Nippon Shokakibyo Gakkai Zasshi

Endosonographic diagnosis of metastatic tumors in the recto-uterine or rectovesical space by transrectal scan

Tohru KAJIYAMA, Masaya OHANA, Mitsunobu MATSUSHITA, Fusako KUSUMI, Yuj ...

1992 Volume 89 Issue 4 Pages 1139-1146
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1139

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A 6-year experience of transrectal ultrasonography (TRUS) in 75 patients with advanced gastrointestinal cancers was reviewed regarding the diagnostic yield of metastatic extrarectal tumors. A diagnostic capability of TRUS (a sensitivity of 82.9%, a specificity of 97.5% and an accuracy of 90.7%) was statistically superior to that of digital rectal examination (a sensitivity of 62.9%, a specificity of 75% and an accuracy of 69.3%). However, TRUS could hardly correctly diagnose a miliary type of extrarectal tumors in contrast to nodular and thickened types. TRUS also had an advantage over conventional ultrasonography in detecting a small amount of ascites with a sensitivity of 75%, a specificity of 93% and an accuracy of 86.6%. Patients with positive signs of extrarectal tumors or ascites on TRUS survived significantly shorter than those with negative signs. TRUS renders a convenient means in the objective diagnosis of peritoneal carcinomatosis, and predicts patient's prognosis.

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Expression of c-erbB-2 protein in gastric carcinomas

Correlation between immunohistochemical study and clinico-pathological factors, DNA ploidy pattern and concentration of c-erbB-2 protein in serum

Tsutomu KAETSU

1992 Volume 89 Issue 4 Pages 1147-1154
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1147

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Expression of c-erbB-2 protein in carcinoma tissue was examined in 56 patients suffered from gastric carcinoma, and the correlation between the expression of c-erbB-2 protein and clinico-pathological factors, DNA ploidy pattern was also examined.
Positive expression of c-erbB-2 protein in carcinoma tissue was detected in 21/56 (37.5%) cases, and the positive rate (71.4%) in tissue of differentiated carcinoma (pap, tub1, tub2) was significantly higher than that in tissue of undifferentiated carcinoma (por, sig, muc) (28.6%). No good correlation between the expression of c-erbB-2 in tissue and other clinoco-pathological factors, such as ly, v, n, tumor size, stage of the tumor, and the location of the tumor was observed. In DNA ploidy, 70.6% of cases was aneuploid pattern, and 29.4% of cases was diploid pattern in positive expression of c-erbB-2 protein in carcinoma tissue. These results suggest that expression of c-erbB-2 protein is involved in promoting DNA synthesis in initial step of differentiated gastric carcinoma.
The concentration of c-erbB-2 in serum of positive expression of c-erbB-2 protein in tissue was significanlty higher than that in serum of negative expression of c-erbB-2 protein in tissue. Good correlation between serum concentration of c-erbB-2 protein and clinical stage of the carcinoma was observed in positive expression of c-erbB-2 protein in carcinoma tissue. The concentration of c-erbB-2 protein in serum can be a sensitive indicator for guess the Stage of the gastric carcinoma that express c-erbB-2 protein in carcinoma tissue.

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The immunohistochemical study on the recurrent mechanism of acetic acid induced gastric ulcer in rats

Extracellular matrix and cellular kinetics

Kazuyoshi YAGI

1992 Volume 89 Issue 4 Pages 1155-1164
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1155

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The localization of fibronectin (FN) and laminin (LM) and cellular kinetics of epithelium in acetic acid induced gastric ulcers were examined by immunohistochemistry, comparing fundic glands ulcer with fundic-pyloric border ulcer. Ulcers on fundic glands had become scars in 30 days and didn't relapse after that. More than half of ulcer on fundic-pyloric border changed into scar in 30 days, however, they started to recur at about 45 days. The localization of LM was observed on basement membrane (BM) beneath epithelia, blood vessel walls and musculature. The percentage change in intra-blood-vessel area compared to total area was analized by immunohistochemical distribution of LM. As for ulcer on fundic glands, the percentage of intra-blood-vessel returned to normal numbers after healing to scars (30 days). On the other hand, the percentage of intra-blood-vessel of ulcer on fundic-pyloric border after changing into scar (30 days) and recurring (45 days) significantly increased compared with initial healing (10 days, 20 days).
The stratum of spindly cells with FN-positive surface appeared under regenerative epithelia of ulcers on fundic-pyloric border from 10 days to 20 days. This part was proven to be spare in blood vessels by distribution of LM. Though this stratum was not observed at every stages after recurrence, the collagen fibers of ulcer on fundic-pyloric border had got mature thickly. These results may lead the following theory; the phenomenon that the distribution of blood supply in stomach seems to be more dominant in submucosal fibrous layer than in mucosa may cause the recurrence of fundic-pyloric border ulcers.
The cell number of S-phase was significantly more numerously observed in relapsed ulcer on fundic-pyloric border than in pre-relapsed one (10 day). The cell number of S-phase on fundic gland ulcer tended to decrease after healing to scar stage. The immediate restoration of connective tissue under the mucosa is considered to promote epithelial cellular kinetics in recovering and maturing.

