Overall mass health survey has been conducted on the I district of Shizuoka Prefecture (a mountain village). The results of gynecological and medical examinations in 91 housewives who never missed their yearly examinations during the past 10 years were analyzed individually and as a group to assess the level of health. The following results were obatained. 1) Results of examinations expressing the level of health of individuals during the past 10 years period were analyzed as to the average (mean±S.D.) and variationcoefficient. Abnormally high mean values and a high variation coefficient probably indicate unhealthy subjects. 2) During the past 10 year period, no abnormalities, especially chronic diseases, were noted in any of the subjects in the 40s. Thefe were 3 in the 50s with chronic disease and 2 in the 60s. As to internal diseases, 7 of the subjects in the 40s, 11 of those in the 50s and 4 of those in the 60s were free of the diseases. 5 of the subjects in the 40s, 13 of those in the 50s and 14 of those in the 60s were free of gynecological diseases. 3) In the gynecological survey, a distinct difference was noted betwwen subjects in their 40s and those in the 50s as to their physiological condition, pregnancy and delivery. In mountain villages where facilities for gynecological examinations are inadequate, many women had undergone sterilizing operations and one man also had such an operation. 4) Gynecological examinations revealed many patients with inflammation of the cervical canal. No uterine cancer was detected in this group. 5) Among the internal diseases, hypertension was found most frequently, followed by heart diseases. No gastric cancer was detected. Anemia was found to be intimately related to gynecological diseases. 6) Obesity was found in 18% of the housewives and transition to obesity was frequently found in the 40s.
In the previous report, we concluded that chances are very slim for Salithion and Sumithion to concentrate in rabbits as these organophosphorous compounds are excreted quickly. This conclusion was inferentially drawn from the results of measurements of concentration of Salithion and Sumithion residues in the blood after experimental exposures of rabbits to the pesticides. In the present report, we will discuss the same toxicological problem based on our findings in a series of experiments using rabbits with hepatic disturbances induced by carbon tetrachloride (CCl4). Rabbits were divided into three groups. One consists of rabbits having light hepatic disorder. They were subcutaneously injected with 0.1ml/kg of 20% CCl4 olive oil for three days consecutively. Under the second group come rabbits with moderate liver disturbance caused by the injection of 0.3 ml/kg of 20% CCl4 olive oil. The injection was also made for three days. The remaining group is the control group. These rabbits were administered orally with 5mg/kg and 20mg/kg of Smithion for three days running. The examination covered (1) Sumithion residue level in the blood, (2) PNMC level in urine, (3) hepatic function (ChE, GOT, GPT, BSP, Al-P, BUN), (4) urinalysis and (5) histopathological examination of the liver and the kidney. The results of these tests were studied in comparison with those of the control group. The following is a summary of our conclusion: 1) In the control group, Sumithion residues in the blood disappeared quickly, and could not be detected 72 hours after administration. 2) As far as the disappearance of Sumithion and the excretion of PNMC are concerned, there was no significant difference between the control and the light and moderate liver disturbance groups of rabbits. 3) In the rabbits with CCl4-induced liver disturbances, it was noted that the administration of Sumithion impeded serum and red-cell ChE activities to a remarkable extent, and delayed the recovery of the liver function. 4) However, the liver disturbance did not deteriorate. The histological observation of the liver and the kidney did not reveal any abnormality due to the administration of Sumithion, either.