The author reported previously on the effects of acid and base-foming diets on calcium metabolism.
This paper presents the observation on calcium metabolism in acid-base imbalance induced by oral administration of two agents, acetazolamide and sodium bicarbonate. The balance study was performed for 3 weeks, using 9 adult men as experimental subjects. The results are summarized as follows:
1) The supplement of basal diet with acetazolamide, 250 mg/day, resulted in slight metabolic acidosis. while the supplement with sodium bicarbonate, 12 mg/day, in slight metabolic alkalosis.
2) Intake of Ca was maintained at the almost same levels throughout the experiment, 721 mg/day during control period, 716 mg/day during acetazolamide-period, and 724 mg/day in Sodium bicarbonate period.
3) Absorption of Ca from intestine was significantly impaired during acetazolamideperiod, 47%, comparing during control period, 60%. Absorption during sod. bicarb-period, 52%, was better than during acetazolamide-period but less than during control period.
4) Urinary excretions of Ca were 192 mg/day in control period, 232 mg/day on acetazolamide-period, and 180 mg/day in sod. bicarb. period. The ratios of urinary excretion to absorption were respectively 45%, 69%, and 47%, indicating that calcium was most readily excreted in acetazolamide-period.
5) Retentions of Ca were of the same degree during control period, 238 mg/day, and sod. bicarb.-period, 200 mg/day, but reduced to the great extent during acetazolamide-period 104 mg/day, due to decreased absorption and increased urinary excretion.
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