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[in Japanese], [in Japanese]
1994 Volume 91 Issue 5 Pages
949-955
Published: 1994
Released on J-STAGE: February 26, 2008
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Masatoshi SAKAKIBARA, Kimitomo MORISE, Hitomi TAKASHI, Michio OHTA
1994 Volume 91 Issue 5 Pages
956-968
Published: 1994
Released on J-STAGE: February 26, 2008
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The distribution and localization of
Helicobacter pylori (HP) and mononuclear cells (MNC) in the gastric mucosa were investigated immunohistochemically in 120 patients with gastritis or peptic ulcer. HP was detected in the gastric mucosa of 58% of 40 gastritis patients, 82% of 56 gastric ulcer (GU) patients, and 88% of 24 duodenal ulcer (DU) patients. In the HP-positive mucosa, cells positive for IgG or IgA were increased significantly when compared to the HP-negative mucosa. Neutrophils and eosinophils were also increased under the HP-infected surface and therefore these cells were likely involved in the mucosal damage. Enhancement of the expression of HLA-DR antigen was observed in the gastric epithelium with HP infection and it was associated with a significant increase of lymphoid follicles and B cells in the mucosa. In comparison with the HP-infected mucosa of gastritis patients, the number of MNC were increased significantly in the mucosa of both DU and GU patients. The number of HP in the gastric mucosa of DU patients was significantly higher than those of both gastritis and GU patients. In addition, the grade of the infiltration of MNC and IgA positive cells were always greater in DU than in gastritis, regardless of the number of HP. These findings suggested that activation of the local immunity in the gastric mucosa of gastritis and peptic ulcer patients by HP infection may participate in the pathogenesis of gastroduodenal mucosal damage.
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Takao WAKABAYASHI, Saburo NAKAZAWA, Junji YOSHINO, Kenji YAMAO, Kazuo ...
1994 Volume 91 Issue 5 Pages
969-975
Published: 1994
Released on J-STAGE: February 26, 2008
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To study the influence of gastric acid on the extension of the regenerative epithelium, 26 patients (28 ulcers) of gastric ulcer were examined by the stereo video-endoscope being able to measure the length and 24-hours intragastric pH monitoring. Extending speeds of the regenerative epithelium were measured from the time the regenerative epithelium of the ulcer was observed till the last examination, but which was limited 8 weeks after the first observation of the regenerative epithelium. The relationship was not observed between the extending speeds and the stages (A
2-H
1, H
1-H
2, H
2-S
1) of the ulcer. For 21 ulcers followed up by the stereo video-endoscope from active stage, the extending speed of the regenerative epithelium and the pH 3 holding time in a day were significantly correlated (
r=0.51,
p=0.014), and the same relationship (
r=0.56,
p=0.008) were observed in the nighttime. It was confirmed that the gastric acid regulated strongly the extending speed of regenerative epithelium of gastric ulcer. The intragastric circumstance of the low acid secretion induced by the antacid-drugs was considered to accelerate the extension of regenerative gastric epithelium.
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Chihiro KAWASAKI, Yohei HOSOKAWA, Takanori HATTORI, Masashi SUWO, Masa ...
1994 Volume 91 Issue 5 Pages
976-987
Published: 1994
Released on J-STAGE: February 26, 2008
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In order to clarify the biological behavior of mucin producing cancers of colon, we analyzed 32 cases showing histological heterogeneity in the tumors, by mucin histochemistry. 28 cases were mucinous adenocarcinoma, forming with tubular structures, and the remaining 4 cases were signet-ring cell carcinomas. HID-AB stain demonstrated that the mucin component was almost similar to that of normal mucosa around the cancer. In the tubular forming portions, in which polyploid or aneuploid cells were often detected, the growth fraction of cancers was significantly higher than in that of the other portions.
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Hiroko MATSUMOTO, Masahiro MATSUMOTO, Masaki NEMOTO, Fumitaka SUZUKI, ...
1994 Volume 91 Issue 5 Pages
988-994
Published: 1994
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Changes of liver functions associated with endoscopic injection sclerotherapy (EIS) were investigated in 143 patients with remarkable esophageal varices. The index used for evaluating hepatic reserve was the ratio between the increase of total bilirubin and the increase of LDH after EIS [I.I. index=(ΔT.Bil./ΔLDH)×100] in cases treated by intravariceal injection of 5% ethanolamine oleate. I.I. index value caused by hemolysis was stable and always below 0.2, while the elevation of I.I. index above 0.2 was regarded as the reflection of the deterioration of liver function. After the entire sessions of EIS, the changes of liver function tests before and after EIS were estimated in 104 cases using 3 factors as follows ; (1) ΔT.Bil.; increase of total bilirubin more than 0.5mg/dl (2) ΔPT; decrease of prothrombin time more than 5% (3) ΔICG R
15 ; increase of ICG R
15 more than 5%. I.I. index of group I (without any changes of 3 factors mentioned above ;
n=66) was 0.22±0.16, approximately within normal range. However, in group II (with 1 factor ;
n=29), group III (with 2 factors ;
n=5), group IV (with all factors ;
n=4), I.I. index was elevated according to the severity of their liver dysfunction. The cases whose I.I. index value increased gradually during the course of EIS, were apt to deteriorate the liver functions and therefore, should be carefully observed. Also, I.I. index seems to reflect the prognosis of the patients treated by EIS for some extent, since the survival period of the cases treated by EIS were correlative with the value of I.I. index (
r= -0.542,
p<0.01), and I.I. index of 32 cases who survived for longer than 5 years after EIS was almost normal (0.22±0.15).
