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Volume 78, Issue 6
Displaying 1-23 of 23 articles from this issue
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A Clinical and Experimental Study on the Natural History of Gastric UlcerTakeshi OOHARA, Toku OZAKI, Hiroyuki TOHMA, Giichi AONO, Shiro UKAWA1981 Volume 78 Issue 6 Pages 1177-1184
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe reason of alteration of acute gastric lesion into chronic gastric ulcer or the process of development of chronic gastric ulcer is still unknown. In order to solve this problem we performed follow-up studies of acute gastric lesions using endoscopes in clinical cases. We also attempted to observe the natural history of chronic gastric ulcers, experimentally produced in rats by two methods designed by us for this prupose.
The clinical material consisted of a total of 397 gastric lesions, including hemorrhagic erosions, trench ulcers, acute kissing ulcers in the antrum, which were followed for 3 to 19 months. The lesions were located near the cardia in 17 cases (4.3%), at the body in 123 (31.0%), at the angulus in 77 (19.4%), and at the antrum in 180 (45.3%). Most of the acute gastric lesions showed rapid healing without changing into chronic open ulcer, but some lesions at the fundopyloric border (FP-border) exhibited delayed healing or recurred though rarely.
In the Experiment I gastric mucosal defects were formed in rats in various locations, sizes and depths. It was then found that no erosions changed into chronic ulcer. On the other hand, all Ul-II over 7×7mm in size at the FP-border were found to become chronic gastric ulcers up to 540 days. In the Experiment II, the entire gastric mucosa was destructed by application of caustic soda. In its healing process, multiple or linear ulcers were formed only at the FP-border.
In conclusion, alteration of acute gastric lesions into chronic ulcer seems to require certain circumstances as follows;(1) the size over certain degree, (2) the depth over Ul-II and (3) the localizationn at the FP-border.View full abstractDownload PDF (7959K) -
Seiichi ISONO, Tetsutaro TAKEDA, Hitoshi AMAKASU, Hiroshi ASAKAWA, Sho ...1981 Volume 78 Issue 6 Pages 1185-1190
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe smears of the biopsy and resected specimens obtained from 74 cases of irradiated gastric cancer were cytologically analyzed for effects of irradiation. Irradiation increased the amount of both necrotic materials and neutrophils in the smears. Cancer cells were decreased in number almost in inverse proportion to irradiation dose. Clusters of cancer cells shrank in size and cells were less stratified after irradiation. Irradiated cytoplasms were swollen, vacuolated and stained abnormally. Irradiation with less than 3, 000 rads gave rise to swelling of cytoplasms in almost all cases. Nuclei became enlarged, multiple, pyknotic and/or stained pale after irradiation. Nuclear swelling was more remarkable in cancer cells of differentiated adenocarcinomas.View full abstractDownload PDF (5355K) -
Miyako BABA, Masaharu TATSUTA, Shigeru OKUDA, Hiroshi TAMURA, Tadao IT ...1981 Volume 78 Issue 6 Pages 1191-1197
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSA high performance liquid-chromatographic method was developed in our clinic for measuring picogram amounts of catecholamines, adrenaline and noradrenaline, in plasma, gastric juice and gastric tissues. By this method, adrenaline and noradrenaline were measured in gastric juice and gastric tissues to investigate the effects of gastrin on catecholamines in gastric juice and gastric tissues during gastrin-stimulated gastric acid secretion.
After subcutaneous administration of 0.75 mg/kg of tetragastrin in rats, noradrenaline secretion into gastric juice for 4hours was decreased by 42%, and noradrenaline concentration of body part of the glandular stomach was also decreased by 29%. The differences from values at the basal state were statistically significant (both p<0.05). On the contrary, tetragastrin had no effects on adrenaline secretion into gastric juice. Since noradrenaline is highly localized in peripheral sympathetic nerves, our results indicated that tetragastrin had some influence on sympathetic nerves during tetragastrin-stimulated gastric acid secretion.View full abstractDownload PDF (5744K) -
Changes in Antral Mucosal Gastrin Content in the Course of Peptic UlcerNaoyuki YAMADA, Hiromitsu KUMADA, Sotaro FUKUCHI, Masaki YANAGISHITA, ...1981 Volume 78 Issue 6 Pages 1198-1208
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSTo investigate pathophysiological roles of gastrin in the process of peptic ulcer disease, we measured immunoreactive gastrin (IRG) content and the number of G-cells in endoscopically biopsied gastric antral mucosa of peptic ulcer patients together with fasting serum IRG concentration. Patients were classified into three groups depending on the location of ulcers, i. e. duodenal ulcer, gastric ulcer (angle) and gastric ulcer (body), each group was further subdivided by the stage of the disease, i. e. the acute and the healing stage.
