Twelve patients with eosinophilic granuloma in the alimentary tract were treated in our surgical clinic, and in 6 cases of them larva of anisakis was identified.
In surgical clinic, anisakiasis in the stomach, so-called gastric anisakiasis, plays a respective role in differential diagnosis of the stomach disease.
Similary anisakiasis in the intestine, so-called intestinal anisakiasis, does not only import as one of acute abdomen but also indispensable in the research on the etiology of ileitis terminalis.
This paper will review the route of infection of anisakis larva to the human being, and make reference to the examination of several fishes and shells, the animal experiments of its implantation and prevention.

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We present a case of Pierre Robin syndrome with microcephaly and the result of our statistical approach to 130 cases of this malformation reported in Japan.
Results obtained as follows:
1) Pierre Robin syndrome found to be caused frequently by hereditary factors.
2) Many patients had not only the troubles of their mandible but also underdevelopment of their bodies at birth.
3) The symptoms were mainly difficulties in sucking and breathing. Therefore the patients tend to suffer from malnutrition.
4) Most of those babies had other additional malformation, especially cleft palate were observed in 54% of the cases.
5) Many of them died within 6 months after birth and the main causes of death were respiratory failure and pulmonary infections.

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In the treatment of patients with severe chronic bronchial asthma, administration of a large dose of adrenocortico-steroid hormon is necessary along with improvement of general status and oxygen supplement.
For the gradual decrease in dose and withdrawal of cortico-steroid, usefulness of the intra-muscular injection of triamcinolone acetonide has been recognized. We have used this drug in 13 patients, and we found positive effect and insignificant side effect. This appeared to be especially effective for the reduction in the total dose of steroid and its withdrawal.

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In the treatment of patients with severe chronic bronchial asthma, administration of a large dose of adrenocortico-steroid hormon is necessary along with improvement of general status and oxygen supplement.
For the gradual decrease in dose and withdrawal of cortico-steroid, usefulness of the intra-muscular injection of triamcinolone acetonide has been recognized. We have used this drug in 13 patients, and we found positive effect and insignificant side effect. This appeared to be especially effective for the reduction in the total dose of steroid and its withdrawal.

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One hundred and thirty-three patients with asthma were treated with auro-thioglucose (Romosol).
1) The treatment was continued for a period longer than one year in 31 of the 133 cases. Clinical effects were evaluated from changes in severity of asthmatic symptoms before and after the administration of auro-thioglucose. Good results were obtained in 23 (74.2%) of 31 cases, including excellent results in 9 (29.0%).
2) The effects of the drug appeared after the cumulative dose had amounted to approximately 300mg, to which it takes about 3 months from the start of the treatment. Clinical effects were manifest within 6 months in 15 cases (65%), and between 6 months and one year in 3 cases (35%). Increased effectiveness of the drug after the lapse of 6 months was observed in 4 cases (17%).
3) The level in plasma gold content at one week after an intramuscular injection showed a small amount of increment compared to the level of one week before in the cases with a less cumulative total of the drug, while in the cases with a cumulative total of more than 300 mg no increment in the level of plasma gold content was observed at each week measurement.
The plasma gold content were: when given 10 mg, up to 150 μg/dl; when given 25 mg, 150 to 250 μg/dl; when given 50 mg, 250 to 350 μg/dl.
4) The side effects observed were: proteinuria (mostly evanescent) in 44 %; skin disorders in 56 %; stomatitis in 9 %; that is, almost the same as previously repoted with other kinds of gold preparation. The treatment with this preparation had to be withdrawn because of the side effects in 21 cases (15 %).
5) Considering the side effects, the dosage of this preparation should be kept at the minimal effective amount, by evaluating clinical effects against accumulation of gold, and speed of excretion in individual cases.

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The bronchial asthma can be recognized clinically by episodes of breathlessness and wheezing. While many factors have been discussed about the cause of the bronchial asthma, hypersusceptibility of the asthma apparatus may be indispensable.
In this respect, following patients were observed as 64 cases of out-come asthmatics, 25 cases of admitted asthmatic patients and 16 cases of chronic bronchitis with asthmatic symptoms.
The immunological response including reaginic and non-reaginic types may play an important role to build such hypersusceptibility. In all asthmatic cases, however, immunological response may not always be detacteble clinically either on skin testing or after inhalation challenge. Another factors may be concerned with producing the hypersusceptibility in each asthmatic patient, such as hereditary, environmental, bodily and emotional factors and so on.
Treatment of the asthmatic patients must be indicated to eliminate the factors which have pro-duced the hypersusceptible asthma apparatus of each case. It may be different ways in individual asthmatics how they have acquired the hypersuscetibility. It may be necessary to analyse the factors in each case, and then physicians together with patients themselves have to strive to elimi-nate each hypersusceptibility from respective asthma apparatus for long duration.
It may be thought that the treatment of asthma must be pointed not only to the bronchial asthma as disease but also to the asthma patients as human beings.

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The number of patient of bronchial asthma, seen at allergic center of Beppu National Hospital since May 1965 to April 1970, is estimated to 447 persons (0.4 % of total O. P. T.).
We performed intra-dermal test for hypersensitivity on these patients, showed as follows.
Housedust;44 %
Ragweed;19 %
Cedar;15 %
Pinus densiflora;9 %
Pinus thrunbergii;7 %
Japanese mat;9 %
For negative patients to housedust antigen desensitization were given.
For positive patients “chloloquine phosphate”, or “paspat” were administered upto 1963 after that, “Solganal”, “histaglobin”etc, were given.
A total of 129 patients were observed about clinical effect over one year and the results were as follows:
improvement;
Desensitization;23 of 51 cases
Chloloquine Ph;3 of 21 cases
Solganal B;3 of 4 cases
Paspat;1 of 8 cases
Desensitization with histaglobin;6 of 27 cases
effective;
131 cases, reduced the term of attacks or clinical symptoms.
Recently we use more often “triamcinolone acetate” and derive good effects on acute asthma attack for the benefit of its long acting effect.

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A 53-years-old housewife was admitted with the complaints of fever, dyspnea and pain in the right chest. She was suspected to have pulmonary A-V fistula according to the clinical findings. The rentgenological examination, including tomography, revealed the dense abnormal shadow, which was finally diagnosed as A-V fistula by cardiac catheterization. However, because of bilateral in-volvement, the operation was not carried out.
On the establishment of diagnosis of the pulmonary A-V fistula, it can be stressed that the tomography, especially in the oblique position, is a simple and most valuable examination.

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