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Volume 81, Issue 2
Displaying 1-15 of 15 articles from this issue
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Yoshiyuki WATANABE, Masahiro TADA, Kazutoshi KAWAMOTO, Gentsu UOZUMI, ...1984 Volume 81 Issue 2 Pages 185-193
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIn order to elucidate risk factors of cancer of the rectum and the colon, a case-control study by a questionnaire was conducted on 65 pairs of cancer of the rectum and their controls and 138 pairs of cancer of the colon and their controls.
There was no definite relation between the past histories and cancer of the rectum and the colon. And also no definite relation was recognized between the blood types and cancer of the rectum and the colon.
It is suggested that family history of gastric cancer was an increased risk factor for cancer of the rectum.
It is suggested that eating beans and curds and drinking black tea were low risk factors for cancer of the rectum.
Smoking seemed to be a low risk factor for cancer of the colon. However, it is dangerous to interpret that smoking lessens the risk of getting cancer of the colon, because controls mainly consisted of patients with peptic ulcer and other digestive diseases, among whom the proportion of smokers was considered to be high.View full abstractDownload PDF (999K) -
Yoshikazu AKAHONA, Yasuhiro KAWAKAMI, Takashi ABE, Akira YACHI1984 Volume 81 Issue 2 Pages 194-200
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe occurrence of glycoprotein antigens (M1, M2 and M3) was investigated in tissues of colonic adenoma and colonic adenocarcinoma by immunoperoxidase methods as compared with that in human fetal colonic mucosa.
M3 was detected in all cases with colonic adenoma, and in 30% of them, M1 was also detected. In approximately 60% of cases with colonic adenocarcinoma, M3 was detected and, in addition, M1 was simultaneously detected in 22% of the M3-positive cases. However, none of antigens were detected in the remaining cases. In the mucosa adjacent to colonic adenocarcinoma, M1 which was never detected in normal colonic mucosa was observed. Both M3 and M1 were simultaneously detected in the colonic mucosa in a middle stage of fetal gestation. In a late stage followed by differentiation and maturation of the colonic mucosa, M3 became the main antigen, since M1 gradually disappeared.
From these results, these glycoprotein antigens seem to be of a significance as differentiated antigens in human gastrointestinal mucosa.View full abstractDownload PDF (2430K) -
Kenju KUSUMOTO, Yoshinobu HATA, Yuji SATO, Yoichi KASAI, Kazuo ITO1984 Volume 81 Issue 2 Pages 201-207
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSA simple method for measuring liver volume and hepatic blood flow using hepatic scintigraphy with a computer system was developed and evaluated for the clinical application.
The hepatic blood flow which was represented by the index was measured with the accumulation curve from 50 to 90 seconds after injection of Tc-Sn colloid. The liver volume was measured as an assumption of ellipsoid.
The whole hepatic blood flow (A) was markedly decreased in patients with liver cirrhosis and correlated with ICG R15 and KICG. V (whole liver volume)×A was correlated with serum cholinesterase.
As A and V were inaccurate for patients with the solitary disease in the liver, the lateral segment blood flow (AL) and the lateral segment volume (VL) were measured. The patients with preoperative low level of AL×VL tended to have liver failure after operation.
Therefore, AL×VL was useful for the estimation of the functional reserve of the liver.View full abstractDownload PDF (624K) -
Norio HAYASHI, Akinori KASAHARA, Mitsunori SAITO, Yutaka SASAKI, Haruy ...1984 Volume 81 Issue 2 Pages 208-212
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe investigated the hepatic hemodynamics in cirrhotics with or without esophageal varices by reflectance spectrophotometry during peritoneoscopy. The regional hepatic blood volume (ΔEr569-650), the saturation level of hemoglobin in regional liver blood (SO2) and the in vivo oxygen consumption in regional liver (VO2) decreased significantly in cirrhotis with varices as compared to cirrhotics without varices. ΔEr569-650 was significantly correlated with SO2 and VO2. Also, the serum albumin level decreased in cirrhotics with varices.
