A study was performed on the liver functions of persons using alkylphosphates as agricultural chemicals to cultivate apples in the rural sections of Aomori Prefecture.The results obtained can be summarized as follows.
1) GOT-test was one sharp reaction of many liverfunction tests, being carried out after using alkylphosphates. But, a extremly high value of GOT was not found and its value returned to the normal level gradually after ending these works.
2) From the investigation of GOT-value and various conditions during using alkylphosphates, the relationship of GOT and the length of time or period for using them was not found clearly in this study.
3) ChE is a ferment against alkylphosphates and one special reaction of liverfunction test also, but the results of ChE-test was not refered in this paper. When we think of ChE-test as a liverfunction, ChE-value of some persons having the low value of ChE do not return to the normal level as shown in (I) report.
4) From the long term observation on GOT-test, a high value was seen clearly about one month after using of alkylphosphates, specially scattering of them.
5) The abnormal values of TTT, ZTT and CCLF of liverfunctions were not found in acut intoxications of alkylphosphates.
6) From the urine urobilinogen-test. the positive cases were present to some degree, but the relationship of the urine urobilinogen-test and GOT was not seen in all cases.
7) From the finding of the liverfunction-tests after the long term observation, it is quite possible that the liverfunctionslesion will advance after the repeating using of alkylphosphates, scattering or mixing of them every year. Because, the farmers, living in Aomori prefecture, used them to culivate apples since about fifteen years.
8) So I think of, may be in future. being found some persons having the liverfunctions-lesion with the another findings or symptomes. These persons may be diagnosed as the so called chronic intoxication caused by alkylphcsphates after some yedrs.
9) As he shown in next paper. a being of the chronic intoxication caused by alkylphosphates is doutful now, but some persons having the liverfunctions-lesion and the another findings are found in the rural sections of Aomori Prefecture.
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