Parsitological surveys were conducted to study the recent trend of hookworm infection in remote rural areas of Miyazaki Prefecture, south Japan. Kate's thich smear and test-tube filter paper culture techniques were performed on 837 fecal samples collected from four villages. Prevalence rate of hookworm infection was 13.0% average and that of other intestinal helminths was less than 2.0%. In these districts Ancylostoma duodenale was predominant and species ratio with Necator americanus was 81: 27. Mixed infecttion was few as compared with past record. Prevalence rate and age distribution of N. americanus infection showed a considerable difference between sexes and especially the infection rate was higher in women than man, also the carriers ratio with man was 8: 1. As to the geographical distribution of both species in a village there was a certain tendency of single species infection in a unit of small community. However, prevalence of hookworm infection in these communities showed a considerable distinction with one another.
The degree of obesity, serum lipids (total cholesterol, HDL cholesterol, triglyceride) and serum uric acid, which are regarded as the risk factor of the atherosclerosis were measured among the farmers living in the three different areas in chiba prefecture, which are Abiko (A), Kamagaya (B), and Funabashi (C), respectively. The difference of these data between three areas were examined. The results are summarised as follows; 1) The degree of obesity increased with aging in both sexes. Triglyceride (TG), total cholesterol (TC), and atherogenic index (AI) increased with aging in female alone. 2) The mean values of TC in A and C areas were significantly higher than that in B area. 3) The degree of obesity, the mean value of TC in C area were higher than those in other ones. 4) Significant correlation was observed between TG and other atherogenic risk factors such as the degree of obesity, TC, HDL-C, AI and uric acid (UA). 5) The incidence of abnormal values of atherogenic risk factors in male was higher than that in female. 6) The incidence of anemia in B and C areas was relating low. 7) We emphasized that the survey of the risk factors of adult diseases became more neccessary to maintain the healthy life among the farmers living in urban districts.
We have established NICU (Neonatal Intensive Care Unit) in our hospital and have made efforts to improve the contents of medical treatment since 1976 in order to establish a regionalization of neonatal medical treatment. Thus are main items of the improvement: 1. Completed the apparatuses and equipments needed in Intensive Care. 2. Promoted the communication with regional facilities of delivery so as to enable immature or stressed mature babies to be transported to our hospital at all hours. 3. Made Pediatrician attend all the deliveries with high risk factors and treat the asphyxiated newborn right after the delivery. We have recorded the results of comparison of the death rate of immature babies at different birth weight treated in our hospital, and of the perinatal mortality in our Obstetric Department in the pie-improvement period of 5 years (1971-1975) and in the post-improvement period of 4 years (1976-1979) respectively. The results are as follows: 1. A comparison of the death rate of immature babies at different birth weight. In comparison of pre and post improvement, under 1, 000 g we haven't had enough cases to compare, besides most of the babies have died. However, at the weight between 1, 001-1, 500 g, the death rate has decreased from 39.4% down to 14.3%, at between 1, 501-2, 000g it has decreased from 11.4% down to 8.9%, and at between 2, 001-2, 500 g, from 6.9% to 1.1%. 2. A comparison of the perinatal mortality in our Obstetric Department. The perinatal mortality has decreased from 18.5% down to 11.8% when we compare pre and post improvement. This result of the decrease depends on the decrease of fetal death at delivery and baby's death in the early neonatal period. Items of the causes of early neonatal death reveals that the deaths of immature babies and asphyxiated mature babies have decreased significantly. From these results, we are fully realized the benefit of the regionalization of the neonatal medical treatment and I think we ought to promote such regionalization especially in rural area.
Based on previous anther's obsarbations of pseudocholinesterase (PCE) activity correlated with total cholesterol, fluctuation of this enzyme was epidemiologically studied in connection with changes of serum lipids on 225 sprayers of pesticides in citrut fruit area, and results are as follows; 1. PCE activity was slightly correlated with serum triglyceride (γ=0.277) and total cholesterol (γ=0.431) in females but not correlated in males. 2. PCE activity was significantly higher (P<0.05) in hyperlipemic subjects than normolipemic, and obviously higher (P<0.001) in hyperlipemic over weight subjects than hyperlipemic normal weight. 3. The enzyme activity was significantly higher (P<0.05) in hypertriglyceridemic subjects than in normolipemic, and highest (P<0.01) in subjects with hypertriglyceridemia and hypercholesteremia. 4. Serum triglyceride values in males and serum cholesterol values in females were obviously higher (P<0.05) in the high level group of PCE activity than in the low level group. 5. PCE activity was exhibited a tendency of elevation in hypertensive females than in normal blood pressure, and slightly correlated with systoric blood pressure (γ=0.286) and diastoric blood pressure (γ=0.358) in females. 6. PCE activity was found to be lower (P<0.05) in arterioslerotic subjects than nonsclerotic subjects with ocular funduscopic findings. These epidemiological findings suggested that PCE might play a role in lipid metabolism and reduction of this enzyme might cause disturbances of lipid metabolism.
A 30-year-old male with manic-depressive psychosis took in 30ml of undiluted Smithion to commit suicide. Ten hours or so later, he was found in state of subconsciousness and admitted into our hospital. 1. From the initial trance, he fell into a twilight state. After suffering from an amnestic syndrome and encountering difficulties in concentrating his attention, he was found in a depressive state on the 18th day. This depressive state was presumably a recurrence of the depression with which he had once suffered and therefore proved different from the depressive state unique to organophosphate poisoning. 2. In respect to the psychatric symptoms caused by acute and subacute organophosphate poisoning and its sequela, a study is made on the basis of literature to make some comment. 3. After a clinical course of two-and-a-half years, it was found that there were a slight degree of disturbance to registration and a drop in mental capacity. These were considered sequelas. These symptoms would not hamper his everyday life, but there were signs of a rise in the sense of quilty conscience and misery when he was in a depressive state. 4. EEG indicates that the waves were slowing and paroxismal or sporadic small spikes. Two years later, EEG-findings were slightly abnormal with many sporadic slow α waves. No abnormalities were observed in computerized tomogram.