It is concluded that the liver blood flow decreases due to esophageal verices in cirrhosis, and this decrease is concomitant with a decrease in hepatic oxygen consumption, which is not compensated by an increased hepatic oxygen extraction.View full abstractDownload PDF (614K) -
Yasuhiro MIZOGUCHI, Hiroko SAWAI, Hiroko TSUTSUI, Yoshiharu MIYAJIMA, ...1984 Volume 81 Issue 2 Pages 213-220
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe production of cholestatic factor from the activated mononuclear cells prepared from peripheral blood of patients with drug-induced allergic hepatitis was augmented by interleukin-2. In these experiments, the mononuclear cells from patients were cultured with the causative drug and a carrier in the presence of interleukin-2 and the culture supernatants were separated. When these culture fluid were injected into the mesenteric vein of rat, a marked reduction in bile flow was demonstrated. The in vitro production of cholestatic factor from the activated lymphocytes seemed to be dissociated from lymphocyte blastogenesis, because the blocking of DNA synthesis in the activated lymphocytes by treatment with 5-bromo-2-deoxyuridin and light did not show effect on the production of cholestatic factor. Moreover, the long-termed maintenance of cholestatic factor producing cells were capable by culturing them with fresh medium including the offensive drug and carrier in the presence of interleukin-2.View full abstractDownload PDF (1095K) -
Yoshihiro IKEMOTO, Yasuhiro MIZOGUCHI, Hiroko SAWAI, Hiroko TSUTSUI, T ...1984 Volume 81 Issue 2 Pages 221-226
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSAntibody forming cells against TNP-SRBC were induced to a simillar extent when the peripheral blood mononuclear cells from normal, patients with chronic active hepatitis or asymptomatic HBV carriers were stimulated in vitro with pokeweed mitogen (PWM). Although these antibody responses were significantly augmented by adding the estrogen simultaneously with PWM to the mononuclear cells cultures prepared from normal or patients with chronic active hepatitis, no such augmentation of antibody response by estrogen were demonstrable in asymptomatic carriers. The DNA synthesis in PWM-stimulated mononuclear cells was also increased by estrogen in normal or patients with chronic active hepatitis, but this was not the case in asymptomatic carriers.
These observations suggest that a factor (or factors) may correlate with the induction of asymptomatic carrier state such as a unresponsiveness to the estrogen at least partially.View full abstractDownload PDF (714K) -
Hideko KAWAI, Takao KOJIMA, Takashi KANO, Yasutoshi MUTO1984 Volume 81 Issue 2 Pages 227-237
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSResponses of plasma c-AMP to exogenous glucagon were studied in sixty nine jaundiced patients with hepatobiliary disorders. The present study was undertaken to investigate whether or not this response to glucagon differs in patients with intrahepatic cholestasis (IHC), obstructive jaundice (OJ) and parenchymatous liver diseases.
All patients with IHC showed high responses of plasma c-AMP, compared with those of the normal controls, irrespective of the serum concentrations of total bilirubin and hepaplastin test. On the other hand, in patients with OJ, heterogeneous responses of plasma c-AMP were obtained. These heterogeneous responses of plasma c-AMP in patients with OJ may be due to the serum total bilirubin levels and durations of jaundice. High or normal responses were found in patients with OJ due to stones or showing the serum total bilirubin under 20mg/dl in accordance with those of other reports. However, marked reductions of plasma c-AMP responses were observed in deeply jaundiced patients with OJ, showing more than 20mg/dl of total bilirubin. The patients with decompensated liver cirrhosis and fulminant hepatitis showed extremely lower or no responses.
Thus, plasma c-AMP responses proved to be useful in differentiating IHC from OJ with deep jaundice and severe parenchymatous liver diseases. These differences were highly significant.
In patients with OJ, high responded group showed good decreasing rate of bilirubin after percutaneous transhepatic biliary drainage and better prognosis. On the other hand, low responded group showed little or no decreasing rate of serum bilirubin and prognosis was extremely poor. In addition, significant correlation between the responses of c-AMP and bilirubin decreasing rate (b) was observed.
These results suggest that the response of plasma c-AMP to glucagon is of practical importance for differential diagnosis of jaundice as well as for evaluation of decreasing rate of bilirubin and prognosis in patients with OJ.View full abstractDownload PDF (1463K) -
Shigeyuki TAKAMORI, Takao MOTONAGA, Masuyuki INUI, Tadaaki MIYAZAKI, T ...1984 Volume 81 Issue 2 Pages 238-248
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSNicotinic acid (NA) loading test was performed in 10 patients with Gilbert's syndrome (G syndrome), 13 compensated liver cirrhosis, 2 posthepatitic hyperbilirubinemia, 2 cholestatic hepatitis, one Dubin-Johnson syndrome and 8 normal subjects. In G syndrome, the increment of serum indirect bilirubin in 120 min. after the intravenous NA loading was more than 1.0mg/dl and it was less than 0.6mg/dl in normal subjects. These figures were significant differences between them. In G syndrome, there was a positive correlation between the increment of serum indirect bilirubin 120 min. after NA loading and that in low caloric diet test. A positive correlation between the increments of serum indirect bilirubin and of serum iron after NA loading was also noted in G syndrome. The increment of serum indirect bilirubin afte NA loading in cirrhotic patients with splenomegaly was significantly higher than that in splenectomized patients with cirrhosis in whom there was little increment of serum indirect bilirubin.