In the acute stage of the ulcers, antral mucosal IRG content was in the order, duodenal ulcer> gastric ulcer (angle) > gastric ulcer (boy). There was no significant difference in the number of G-cells between these three groups. In both duodenal ulcer and gastric ulcer (angle) patient groups, the antral mucosal IRG content was significantly higher in the acute stage than in the healing stage for each patient and showed positive correation with fasting serum IRG concentration in the acute stage of the disease. However, no such correlation was observed in gastric ulcer (body).
These findings suggest the presence of hyperactivity of G-cells in the acute stage of duodenal ulcer and gastric ulcer (angle).View full abstractDownload PDF (8627K) -
Richiko OTANI, Toshikazu OKOCHI, Kazuya HIGASHINO, Fumio ITO1981 Volume 78 Issue 6 Pages 1209-1215
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe alkaline phosphatase (AP) isoenzyme from colonic carcinoma of the highly inbred Wistar-Furth (W-F) strain rat (carcinoma AP) was compared with AP from colonic mucosa of the same strain rat without colonic carcinoma (non-carcinoma AP), and also AP from normal rat colon of Wistar strain (normal AP) from which WF strain is derived.
The sepcific activity of carcinoma AP was ten-fold higher than that of normal AP, whereas that of non-carcinoma AP was almost the same as that of normal AP.
On polyacrylamide gel electrophoresis, carcinoma AP migrated as a slow-moving band, which was retarded by the treatment with neuraminidase.
Non-carcinoma AP and normal AP electrophoresed in three bands and two bands, respectively. Their electrophoretic mobilities were not affected by the treatment with neuraminidase. No significant differences between non-carcinoma AP and normal AP were found in other enzymatic properties. However, carcinoma AP was found to be completely different from APs of the other two sources.View full abstractDownload PDF (1071K) -
Yushiro WATANABE1981 Volume 78 Issue 6 Pages 1216-1225
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe mechanism of the thrombocytopenia in patients with hepatic cirrhosis was inve-tigated. In patients with hepatic cirrhosis, the platelet production in the bone marrow was depressed and platelet life span was shortened, which may be due to the decrease of sialoglycoprotein of the platelet plasma membrane, whereby thrombocytophagia is promoted in the reticuloendothelial system.
The platelets from patients with hepatic cirrhosis strongly resemble to those from the patients with Bernard-Soulier syndrome from both functional and biochemical standpoints, namely in the facts of the reduced ADP and ristocetin induced platelet aggregation, decreased sialic acid, surface protein and glycoprotein of the platelets.View full abstractDownload PDF (7859K) -
Mamoru KOBAYASHI, Hiroshi SHIMADA, Fumihiko KITO, Tetsuo ABE, Koichiro ...1981 Volume 78 Issue 6 Pages 1226-1231
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSIntravenous glucose tolerance test (IV-GTT) was studied in 20 patients with obstructive jaundice and 15 normal subjects as control. Glucagon test was studied in 15 patients with obstructive jaundice and 13 normal subjects as control.
The obstructive jaundice group had no initial insulin rise after glucose stimulation but moderate initial insulin rise after glucagon stimulation. It is considered that the insulin secretion mechanism with glucose stimulation is different from that with glucagon stimulation.
Experimentally, the changes of insulin level in portal- and peripheral-vein, and its hepatic extraction were studied in jaundiced dogs, which were made by ligation of the common bile duct 2 weeks before the study. IV-GTT and glucagon test were pei formed in 5 jaundiced dogs and 5 normal dogs as control respectively.
After glucose stimulation, the jaundiced group had no initial insulin rise in peripheral and portal vein. But after glucagon stimulation, the jaundiced group had higher initial insulin rise in portal vein and lower initial insulin rise in peripheral vein than the control group. Accordingly, there is accelerated hepatic extraction of insulin on glucagon stimulation in obstructive jaundice.View full abstractDownload PDF (4367K) -
Part I. Effect of Bile Acid on Endotoxin Masataka IWASAKIMasataka IWASAKI1981 Volume 78 Issue 6 Pages 1232-1240
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSBiological properties of endotoxin treated with various bile acids were investigated in this study. The Limulus Amoebocyte Lysate Test (Limulus Test) was performed after mixing the endotoxin solution (0111 B 4, Difco Co., ) with each of the following agents; human bile, direct and indirect bilirubin, and 6 different kinds of bile acids (Deoxycholic acid, Chenodeoxycholic acid, Glycochenodeoxycholic acid, Taurochenodeoxycholic acid, Taurocholic acid, Taurolithocholic acid).
The human bile inhibited the Pregel coagulation in Limulus Test, but direct and indirect bilirubin did not inhibit it. One percent solution of each of the six bile acids completely inhibited the Pregel coagulation. Further, Deoxycholic acid, the strongest inhibiting agent, required dilution to 1×10-6% before losing its ability to inhibit the reaction. Our studies revealed similar blood coagulation factors in both the human and Limulus poliphemus.