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Bio- and histochemical changes of tissue kallikrein in the rat stomach after water immersion-induced gastric ulcer

Yasuaki KOJIMA

1992 Volume 89 Issue 4 Pages 1165-1172
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1165

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The posterior stomach was isolated from each male Donryu rat and separated into two parts: the tunicae mucosa and submucosa and the tunicae muscularis and serosa. Active and inactive tissue kallikrein were measured using sandwich type enzyme linked immunosorbent assay (s-ELISA) and H-Pro-Phe-Arg-MCA to complement each other. Inactive tissue kallikrein was determined (1) by measuring total tissue kallikrein and active tissue kallikrein in trypsin-treated samples and trypsinnontreated ones, respectively; and (2) by subtracting active tissue kallikrein from total tissue kallikrein. Although tissue kallikrein was not demonstrable in the tunicae muscularis and serosa, inactive tissue kallikrein in the tunicae mucosa and submucosa reached 79.6% with s-ELISA and 99.1% with H-Pro-Phe-Arg-MCA. Water-immersion stress significantly decreased total tissue kallikrein at Stage IV of ulcers compared with the control value (p<0.001 in both measuring methods). Immunohistochemical staining was made using the avidin-biotin-horseradish peroxidase complex method. Tissue kallikrein was proved to be diffusely present as the inactive type within the epithelial cells of the pits in the gastric mucosa of the normal rats. With the progress of ulcers, however, it disappeared from the cells and appeared in the intercellular space. At Stage IV, it began to disappear even from the intercellular space. Based on the previously proposed process of tissue kallikrein release into blood in man, a possible interpretation of the above findings is that inactive tissue kallikrein may serve to maintain the gastric mucosa in a normal state; and that it may be transformed into the active type with ulceration and eliminated in a form of complex with some protease inhibitor in the course of aggravation.

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Prevalence of HCV antibodies in Yatsuka town of Simane prefecture, Japan

Takeaki SUOU, Yujiro IKUTA, Mayumi HASEGAWA, Hironaka KAWASAKI

1992 Volume 89 Issue 4 Pages 1173-1178
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1173

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To clarify the potential role for HCV in the development of chronic liver disease in Yatsuka town with a high morbidity of liver disease, epidemiological studies were taken in 459 subjects of Yatsuka town compared with 219 subjects of Mihonoseki town with a low one. In Yatsuka town, the mortality rate of liver cirrhosis was three times higher than the overall rate in Simane prefecture, and the rate of liver cancer rapidly increased in recent years. Age and sex-matched epidemiological studies showed a significantly higher incidence of hepatic dysfunction compared with Mihonoseki town (11.5% vs 3.7%, P<0.01). The prevalence of HCV antibody was significantly higher in Yatsuka town than Mihonoseki town (16.6% vs 3.7%, P<0.001), although there were no differences in frequencies of HBs antigen and habitual alcohol drinker between the two districts. These data strongly suggest that the high prevalence of HCV may be associated with the high morbidity of chronic liver disease, especially hepatocellular carcinoma in Yatsuka town.

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Choleretic effects of taurine on experimentally-induced intrahepatic cholestasis

Chihiro SAKAGAMI, Kiyohide KIOKA, Yasuhiro MIZOGUCHI, Touru KIDA, Itar ...

1992 Volume 89 Issue 4 Pages 1179-1184
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1179

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When a lymphokine, the cholestatic factor, is intravenously injected into rats through a mesenteric vein, remarkable reductions in bile flow and bile acid excretion are observed. However when taurine was injected with the cholestatic factor, the reduction in bile flow and bile acid excretion were significantly supressed. Moreover, injection of taurine with cholestatic factor resulted in the decreases of both bile acid-dependent bile flow and vesicular transport but not bile acid-independent bile flow. Not significant choleretic effects were noted when taurine alone was administered to normal rats.

