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Daiki HABU, Masayuki MIZUNO, Kyoko OHNISHI, Akihiko WATANABE, Juntoku ...
1997 Volume 94 Issue 5 Pages
319-327
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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Thirty-two patients with chronic active hepatitis C were initially treated with 9 milion units of interferon (IFN)-α2a daily for 4 weeks and then thrice weekly for 20 weeks. The incidence of development and influence on clinical effectiveness of anti-IFNα2a neutralizing antibodies measured by bioassay were investigated. Thirteen (41%) of the 32 patients developed antibodies, 4 (12.5%) of whom exhibited a high titer of 128 NU or greater. There was a significant difference (
p<0.05) between responders and non-responders in the low viral load group (less than 10
5 copies/50
μl) in the incidence of antibody development, with antibodies present in 2 of the 9 responders (22%) and 5 of the 7 non-responders (71%). There was also a significant difference between the antibody-negative and antibody-positive patients in circulating HCV-RNA, 2-5AS activity and average ALT levels at the latter half of treatment. In addition, 2-5AS activity was significantly lower (
p<0.05) at completion of treatment in-the high antibody titer group (128 NU or greater) than in the low antibody titer group. These results indicate that the development of anti-IFN neutralizing antibodies had a definite influence on the clinical course of IFN treatment for chronic hepatitis C.
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With special reference to effects of ethyl icosapentate
Takeshi KURIHARA, Mariko TSUCHIYA, Masumi AKIMOTO, Hiroshi HASHIMOTO, ...
1997 Volume 94 Issue 5 Pages
328-335
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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A blood rheological study was conducted using Kikuchi's micro-channel method in rats with fatty liver. Effects of eicosapentaenoic acid (EPA) on blood rheology were also evaluated. Male SD rats given normal feed served as the control. One group was given choline-deficient feed for 4 weeks (EPA (-) group), while another group was daily given EPA (1000mg/kg) for 4 weeks together with choline-deficient feed (EPA (+) group). The micro-channel passage time was determined using 100μl of whole blood. The passage time significantly increased in the EPA (-) group compared to the control (
p<0.01). It significantly decreased in the EPA (+) group compared to the EPA (-) group (
p<0.01). Findings obtained in the present study suggested that blood rheological factors are related to the development of fatty liver and that EPA inhibits fatty changes of the liver by improving these rheological factors.
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Nobuyuki HAYASHI, Ryuichi HAYASHI, Yuichiro SAITO, Shigeo ENDO, Hajime ...
1997 Volume 94 Issue 5 Pages
336-339
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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Makoto CHUMA, Hiroki NAKAYA, Hisashi ODA, Shigeki HATAKEYAMA, Shunsuke ...
1997 Volume 94 Issue 5 Pages
340-345
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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Chizu MUKOUBAYASHI, Akiko SHIOTANI, Tadashi ISHIGUCHI, Hisato OKA, Tet ...
1997 Volume 94 Issue 5 Pages
346-350
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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Atsuya SHIMIZU, Mutsumi KOYAMA, Kouichi MIYAZAKI, Sinsei TAGAWA, Kouji ...
1997 Volume 94 Issue 5 Pages
351-355
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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Akiko OGAWA, Kunimi SUZUKI, Kaoru OHASHI, Ryo NAKANISHI, Kuniaki KOJIM ...
1997 Volume 94 Issue 5 Pages
356-360
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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Kazufumi DOHMEN, Kotaro KOYANAGI, Shingo ONOHARA, Masafumi SHIRAHAMA, ...
1997 Volume 94 Issue 5 Pages
361-365
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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Tatsuya TOYOKAWA, Nobumasa IKEDA, Masaki OHARA, Masaharu ANDO, Kinichi ...
1997 Volume 94 Issue 5 Pages
366-370
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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Kazuhiko TOKITA, Yoshiki AMURO, Masao OHNO, Naoki HARA, Hiroko IIJIMA, ...
1997 Volume 94 Issue 5 Pages
371-375
Published: May 05, 1997
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Yuji MATSUI, Tadashi HIGASHINO, Akiko MAKIURA, Junichi YOSHII, Hiroshi ...
1997 Volume 94 Issue 5 Pages
376-380
Published: May 05, 1997
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Hitoshi OHMI, Hiroshi SUKIGARA, Tomihiro HAYAKAWA, Hayato OHNISHI, Tom ...
1997 Volume 94 Issue 5 Pages
381-385
Published: May 05, 1997
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
1997 Volume 94 Issue 5 Pages
415-435
Published: May 05, 1997
Released on J-STAGE: February 26, 2008
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