I would like to report on the statistical observation of major zoonoses in the rural districts of our country. The agricultural management of Japan is on a small scale, especially that of livestock.Recently domestic animals have been slightly on the increase (see Table 7). Of late, livestock hygiene centres have increased (from 107 in 1948 to 532 in 1965), which are equipped with modern facilities.The number of investigations have also increased.For these reasons, our investigation of zoonoses will become more modernized hereafter. Salmonellosis and Encephalitis are not so closely linked with agriculture, but it is true that these diseases mainly break out in rural districts. Preventive measures must be taken from the point of view of rural medicine.