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Takeshi OKANOUE, Shinichi SAKAMOTO, Koichiro YASUI, Shiro TAKAMI, Fumi ...
1994 Volume 91 Issue 5 Pages
995-1002
Published: 1994
Released on J-STAGE: February 26, 2008
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We investigated the side effects of interferon (IFN) on the endocrine and respiratory system in 545 cases of chronic hepatitis C. Eleven of 494 (2.2%) patients with chronic hepatitis C who were treated with natural or recombinant interferon (IFN) developed thyroid disease while on treatment. Eight patients developed hyperthyroidism and 3 patients developed hypothyroidism. All 11 patients required definitive therapy, who became euthyroid after the therapy. Two patients received nIFNα and one patient received rIFNα2b developed diabetes mellitus. Two patients received rIFNα2a and rIFNα2b, respectively, developed interstitial pneumonia 12 weeks and 24 weeks later, respectively. One patient showed positive reaction for RA test and LE factor and positive LE cell, and complained of fever, arthralgia and dry cough. These phenomenon disappeared after the cessation of IFN therapy.
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Hiroyuki MAGUCHI
1994 Volume 91 Issue 5 Pages
1003-1015
Published: 1994
Released on J-STAGE: February 26, 2008
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A total of 80 cases (40 operated cases and 40 follow-up cases) of mucin producing tumor (MPT) of the pancreas was studied to elucidated its clinicopathologic characteristics and assess therapeutic strategy. This disease was encountered histologically in various such as hyperplasia and carcinoma with invasion. 75% of carcinoma cases of branch duct type were accompanied by intraductal spread to the main duct and most of those cases had intraductal extension of less than 5mm in length to the main duct. Multicentricity was found in 28.6% of carcinoma cases. Parenchymal invasion was observed in 28.6% of carcinoma cases and lymph node involvement was seen in one case. Thus, prognosis of the patients with MPT was better than that with “common” duct cell carcinoma of the pancreas. Among diagnostic modalities, Selective ERP and EUS were useful especially in demonstrating precise pancreatograms and excrescent nodules. For histocytologic diagnosis prior surgery, EPB proved very useful in combination with pancreatic juice cytology.
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Norimasa MIURA, Naoya MIURA, Masafumi FUJISE, Hiroshi TANAKA, Hiroaki ...
1994 Volume 91 Issue 5 Pages
1016-1021
Published: 1994
Released on J-STAGE: February 26, 2008
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Takeshi OINUMA, Masaki KAWANO, Hijiri OGONUKI, Koji MIZOGUCHI, Tetsuro ...
1994 Volume 91 Issue 5 Pages
1022-1026
Published: 1994
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Hiromi KATAOKA, Kohei KATSUMI, Takeo KUTSUNA, Hiroshi SUZUMURA, Masaak ...
1994 Volume 91 Issue 5 Pages
1027-1031
Published: 1994
Released on J-STAGE: February 26, 2008
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Hiroya SAITO, Yasuo SAKURAI, Akio TAKAMURA, Takashi HASEGAWA, Hiroaki ...
1994 Volume 91 Issue 5 Pages
1032-1036
Published: 1994
Released on J-STAGE: February 26, 2008
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Hiroshi KATAMURA, Shigeo OHKI, Akira SUGITA, Shinichi ISHIHARA, Masayo ...
1994 Volume 91 Issue 5 Pages
1037-1041
Published: 1994
Released on J-STAGE: February 26, 2008
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Kunihiko NAKAZAWA, Yasutsugu BANDAI, Yumiko OHTOMO, Jun EGAMI, Kenshou ...
1994 Volume 91 Issue 5 Pages
1042-1046
Published: 1994
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Fumihiko INOUE, Yoichi SAKA, Tateo SUGIYAMA, Hiroo FURUKAWA, Tatsuyosh ...
1994 Volume 91 Issue 5 Pages
1047-1051
Published: 1994
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Yutaka OZEKI, Junnosuke MIURA
1994 Volume 91 Issue 5 Pages
1052-1056
Published: 1994
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Yasutaka INAGAKI, Kiyomitsu MIYACHI, Tomoyoshi KAMIYA, Kei MIYAMOTO, N ...
1994 Volume 91 Issue 5 Pages
1057-1061
Published: 1994
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Takanori KYOKANE, Yukihiko AKITA, Makoto KATAYAMA, Yoshimi KITAGAWA, S ...
1994 Volume 91 Issue 5 Pages
1062-1066
Published: 1994
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Kiyofumi KONNO, Hiroshi TERASHIMA, Nagako MIYANO, Shinji YABUUCHI, Shi ...
1994 Volume 91 Issue 5 Pages
1067-1072
Published: 1994
Released on J-STAGE: February 26, 2008
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