The results of this study suggest that the inhibitory effect of bile acid on the reaction between endotoxin and Pregel is due to the detergent effect of bile acid, possibly by either dissociating endotoxin into nontoxic subunits, or distributing endotoxin into micellar aggregates.View full abstractDownload PDF (7622K) -
AND DIFEERENTIAL DIAGNOSIS OF CHOLELIASISHisao SHIBATA, Nobuo YAMADA, Atsushi KIYOHASHI, Kenichi ODAGIRI, Katsu ...1981 Volume 78 Issue 6 Pages 1241-1247
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSSerum immunoreactive cholylglycine (CG) and sulfolithocholylglycine (SLOG) were measured and their ratio (C/S) was calculated to differentiate cholelithiasis from other hepatobiliary disorders. Low CG, high SLCG and low C/S ratio were observed in cholelithiasis without rentogenologically proven calcification. These values were CG 33.2±28.2tg/dl, SLCG 114.7±66.6μg/dl and the C/S ratio 0.32±0.32. These changes were not detected in cholelithiasis with rentogenologically proven calcification.
Loading of UDCA for two weeks produced a marked increase of SLCG in cholelithiasis without rentogenologically proven calcification, while in cholelithiasis with rentogenologically proven calcification there were no changes in the conjugated bile acids.
These results indicated that the measurement of CG and SLOG is important in the detection of gallstones and their differentiation from other hepatobiliary disorders. Moreover it is felt that these tests could be very important in separation of UDCA sensitive cases from UDCA resistent cases.View full abstractDownload PDF (5777K) -
II. The Effect of Gallstones and related Diseases on the Motor Function of the Biliary SystemMasayoshi URAOKA1981 Volume 78 Issue 6 Pages 1248-1257
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSCholescintigraphy was performed on 89 subjects with gallstones and related diseases and 12 normal subjects as controls, using 99mTc(p-Butyl)IDA. Analytical studies were done on the influence of gallstones on the motor function of biliary system. The results were as follows.
1) Gallstones remarkably influenced the motor function of not only the gallbladder but also the distal common bile duct, and especially influenced the contraction of the gallbladder.
2) Both the gallbladder and the Oddi sphincter gained tonus with the expansion of stones in cholecystolithiasis.
3) It was found that stenosis of distal common bile ducts was positively correlated to both expansion of stones and duration time of pains from common bile duct stones.
4) Cholecystitis resulted in poor contraction of the gallbladder and increasing resistance to the bile flow by the distal common bile duct in acute stages.
5) There existed a proportional relation between the tonus of the gallbladder and that of the Oddi's sphincter in patients with gallstones and related diseases.View full abstractDownload PDF (8565K) -
Takao AIZAWA1981 Volume 78 Issue 6 Pages 1258-1267
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSHLA-A, B and C antigens in 46 patients with chronic pancreatitis were studied. Patients were divided into the following two groups; one was chronic alcoholic pancreatitis (28 patients) and the other was chronic idiopathic pancreatitis (18 patients). One handred and twenty unrelated healthy controls were also examined.
Fourteen of 18 patients with chronic idiopathic pancreatitis were found to have HLA-B 5 compared to 41 of 120 controls. This was statistically significant (x2=10.666, P<0.002, corrected P<0.05).
Recently HLA-B5 was splited into the two antigens; one was HLA-BW51 and the other was HLA-BW52. These antigens were typed in 14 patients with chronic idiopathic pancreatitis and 70 healthy controls. HLA-BW51 was recongnized in 50% of the patients with chronic idiopathic pancreatitis whereas only 14.3% of controls had this antigen which was statistically significant (x2=10.788, P<0.002, corrected P<0.05).
No HLA antigens of locus A, B and C were found which had a close correlation with chronic alcoholic pancreatitis. However six of 7 patients with the onset of the disease in 40 years of age or older but no pancreatic calcification were found to have HLA-B7. This frequency was significantly increased (x2=13.061, P<0.001, corrected P<0.05).
These results suggest that some genetic factors associated with HLA-BW51 may contribute to the development of chronic idiopathic pancreatitis. And also the presense of HLA-B7 may be one of the contributing factors for the progression of some type of chronic alcoholic pancreatitis.View full abstractDownload PDF (9049K) -
I. Ribonuclease Assay, Effect of Storing Samles and Isolation of the Ribonucleases in Pure Pancreatic juiceKozo KAWAI1981 Volume 78 Issue 6 Pages 1268-1274
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe assay method of ribonuclease (RNase) activity in duodenal juice after ancreozyminsecretin test and the effect of storing samles were studied. Furthermore, the RNase in ure ancreatic juice was searated on hoshocellulose column chromatograhy.