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A study of the dynamics of gallbladder contraction in irritable bowel syndrome

Fumitaka KANAZAWA, Kazunori MINE, Norio MISHIMA, Mamoru MURAOKA, Tetsu ...

1992 Volume 89 Issue 4 Pages 1185-1190
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1185

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We examined gallbladder motility function after intramuscular injection of caerulein (0.2μg/kg) to the cases of irritable bowel syndrome (IBS) by using ultrasonography.
We measured gallbladder area pre and after caerulein injection (0'5'10'15'20'25'30'40'50'60') and calculated contraction rate of gallbladder in each time. We applied one way analysis of variance among the four groups [diarrhea group (N=9), alternative group (N=8), constipation group (N=8), control group (N=15)]. Gallbladder contraction rate was low in diarrhea group and high in constipation group (p<0.05). And then we classified gallbladder contraction pattern to three groups (hyperkinetic, intermediate, hypokinetic). These three groups correlated bowel habits and biliary knocked pain.
Therefore, constipation group showed hyperkinetic tendency and diarrhea group showed hypokinetic tendency (χ² analysis: p=0.004 CMH analysis: p=0.001).
And biliary knocked pain significantly appeared in constipation group and hyperkinetic type of gallbladder (χ² analysis: p=0.026, CMH analysis: p=0.019).
Consequently, it was suggested that bowel habits concerned with abnormality of gallbladder motility function in IBS.

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A case of minute remnant stomach cancer derived from gastritis cystica polyposa

Hironobu KIMURA, Hiroyuki TAKAMURA, Kiichi MAEDA, Makoto UOGISHI, Hiro ...

1992 Volume 89 Issue 4 Pages 1191-1196
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1191

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Bleeding Meckel's diverticulum in a patient with Crohn's disease

Akiko SHIOTANI, Yukinori NAKAE, Syosuke YOKOYAMA, Hiroyuki KATAYAMA, M ...

1992 Volume 89 Issue 4 Pages 1197-1200
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1197

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A case of ileal carcinoid tumor penetrating mesocolon with asthma attack

Tetsuro YAMASHINA, Hidekazu TAKEUCHI, Hiroshi EDAZAWA, Kuniaki YANOH, ...

1992 Volume 89 Issue 4 Pages 1201-1206
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1201

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A case of hepatic amyloidosis with hepatic failure

Tomohiro TAMAKI, Toshinori KODAMA, Hirokio YOSHIDA, Johji MASUKAWA, Ke ...

1992 Volume 89 Issue 4 Pages 1207-1211
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1207

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A case of epidermal appendage cyst with extremely high value of CA19-9 in serum and the contents

Osamu KAWAMURA, Mitsuya HARIGANE, Hiroyasu OHARA, Kunio NAGAI, Hirofum ...

1992 Volume 89 Issue 4 Pages 1212-1215
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1212

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A case of hypervascular polypoid lesion of the gallbladder

Shigeki LEE, Naotaka FUJITA, Go KOBAYASHI, Katsumi KIMURA, Hiromitsu W ...

1992 Volume 89 Issue 4 Pages 1216-1220
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1216

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A case of chronic pancreatitis which was difficult to be differentiated from small pancreatic tumor

Tadashi KATO, Shozo OKAMURA, Shinji OHASHI, Hiroshi NAKAGAWA, Hisayosh ...

1992 Volume 89 Issue 4 Pages 1221-1224
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1221

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A case of pancreatic fistula cured spontaneous internal fistulization

Yoshihisa SUMINAGA, Hiroshi YAMAMOTO, Toshihiro KIMURA, Michio MIYATA

1992 Volume 89 Issue 4 Pages 1225-1228
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1225

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A trial of peroral cholecystoscopy after dilatation by baloon in the cystic duct

Hajime HOSHI, Iruru MAETANI, Tamotsu ANZAI, Shigeki OOHASHI, Manabu FU ...

1992 Volume 89 Issue 4 Pages 1229
Published: 1992
Released on J-STAGE: December 26, 2007

DOIhttps://doi.org/10.11405/nisshoshi1964.89.1229

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