From these results, NA loading test was an useful test for the diognosis of G syndrome. It was suggested that the increment of serum indirect bilirubin after NA loading might be related to hemolysis induced by activated reticuloendothelial system, especially in the spleen.View full abstractDownload PDF (1257K) -
Kenji IKEDA, Eiji OYAKE, Hiromitsu KUMADA, Kazuo TAKEUCHI, Masao NAKAJ ...1984 Volume 81 Issue 2 Pages 249-253
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSWe treated fifty patients with hepatocellular carcinoma by transcatheter arterial embolization (TAE) for these three years.
Six-months survival rate of these patients was 84.6 percent (33/39), and one-year survival rate 70.4 percent (19/27). As to eighteen decompensated cases with ascites and/or encephalopathy, six-months survival rate was 75.0 percent (12/16), and one-year survival rate 60.0 percent (6/10).
Effectiveness of TAE for each patient was classified into five degrees by image of CT scan with contrast enhancement (CE)."Excellent effectiveness"means complete necrosis of the tumor with negative CE by CT scan image, and"ordinary effectiveness"means partial necrosis of the tumor with positive CE. If positive CE was found in the cancer after TAE therapy, we made additional TAE therapy against the surviving tumor within three months. According to this criteria by CT scan after the therapy, when one course of TAE therapy was performed, "excellent effect"was found only 20 percent (10/50), and"ordinary effect"72 percent (36/50). But when additional TAE therapy was performed for patients with CE-positive tumor, "excellent effect"was achieved in 46 percent of the cases. Thus repeated TAE therapy is necessary to achieve more complete necrosis of the tumor.
In order to make better treatment for hepatocellular carcinoma and to attain higher survival rate, intensive medical care for liver cirrhosis is essential, and repeated TAE therapy should be emphasized.View full abstractDownload PDF (621K) -
II. Roentgenological Follow-up Study in Canine Experimental Pancreatic StonesAiji NODA, Tokimune SHIBATA, Tetsuo HAYAKAWA, Takaharu KONDO, Kenji NA ...1984 Volume 81 Issue 2 Pages 254-262
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThis paper is a sequel to our previous report concerning pancreatic stones dissolution with Dimethadione (DMO). The effect of DMO on the stones dissolution was studied roentgenologically in dogs prepared with both gastric fistula and complete obstruction of the greater pancreatic duct, setting markers of a stainless steel wire around the pancreatoduodenal junctions. Abdominal plain films were taken once a month from three months after the operation.
Pancreatic calcifications were observed in 50% of the dogs (9 of 18). Trimethadione (TMD), the precursor of DMO, was given orally at a dose of 1000 to 1500mg/day to seven dogs presented with pancreatic calcifications. In all but one dog the calcifications disappeared completely or partially in 1 to 10 months after the administration of TMD. In one of two dogs in which the calcifications disappeared completely within two months, the calcifications reappeared two months after the cessation of the dose and again disappeared completely three months after the readministration of TMD. In another dog the calcifications reappeared seven months after the cessation of the dose. Without any treatment of TMD the calcification was gradually increased in its size and number in one dog.
The present results suggest that TMD, as a precursor of DMO, can become one of the promising agents for the oral dissolution of pancreatic stones.View full abstractDownload PDF (2918K) -
Yasuni NAKANUMA, Goroku OHTA, Noriaki SAKATA, Hiroshi SAKUMA, Toshihis ...1984 Volume 81 Issue 2 Pages 263-266
Published: 1984
Released on J-STAGE: December 26, 2007
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Y. SUMINO, K. KIKUCHI, K. HOSAKA, K. FURUKAWA, H. NUKADA, Y. FUKUSHIMA ...1984 Volume 81 Issue 2 Pages 267-271
Published: 1984
Released on J-STAGE: December 26, 2007
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Tomoyoshi KAMIYA, Masahiro KIZAKI, Yasufumi AKAIWA, Takashi MASUDA, Os ...1984 Volume 81 Issue 2 Pages 272-276
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (1169K) -
O. KOBORI, [in Japanese], [in Japanese], O. Wiestler, P. Kleihues1984 Volume 81 Issue 2 Pages 277
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (157K) -
Takehide ASANO, [in Japanese], [in Japanese], [in Japanese], [in Japan ...1984 Volume 81 Issue 2 Pages 278
Published: 1984
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSDownload PDF (149K)
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