The author reviewed 48 cases of tumors of the male mammary gland treated at the Surgical Department of the Kanazawa National Hospital. The results are as follows:
1) Out of 48 caces, 2 cases (4.2 percent) were cancer, 43 cases (87.5 percent) gynecomastia, 1 case (2.1 percent) gynecomastia with fibroma and 3 cases (6.3 percent) fibroadenoma.
2) Average age of the patients is 75 years old for cancer, 45 years old for gynecomastia, 28 years old for gynecomastia with f ibroma and 56 years old for fibroadenoma.
3) Main complaints of the patients at their first visit our clinic were mostly local swelling. In addition to the swelling 7 cases of gynecomastia had pain. Tenderness was present in 18 cases of gynecomastia, 1 case of gynecomastia with fibroma and 2 cases of fibroadenoma.
4) Most of the patients sought medical aid within 6 months after noticing the disorder at which time the swelling was less than 3 cm.
5) All tumors were located at or near the center of the mammary gland. Roughly as many patients were affected on the right side as on the left, and there were 4 cases of gynecomastia involving both breasts.
6) No hereditary relation could be found.

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The appearance and type of healing process of dog and human periapical tissue were compared histopathologically. The periapical tissues of 77 dogs which were experimentally infected and 43 humans were used for this study.
The filling materials used were calcium hydroxide paste, triozinc paste (Hanazawa), and guttapercha. The results were as follows:
1) In both dog and human teeth, the appearance of the healing processes in the periapical tissues after canal treatment can be classified in the following three basic types;
a) Diminution and healing of chronic periodontitis.
b) Regeneration of periapical tissues injured by inflammation during treatment.
c) Closure of the apical foramen.
2) Perfect healing of periapical tissues of both after treatment could be classified in the following five basic types.
a) Foramen of the cicatrized root canal polyp. (Type 1)
b) Perfect encapsulation of the filling material pushed out from the apical end with fibrous connective tissues or new osteoid tissues. (Type 2)
c) Natural closing of the apical foramen with newly organized cementoid or osteoid tissues. (Type 3)
d) Replacement by healthy fibrous or marrow-like coarse connective tissue. (Type 4)
e) Active regeneration of the alveolar bone. (Type 5)
3) The frequency of appearance of each type was as follows;
The healing Process was less active in human than in dag teeth.

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Daily E. E. G.'s were performed on 18 guinea-pigs to determine their normal pattern. “Rebase”, a newly available synthetic resin, was used in order to obtain the recording from the same area on successive days.
Electrodes were placed on the dura and the measurement was made through periodic average, amplitude average, appearance percentage, and histogram of amplitude summation searching the main wave of E. E. G.
Obtained results are as follows.
1) A small numbers of the guinea-pigs showed normal E. E. G. successively.
2) The majority of the guinea-pigs generally demonstrated abnormal patterns.
3) A strong tendency was noticed in daily variation.
4) Based upon the above results the author is able to a classify the E. E. G, of the guinea-pigs as a) normal type: 3 cases (16.67%), b) abnormal type: 6 cases (33.33%) and c) variable type: 9 cases (50.00%).

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Among several theories on electrocardiographic abnormality of patients with pulmonary tuberculosis, the theory of myocardiac damage resulting from anoxemia has held an important position. Applying a simple method of oxygen inhalation the author studied on the electrocardiographic change of patients with pulmonary tuberculosis and the following results were obtained.
1) Condition of Test
a) ECG in supine position immediately after laying down.
b) ECG after 10 minutes of rest.
c) ECG after 20 minutes of oxygen inhalation.
d) ECG 20 minutes after censure of oxygen inhalation in supine position.
2) Conclusion
a) Electrocardiographic abnormalities of patients with pulmonary tuberculosis are pri-marily due to the myocardiac damage caused by anoxemia. We are able to differentiate clearly whether this myocardiac damage is reversible or irreversible.
b) The electrocardiographic change enables us to predict the seriousness of the pulmonary involvement.
C) The relation between reduction of vital capacity and electrocardiographic abnormalities are additional evidence in favor of myocardiac damage resulting from anoxemia.

