked as compared to the positivity of pathological TPA in the urine, which was 47/51 (92.2%).
The determination of U-TPA may be a useful tumor marker in diagnosis and post-treatment monitoring of urothelial cancer.View full abstractDownload PDF (894K) -
Hitoshi Takeshima, Hiromichi Ishikawa, Atsushi Aikawa, Takahisa Kageya ...1984 Volume 75 Issue 6 Pages 967-972
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSFifteen patients with carcinoma in the lower colon had been treated at our hospital between January, 1982 and January, 1983.
Five, 4 males and 1 female, of the 15 patients had total pelvic exenteration.
The patients ranged in age from 35 to 74 years. The chief complaint was bloody stool, constipation, abdominal fullness and rectal tumor. The duration of illnesss ranged from 10 days to 25 months. Two of them had undergone colostomy before the pelvic exenteration.
The primary lesion existed in the rectum in 4 patients and in both the rectum and sigmoid colon in 1 patient. The analysis of spread patterns showed that the bladder was invaded by carcinoma in all patients; and especially in a female patient the invasion of carcinoma to the vagina and ileum appeared and two of the male patients had invasive lesions in the prostate and sigmoid colon which was aboral to the primary lesion. The operation time ranged from 310 to 695 minutes with blood loss from 800 to 5200 ml.
Histopathological study disclosed 2 cases of moderately differentiated adenocarcinoma, 3 cases of well differentiated adenocarcinoma; one of them had metastatic lesion in lymph nodes and the other one had a peritoneal invasion.
Three of the 5 patients developed minor complications. One of them died of cancer 6 months after the pelvic exenteration.
Since the results of previous reports showed that, from the 5-year survival rate, this surgical procedure with pelvic exenteration was remarkably superior to other treatments without pelvic exenteration and, as shown in the present study, operative mortality rate was markedly low, total pelvic exenteration may be useful for treatment of invasive carcinoma of the lower colon. However, further improvement in the surgical procedures would be desirable.View full abstractDownload PDF (790K) -
Kaoru Nakamura, Miki Shiramizu, Tadashi Yamamoto, Satoru Kimura1984 Volume 75 Issue 6 Pages 973-978
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSA case of renal leiomyosarcoma with extension into the renal vein is presented. We believe this is the first report of renal leiomyosarcoma associated with a main renal vein tumor thrombus.
A 51-year-old male was admitted because of a left flank mass and pain on July, 18, 1983. Excretory urogram did not visualize the left kidney. A left retrograde pyelogram showed a shift and displacement of pelvis and calyx due to a large mass. CT scan showed a large mass with cystic pattern and irregular wall. Aortogram showed left renal artery occlusion. The mass was fed by parasitic arterial vessels from the splenic and lumbar arteries. There was poor vascularity in the central portion of the mass. Selective celiac arteriogram in the late phase showed “thread and streak pattern” around the left renal vein, which suggested renal vein thrombosis.
Transperitoneal radical left nephrectomy was performed on Aug., 16, 1983. During the operation about 500ml of yellowish serous fluid was aspirated and the tumor thrombus in the left renal vein was excised. The tumor measured 17 by 12 by 8cm and weighed 1300gm. The tumor was continuous with the left renal capsule and the left kidney was enveloped by the tumor. Histological diagnosis was renal leiomyosarcoma originating from renal capsule and renal vein thrombosis by leiomyosarcoma. After operation irradiation of 30Gy Linac was done at the tumor bed. The patient was well without recurrence 4 months after operation.
Diagnostic problems and clinical features of renal leiomyosarcoma are discussed.View full abstractDownload PDF (6214K) -
A CASE REPORTKikuo Okamura, Koichi Ito, Masahumi Sahashi, Toshio Shimoji1984 Volume 75 Issue 6 Pages 979-983
Published: June 20, 1984
Released on J-STAGE: July 23, 2010
JOURNAL FREE ACCESSA case of squamous cell carcinoma of the prostate is reported. This form of the prostatic cancer is extremely rare and has a poor prognosis.
A 59-year-old man who complained of dysuria underwent transurethral resection. Histological diagnosis was squamous cell carcinoma. Radical prostatectomy was performed but he died 8 months after operation.View full abstractDownload PDF (3386K)
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