The otimal H of the incubation medium for determination of RNase activity in the duodenal juice, when poly C or poly U was used as the substrate, was 6.0 and 5.5 resectively. RNase activity in the duodenal juice was comletely lost when ket at 80°C for more than half an hour or at room temerature for more than a day. The enzyme was reduced to 78% after 3 months, even if it was ket at -20°C. Whereas, 100% of the activity was reserved at least for 3 months, when arotinin was added to the samle and it was ket at -20°C. Therefore the samle should be ket at -70°C and assayed in a week.
By searation of roteins in the ure ancreatic juice on hoshocellulose chromatograhy, three eaks of RNase activity were observed and all of these RNases exhibited a higher reference to poly C than poly U. Poly A or oly G were not hydrolysed by these fractions. By this method, RNase in the ancreatic juice was searated from immunoreactive trysin.View full abstractDownload PDF (2700K) -
Kinichiro SUWAKI1981 Volume 78 Issue 6 Pages 1275-1281
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe SC and Igs were measured by radioimmunoassay (double antibody method) and single radial immunodiffusion method, respectively.
The sample of human bile and pancreatic juice were stored at -70°C just before used.
The SC and Igs measured every week were quite stable for 10 weeks. However, their values were unexpectedly low when either of three kinds protease inhibitors were added to the samples to protect them from digestion by the trypsin and other proteases.
The association between SC and Igs was analyzed by micro-Ouchterlony method and a column chromatography on Sephadex G-200. It was found that the major part of SC in normal human bile and pancreatic juice was bound to IgA dimer (sIgA). Free SC and secretory IgM were not detected in these materials.View full abstractDownload PDF (1448K) -
Vascular Architecture and its Relation to Langerhans Islets and LobulesNobuhisa YAGINUMA, Tohru TAKAHASHI, Ken SAITO, Masahisa KYOGOKU1981 Volume 78 Issue 6 Pages 1282-1292
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
JOURNAL FREE ACCESSThe 3D relation between the lobules, terminal blood vessels and Langerhans islets of human pancreas was established by graphic reconstruction from serial histologic sections. The material included 3 pancreases obtained at autopsy. It was found that the lobule is an assembly of sublobular parenchymal units which have a terminal arteriole at the center. These, being considered to be an elemental structure of microcirculation, werenamed the 'primary lobule' of the pancreas. This concept was also supported by the 3D analysis of a pancreas'pseudolobulated' due to chronic venous congestion, in which 'primary lobules' were clearly demarcated by atrophic zones distributed along the periphery of circulation. Four types of terminal arterioles were discriminated: 1) those terminating at an islet, 2) those having no relation with islet, 3) those with isletsdispersed near the ending and 4) those coming directly from an interlobular artery. More than half the endings were found to belong to either Type 2 or 3, which was quite different from the traditional assumption of complete arterio-insular correlation.Consequently, islets could also be classified according to whether or not having an afferent arteriole, namely, into' arterial' and' non-arterial' islets. The 'arterial'islets amounted to 75% in the total islet volume, although in isletnumber, the ' non-arterial' ones accounted for as much as 72.5%. Thus, at least in man, functional correlation between islets and exocrine gland is not so tight as claimed by the insulo-acinar axis theory.View full abstractDownload PDF (11366K) -
Naoki YAMANAKA, Eizo OKAMOTO, Keiji KUWATA, Akihiro TOYOSAKA, Shuichi ...1981 Volume 78 Issue 6 Pages 1293-1297
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1981 Volume 78 Issue 6 Pages 1298-1302
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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Hidenobu MIYAKAWA, Jinichi KAMEYAMA, Iwao SASAKI, Mikio IMAMURA, Masar ...1981 Volume 78 Issue 6 Pages 1303-1306
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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K. HIRAMATSU, [in Japanese], [in Japanese], [in Japanese]1981 Volume 78 Issue 6 Pages 1307
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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Tatsuo TOZAWA, [in Japanese], [in Japanese]1981 Volume 78 Issue 6 Pages 1308
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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Yasuni NAKANUMA, [in Japanese], [in Japanese], [in Japanese]1981 Volume 78 Issue 6 Pages 1309
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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Hideki YABE, [in Japanese], [in Japanese], [in Japanese], [in Japanese ...1981 Volume 78 Issue 6 Pages 1310
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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Yoshitane KOSAKA, [in Japanese], [in Japanese], [in Japanese], [in Jap ...1981 Volume 78 Issue 6 Pages 1311
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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Takuji NISHISATO, [in Japanese], [in Japanese], [in Japanese], [in Jap ...1981 Volume 78 Issue 6 Pages 1312
Published: June 05, 1981
Released on J-STAGE: December 26, 2007
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