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The capsule of nodular lesions resulting from the administration of anti-tuberculous agents r are commonly roentogenologically contracted successively and showed linear or scar-like shadow, in case that the caseous necrotic substance are removed.
However, in a small instances, cavitary shadows are reserved. It is considered that these phenomena are caused by the pathological variety of lesion. This report was made to investigate the pathological factors which give the influences on the attitude of capsule after the removal of necrotic substance of caseous lesion. The results were as follows.
1) The pathological changes of the capsule of caseous lesions were pararell to the internal changes of caseous variated portion and its inflammatory changes were intense when the softening processes of caseous tissue are reserved.
2) Drainage bronchi of the encapsulated lesions were commonly closed or showed high stenotic changes. But in the lesions showing the intensive inflammatory changes of capsule, these were patent.
3) Enlargement of the lesion due to its reactivation were commonly occured pen-capsular.
4) The indurative changes of surrounding lung tissue was rare in isolated encapsulated lesion, however, was common in the lesions having the numerous scattered lesions.
5) The transformation of capsule after removal of caseous tissue are controlled by change of capsule, existense of patency of drainage bronchi and the indurative change of the surrounding lung tissue.
6) The capsule is used to contracted and showed the scarlike shadow roentogenologically after the removal of caseous tissue does not exist and drainage bronchi are closed.
7) The capsule does not commonly contract and reserve cavitary shadow roentogenologically in case that fibrous changes of surrounding lung tissue are intense and drainage bronchi are patent.

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In 88 patients with pulmonary tuberculosis, the relation between the clinical symptoms and the eosinophil reduction rate was examined 4 hours after the subcutaneous administration of 0.1% adrenaline (0.3cc). The following results were obtained.
1) In patients with pulmonary tuberculosis the eosinophil reduction was lower and the variation was larger than in normal persons.
2) The more severe the pulmonary tuberculosis, the lower was the reduction and the larger was the variation.
3) In the cases of exsudative tuberculosis, the reduction was lower than in those of the proliferative type. In the mixed form, variation of reduction rate was somewhat at greater than in other types.
4) The positivity of the sputum for tubercle bacilli and the subjective symptoms has almost no connection with change of eosinophil count. Patients with a moderate or marked acceleration in erythrocyte sedimentation rate showed relatively large variation in the eosinophil count.
We are unable to ignore the fact that the eosinophil number variation caused by adrenaline has close relation with the adrenocortical function and the protective or adaptive mechanism of the body.
The above results obtained in pulmonary tuberculosis, a general consumtive disease, are indicating an evidence for this theory.

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The author has already made reports on the study of antibiotic resistance and phagetyping of staphylococcus pyogenes. Data has been obtained from 16 national hospitals in this country during August 1957 to July 1958. (The Iryo 13(3), 191, 1959)
Continuously observing their transition up to July 1959, the author compared them with the results reported previously. The methods of the experiment were the same as in the previous report. 811 strains were examined.
From latter half of the 2nd year, a test of resistance for Kanamycin (KM) was added. The resistance of 209P against KM is 0.1γ/ml.
The increased resistant strains in the 2nd year were PC 10μ/ml, SM 10γ/ml, CP 10γ/ml, and TC 100γ/ml, especially TC 100γ/ml increased remarkably.
We were unable to prove any increase on resistance of EM in the both years. About the difference in district, the resistant strains of PC increased noticeably at the hospitals in Kinki, Chugoku and Kyushu area, but the regional differences and the transition in ages of SM were not remarkable.
In the 2nd year, TC showed remarkable increase in resistance and this tendency was recognized in all parts of Japan. Out of 216 strains we could not recognize any resistance to KM. On the multi resistance, the combination of PC and TC showed a most remarkable increase, indicating an increase of 21.4% in the first year and 34.5% in the second year.
In the combination of PC, SM and TC, the resistance increased from 12.5% to 22.5%. This tendency was observed all over the country. Regarding the phagetyping, groups of unknown type increased. Of the typable groups, Group I was most common in Kanto, Group II in Kyushu, and Group III in Kinki area. We presume that the tendencies for this Group localization is related to antibiotic resistance.

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