As medical treatments of leprosy develop, the treatment of its residua becomes an important clinical problem. One of the most important residua of leprosy is leprotic motor paralysis. As for the muscle's motor paralysis, the authors conducted clinical observations on the cases in the Rakusenen leprosarium, and investigated the locality of disturbed innervating nerves.
1) By the statistical study of limb-muscles paralysis in 1, 029 cases, the occurrence was more frequent at the peripheral side than at the central side, and the same result at the extensor side than at flexor side. There were no difference in the frequency by right or left.
2) By observation of motor disturbance in wrists and ankle joints of 125 cases of various types of leprosy with paralysis of skin sensitivity in their limbs at more distal than the elbows and the knee joints, few joints motor invalids were found.
It seemed that there is little number of cases of paralysis due to disturbance of central part of spinal nerves, in the cases with joint lesions. By clinical observation of muscles innervated by median nerve, ulnar nerve and radial nerve, it was found that there were few cases in which every motor branches of nerves were throughout continuously paralysed to the last motor branch, and that the paralysis were generally in pieces, discontinuously.
The parts of the nerve, which result leprotic muscle's motor paralysis, are found generally at the periphery of the spinal nerve, and very few at its trunk. In other words, leprotic paralysis is mostly caused by the disturbance of distal part of peripheral nerve.

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According to the previous reports, hookworm larvae, which were inoculated percutaneously into white rat, will generally migrate into the muscles of the animal, where the larvae will live for considerably long period and gradually disappear by death. On the other hand, ennerally inoculated larvae will mostly migrate through the lung of the rat and then follow the same fate as in the above.
The present investigation was made to elucidate whether there is any difference in the rise or fall in the blood eosinophile cell counts by different courses of the inoculation of the larvae into white rats.
The results indicated that percentage of eosinophile cells was remarkably higher in the percutaneous inoculation than the enteral inoculation. The period, when the highest eosinophile cell counts measured in the percutaneous inoculation cases, was corresponding to the period when the larvae mostly died in the muscles of the animal. It was assumed that the eosinophilia observed by the experimental infection of ancylostoma larvae shall be due to some substances liberated by the disintegration of the larvae in the tissues of the animal.

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For two years, the author conducted the tests of urine by O. M. K, reaction method, that had been previously reported in the Part 1 of his reports. The urine for the test was mixed with immunized horses sera and they developed antigen-antibody reaction. Then the human erythrocytes sensitized with tuberculin were added to them and their agglutination was examined. If the agglutination was positive, it was tuberculin negative, on the contrary, if urine contained tuberculin, the agglutination was negative.
The tests were conducted on normal persons urines and that of the inpatients at our sanatorium.
The results revealed that the rate of positive reaction was different among severe, moderate and slight cases. The rate was high in open cases.
Positive results were also found in healthy men, however, the rate was very low.
Clinical significance of the positive reaction should be discussed with further data.

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Lloyd, Eccles, Granit and others have clarified many brilliant fundamental facts in the observation of the electrical potentials at anterior horn, by direct electric stimulation of peripheral nerve in animal. Meanwhile, Hoffmann tried observation of evoked electromyogram, especially its wave-form, of innervating muscle by indirect, per-cutaneous, electric stimulation of human nerve, however, few successful results have been reported except Magladery's, due to difficulties in apparatus. Magladery conducted since 1950 remarkable studies on the evoked EMG, especially on its H-wave, of spinal reflex nature, by per-cutaneous stimulation of human N. tibialis, and reported his results in 1955. The author conducted experiments in order to, in part, test the results by Magladery and others and also to obtain some data for the clinical application of the evoked EMG method, upon 7 normal adults and 32 patients, by per-cutaneous electric stimulation of peripheral nerve, N. tibiailis, and observed the evoked EMG, Magladery's direct M-wave and H-wave of spinal reflex nature. Results were as follows:
1) Relation between duration of spare wave stimulation voltage and M-, H-waves of evoked EMG: If the duration of the electrical stimulation was altered from 1 m. sec. to 300 m. sec., the threshold of stimulation decreased and the effect of stimulation increased as the duration was increased.
2) When the H-wave by cutaneous induction is taken as index, the evoked EMG, for instance of M. gastrocnemius, will be transmitted to remarkably wide region, from several cm. above knee-joint to the end of foot, . Therefore, in case of diagnosis of muscular paralysis, it should be kept in mind that the evoked EMG will physically transmitted beyond asumption to very wide region.
3) In 15 cases of peripheral nervous disorders, abnormal findings such as raised threshold, lower potentials of evoked EMG or disappearance of its waves, extended latency and abnormal forms of wave etc. were observed. Through these abnormal findings, it is possible to know the degrees of nervous lesion and the process of nervous regeneration. Incidentally, in 1 cases, EMG of “Wurmartige Kontraktion” in EaR (electrical reaction of degeneration) could be observed. It was also applied in the diagnosis of symptoms in mysthenia gravis.
4) In 17 cases of motor disorders of lower extremities due to deseases of spinal cord, more or less deformations of H-wave were observed and the deformation was quite distinct in case of tumor or syphilis of spinal cord. In 3 cases of amyotrophic lateral sclerosis, poliomyelitis and lumbago, in which synchronization voltage were seen in their EMG, distinctly magnified amplitude of H-wave was observed.
In conclusion, it seems that method of evoked EMG will contribute, in addition to the diagnosis of peripheral nervous disorders, to the diagnosis of the disorders of spinal reflex tracts, through the investigation of the H-wave.

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